T. Pozzan

Most-cited papers

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
R. Filadi, Elisa Greotti, Gabriele Turacchio, A. Luini +2 more
2015Proceedings of the National Academy of Sciences of the United States of America556 citations Open access
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Enjoy the Trip: Calcium in Mitochondria Back and Forth.
Diego De Stefani, R. Rizzuto, T. Pozzan
2016Annual Review of Biochemistry392 citations
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Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.
M. Giacomello, I. Drago, M. Bortolozzi, M. Scorzeto +3 more
2010Molecules and Cells390 citations Open access
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Mitochondria: the calcium connection.
Laura Contreras, I. Drago, Enrico Zampese, T. Pozzan
2010Biochimica et Biophysica Acta356 citations Open access
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Presenilin 2 modulates endoplasmic reticulum (ER)–mitochondria interactions and Ca2+ cross-talk
Enrico Zampese, C. Fasolato, M. Kipanyula, M. Bortolozzi +2 more
2011Proceedings of the National Academy of Sciences of the United States of America295 citations Open access
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Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening
H. Baumgartner, J. Gerasimenko, Christopher Thorne, P. Ferdek +6 more
2009Journal of Biological Chemistry271 citations Open access
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SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition
Domenico Cieri, Mattia Vicario, M. Giacomello, F. Vallese +7 more
2017Cell Death and Differentiation229 citations Open access
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An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold
M. Gómez-Gonzalo, G. Losi, A. Chiavegato, Micaela Zonta +8 more
2010PLoS Biology223 citations Open access
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Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes
I. Drago, Diego De Stefani, R. Rizzuto, T. Pozzan
2012Proceedings of the National Academy of Sciences of the United States of America220 citations Open access
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H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca2+-dependent scavenging system
A. Costa, I. Drago, Smrutisanjita Behera, M. Zottini +4 more
2010The Plant Journal209 citations Open access
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After half a century mitochondrial calcium in‐ and efflux machineries reveal themselves
I. Drago, P. Pizzo, T. Pozzan
2011EMBO Journal194 citations Open access
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Mitochondrial Ca²⁺ uptake induces cyclic AMP generation in the matrix and modulates organelle ATP levels.
G. Di Benedetto, E. Scalzotto, M. Mongillo, T. Pozzan
2013Cell Metabolism184 citations Open access
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Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
N. M. Connolly, Pierre Theurey, V. Ádám-Vizi, N. Bazan +42 more
2017Cell Death and Differentiation180 citations Open access
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Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.
R. Filadi, Elisa Greotti, Gabriele Turacchio, A. Luini +2 more
2016Cell Reports167 citations Open access
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Mitochondrial matrix calcium is an activating signal for hormone secretion.
A. Wiederkehr, G. Szanda, Dmitry Akhmedov, C. Mataki +5 more
2011Cell Metabolism152 citations Open access
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Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease
M. Khan, D. Lustrino, Willian A. Silveira, Franziska Wild +16 more
2016Proceedings of the National Academy of Sciences of the United States of America151 citations Open access
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Mitochondrial Ca2+ homeostasis: mechanism, role, and tissue specificities
P. Pizzo, I. Drago, R. Filadi, T. Pozzan
2012Pflügers Archiv: European Journal of Physiology144 citations
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Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process
M. Bonora, E. De Marchi, S. Patergnani, J. Suski +9 more
2014Cell Death and Differentiation140 citations Open access
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Ca(2+) signalling in the Golgi apparatus.
P. Pizzo, Valentina Lissandron, P. Capitanio, T. Pozzan
2011Cell Calcium138 citations
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Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment
Valentina Lissandron, P. Podini, P. Pizzo, T. Pozzan
2010Proceedings of the National Academy of Sciences of the United States of America134 citations Open access
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Targeting of Cameleons to various subcellular compartments reveals a strict cytoplasmic/mitochondrial Ca²⁺ handling relationship in plant cells.
Giovanna Loro, I. Drago, T. Pozzan, F. L. Schiavo +2 more
2012The Plant Journal107 citations Open access
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The elusive importance of being a mitochondrial Ca(2+) uniporter.
Diana Pendin, Elisa Greotti, T. Pozzan
2014Cell Calcium99 citations Open access
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Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2
M. Kipanyula, Laura Contreras, Enrico Zampese, C. Lazzari +4 more
2012Aging Cell92 citations Open access
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Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy
T. Zaglia, Paola Ceriotti, Antonio Campo, G. Borile +17 more
2017Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
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Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
L. Brunello, Enrico Zampese, Cristina Florean, T. Pozzan +2 more
2009Journal of Cellular and Molecular Medicine87 citations Open access
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Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic β‐cell activation
A. Wiederkehr, Kyu-Sang Park, O. Dupont, N. Demaurex +3 more
2009EMBO Journal72 citations Open access
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The Pathophysiology of LETM1
K. Nowikovsky, T. Pozzan, R. Rizzuto, L. Scorrano +1 more
2012The Journal of General Physiology70 citations Open access
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Measurements of mitochondrial calcium in vivo.
