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M. Sedegah · SciRah

Researcher profile · Semantic Scholar

M. Sedegah

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M. Sedegah — researcher profile on SciRah

h-index: 48
Works: 160
Citations: 11K

Most-cited papers

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
R. Seder, Lee-Jah Chang, Mary E. Enama, Kathryn L. Zephir +38 more
2013Science779 citations
Semantic Scholar
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
S. Hoffman, Lucy M L Goh, T. Luke, I. Schneider +13 more
2002Journal of Infectious Diseases763 citations
Semantic Scholar
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
J. Carlton, Samuel V. Angiuoli, Bernard B. Suh, Taco W. A. Kooij +40 more
2002Nature728 citations Open access
Semantic Scholar
Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity
J. Epstein, K. Tewari, K. Lyke, B. K. Sim +30 more
2011Science531 citations
Semantic Scholar
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
Stephen L. Hoffman, P. Billingsley, Eric R. James, Adam Richman +17 more
2010Human Vaccines325 citations Open access
Semantic Scholar
Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers.
Thong P. Le, K. Coonan, R. Hedstrom, Y. Charoenvit +10 more
2000Vaccine253 citations
Semantic Scholar
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.
J. Epstein, Kristopher M. Paolino, T. L. Richie, M. Sedegah +43 more
2017JCI Insight223 citations Open access
Semantic Scholar
Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice
R. Gramzinski, D. Doolan, M. Sedegah, H. Davis +2 more
2001Infection and Immunity166 citations Open access
Semantic Scholar
DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
I. Chuang, M. Sedegah, S. Cicatelli, M. Spring +42 more
2013PLoS ONE139 citations Open access
Semantic Scholar
Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update.
J. Epstein, Suchitra Rao, F. Williams, D. Freilich +6 more
2007Journal of Infectious Diseases129 citations
Semantic Scholar
Plasmid Vaccine Expressing Granulocyte-Macrophage Colony-Stimulating Factor Attracts Infiltrates Including Immature Dendritic Cells into Injected Muscles1
D. Haddad, J. Ramprakash, M. Sedegah, Y. Charoenvit +4 more
2000Journal of Immunology120 citations Open access
Semantic Scholar
Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component
C. Tamminga, M. Sedegah, David Regis, I. Chuang +38 more
2011PLoS ONE81 citations Open access
Semantic Scholar
Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults
C. F. Ockenhouse, J. Regules, Donna M. Tosh, J. Cowden +30 more
2015PLoS ONE78 citations Open access
Semantic Scholar
Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults
M. Sedegah, C. Tamminga, S. Mcgrath, Brent L. House +30 more
2011PLoS ONE73 citations Open access
Semantic Scholar
Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice
K. Mallory, Justin A. Taylor, Xiaoyan Zou, Ishita N. Waghela +13 more
2021npj Vaccines70 citations Open access
Semantic Scholar
A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques
Lan Chen, D. Ewing, H. Subramanian, Karla Block +6 more
2007Journal of Virology63 citations Open access
Semantic Scholar
Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes
M. Sedegah, M. Hollingdale, Fouzia Farooq, Harini Ganeshan +16 more
2014PLoS ONE58 citations Open access
Semantic Scholar
Persistence of Protective Immunity to Malaria Induced by DNA Priming and Poxvirus Boosting: Characterization of Effector and Memory CD8+-T-Cell Populations
M. Sedegah, G. Brice, W. Rogers, D. Doolan +8 more
2002Infection and Immunity51 citations Open access
Semantic Scholar
A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates
Neal N. Padte, Mar Boente-Carrera, Chasity D. Andrews, J. McManus +13 more
2013PLoS ONE50 citations Open access
Semantic Scholar
Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
D. Dodoo, M. Hollingdale, Dorothy Anum, K. Koram +16 more
2011Malaria Journal49 citations Open access
Semantic Scholar
Investigating the prevalence of transfusion transmission of Plasmodium within a hyperendemic blood donation system
Graham Freimanis, M. Sedegah, S. Owusu-Ofori, Sanjai Kumar +1 more
2013Transfusion47 citations
Semantic Scholar
Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA
T. Richie, Y. Charoenvit, Ruo-Bing Wang, J. Epstein +31 more
2012Human Vaccines & Immunotherapeutics46 citations Open access
Semantic Scholar
Recombinant Attenuated Toxoplasma gondii Expressing the Plasmodium yoelii Circumsporozoite Protein Provides Highly Effective Priming for CD8+ T Cell-Dependent Protective Immunity Against Malaria1
H. Charest, M. Sedegah, G. Yap, R. Gazzinelli +3 more
2000Journal of Immunology43 citations Open access
Semantic Scholar
Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites
M. Sedegah, W. Weiss, Stephen L. Hoffman
2007Parasite immunology (Print)42 citations Open access
Semantic Scholar
Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development
J. Aguiar, Jessica S. Bolton, Joyce Wanga, J. Sacci +13 more
2015PLoS ONE41 citations Open access
Semantic Scholar
Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection
C. Tamminga, M. Sedegah, S. Maiolatesi, C. Fedders +29 more
2013Human Vaccines & Immunotherapeutics41 citations Open access
Semantic Scholar
Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF
M. Sedegah, Y. Charoenvit, J. Aguiar, J. Sacci +12 more
2004Genes and Immunity41 citations
