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S. Korsmeyer · SciRah

Researcher profile · Semantic Scholar

S. Korsmeyer

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S. Korsmeyer — researcher profile on SciRah

h-index: 170
Works: 409
Citations: 134K

Most-cited papers

An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T. Oltersdorf, S. Elmore, Alexander R. Shoemaker, R. Armstrong +29 more
2005Nature3,453 citations
Semantic Scholar
BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis
L. Scorrano, Scott A. Oakes, J. Opferman, Emily H. Cheng +3 more
2003Science1,491 citations
Semantic Scholar
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
M. Certo, V. Del Gaizo Moore, Mari Nishino, G. Wei +3 more
2006Cancer Cell1,321 citations Open access
Semantic Scholar
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
L. Walensky, A. Kung, I. Escher, T. Malia +5 more
2004Science1,282 citations Open access
Semantic Scholar
Exercise–induced BCL2–regulated autophagy is required for muscle glucose homeostasis
Congcong He, M. Bassik, V. Moresi, K. Sun +16 more
2012Nature1,119 citations Open access
Semantic Scholar
VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis
Emily H. Cheng, T. Sheiko, J. Fisher, W. Craigen +1 more
2003Science865 citations
Semantic Scholar
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.
A. Schinzel, O. Takeuchi, Zhi-Hong Huang, J. Fisher +6 more
2005Proceedings of the National Academy of Sciences of the United States of America842 citations Open access
Semantic Scholar
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members.
L. Scorrano, S. Korsmeyer
2003Biochemical and Biophysical Research Communications - BBRC735 citations
Semantic Scholar
Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells
J. Opferman, H. Iwasaki, C. Ong, Heikyung Suh +3 more
2005Science616 citations
Semantic Scholar
Apoptosis in the development and maintenance of the immune system
J. Opferman, S. Korsmeyer
2003Nature Immunology548 citations
Semantic Scholar
Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α
C. Hetz, P. Bernasconi, J. Fisher, Ann-Hwee Lee +7 more
2006Science545 citations
Semantic Scholar
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Scott A. Oakes, L. Scorrano, J. Opferman, M. Bassik +3 more
2005Proceedings of the National Academy of Sciences of the United States of America465 citations Open access
Semantic Scholar
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
S. Armstrong, A. Kung, M. Mabon, L. Silverman +9 more
2003Cancer Cell424 citations
Semantic Scholar
A stapled BID BH3 helix directly binds and activates BAX.
L. Walensky, K. Pitter, Joel G. Morash, K. J. Oh +5 more
2006Molecules and Cells396 citations Open access
Semantic Scholar
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
A. Ferrando, Scott A. Armstrong, D. Neuberg, S. Sallan +3 more
2003Blood374 citations
Semantic Scholar
Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide
F. Bernal, A. Tyler, S. Korsmeyer, L. Walensky +1 more
2007373 citations Open access
Semantic Scholar
Cell death: critical control points.
N. Danial, S. Korsmeyer
2004Cell329 citations Open access
Semantic Scholar
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.
H. Harada, B. Quearry, A. Ruiz-Vela, S. Korsmeyer
2004Proceedings of the National Academy of Sciences of the United States of America322 citations Open access
Semantic Scholar
A spatially and temporally restricted mouse model of soft tissue sarcoma
D. Kirsch, Daniela M. Dinulescu, John B Miller, J. Grimm +14 more
2007Nature Medicine317 citations
Semantic Scholar
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
N. Danial, L. Walensky, Chen-Yu Zhang, C. Choi +18 more
2008Nature Medicine309 citations Open access
Semantic Scholar
Phosphorylation of BCL‐2 regulates ER Ca2+ homeostasis and apoptosis
M. Bassik, L. Scorrano, Scott A. Oakes, T. Pozzan +1 more
2004EMBO Journal295 citations Open access
Semantic Scholar
Definitive hematopoiesis requires the mixed-lineage leukemia gene.
Patricia Ernst, J. Fisher, W. Avery, Stacey F. Wade +2 more
2004Developmental Cell284 citations Open access
Semantic Scholar
Bad-deficient mice develop diffuse large B cell lymphoma
A. Ranger, J. Zha, H. Harada, S. R. Datta +6 more
2003Proceedings of the National Academy of Sciences of the United States of America277 citations Open access
Semantic Scholar
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
A. Davidson, Patricia Ernst, Yuan Wang, M. Dekens +5 more
2003Nature274 citations
Semantic Scholar
FLT3 mutations in childhood acute lymphoblastic leukemia.
S. Armstrong, M. Mabon, L. Silverman, Aihong Li +4 more
2004Blood263 citations Open access
Semantic Scholar
Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization
James J. Hsieh, Patricia Ernst, H. Erdjument-Bromage, P. Tempst +1 more
2003Molecular and Cellular Biology260 citations Open access
Semantic Scholar
A role for proapoptotic BID in the DNA-damage response.
Sandra S. Zinkel, Kristen E. Hurov, C. Ong, Farvardean M. Abtahi +2 more
2005Cell251 citations
Semantic Scholar
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.
L. Dejean, Sonia Martínez-Caballero, Liang Guo, Cynthia Hughes +7 more
2005Molecular Biology of the Cell244 citations Open access
Semantic Scholar
p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis
