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A. Speers · SciRah

Researcher profile · Semantic Scholar

A. Speers

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A. Speers — researcher profile on SciRah

h-index: 24
Works: 130
Citations: 3,820

Most-cited papers

Confirming Target Engagement for Reversible Inhibitors In Vivo by Kinetically Tuned Activity-Based Probes
Alexander Adibekian, Brent R. Martin, J. Chang, Ku-Lung Hsu +10 more
2012Journal of the American Chemical Society136 citations Open access
Semantic Scholar
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
D. Bachovchin, J. Mohr, A. Speers, Chu Wang +10 more
2011Proceedings of the National Academy of Sciences of the United States of America104 citations Open access
Semantic Scholar
Potent and Selective Inhibitors of Glutathione S-transferase Omega 1 that Impair Cancer Drug Resistance
K. Tsuboi, D. Bachovchin, A. Speers, T. Spicer +4 more
2011Journal of the American Chemical Society85 citations Open access
Semantic Scholar
Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and In Vivo-Active Inhibitors of Alpha/Beta-Hydrolase Domain Containing 6 (ABHD6)
Ku-Lung Hsu, K. Tsuboi, J. Chang, L. Whitby +3 more
2013Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Impacts of climate change and ocean acidification on coral reef fisheries: An integrated ecological–economic model
A. Speers, Elena Y. Besedin, James E. Palardy, C. Moore
201679 citations
Semantic Scholar
Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1
D. Bachovchin, A. Zuhl, A. Speers, M. R. Wolfe +4 more
2011Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Development and Optimization of Piperidyl-1,2,3-Triazole Ureas as Selective Chemical Probes of Endocannabinoid Biosynthesis
Ku-Lung Hsu, K. Tsuboi, L. Whitby, A. Speers +3 more
2013Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Phosphatidylinositol (3,4,5)-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners
Meng M. Rowland, H. Bostic, D. Gong, A. Speers +4 more
2011Biochemistry55 citations Open access
Semantic Scholar
A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival
J. Chang, A. Zuhl, A. Speers, S. Niessen +15 more
2015ACS Chemical Biology46 citations Open access
Semantic Scholar
A Meta-Analysis of Hedonic Studies to Assess the Property Value Effects of Low Impact Development
Marisa J. Mazzotta, Elena Y. Besedin, A. Speers
201433 citations Open access
Semantic Scholar
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.
Jessica L. Ward, Samantha N Spath, B. Pabst, P. Carpino +5 more
2013Biochemistry33 citations Open access
Semantic Scholar
Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis
Nan Zhao, Crystal M. Darby, Jennifer L. Small, D. Bachovchin +14 more
2014ACS Chemical Biology30 citations Open access
Semantic Scholar
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A2
Joseph M G Nagano, Ku-Lung Hsu, L. Whitby, M. Niphakis +11 more
2012Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)
Alexander Adibekian, Brent R. Martin, J. Chang, Ku-Lung Hsu +10 more
201427 citations
Semantic Scholar
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors
A. M. Lone, D. Bachovchin, D. Westwood, A. Speers +7 more
2011Journal of the American Chemical Society24 citations Open access
Semantic Scholar
Creating opportunities for improving lake-focused stakeholder engagement: knowledge–action systems, pro-environment behaviour and sustainable lake management
K. Bell, Laura Lindenfeld, A. Speers, M. Teisl +1 more
201322 citations Open access
Semantic Scholar
Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)
Alexander Adibekian, Brent R. Martin, A. Speers, Steven J. Brown +6 more
201316 citations
Semantic Scholar
Rapid Development of a Potent Photo-Triggered Inhibitor of the Serine Hydrolase RBBP9
Xiaodan Liu, M. Dix, A. Speers, D. Bachovchin +3 more
2012ChemBioChem16 citations Open access
Semantic Scholar
Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase
S. Saario, Michele K. McKinney, A. Speers, Chu Wang +1 more
2011Chemical Science11 citations Open access
Semantic Scholar
Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor
C. J. Dreyton, Justin Jones, B. Knuckley, Venkatamaran Subramanian +14 more
201310 citations
Semantic Scholar
Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211
Alexander Adibekian, Ku-Lung Hsu, A. Speers, Steven J. Brown +6 more
20138 citations
Semantic Scholar
Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6)
