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C. Ockenhouse · SciRah

Researcher profile · Semantic Scholar

C. Ockenhouse

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C. Ockenhouse — researcher profile on SciRah

h-index: 59
Works: 175
Citations: 11K

Most-cited papers

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
D. Neafsey, M. Juraska, T. Bedford, D. Benkeser +59 more
2015New England Journal of Medicine386 citations Open access
Semantic Scholar
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans
D. Kazmin, H. Nakaya, Eva K. Lee, Matthew J. Johnson +13 more
2017Proceedings of the National Academy of Sciences of the United States of America264 citations Open access
Semantic Scholar
Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study.
J. Regules, Susan B. Cicatelli, Jason Bennett, Kristopher M. Paolino +32 more
2016Journal of Infectious Diseases212 citations
Semantic Scholar
Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac – PROFISCOV: A structured summary of a study protocol for a randomised controlled tr
Ricardo Palacios, E. G. Patiño, Roberta de Oliveira Piorelli, M. Conde +7 more
2020Trials184 citations Open access
Semantic Scholar
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection
Michael T. White, P. Bejon, A. Olotu, J. Griffin +4 more
2013PLoS ONE174 citations Open access
Semantic Scholar
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
B. Pybus, S. Marcsisin, Xian-Nu Jin, G. Deye +10 more
2013Malaria Journal172 citations Open access
Semantic Scholar
Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention.
D. Chandramohan, I. Zongo, I. Sagara, M. Cairns +26 more
2021New England Journal of Medicine171 citations Open access
Semantic Scholar
Multiplex qPCR for Detection and Absolute Quantification of Malaria
E. Kamau, Saba Alemayehu, Karla Feghali, D. Saunders +1 more
2013PLoS ONE150 citations Open access
Semantic Scholar
Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
D. Oyen, J. Torres, U. Wille-Reece, C. Ockenhouse +8 more
2017Proceedings of the National Academy of Sciences of the United States of America143 citations Open access
Semantic Scholar
Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria.
J. Bennett, B. Pybus, A. Yadava, Donna M. Tosh +5 more
2013New England Journal of Medicine140 citations
Semantic Scholar
DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
I. Chuang, M. Sedegah, S. Cicatelli, M. Spring +42 more
2013PLoS ONE139 citations Open access
Semantic Scholar
First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.
M. Spring, J. Murphy, R. Nielsen, M. Dowler +24 more
2013Vaccine134 citations
Semantic Scholar
Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults
Jessica A. Chichester, B. Green, R. M. Jones, Y. Shoji +7 more
2018Vaccine110 citations Open access
Semantic Scholar
Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy
J. Bennett, A. Yadava, Donna M. Tosh, J. Sattabongkot +22 more
2016PLoS Neglected Tropical Diseases109 citations Open access
Semantic Scholar
Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01.
R. Payne, Kathryn H. Milne, S. Elias, N. Edwards +34 more
2016Journal of Infectious Diseases104 citations Open access
Semantic Scholar
Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP
T. Rampling, K. Ewer, Georgina S. Bowyer, C. Bliss +27 more
2016Journal of Infectious Diseases98 citations Open access
Semantic Scholar
Controlled human malaria infection.
M. Spring, M. Polhemus, C. Ockenhouse
2014Journal of Infectious Diseases89 citations
Semantic Scholar
The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity
S. Chaudhury, C. Ockenhouse, J. Regules, Sheetij Dutta +5 more
2016Malaria Journal75 citations Open access
Semantic Scholar
Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity
Pei-Fang Sun, Josefina García, G. Comach, M. Vahey +13 more
2013PLoS Neglected Tropical Diseases72 citations Open access
Semantic Scholar
IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice
R. Schwenk, M. Debot, Michael D. Porter, J. Nikki +6 more
2014PLoS ONE71 citations Open access
Semantic Scholar
Comparative evaluation of published real-time PCR assays for the detection of malaria following MIQE guidelines
Saba Alemayehu, Karla Feghali, J. Cowden, J. Komisar +2 more
2013Malaria Journal71 citations Open access
Semantic Scholar
A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model
Isaie J. Reuling, Lisanne A. van de Schans, L. Coffeng, K. Lanke +17 more
2017eLife60 citations Open access
Semantic Scholar
Development of a Chimeric Plasmodium berghei Strain Expressing the Repeat Region of the P. vivax Circumsporozoite Protein for In Vivo Evaluation of Vaccine Efficacy
Diego A. Espinosa, A. Yadava, E. Angov, Paul L Maurizio +2 more
2013Infection and Immunity57 citations Open access
Semantic Scholar
Efficacy of RTS,S/AS01E malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5–17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial
Aaron M. Samuels, D. Ansong, S. Kariuki, S. Adjei +22 more
2022Lancet. Infectious Diseases (Print)51 citations Open access
Semantic Scholar
Transgenic Parasites Stably Expressing Full-Length Plasmodium falciparum Circumsporozoite Protein as a Model for Vaccine Down-Selection in Mice Using Sterile Protection as an Endpoint
Michael D. Porter, Jennifer Nicki, Christopher D Pool, M. Debot +12 more
2013Clinical and Vaccine Immunology51 citations Open access
Semantic Scholar
Seasonal vaccination with RTS,S/AS01E vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial.