T. Pozzan, R. Rudolf
2009Biochimica et Biophysica Acta70 citations Open access
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Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins
Tatiana Tkatch, Elisa Greotti, G. Baranauskas, Diana Pendin +12 more
2017Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
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Myosin Va cooperates with PKA RIα to mediate maintenance of the endplate in vivo
Ira V. Röder, Kyeong-rock Choi, M. Reischl, Yvonne Petersen +4 more
2010Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism‐secretion coupling in INS‐1E clonal β cells
Dmitry Akhmedov, M. Braun, C. Mataki, Kyu-Sang Park +5 more
2010The FASEB Journal64 citations Open access
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Foxg1 localizes to mitochondria and coordinates cell differentiation and bioenergetics
L. Pancrazi, G. Di Benedetto, L. Colombaioni, G. Della Sala +6 more
2015Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
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Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
Annamaria Lia, Gabriele Sansevero, A. Chiavegato, Miriana Sbrissa +7 more
2023Nature Communications60 citations Open access
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PKA compartmentalization links cAMP signaling and autophagy
F. Grisan, L. F. Iannucci, N. C. Surdo, A. Gerbino +4 more
2021Cell Death and Differentiation59 citations Open access
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Aβ42 oligomers selectively disrupt neuronal calcium release.
C. Lazzari, M. Kipanyula, M. Agostini, T. Pozzan +1 more
2015Neurobiology of Aging59 citations
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On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering
R. Filadi, Elisa Greotti, Gabriele Turacchio, A. Luini +2 more
2017Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
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Generation and functions of second messengers microdomains.
R. Filadi, T. Pozzan
2015Cell Calcium58 citations
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Altered Store Operated Calcium Entry Increases cAMP production and ERK1/2 phosphorylation in Polycystin-2 Defective Cholangiocytes
C. Spirli, L. Locatelli, R. Fiorotto, C. Morell +3 more
2012Hepatology58 citations Open access
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Exploring cells with targeted biosensors
Diana Pendin, Elisa Greotti, Konstantinos Lefkimmiatis, T. Pozzan
2017The Journal of General Physiology57 citations Open access
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Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea
Federico Ceriani, T. Pozzan, F. Mammano
2016Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
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Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisition
Laura Rodríguez, Elena Simeonato, P. Scimemi, F. Anselmi +10 more
2012Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
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Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2
L. Galla, Nelly Redolfi, T. Pozzan, P. Pizzo +1 more
2020International Journal of Molecular Sciences53 citations Open access
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Familial Alzheimer's disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis.
Elisa Greotti, P. Capitanio, Andrea K. C. Wong, T. Pozzan +2 more
2019Cell Calcium53 citations Open access
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Heterogeneity of Ca2+ handling among and within Golgi compartments.
Andrea K. C. Wong, P. Capitanio, Valentina Lissandron, M. Bortolozzi +2 more
2013Journal of Molecular Cell Biology53 citations Open access
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A Synthetic Fluorescent Mitochondria-Targeted Sensor for Ratiometric Imaging of Calcium in Live Cells.
Diana Pendin, R. Norante, André Morais de Nadai, G. Gherardi +7 more
2019Angewandte Chemie50 citations
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Ca2+ and cAMP cross‐talk in mitochondria
G. Di Benedetto, Diana Pendin, Elisa Greotti, P. Pizzo +1 more
2014Journal of Physiology47 citations Open access
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Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane
A. Burdyga, N. C. Surdo, Stefania Monterisi, G. Di Benedetto +8 more
2018Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
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Interplay among cGMP, cAMP, and Ca2+ in Living Olfactory Sensory Neurons In Vitro and In Vivo
M. Pietrobon, I. Zamparo, M. Maritan, S. A. Franchi +2 more
2011Journal of Neuroscience44 citations Open access
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Mitochondrial Ca2+ homeostasis: mechanism, role, and tissue specificities
P. Pizzo, I. Drago, R. Filadi, T. Pozzan
2012Pflügers Archiv: European Journal of Physiology43 citations
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Presenilin-2 modulation of ER-mitochondria interactions
Enrico Zampese, C. Fasolato, T. Pozzan, P. Pizzo
2011Communicative & Integrative Biology40 citations Open access
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