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T. Oltersdorf · SciRah

Researcher profile · Semantic Scholar

T. Oltersdorf

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T. Oltersdorf — researcher profile on SciRah

h-index: 36
Works: 60
Citations: 15K

Most-cited papers

An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T. Oltersdorf, S. Elmore, Alexander R. Shoemaker, R. Armstrong +29 more
2005Nature3,454 citations
Semantic Scholar
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
M. Citron, T. Oltersdorf, C. Haass, L. McConlogue +5 more
1992Nature1,639 citations
Semantic Scholar
Cleavage of amyloid beta peptide during constitutive processing of its precursor.
F. Esch, P. Keim, E. Beattie, R. Blacher +4 more
1990Science1,417 citations
Semantic Scholar
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
T. Lovenberg, C. Liaw, D. Grigoriadis, W. Clevenger +3 more
1995Proceedings of the National Academy of Sciences of the United States of America859 citations Open access
Semantic Scholar
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
M. Citron, T. Oltersdorf, C. Haass, L. McConlogue +5 more
1992Nature620 citations
Semantic Scholar
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
D. Selkoe, M. Podlisny, C. Joachim, E. Vickers +3 more
1988Proceedings of the National Academy of Sciences of the United States of America551 citations Open access
Semantic Scholar
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
R. Easton, Han Cho, K. Roovers, D. Shineman +9 more
2005Molecular and Cellular Biology523 citations Open access
Semantic Scholar
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
P. Seubert, T. Oltersdorf, Michael G. Lee, R. Barbour +8 more
1993Nature515 citations
Semantic Scholar
Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
T. Saitoh, M. Sundsmo, J. Roch, Naohiro Kimura +4 more
1989484 citations
Semantic Scholar
Solution structure of the antiapoptotic protein bcl-2
A. Petros, A. Medek, D. Nettesheim, Daniel H. Kim +5 more
2001Proceedings of the National Academy of Sciences of the United States of America457 citations Open access
Semantic Scholar
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II
T. Oltersdorf, L. Fritz, D. Schenk, I. Lieberburg +6 more
1989Nature444 citations
Semantic Scholar
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
T. Oost, Chao-Hong Sun, R. Armstrong, A. Al-Assaad +13 more
2004Journal of Medicinal Chemistry374 citations Open access
Semantic Scholar
Role for Akt3/protein kinase Bgamma in attainment of normal brain size.
R. Easton, Han Cho, K. Roovers, D. Shineman +9 more
2005Molecular and Cellular Biology339 citations
Semantic Scholar
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
M. Bruncko, T. Oost, B. Belli, H. Ding +18 more
2007Journal of Medicinal Chemistry285 citations Open access
Semantic Scholar
Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells.
K. Seedorf, T. Oltersdorf, G. Krämmer, Walter G. Röwekamp
1987EMBO Journal278 citations Open access
Semantic Scholar
The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.
T. Oltersdorf, P. Ward, T. Henriksson, E. Beattie +3 more
1990Journal of Biological Chemistry252 citations Open access
Semantic Scholar
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
Yan Luo, Alexander R. Shoemaker, X. Liu, K. Woods +25 more
2005Molecular Cancer Therapeutics235 citations
Semantic Scholar
Oral IDN‐6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
P. Pockros, E. Schiff, M. L. Shiffman, J. Mchutchison +7 more
2007Hepatology193 citations Open access
Semantic Scholar
Clinical Trial of the Pan‐Caspase Inhibitor, IDN‐6556, in Human Liver Preservation Injury
E. Baskin-Bey, K. Washburn, Sandy Feng, T. Oltersdorf +8 more
2007American Journal of Transplantation180 citations Open access
Semantic Scholar
A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo.
Alexander R. Shoemaker, A. Oleksijew, J. Bauch, B. Belli +23 more
2006Cancer Research145 citations
Semantic Scholar
Dimerization Properties of Human BAD
Sabine Ottilie, J. Díaz, W. Horne, Julia Chang +6 more
1997Journal of Biological Chemistry135 citations Open access
Semantic Scholar
A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members*
J. Diaz, T. Oltersdorf, W. Horne, Michael McConnell +4 more
1997Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.
P. Seubert, T. Oltersdorf, M. Lee, R. Barbour +6 more
1993Nature124 citations
Semantic Scholar
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
M. Wendt, W. Shen, Aaron R. Kunzer, W. Mcclellan +18 more
2006Journal of Medicinal Chemistry118 citations Open access
Semantic Scholar
Normal Cellular Processing of the β‐Amyloid Precursor Protein Results in the Secretion of the Amyloid β Peptide and Related Molecules a
C. Haass, Albert Y. Hung, M. Schlossmacher, T. Oltersdorf +2 more