Semantic Scholar
Polymerase chain reaction–based tests for pan‐species and species‐specific detection of human Plasmodium parasites
B. Mahajan, Hong Zheng, P. T. Pham, M. Sedegah +9 more
2012Transfusion40 citations
Semantic Scholar
Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation
K. Kusi, S. Bosomprah, D. Dodoo, Eric Kyei-Baafour +6 more
2014Malaria Journal38 citations Open access
Semantic Scholar
Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)
M. Sedegah, Yohan Kim, Harini Ganeshan, Jun Huang +14 more
2013Malaria Journal38 citations Open access
Semantic Scholar
Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates
K. Limbach, J. Aguiar, K. Gowda, N. Patterson +4 more
2011Malaria Journal37 citations Open access
Semantic Scholar
A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults
James E. Moon, C. Ockenhouse, J. Regules, J. Vekemans +37 more
2020Journal of Infectious Diseases36 citations Open access
Semantic Scholar
Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
M. Sedegah, Yohan Kim, Bjoern Peters, S. Mcgrath +19 more
2010Malaria Journal36 citations Open access
Semantic Scholar
Successful Induction of CD8 T Cell-Dependent Protection Against Malaria by Sequential Immunization with DNA and Recombinant Poxvirus of Neonatal Mice Born to Immune Mothers 1
M. Sedegah, M. Belmonte, J. Epstein, C. Siegrist +5 more
2003Journal of Immunology33 citations Open access
Semantic Scholar
Development of whole sporozoite malaria vaccines
M. Hollingdale, M. Sedegah
2017Expert Review of Vaccines32 citations
Semantic Scholar
Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines.
G. Brice, C. Dobaño, M. Sedegah, Maureen E. Stefaniak +4 more
2007Microbes and infection32 citations Open access
Semantic Scholar
Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.
E. K. Maina, C. Z. Abana, E. Bukusi, M. Sedegah +2 more
2016Cytokine30 citations Open access
Semantic Scholar
Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity
Bradley W. Hickey, J. Lumsden, S. Reyes, M. Sedegah +22 more
2016Malaria Journal27 citations Open access
Semantic Scholar
A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230.
Sarah L. Fanning, Beata Czesny, M. Sedegah, D. Carucci +3 more
2003Vaccine27 citations
Semantic Scholar
In vitro production of infectious Plasmodium falciparum sporozoites
A. Eappen, Tao Li, M. Marquette, S. Chakravarty +24 more
2022Nature25 citations
Semantic Scholar
Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines.
M. Sedegah, W. Rogers, A. Belmonte, M. Belmonte +7 more
2006Vaccine25 citations
Semantic Scholar
IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents
Bradley W. Hickey, Nimfa Teneza-mora, J. Lumsden, S. Reyes +30 more
2020PLoS ONE23 citations Open access
Semantic Scholar
Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults
Dorothy Anum, K. Kusi, Harini Ganeshan, M. Hollingdale +12 more
2015Malaria Journal22 citations Open access
Semantic Scholar
T-cell responses against Malaria: Effect of parasite antigen diversity and relevance for vaccine development.
O. N. Nlinwe, K. Kusi, B. Adu, M. Sedegah
2018Vaccine21 citations
Semantic Scholar
Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity.
C. Dobaño, M. Sedegah, W. Rogers, Sanjai Kumar +3 more
2009Experimental parasitology21 citations
Semantic Scholar
Multidose Priming and Delayed Boosting Improve PfSPZ Vaccine Efficacy against Heterologous P. falciparum Controlled Human Malaria Infection.
K. Lyke, Alexandra Singer, Andrea A. Berry, S. Reyes +24 more
2020Clinical Infectious Diseases20 citations
Semantic Scholar
Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice
R. Gramzinski, D. Doolan, M. Sedegah, H. Davis +2 more
2002Infection and Immunity20 citations Open access
Semantic Scholar
Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1
R. Schwenk, Glenna Banania, J. Epstein, Yohan Kim +10 more
2013Malaria Journal19 citations Open access
Semantic Scholar
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infection
M. Sedegah, C. Porter, Emilie Goguet, Harini Ganeshan +22 more
2022PLoS ONE18 citations Open access
Semantic Scholar
A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults
M. J. Sklar, S. Maiolatesi, N. Patterson, M. Sedegah +40 more
2021PLoS ONE18 citations Open access
Semantic Scholar

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T. Richie×23
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T. Richie — researcher profile on SciRah
J. Epstein×20
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J. Epstein — researcher profile on SciRah
M. Belmonte×18
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M. Belmonte — researcher profile on SciRah
S. Hoffman×16
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S. Hoffman — researcher profile on SciRah

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M. Hollingdale — researcher profile on SciRah

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D. Doolan — researcher profile on SciRah

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Harini Ganeshan — researcher profile on SciRah

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D. Carucci — researcher profile on SciRah

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E. Abot — researcher profile on SciRah

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Jun Huang — researcher profile on SciRah

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C. Tamminga — researcher profile on SciRah