Researcher profile · Semantic Scholar

Eusebio Manchado

h-index: 19
Works: 30
Citations: 3,724

Most-cited papers

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti +8 more
2014Nature626 citations Open access
Semantic Scholar
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling
Susann Weissmueller, Eusebio Manchado, M. Saborowski, John P. Morris +14 more
2014Cell453 citations Open access
Semantic Scholar
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
I. García-Higuera, Eusebio Manchado, P. Dubus, M. Cañamero +3 more
2008Nature Cell Biology384 citations Open access
Semantic Scholar
A combinatorial strategy for treating KRAS mutant lung cancer
Eusebio Manchado, Susann Weissmueller, John P. Morris, Chi-Chao Chen +10 more
2016Nature383 citations Open access
Semantic Scholar
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
M. Ruscetti, J. Leibold, M. Bott, M. Fennell +16 more
2018Science372 citations Open access
Semantic Scholar
Killing cells by targeting mitosis
Eusebio Manchado, Maria Guillamot, Marcos Malumbres
2012Cell Death and Differentiation237 citations Open access
Semantic Scholar
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
K. O'Rourke, Evangelia Loizou, Geulah Livshits, Emma M Schatoff +11 more
2017Nature Biotechnology215 citations Open access
Semantic Scholar
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Eusebio Manchado, Maria Guillamot, G. de Cárcer, M. Eguren +6 more
2010Cancer Cell201 citations Open access
Semantic Scholar
Kinase regulation of Human MHC Class I Molecule Expression on Cancer Cells
E. Brea, C. Oh, Eusebio Manchado, S. Budhu +14 more
2016Cancer immunology research154 citations Open access
Semantic Scholar
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions.
Eusebio Manchado, M. Eguren, Marcos Malumbres
2010Biochemical Society Transactions120 citations
Semantic Scholar
Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice
Lukas E. Dow, Z. Nasr, M. Saborowski, S. Ebbesen +5 more
2014PLoS ONE91 citations Open access
Semantic Scholar
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer
Mónica Álvarez-Fernández, María Sanz-Flores, Belén Sanz-Castillo, María Salazar-Roa +10 more
2017Cell Death and Differentiation85 citations Open access
Semantic Scholar
Non-mitotic functions of the Anaphase-Promoting Complex.
M. Eguren, Eusebio Manchado, Marcos Malumbres
2011Seminars in Cell and Developmental Biology77 citations
Semantic Scholar
SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors
Hengyu Lu, Chen Liu, Roberto Velazquez, Hong-Yun Wang +12 more
2019Molecular Cancer Therapeutics74 citations Open access
Semantic Scholar
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors
M. Eguren, E. Porlan, Eusebio Manchado, I. García-Higuera +3 more
2013Nature Communications50 citations Open access
Semantic Scholar
USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer*
Julia M. Fraile, Eusebio Manchado, A. Lujambio, V. Quesada +5 more
2017Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Maria Guillamot, Eusebio Manchado, Massimo Chiesa, G. Gómez-López +3 more
2011Scientific Reports39 citations Open access
Semantic Scholar
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Zhu-Xuan Li, Xue-Qian Zhuang, Chun-Hao Pan, Yan Yan +13 more
2023bioRxiv35 citations Open access
Semantic Scholar
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Zhu-Xuan Li, Xue-Qian Zhuang, Chun-Hao Pan, Yan Yan +13 more
2023Cancer Discovery28 citations Open access
Semantic Scholar
INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas
Ahmed M. O. Elbatsh, Ali Amin-Mansour, Anne Haberkorn, C. Textor +18 more
2024Nature Cancer18 citations Open access
Semantic Scholar
A Pipeline for Drug Target Identification and Validation
Eusebio Manchado, Chun-Hao Huang, N. Tasdemir, D. Tschaharganeh +2 more
2017Cold Spring Harbor Symposia on Quantitative Biology18 citations Open access
Semantic Scholar
Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction.
Matthew Jones, P. Grosche, A. Floersheimer, J. André +12 more
2023Biochemistry6 citations
Semantic Scholar
Promoter-driven overexpression in Chromobacterium vaccinii facilitates access to FR900359 and yields novel low abundance analogs.
D. Pistorius, Kathrin Buntin, E. Weber, Etienne Richard +15 more
2021Chemistry6 citations
Semantic Scholar
Corrigendum: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti +8 more
2015Nature6 citations Open access
Semantic Scholar
Abstract A44: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS-mutant tumors treated with MEK inhibitors
Hengyu Lu, Chen Liu, Roberto Velazquez, Hong-Yun Wang +12 more
2020Poster Presentations - Proffered Abstracts1 citations
Semantic Scholar
Abstract 954: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitors
Hengyu Lu, Chen Liu, Roberto Velazquez, Hong-Yun Wang +12 more
2019Molecular and Cellular Biology / Genetics1 citations
Semantic Scholar
Abstract C54: Pdgfrb is an essential mediator of p53(mut)-driven metastasis in pancreatic cancer
Susann Weissmueller, M. Saborowski, Eusebio Manchado, V. Thapar +1 more
20131 citations
Semantic Scholar
Targeted therapy-induced senescence enhances immune surveillance of KRAS mutant lung cancers
M. Ruscetti, J. Leibold, M. Bott, M. Shields +13 more
20180 citations
Semantic Scholar
Modeling lung cancer with CRISPR/Cas9
Joana A. Vidigal, Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion +7 more
20160 citations Open access
Semantic Scholar
Abstract 4899: The regulation by kinases of the expression of human major histocompatibility class I molecules
E. Brea, C. Oh, Eusebio Manchado, Ron S. Gejman +5 more
20160 citations
Semantic Scholar

Anne Haberkorn

×5

J. Engelman×4

M. Eguren×4

Danilo Maddalo×3

Carla P. Concepcion×3

Ciro Bonetti×3

Joana A. Vidigal×3

Yoon-chi Han×3