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B. Knuckley · SciRah

Researcher profile · Semantic Scholar

B. Knuckley

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B. Knuckley — researcher profile on SciRah

h-index: 20
Works: 42
Citations: 2,389

Most-cited papers

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Yuan Luo, K. Arita, M. Bhatia, B. Knuckley +4 more
2006Biochemistry294 citations Open access
Semantic Scholar
N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis
V. Willis, Alison M. Gizinski, N. Banda, Corey P. Causey +11 more
2011Journal of Immunology291 citations Open access
Semantic Scholar
Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential
Justin Jones, Corey P. Causey, B. Knuckley, Jessica L Slack-Noyes +1 more
2009Current opinion in drug discovery & development244 citations
Semantic Scholar
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
A. Chumanevich, Corey P. Causey, B. Knuckley, Justin Jones +6 more
2011American Journal of Physiology - Gastrointestinal and Liver Physiology218 citations Open access
Semantic Scholar
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of Protein Arginine Deiminase 3
B. Knuckley, Corey P. Causey, Justin Jones, M. Bhatia +4 more
2010Biochemistry178 citations Open access
Semantic Scholar
A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.
Yuan Luo, B. Knuckley, Young-Ho Lee, M. Stallcup +1 more
2006Journal of the American Chemical Society146 citations Open access
Semantic Scholar
Felty’s Syndrome Autoantibodies Bind to Deiminated Histones and Neutrophil Extracellular Chromatin Traps
N. Dwivedi, Jagriti Upadhyay, Indira Neeli, Salar N. Khan +10 more
2011Arthritis & Rheumatism128 citations Open access
Semantic Scholar
The development of N-α-(2-carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N α-(2-carboxyl)benzoyl-N5-(2-Chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation Protein Arginine Deiminase (PAD) inhibitors.
Corey P. Causey, Justin Jones, Jessica L. Slack, D. Kamei +10 more
2011Journal of Medicinal Chemistry106 citations Open access
Semantic Scholar
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
B. Knuckley, M. Bhatia, P. Thompson
2007Biochemistry96 citations Open access
Semantic Scholar
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
B. Knuckley, Yuan Luo, P. Thompson
2008Bioorganic & Medicinal Chemistry92 citations Open access
Semantic Scholar
A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors
B. Knuckley, Justin Jones, D. Bachovchin, Jessica L. Slack +5 more
2010Chemical Communications88 citations Open access
Semantic Scholar
Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe.
Yuan Luo, B. Knuckley, M. Bhatia, P. Pellechia +1 more
2006Journal of the American Chemical Society67 citations Open access
Semantic Scholar
Haloacetamidine-based inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation
B. Knuckley, Corey P. Causey, P. J. Pellechia, P. Cook +1 more
2010ChemBioChem66 citations Open access
Semantic Scholar
Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism
C. J. Dreyton, B. Knuckley, Justin Jones, Daniel M. Lewallen +1 more
2014Biochemistry48 citations Open access
Semantic Scholar
Post-Training Lesions of the Medial Prefrontal Cortex Interfere with Subsequent Performance of Trace Eyeblink Conditioning
B. Simon, B. Knuckley, J. Churchwell, D. A. Powell
2005Journal of Neuroscience48 citations Open access
Semantic Scholar
Prefrontal control of trace versus delay eyeblink conditioning: role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus).
Barbara B. Oswald, B. Knuckley, K. Mahan, C. Sanders +1 more
2006Behavioral Neuroscience36 citations
Semantic Scholar
Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product.
E. James, B. Knuckley, Norah Alqahtani, S. Porwal +4 more
2016ACS Synthetic Biology35 citations Open access
Semantic Scholar
Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates.
Daniel M. Lewallen, Caitlin Steckler, B. Knuckley, Michael J. Chalmers +1 more
2012Molecular Biosystems31 citations
Semantic Scholar
Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits.
B. Simon, B. Knuckley, D. A. Powell
2004Learning & memory (Cold Spring Harbor, N.Y.)26 citations Open access
Semantic Scholar
Characterization and Inactivation of an Agmatine Deiminase from Helicobacter Pylori
Justin Jones, Corey P. Causey, L. Lovelace, B. Knuckley +3 more
2009Bioorganic chemistry (Print)21 citations Open access
Semantic Scholar
Prefrontal control of trace eyeblink conditioning in rabbits (Oryctolagus cuniculus) II: effects of type of unconditioned stimulus (airpuff vs. periorbital shock) and unconditioned stimulus intensity.
Barbara B. Oswald, B. Knuckley, K. Mahan, C. Sanders +1 more
