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C. Ong · SciRah

Researcher profile · Semantic Scholar

C. Ong

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C. Ong — researcher profile on SciRah

h-index: 13
Works: 27
Citations: 2,592

Most-cited papers

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
J. Opferman, A. Letai, Caroline Beard, Mia D. Sorcinelli +2 more
2003Nature860 citations
Semantic Scholar
Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells
J. Opferman, H. Iwasaki, C. Ong, Heikyung Suh +3 more
2005Science616 citations
Semantic Scholar
A role for proapoptotic BID in the DNA-damage response.
Sandra S. Zinkel, Kristen E. Hurov, C. Ong, Farvardean M. Abtahi +2 more
2005Cell251 citations
Semantic Scholar
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
C. Ong, A. Jubb, P. Haverty, W. Zhou +11 more
2011Proceedings of the National Academy of Sciences of the United States of America219 citations Open access
Semantic Scholar
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Sandra S. Zinkel, C. Ong, D. Ferguson, H. Iwasaki +5 more
2003Genes & Development183 citations Open access
Semantic Scholar
P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma.
C. Ong, A. Jubb, Diana Jakubiak, Wei Zhou +13 more
2013Journal of the National Cancer Institute90 citations Open access
Semantic Scholar
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents
C. Ong, S. Gierke, C. Pitt, Meredith S. Sagolla +27 more
2015Breast Cancer Research70 citations Open access
Semantic Scholar
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.
J. Rudolph, Lesley J. Murray, C. Ndubaku, T. O'Brien +25 more
2016Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition
Wei Zhou, A. Jubb, Karen S. Lyle, Q. Xiao +24 more
2014Journal of Pathology55 citations Open access
Semantic Scholar
p21-activated kinase 1: PAK'ed with potential
C. Ong, A. Jubb, Wei Zhou, P. Haverty +5 more
2011OncoTarget55 citations Open access
Semantic Scholar
Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics*
Florian Gnad, Amy Young, Wei Zhou, Karen S. Lyle +8 more
2013Molecular & Cellular Proteomics48 citations Open access
Semantic Scholar
Group I Paks as therapeutic targets in NF2-deficient meningioma
Hoi-Yee Chow, Biao Dong, S. Durón, D. Campbell +6 more
2015OncoTarget47 citations Open access
Semantic Scholar
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
Sayantanee Paul, Thijs J. Hagenbeek, Julien Tremblay, Vasumathi Kameswaran +19 more
2025Nature Communications25 citations Open access
Semantic Scholar
Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model
Thijs J. Hagenbeek, J. Zbieg, Russell Smith, Sayantanee Paul +50 more
2026Nature Communications4 citations Open access
Semantic Scholar
Abstract P3-04-24: Identification of preclinical mechanisms driving acquired resistance to selective ERa degraders (SERDs), CDK4/6 inhibitors, or to combinations of both agents
T. O'Brien, Xiao Yang, C. Ong, A. Daemen +1 more
20173 citations
Semantic Scholar
Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2− locally-advanced or metastatic breast cancer
Jackson Liang, C. Ong, Kareem A. Heslop, Jane Guan +15 more
2026Nature Communications2 citations Open access
Semantic Scholar
KRAS Codon-Specific Mutations Differentially Toggle PI3K Pathway Signaling and Alter Sensitivity to Inavolisib (GDC-0077)
Kyung Song, C. Ong, Eva Lin, Jeff Lau +11 more
2025Molecular Cancer Therapeutics2 citations
Semantic Scholar
Abstract PS17-01: Key drivers of therapeutic response and resistance to giredestrant from GO39932: a Phase Ia/b study in patients with estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Jackson Liang, C. Ong, J. Giltnane, J. Aimi +8 more
2024Cancer Research2 citations
Semantic Scholar
Abstract 1803: Breast cancer cell lines with acquired resistance to selective ERα degraders (SERDs) are dependent on PI3K signaling
C. Ong, A. Daemen, J. Oeh, E. Ingalla +5 more
20161 citations
Semantic Scholar
Abstract P5-04-26: Identification of preclinical mechanisms driving acquired resistance to endocrine therapy in estrogen-receptor positive (ER+) breast cancer cells
C. Ong, A. Daemen, Karl A. Merrick, T. O'Brien +2 more
2019Poster Session Abstracts0 citations
Semantic Scholar
Abstract PD3-04: PAK-1 amplified breast cancer cell lines are preferentially sensitive to PAK inhibition with G-5555
C. Ong, E. Blackwood, Diana Jakubiak, A. Daemen +11 more
20160 citations
Semantic Scholar
Abstract A067: Targeting p21-activated kinases in breast cancer
K. Hoeflich, C. Ong, Karen S. Lyle, A. Jubb +7 more
20130 citations
Semantic Scholar
Abstract B8: Targeting p21-activated kinases in human lung cancer
C. Ong, A. Jubb, P. Haverty, Wei Zhou +5 more
2012Clinical Cancer Research0 citations
Semantic Scholar
Abstract 4004: P21-activated kinases (PAKs) are novel therapeutic targets in human breast cancer
C. Ong, A. Jubb, P. Haverty, Wei Zhou +6 more
20120 citations
Semantic Scholar
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells
K. Hoeflich, C. Ong, A. Jubb, P. Haverty +6 more
20100 citations
Semantic Scholar
Mcl-1, which can prevent leukemia cell death, is necessary for bone marrow stem cell survival
H. Iwasaki, C. Ong, Heikyung Suh, S. Mizuno +2 more
20050 citations Open access
Semantic Scholar
Antioxidant Capacity of Selected Tissues in Chickens During Development and Growth
C. Ong
19990 citations
Semantic Scholar

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