A. Dicko, J. Ouédraogo, I. Zongo, I. Sagara +32 more
2023Lancet. Infectious Diseases (Print)49 citations Open access
Semantic Scholar
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
P. Griffin, C. Pasay, S. Elliott, S. Sekuloski +9 more
2016PLoS Neglected Tropical Diseases48 citations Open access
Semantic Scholar
Computational and Experimental Validation of B and T-Cell Epitopes of the In Vivo Immune Response to a Novel Malarial Antigen
E. Bergmann-Leitner, S. Chaudhury, N. Steers, M. Sabato +4 more
2013PLoS ONE48 citations Open access
Semantic Scholar
Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP
T. Rampling, K. Ewer, Georgina S. Bowyer, N. Edwards +31 more
2018npj Vaccines47 citations Open access
Semantic Scholar
Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidates
Shwu-Maan Lee, Chia-Kuei Wu, Jordan Plieskatt, D. McAdams +3 more
2016Malaria Journal44 citations Open access
Semantic Scholar
Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults
Saskia C. van der Boor, M. Smit, Stijn W. van Beek, J. Ramjith +18 more
2022Lancet. Infectious Diseases (Print)42 citations Open access
Semantic Scholar
The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants
A. Ajua, B. Lell, S. Agnandji, Kwaku Poku Asante +13 more
2015Malaria Journal42 citations Open access
Semantic Scholar
Controlled Human Infection Models To Accelerate Vaccine Development
R. Choy, A. Bourgeois, C. Ockenhouse, Richard Walker +2 more
2022Clinical Microbiology Reviews39 citations Open access
Semantic Scholar
Comparison of the immune responses induced by soluble and particulate Plasmodium vivax circumsporozoite vaccine candidates formulated in AS01 in rhesus macaques.
Y. Vanloubbeeck, S. Pichyangkul, B. Bayat, K. Yongvanitchit +6 more
2013Vaccine37 citations
Semantic Scholar
A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults
James E. Moon, C. Ockenhouse, J. Regules, J. Vekemans +37 more
2020Journal of Infectious Diseases36 citations Open access
Semantic Scholar
Protective Efficacy of a Plasmodium vivax Circumsporozoite Protein-Based Vaccine in Aotus nancymaae Is Associated with Antibodies to the Repeat Region
A. Yadava, C. E. Hall, Joann S. Sullivan, Douglas Nace +4 more
2014PLoS Neglected Tropical Diseases35 citations Open access
Semantic Scholar
Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites
Sergei Biryukov, E. Angov, Mary E. Landmesser, M. Spring +2 more
2016EBioMedicine30 citations Open access
Semantic Scholar
Sample-ready multiplex qPCR assay for detection of malaria
E. Kamau, Saba Alemayehu, Karla Feghali, D. Juma +5 more
2014Malaria Journal29 citations Open access
Semantic Scholar
Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naïve Subjects at a New Facility for Sporozoite Challenge
A. Talley, S. Healy, O. Finney, S. Murphy +11 more
2014PLoS ONE29 citations Open access
Semantic Scholar
Measurement of parasitological data by quantitative real-time PCR from controlled human malaria infection trials at the Walter Reed Army Institute of Research
E. Kamau, Saba Alemayehu, Karla Feghali, J. Komisar +3 more
2014Malaria Journal28 citations Open access
Semantic Scholar
Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS,S/AS01 vaccination
H. Thompson, A. Hogan, P. Walker, Michael T. White +3 more
2020Vaccine25 citations Open access
Semantic Scholar
An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria
Isaie J. Reuling, A. Mendes, G. D. de Jong, A. Fabra-García +15 more
2020Science Translational Medicine25 citations
Semantic Scholar
The frontline of controlled human malaria infections: A report from the controlled human infection models Workshop in Leiden University Medical Centre 5 May 2016.
M. Roestenberg, B. Mordmüller, C. Ockenhouse, An-Nie X. Y. Mo +2 more
2017Vaccine25 citations Open access
Semantic Scholar
A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection
M. Alkema, Isaie J. Reuling, G. D. de Jong, K. Lanke +11 more
2020Journal of Infectious Diseases24 citations Open access
Semantic Scholar
Resurgent and delayed malaria
B. Greenwood, I. Zongo, A. Dicko, D. Chandramohan +2 more
2022Malaria Journal22 citations Open access
Semantic Scholar
Comprehensive Data Integration Approach to Assess Immune Responses and Correlates of RTS,S/AS01-Mediated Protection From Malaria Infection in Controlled Human Malaria Infection Trials
W. Young, L. Carpp, S. Chaudhury, J. Regules +21 more
2021Frontiers in Big Data19 citations Open access
Semantic Scholar
Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1
R. Schwenk, Glenna Banania, J. Epstein, Yohan Kim +10 more
2013Malaria Journal19 citations Open access
Semantic Scholar
Electronic Supplementary Material for: "Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections"
A. Early, M. Lievens, B. MacInnis, C. Ockenhouse +18 more
201818 citations
Semantic Scholar
Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomized safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine, and primaquine in healthy Thai adult volunteers
L. von Seidlein, B. Hanboonkunupakarn, P. Jittamala, Pongphaya Pongsuwan +18 more
2019Human Vaccines & Immunotherapeutics15 citations Open access
Semantic Scholar
A phase IIA extension study evaluating the effect of booster vaccination with a fractional dose of RTS,S/AS01E in a controlled human malaria infection challenge.
James E. Moon, Melissa E. Greenleaf, J. Regules, M. Debois +13 more
2021Vaccine14 citations Open access
Semantic Scholar

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