H. Loke

Most-cited papers

1. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.

   J. Brownell, M. Sintchak, James M. Gavin, H. Liao +23 more

   2010Molecules and Cells457 citations Open access

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2. Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

   M. Milhollen, Michael P. Thomas, U. Narayanan, T. Traore +17 more

   2012Cancer Cell114 citations Open access

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3. Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

   Jesse J. Chen, C. Tsu, James M. Gavin, M. Milhollen +12 more

   2011Journal of Biological Chemistry83 citations Open access

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4. The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site.

   Xiang-Shi Tan, H. Loke, Shawn B Fitch, P. Lindahl

   2005Journal of the American Chemical Society51 citations

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5. Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6*

   James M. Gavin, Jesse J. Chen, H. Liao, Neil Rollins +10 more

   2012Journal of Biological Chemistry44 citations Open access

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6. Active acetyl-CoA synthase from Clostridium thermoaceticum obtained by cloning and heterologous expression of acsAB in Escherichia coli.

   H. Loke, G. Bennett, P. Lindahl

   2000Proceedings of the National Academy of Sciences of the United States of America32 citations Open access

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7. Identification and preliminary characterization of AcsF, a putative Ni-insertase used in the biosynthesis of acetyl-CoA synthase from Clostridium thermoaceticum.

   H. Loke, P. Lindahl

   2003Journal of Inorganic Biochemistry26 citations Open access

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8. A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

   M. Gallery, Julie Zhang, D. Bradley, P. Brauer +15 more

   2018PLoS ONE23 citations Open access

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9. Genetic construction of truncated and chimeric metalloproteins derived from the alpha subunit of acetyl-CoA synthase from Clostridium thermoaceticum.

   H. Loke, Xiang-Shi Tan, P. Lindahl

   2002Journal of the American Chemical Society19 citations Open access

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10. Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry

    Xiaofeng Yang, J. Brownell, Qing Xu, Feng Zhu +10 more

    2013Cell Biochemistry and Biophysics17 citations

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11. Development of a charcoal paper adenosine triphosphate:pyrophosphate exchange assay: kinetic characterization of NEDD8 activating enzyme.

    F. Bruzzese, C. Tsu, Jingya Ma, H. Loke +4 more

    2009Analytical Biochemistry15 citations

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12. Determination of complementary antibody pairs using protein A capture with the AlphaScreen assay format.

    Michael E. Bembenek, A. Burkhardt, Jingya Ma, Zhi Li +7 more

    2011Analytical Biochemistry12 citations

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13. Analysis of two pharmacodynamic biomarkers using acoustic micro magnetic particles on the ViBE bioanalyzer.

    Zhong-Hua Yan, Lara L. Madison, A. Burkhardt, Jie Yu +10 more

    2011Analytical Biochemistry11 citations

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14. Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen.

    Zhong-Hua Yan, A. Burkhardt, H. Loke, Jesse J. Chen +7 more

    2013Analytical Biochemistry7 citations

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15. Abstract PR009: Discovery of covalent NRAS inhibitors targeting the Palmitoylation site through imaging-based high-throughput screening

    Zhao Wang, Keith Moore, Simon Ng, Chao Wang +4 more

    2023Molecular Cancer Therapeutics0 citations

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16. Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry

    Xiaofeng Yang, J. Brownell, Qing Xu, Feng Zhu +10 more

    2013Cell Biochemistry and Biophysics0 citations

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17. TheIntermediary Roleof5-Pregnene-3p,20P-diol intheBiosynthesis of 16-Unsaturated C1,Steroids inBoarTestis

    H. Loke, A. Gower

    19720 citations

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