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J. Freije · SciRah

Researcher profile · Semantic Scholar

J. Freije

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J. Freije — researcher profile on SciRah

h-index: 34
Works: 58
Citations: 5,572

Most-cited papers

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
J. Freije, I. Diez-Itza, M. Balbín, Luis M. Sánchez +3 more
1994Journal of Biological Chemistry777 citations
Semantic Scholar
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Clea Bárcena, R. Valdés-Mas, Pablo Mayoral, Cecilia Garabaya +13 more
2019Nature Medicine575 citations Open access
Semantic Scholar
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
I. Varela, J. Cadiñanos, A. M. Pendás, A. Gutiérrez-Fernández +9 more
2005Nature489 citations
Semantic Scholar
Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
F. Osorio, C. Navarro, J. Cadiñanos, Isabel C. Lopez-Mejia +14 more
2011Science Translational Medicine428 citations Open access
Semantic Scholar
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
I. Varela, Sandrine Pereira, Alejandro P Ugalde, C. Navarro +10 more
2008Nature Medicine422 citations Open access
Semantic Scholar
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.
C. Navarro, J. Cadiñanos, A. De Sandre-Giovannoli, R. Bernard +13 more
2005Human Molecular Genetics292 citations
Semantic Scholar
A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.
N. J. MacDonald, Á. J. De la Rosa, M. Benedict, J. Freije +2 more
1993Journal of Biological Chemistry213 citations Open access
Semantic Scholar
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
J. Espada, I. Varela, Ignacio Flores, Alejandro P Ugalde +7 more
2008Journal of Cell Biology173 citations Open access
Semantic Scholar
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
Clea Bárcena, Pedro M. Quirós, S. Durand, Pablo Mayoral +8 more
2018Cell Reports160 citations Open access
Semantic Scholar
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
G. Mariño, Alejandro P Ugalde, Natalia Salvador-Montoliu, I. Varela +5 more
2008Human Molecular Genetics155 citations Open access
Semantic Scholar
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome
Olaya Santiago-Fernández, F. Osorio, V. Quesada, Francisco Rodríguez +8 more
2019Nature Medicine151 citations Open access
Semantic Scholar
Protein Kinase C θ Is Highly Expressed in Gastrointestinal Stromal Tumors But Not in Other Mesenchymal Neoplasias
P. Blay, A. Astudillo, J. Buesa, E. Campo +10 more
2004Clinical Cancer Research148 citations Open access
Semantic Scholar
Site-directed Mutation of Nm23-H1
J. Freije, P. Blay, N. J. MacDonald, R. E. Manrow +1 more
1997Journal of Biological Chemistry139 citations Open access
Semantic Scholar
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.
Silvia Álvarez-Díaz, N. Valle, J. García, C. Peña +6 more
2009Journal of Clinical Investigation128 citations Open access
Semantic Scholar
ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism
S. Cal, J. Freije, José M. López, Y. Takada +1 more
2000121 citations Open access
Semantic Scholar
Site-directed Mutagenesis of nm23-H1
N. J. MacDonald, J. Freije, M. Stracke, R. E. Manrow +1 more
1996Journal of Biological Chemistry93 citations Open access
Semantic Scholar
Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions
C. L. Ramirez, J. Cadiñanos, I. Varela, J. Freije +1 more
2006Cellular and Molecular Life Sciences83 citations Open access
Semantic Scholar
The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
Xurde M. Caravia, Víctor Fanjul, Eduardo Oliver, David Roiz-Valle +16 more
2018PLoS Biology70 citations Open access
Semantic Scholar
Proteomic Profiling of Adipose Tissue from Zmpste24−/− Mice, a Model of Lipodystrophy and Premature Aging, Reveals Major Changes in Mitochondrial Function and Vimentin Processing*
J. Peinado, Pedro M. Quirós, M. R. Pulido, G. Mariño +5 more
2011Molecular & Cellular Proteomics69 citations Open access
Semantic Scholar
Nm23 and tumour metastasis: basic and translational advances.
J. Freije, N. J. MacDonald, Patricia S. Steeg
1998Biochemical Society Symposium63 citations
Semantic Scholar
Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.
C. López-Otín, J. Freije, Francisco Parra, Enrique Méndez +1 more
1990Virology58 citations
Semantic Scholar
Predict7, a program for protein structure prediction
R. S. Cármenes, J. Freije, M. M. Molina, J. M. Martín
1989Biochemical and Biophysical Research Communications - BBRC56 citations Open access
Semantic Scholar
Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain)
P. Blay, I. Santamaría, A. Pitiot, M. Luque +6 more
2013BMC Cancer53 citations Open access
Semantic Scholar
AtFACE-2, a functional Prenylated Protein Protease from Arabidopsis thaliana Related to Mammalian Ras-converting Enzymes*
J. Cadiñanos, I. Varela, Daniel A. Mandel, Walter K. Schmidt +3 more
