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Andrew D. Huber · SciRah

Researcher profile · Semantic Scholar

Andrew D. Huber

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Andrew D. Huber — researcher profile on SciRah

h-index: 19
Works: 34
Citations: 816

Most-cited papers

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms*
E. Michailidis, Andrew D. Huber, Emily M. Ryan, Ong T. Yee +11 more
2014Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Multiplex single-cell visualization of nucleic acids and protein during HIV infection
M. Puray-Chavez, P. Tedbury, Andrew D. Huber, Obiaara B. Ukah +6 more
2017Nature Communications51 citations Open access
Semantic Scholar
Clobetasol propionate is a heme-mediated selective inhibitor of human cytochrome P450 3A5
William C. Wright, J. Chenge, Jingheng Wang, H. M. Girvan +7 more
2020Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond
Shyaron Poudel, Andrew D. Huber, Tao-Sheng Chen
2022Drug Metabolism And Disposition43 citations
Semantic Scholar
Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity
Sanjeev Kumar V. Vernekar, Jing Tang, Bulan Wu, Andrew D. Huber +8 more
2017Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
J. Kankanala, K. Kirby, Andrew D. Huber, Mary C. Casey +3 more
2017European journal of medicinal chemistry37 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H
Bulan Wu, Jing Tang, Daniel J. Wilson, Andrew D. Huber +6 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
E. Michailidis, Emily M. Ryan, A. Hachiya, K. Kirby +10 more
2013Retrovirology37 citations Open access
Semantic Scholar
Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
Andrew D. Huber, William C. Wright, Wen-Wei Lin, Kinjal Majumder +5 more
2020Cellular and Molecular Life Sciences33 citations Open access
Semantic Scholar
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
Andrew D. Huber, Yong-Tao Li, Wen-Wei Lin, Annalise N. Galbraith +8 more
2022ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors
Andrew D. Huber, E. Michailidis, Megan L. Schultz, Y. T. Ong +8 more
2014Antimicrobial Agents and Chemotherapy31 citations Open access
Semantic Scholar
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
Lei Wang, Jing Tang, Andrew D. Huber, Mary C. Casey +7 more
2018European journal of medicinal chemistry28 citations Open access
Semantic Scholar
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
Lei Wang, Jing Tang, Andrew D. Huber, Mary C. Casey +6 more
2018European journal of medicinal chemistry27 citations Open access
Semantic Scholar
CITCO Directly Binds to and Activates Human Pregnane X Receptor
Wen-Wei Lin, Monicah N Bwayi, Jing Wu, Yong-Tao Li +3 more
2019Molecular Pharmacology24 citations Open access
Semantic Scholar
The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
Andrew D. Huber, J. Wolf, Dandan Liu, A. Gres +11 more
2018Msphere24 citations Open access
Semantic Scholar
5-Aminothiophene-2,4-dicarboxamide Analogues as Hepatitis B Virus Capsid Assembly Effectors
Jing Tang, Andrew D. Huber, Dallas L. Pineda, Kelsey N Boschert +5 more
2018European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Jing Tang, Sanjeev Kumar V. Vernekar, Yue-Lei Chen, L. Miller +5 more
2017European journal of medicinal chemistry23 citations Open access
Semantic Scholar
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an Inhibitor Scaffold of HIV Reverase Transcriptase: Impacts of the 3-OH on Inhibiting RNase H and Polymerase
Jing Tang, K. Kirby, Andrew D. Huber, Mary C. Casey +4 more
2017European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: tolerance of a nonflexible linker
Jing Tang, H. Do, Andrew D. Huber, Mary C. Casey +6 more
2019European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein
Wen-Wei Lin, Andrew D. Huber, Shyaron Poudel, Yong-Tao Li +3 more
2023Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H
Andrew D. Huber, E. Michailidis, Jing Tang, M. Puray-Chavez +11 more
2017Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
Unraveling the structural basis of selective inhibition of human cytochrome P450 3A5
Jingheng Wang, C. Buchman, J. Seetharaman, Darcie J. Miller +7 more
2021Journal of the American Chemical Society16 citations Open access
Semantic Scholar
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus
Dandan Liu, P. Tedbury, S. Lan, Andrew D. Huber +10 more
2019Viruses15 citations Open access
Semantic Scholar
Novel Hepatitis B Virus Capsid-Targeting Antiviral that Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores
Andrew D. Huber, Dallas L. Pineda, Dandan Liu, Kelsey N Boschert +12 more
2018ACS Infectious Diseases15 citations Open access
Semantic Scholar
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, R. Bajpai +3 more
2023Acta Pharmaceutica Sinica B13 citations Open access
Semantic Scholar
Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication
M. Puray-Chavez, Mahmoud H Farghali, V. Yapo, Andrew D. Huber +7 more
2019Viruses13 citations Open access
Semantic Scholar
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
K. Kirby, Nataliya A. Myshakina, Martin T. Christen, Yue-Lei Chen +12 more
2017Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
Monicah N Bwayi, E. García-Maldonado, S. Chai, Boer Xie +11 more
2022Nucleic Acids Research9 citations Open access
Semantic Scholar
Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus
Dandan Liu, Tanyaradzwa P. Ndongwe, Juan Ji, Andrew D. Huber +5 more
2023Viruses4 citations Open access
Semantic Scholar
Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment.
Andrew D. Huber, Tao-Sheng Chen
2019Cell Chemical Biology3 citations Open access
Semantic Scholar
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
E. Michailidis, Emily M. Ryan, A. Hachiya, K. Kirby +10 more
2013Retrovirology1 citations Open access
Semantic Scholar
Structure-guided approach to modulate small molecule binding to the promiscuous pregnane X receptor
Andrew D. Huber, Wen-Wei Lin, Shyaron Poudel, Yong-Tao Li +3 more
2023ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology0 citations Open access
Semantic Scholar
Discovery of novel hepatitis B virus (HBV) antivirals and analysis of mechanisms of action of HBV-targeting agents
Andrew D. Huber
20170 citations
Semantic Scholar
SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase
Andrew D. Huber, E. Michailidis, Megan L. Schultz, Y. T. Ong +9 more
20140 citations
Semantic Scholar

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