Ku-Lung Hsu, K. Tsuboi, A. Speers, Steven J. Brown +6 more
20137 citations
Semantic Scholar
Probe Development Efforts to Identify Novel Inhibitors of ABHD10
Andrea M. Zuhl, J. Mohr, A. Speers, D. Bachovchin +9 more
20136 citations
Semantic Scholar
Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β)
Ku-Lung Hsu, K. Tsuboi, A. Speers, Steven J. Brown +6 more
20136 citations
Semantic Scholar
An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2)
Jonathan J. Hulce, C. Joslyn, A. Speers, Steven J. Brown +6 more
20144 citations
Semantic Scholar
Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1)
K. Tsuboi, D. Bachovchin, A. Speers, Steven J. Brown +6 more
20114 citations
Semantic Scholar
Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2)
Alexander Adibekian, Ku-Lung Hsu, A. Speers, Elizabeth S. Monillas +8 more
20133 citations
Semantic Scholar
Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)
D. Bachovchin, A. Speers, Steven J. Brown, T. Spicer +8 more
20113 citations
Semantic Scholar
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
D. Bachovchin, J. Mohr, A. Speers, Chu Wang +10 more
20112 citations
Semantic Scholar
Managing the Oil and Gas Talent Equation: Location, Skill and Commitment
A. Speers, A. Henchy
20161 citations
Semantic Scholar
Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20141 citations
Semantic Scholar
Table S1, Activity of cherry-picked HTS hits against pPAFAH as assessed by gel-based competitive ABPP (AID 588474)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table S3, Serine Hydrolase (SH) Abbreviations and Names
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.2-1, IC50 curves for probe ML256 (SID 125269079) as determined by gel-based competitive-ABPP with FP-Rh against purified, recombinant human pPAFAH (left) and overexpressed mouse pPAFAH in a complex proteome lysate (293T Hek membrane) (right)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.6-5, Potency and selectivity of ML256 assessed by ABPP-MudPIT
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table 3.1-2, Representative carbamate SH inhibitors
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table 3.1-1, Most promising pPAFAH inhibitor leads by gel-based competitive ABPP
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table S2, Target SAR Analysis: non-carbamate HTS Hits
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.6-3, Selectivity of synthetic SAR compounds as assessed by gel-based competitive ABPP in the mouse brain membrane proteome
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.5-3, Cytotoxicity anaysis of probe ML256 and analogs JMN4 and WWL153 in serum-free (A) and serum-supplemented (B) medium (AID 588768)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 4.1-1, Structure of darapladib, a GlaxoSmithKline drug in phase III clinical trials for the treatment of atherosclerosis
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table 3.4-2, Target SAR Analysis: Triazole Ureas*
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure S1, Gel-based competitive ABPP analysis of cherry-picked HTS hits against over-expressed pPAFAH in a complex proteome (293T Hek cell lysate) at 5 μM compound concentration (AID 588474)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.6-1, Potency of ML256 (SID 125269079) and analogs against recombinant mouse pPAFAH in a complex proteome (293T Hek cell membranes overexpressing the enzyme)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.3-1, Covalent modification of pPAFAH by ML256 (SID 125269079) as determined by LC-MS/MS analysis
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.6-2, Selectivity of HTS hit compounds as assessed by gel-based competitive ABPP with FP-Rh in the mouse brain membrane proteome
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Table 3.4-1, Target SAR Analysis
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 3.5-2, Inhibition of pPAFAH activity in vivo by probe ML256 (SID 125269079)
Joseph M G Nagano, Ku-Lung Hsu, A. Speers, Steven J. Brown +7 more
20140 citations
Semantic Scholar
Figure 8, Potency and selectivity of triazole urea synthetic library compounds at three compound concentrations
Alexander Adibekian, Ku-Lung Hsu, A. Speers, Elizabeth S. Monillas +8 more
20130 citations
Semantic Scholar
Figure 7, In Situ inhibition of target enzymes
Alexander Adibekian, Brent R. Martin, A. Speers, Steven J. Brown +6 more
20130 citations
Semantic Scholar

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