2003Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
O. Aguilera, J. González-Sancho, S. Zazo, R. Rincón +20 more
2015OncoTarget50 citations Open access
Semantic Scholar
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism.
S. Cal, J. Freije, J. López, Y. Takada +1 more
2000Molecular Biology of the Cell48 citations
Semantic Scholar
A gene homologous to topoisomerase II in African swine fever virus.
R. Garcia-Beato, J. Freije, C. López-Otín, R. Blasco +2 more
1992Virology48 citations
Semantic Scholar
USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer*
Julia M. Fraile, Eusebio Manchado, A. Lujambio, V. Quesada +5 more
2017Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Reprogramming aging and progeria.
J. Freije, C. López-Otín
2012Current Opinion in Cell Biology45 citations Open access
Semantic Scholar
Nm23/PuF Does Not Directly Stimulate Transcription through the CT Element in Vivo *
E. Michelotti, S. Sanford, J. Freije, N. J. MacDonald +2 more
1997Journal of Biological Chemistry40 citations Open access
Semantic Scholar
The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis
Julia M. Fraile, Diana Campos-Iglesias, Francisco Rodríguez, Y. Español +1 more
2016OncoTarget38 citations Open access
Semantic Scholar
A functional link between the tumour suppressors ARF and p33ING1
Laura Ferrando González, J. Freije, S. Cal, C. López-Otín +2 more
2006Oncogene36 citations Open access
Semantic Scholar
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma
I. Centeno, P. Blay, I. Santamaría, A. Astudillo +8 more
2011BMC Cancer35 citations Open access
Semantic Scholar
Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines
J. Freije, J. Lawrence, M. Hollingshead, Á. J. De la Rosa +5 more
1997Nature Medicine34 citations
Semantic Scholar
Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice
Julia M. Fraile, Diana Campos-Iglesias, Francisco Rodríguez, A. Astudillo +8 more
2017Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Amino acid sequence and structural properties of protein p12, an African swine fever virus attachment protein
A. Alcamí, Ana Angulo, Carlos López-Otı́n, M. Muñoz +3 more
1992Journal of Virology32 citations Open access
Semantic Scholar
Mapping and sequence of the gene encoding protein p17, a major African swine fever virus structural protein.
Carmen Simón-Mateo, J. Freije, G. Andrés, C. López-Otín +1 more
1995Virology27 citations Open access
Semantic Scholar
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
J. Cadiñanos, Walter K. Schmidt, A. Fueyo, I. Varela +2 more
2003Biochemical Journal26 citations Open access
Semantic Scholar
Differential gene expression in tumor metastasis: Nm23.
J. Freije, N. J. MacDonald, Patricia S. Steeg
1996Current Topics in Microbiology and Immunology24 citations
Semantic Scholar
Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas
Julia M. Fraile, G. Ordóñez, Pedro M. Quirós, A. Astudillo +5 more
2013OncoTarget12 citations Open access
Semantic Scholar
Structure and expression inE. coli of the gene coding for protein p10 of African swine fever virus
M. Muñoz, J. Freije, Margarita Salas, E. Viñuela +1 more
2005Archives of Virology12 citations
Semantic Scholar
Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach
F. Osorio, Jorge de la Rosa, J. Freije
2013Cell Communication and Signaling10 citations Open access
Semantic Scholar
Structure and expression in E. coli of the gene coding for protein p10 of African swine fever virus.
M. Muñoz, J. Freije, M. Salas, E. Viñuela +1 more
1993Archives of Virology8 citations
Semantic Scholar
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
Miriam Fanjul-Fernández, Alicia R. Folgueras, A. Fueyo, M. Balbín +5 more
2018Journal of Biological Chemistry4 citations Open access
Semantic Scholar
Deubiquitination in cancer stem cells
Julia M. Fraile, Diana Campos-Iglesias, J. Freije
2017Aging3 citations Open access
Semantic Scholar
The novel tumor suppressor AIRAPL regulates IGF1R proteostasis
F. Osorio, J. Freije, C. López-Otín
2016Cell Cycle2 citations Open access
Semantic Scholar
Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein.
A. Fueyo, J. Uría, J. Freije, C. López-Otín
1994Gene2 citations
Semantic Scholar
A general method to cleave a known DNA sequence at any site.
J. Freije, M. Muñoz, C. López-Otín, E. Viñuela
1991BioTechniques2 citations
Semantic Scholar
FAβ-gal: an automated fluorescence-based quantification of the senescence-associated beta-galactosidase X-gal assay
Antonio G. Tartiere, David Roiz-Valle, Y. Español, Gabriel Bretones +2 more
2026bioRxiv1 citations Open access
Semantic Scholar
Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach
F. Osorio, Jorge de la Rosa, J. Freije
2013Cell Communication and Signaling1 citations Open access
Semantic Scholar

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J. Cadiñanos×9
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P. Steeg — researcher profile on SciRah