1993117 citations
Semantic Scholar
β-Secretase Processing of the β-Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes*
Jun Zhao, L. Paganini, L. Mucke, M. Gordon +6 more
1996Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Amyloid beta protein precursor is a mitogen.
D. Schubert, G. M. Cole, T. Saitoh, T. Oltersdorf
1989Biochemical and Biophysical Research Communications - BBRC100 citations
Semantic Scholar
Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice.
C. Wiessner, P. Allegrini, Katrin Rupalla, D. Sauer +5 more
1999Neuroscience Letters94 citations
Semantic Scholar
Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).
T. Lovenberg, P. Crowe, Chang-Lu Liu, D. Chalmers +6 more
1996Journal of Neuroimmunology84 citations
Semantic Scholar
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.
K. Woods, J. Fischer, A. Claiborne, Tongmei Li +18 more
2006Bioorganic & Medicinal Chemistry73 citations
Semantic Scholar
Regulated cleavage of Alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail
O. A. B. da Cruz e Silva, K. Iverfeldt, T. Oltersdorf, S. Sinha +6 more
199367 citations
Semantic Scholar
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
C. Haass, Albert Y. Hung, M. Schlossmacher, T. Oltersdorf +2 more
1993Annals of the New York Academy of Sciences66 citations
Semantic Scholar
Distribution pattern of human papilloma virus 16 genome in cervical neoplasia by molecular in situ hybridization of tissue sections
A. Schneider, T. Oltersdorf, Volker Schneider, L. Gissmann
1987International Journal of Cancer65 citations
Semantic Scholar
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Gui-Dong Zhu, V. Gandhi, J. Gong, Yan Luo +16 more
2006Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Structural and Functional Complementation of an Inactive Bcl-2 Mutant by Bax Truncation*
Sabine Ottilie, J. Diaz, Julia Chang, G. Wilson +6 more
1997Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial.
L. Schneider, Ronald G. Thomas, S. Hendrix, R. Rissman +5 more
2019JAMA Neurology36 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Qun Li, K. Woods, Sheela A. Thomas, Gui-Dong Zhu +18 more
2006Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Qun Li, Tongmei Li, Gui-Dong Zhu, J. Gong +17 more
2006Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Gui-Dong Zhu, J. Gong, A. Claiborne, K. Woods +18 more
2006Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth.
X. Liu, Jessica A Powlas, Yan Shi, A. Oleksijew +5 more
2004Anticancer Research31 citations
Semantic Scholar
Cytochrome c dissociation and release from mitochondria by truncated Bid and ceramide.
Hua Yuan, Scott D. Williams, S. Adachi, T. Oltersdorf +1 more
2003Mitochondrion (Amsterdam. Print)31 citations
Semantic Scholar
Mutational analysis of the interacting cell death regulators CED-9 and CED-4
Sabine Ottilie, Yan Wang, Sean Banks, Julia Chang +5 more
1997Cell Death and Differentiation25 citations
Semantic Scholar
Effects of the Acetylcholine Release Agent ST101 with Donepezil in Alzheimer’s Disease: A Randomized Phase 2 Study
S. Gauthier, S. Rountree, B. Finn, Barbra J. LaPlante +2 more
2015Journal of Alzheimer's Disease24 citations
Semantic Scholar
66 Oral IDN-6556, An anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients
E. Schiff, P. Pockros, M. Schiffman, J. Mchutchison +5 more
200414 citations
Semantic Scholar
Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor.
S. Sinha, J. Knops, F. Esch, E. Moyer +1 more
1991Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer’s Disease Clinical Trials: Potential for Confounding by Indication
B. Huisa, Ronald G. Thomas, Shelia Jin, T. Oltersdorf +2 more
2019Journal of Alzheimer's Disease10 citations
Semantic Scholar
A phase I, first-in-human, dose escalation study of intravenous TK216 in patients with relapsed or refractory Ewing sarcoma.
N. Federman, P. Meyers, N. Daw, J. Toretsky +8 more
20177 citations
Semantic Scholar
SAT-429 Final Results from the First in Man Phase 1 Clinical Trial of CRN00808, an Orally Bioavailable sst2-Selective, Nonpeptide Somatostatin Biased Agonist, for the Treatment of Acromegaly: Safety, Pharmacokinetics, Pharmacodynamics, and Midazolam Drug Interaction in Healthy Volunteers
A. Madan, Yun-Fei Zhu, S. Markison, S. Betz +6 more
2019Journal of the Endocrine Society6 citations Open access
Semantic Scholar
Expression of potentially amyloidogenic derivatives of the Alzheimer amyloid precursor protein in cultured 293 cells.
E. Johnstone, T. Oltersdorf, K. Bales, M. Chaney +2 more
1994Neuroscience Letters6 citations
Semantic Scholar
Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
M. Bruncko, T. Oost, B. Belli, H. Ding +16 more
20074 citations
Semantic Scholar

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