2009Physiology and Behavior20 citations
Semantic Scholar
A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells
Mollie A. Brekker, Tala Sartawi, Tina M. Sawatzky, Corey P. Causey +2 more
2022Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Mechanistic studies of the agmatine deiminase from Listeria monocytogenes
C. A. Soares, B. Knuckley
2016Biochemical Journal16 citations Open access
Semantic Scholar
Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms
H. Taki, T. Gomi, B. Knuckley, P. Thompson +15 more
201116 citations Open access
Semantic Scholar
Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes.
H. Nguyễn, Min Wang, Andrew Salsburg, B. Knuckley
2015ACS Combinatorial Science12 citations
Semantic Scholar
Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor
C. J. Dreyton, Justin Jones, B. Knuckley, Venkatamaran Subramanian +14 more
201310 citations
Semantic Scholar
Ibotenic acid lesions to ventrolateral thalamic nuclei disrupts trace and delay eyeblink conditioning in rabbits.
Barbara B. Oswald, B. Knuckley, Stephanie A. Maddox, D. A. Powell
2007Behavioural Brain Research10 citations
Semantic Scholar
Histone H4-based peptoids are inhibitors of Protein Arginine Methyltransferase 1 (PRMT1).
Sarah A. Mann, Megan K. DeMart, B. May, Corey P. Causey +1 more
2020Biochemical Journal7 citations Open access
Semantic Scholar
Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases.
A. Thomson, Seán O'Connor, B. Knuckley, Corey P. Causey
2014Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
The development and characterization of a chemical probe targeting PRMT1 over PRMT5.
Sarah A. Mann, Andrew Salsburg, Corey P. Causey, B. Knuckley
2019Bioorganic & Medicinal Chemistry6 citations Open access
Semantic Scholar
Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases.
M. Marchenko, A. Thomson, T. Ellis, B. Knuckley +1 more
2015Bioorganic & Medicinal Chemistry4 citations
Semantic Scholar
Treatment with Cl-amidine, a peptidyl arginine deiminase (PAD) inhibitor, significantly reduces collagen-induced arthritis (CIA) (50.6)
V. Willis, Alison M. Gizinski, N. Banda, B. Knuckley +12 more
2009Journal of Immunology2 citations
Semantic Scholar
The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay
Tina M. Sawatzky, Sarah A. Mann, Jordan A. Tucker, Aida A. Bibart +2 more
2025Biomolecules1 citations
Semantic Scholar
Abstract A089: UnAcH416 (P2), a selective PRMT1 inhibitor, disrupts tumor cell growth and stress-response pathways
J. Camps, Naomi Laird, Diana Soto, Corey P. Causey +2 more
2025Molecular Cancer Therapeutics1 citations
Semantic Scholar
Investigating the Substrate Specificity of PRMT1 using a Plate Based Screening Method
Tina M. Sawatzky, Sarah A. Mann, B. Knuckley
20200 citations
Semantic Scholar
Identification of Histone H4-Based Peptoids as Inhibitors of PRMT1
Megan K. DeMart, Molly Dubose, Sarah A. Mann, Corey P. Causey +1 more
20200 citations
Semantic Scholar
Figure 2, Preparation of coupling partners A and B
C. J. Dreyton, Justin Jones, B. Knuckley, Venkatamaran Subramanian +14 more
20130 citations
Semantic Scholar
UNIVERSITY OF COLORADO DENVER ANSCHUTZ MEDICAL CAMPUS 23rd ANNUAL STUDENT RESEARCH FORUM and STUDENT RESEARCH AWARDS CONVOCATION GRADUATE SCHOOL SCHOOL OF DENTAL MEDICINE SCHOOL OF MEDICINE SCHOOL OF PHARMACY SCHOOL OF PUBLIC HEALTH
CP Causey, K. Cordova, B. Knuckley, B. Levitt +3 more
20130 citations
Semantic Scholar
Figure 3, IC50 curves for PADs 1–4 with ML325 (SID 118043677) as determined by biochemical substrate assay using the N-α-benzoyl-L-arginine ethyl ester HCl (BAEE) reagent
C. J. Dreyton, Justin Jones, B. Knuckley, Venkatamaran Subramanian +14 more
20130 citations
Semantic Scholar
Arthritis Reduces the Severity of Murine Collagen-Induced Amide , a Protein Arginine Deiminase Inhibitor ,-Benzoyl-N 5-( 2-Chloro-1-Iminoethyl )-l-Ornithine
P. Thompson, V. Holers, L. Kulik, W. Robinson +12 more
20110 citations
Semantic Scholar
Crystal structure of human peptidylarginine deiminase 4 in complex with o-Cl-amidine
Corey P. Causey, Justin Jones, Jessica L. Slack, D. Kamei +11 more
20110 citations
Semantic Scholar
Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
B. Knuckley
20090 citations
Semantic Scholar

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P. Thompson×22
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P. Thompson — researcher profile on SciRah
Corey P. Causey×18
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Corey P. Causey — researcher profile on SciRah
Justin Jones×11
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Justin Jones — researcher profile on SciRah
Yuan Luo×9
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Sarah A. Mann×5

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