D. Kirsch, P. M. Santiago, E. Di Tomasso, J. M. Sullivan +13 more
2009Science240 citations Open access
Semantic Scholar
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
O. Takeuchi, J. Fisher, Heikyung Suh, H. Harada +2 more
2005Proceedings of the National Academy of Sciences of the United States of America223 citations Open access
Semantic Scholar
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
R. T. Woodland, C. Fox, M. Schmidt, P. Hammerman +4 more
2008Blood209 citations Open access
Semantic Scholar
An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Patricia Ernst, M. Mabon, A. Davidson, L. Zon +1 more
2004Current Biology201 citations Open access
Semantic Scholar
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
R. Stam, M. D. den Boer, J. Meijerink, M. E. Ebus +6 more
2003Blood194 citations Open access
Semantic Scholar
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.
Y. Nam, K. Mani, A. Ashton, Chang-Fu Peng +5 more
2004Molecules and Cells189 citations Open access
Semantic Scholar
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Sandra S. Zinkel, C. Ong, D. Ferguson, H. Iwasaki +5 more
2003Genes & Development183 citations Open access
Semantic Scholar
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
F. Bernal, A. Tyler, S. Korsmeyer, L. Walensky +1 more
2007Journal of the American Chemical Society170 citations Open access
Semantic Scholar
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Shugaku Takeda, David Y. Chen, Todd D. Westergard, J. Fisher +6 more
2006Genes & Development169 citations Open access
Semantic Scholar
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival
M. Mandal, Christine Borowski, Teresa Palomero, A. Ferrando +11 more
2005Journal of Experimental Medicine142 citations Open access
Semantic Scholar
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
Scott A. Oakes, J. Opferman, T. Pozzan, S. Korsmeyer +1 more
2003Biochemical Pharmacology136 citations
Semantic Scholar
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Jing Wang, H. Iwasaki, A. Krivtsov, P. Febbo +12 more
2005EMBO Journal120 citations Open access
Semantic Scholar
Proapoptotic BAX and BAK control multiple initiator caspases
A. Ruiz-Vela, J. Opferman, Emily H. Cheng, S. Korsmeyer
2005EMBO Reports119 citations Open access
Semantic Scholar
Cell death induced by granzyme C.
Hillary Johnson, L. Scorrano, S. Korsmeyer, T. Ley
2003Blood117 citations
Semantic Scholar
Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration
Hong-Xin Dong, Alicia G. Fazzaro, Chuan-Xi Xiang, S. Korsmeyer +2 more
2003Journal of Neuroscience114 citations Open access
Semantic Scholar
PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum*
Stephen S. Lin, M. Bassik, Heikyung Suh, Mari Nishino +4 more
2006Journal of Biological Chemistry108 citations Open access
Semantic Scholar
A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro*
K. J. Oh, Scott Barbuto, K. Pitter, Joel G. Morash +2 more
2006Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Traumatic Brain Injury in Mice Deficient in Bid: Effects on Histopathology and Functional Outcome
Daniela Bermpohl, Zerong You, S. Korsmeyer, M. Moskowitz +1 more
2006Journal of Cerebral Blood Flow and Metabolism94 citations Open access
Semantic Scholar
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
A. Chávez-Reyes, J. Parant, L. Amelse, R. M. de Oca-Luna +2 more
2003Cancer Research87 citations
Semantic Scholar
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.
C. Hetz, P. Vitte, A. Bombrun, T. Rostovtseva +7 more
2012Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.
Liang Guo, D. Pietkiewicz, E. Pavlov, Sergey M. Grigoriev +5 more
2004American Journal of Physiology - Cell Physiology79 citations
Semantic Scholar
Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia*
C. Hetz, P. Vitte, A. Bombrun, T. Rostovtseva +7 more
2005Journal of Biological Chemistry78 citations Open access
Semantic Scholar

Frequent co-authors

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J. Fisher×10
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J. Fisher — researcher profile on SciRah
J. Opferman×7
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J. Opferman — researcher profile on SciRah
L. Scorrano×6
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L. Scorrano — researcher profile on SciRah
L. Walensky×6
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L. Walensky — researcher profile on SciRah

×5

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S. Armstrong — researcher profile on SciRah

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M. Bassik — researcher profile on SciRah

B. Antonsson×5

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B. Antonsson — researcher profile on SciRah

Patricia Ernst×5

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Patricia Ernst — researcher profile on SciRah

Scott A. Oakes×4

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Scott A. Oakes — researcher profile on SciRah

Emily H. Cheng×4

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Emily H. Cheng — researcher profile on SciRah

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T. Pozzan — researcher profile on SciRah

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G. Verdine — researcher profile on SciRah