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A. Castonguay · SciRah

Researcher profile · Semantic Scholar

A. Castonguay

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A. Castonguay — researcher profile on SciRah

h-index: 27
Works: 93
Citations: 2,613

Most-cited papers

Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.
N. Rioux, A. Castonguay
1998Cancer Research211 citations
Semantic Scholar
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
N. Rioux, A. Castonguay
1998Carcinogenesis204 citations
Semantic Scholar
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.
A. Castonguay, D. Lin, G. Stoner, P. Radok +4 more
1983Cancer Research150 citations
Semantic Scholar
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
S. Hecht, N. Trushin, A. Castonguay, A. Rivenson
1986Cancer Research146 citations
Semantic Scholar
Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.
Caroline Duperron, A. Castonguay
1997Carcinogenesis133 citations
Semantic Scholar
Metabolism of tobacco-specific N-nitrosamines by cultured human tissues.
A. Castonguay, G. Stoner, H. Schut, S. Hecht
1983Proceedings of the National Academy of Sciences of the United States of America109 citations Open access
Semantic Scholar
Effects of α-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)1
S. Hecht, D. Lin, A. Castonguay
198399 citations
Semantic Scholar
The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK
H. Schuller, L. Zhang, D. Weddle, A. Castonguay +2 more
2002Journal of Cancer Research and Clinical Oncology89 citations Open access
Semantic Scholar
Assay of 1-nitropropane, 2-nitropropane, 1-azoxypropane and 2-azoxypropane for carcinogenicity by gavage in Sprague-Dawley rats.
Emerich S. Fiala, R. Czerniak, A. Castonguay, C. Conaway +1 more
1987Carcinogenesis79 citations
Semantic Scholar
Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin.
A. Castonguay, Hala U. Gali, E. Perchellet, Xiao M. Gao +6 more
1997International Journal of Oncology75 citations
Semantic Scholar
Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N'-nitrosonornicotine in F344 rats.
A. Castonguay, A. Rivenson, N. Trushin, J. Reinhardt +4 more
1984Cancer Research73 citations
Semantic Scholar
Transplacental induction of pancreas tumors in hamsters by ethanol and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
H. Schuller, R. Jorquera, A. Reichert, A. Castonguay
1993Cancer Research66 citations
Semantic Scholar
On the formation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone during smoking.
J. D. Adams, Suk-Jong Lee, Norma Vinchkoski, A. Castonguay +1 more
1983Cancer Letters64 citations
Semantic Scholar
Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa.
E. Brittebo, A. Castonguay, K. Furuya, Stephen S. Hecht
1983Cancer Research61 citations
Semantic Scholar
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA.
J. Cloutier, R. Drouin, M. Weinfeld, T. O'Connor +1 more
2001Journal of Molecular Biology59 citations
Semantic Scholar
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is an active transplacental carcinogen in Syrian golden hamsters.
E. Correa, P. A. Joshi, A. Castonguay, H. Schuller
1990Cancer Research53 citations
Semantic Scholar
Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats.
A. Castonguay, H. Tjãlve, S. Hecht
1983Cancer Research52 citations
Semantic Scholar
Tobacco specific nitrosamines: Carcinogenicity, metabolism, and possible role in human cancer
S. Hecht, A. Castonguay, A. Rivenson, B. Mu +1 more
198349 citations
Semantic Scholar
The carbon‐13 nuclear magnetic resonance spectra of anthraquinone, eight polyhydroxyanthraquinones and eight polymethoxyanthraquinones
Y. Berger, A. Castonguay
197843 citations
Semantic Scholar
Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice.
A. Castonguay, H. Tjãlve, N. Trushin, S. S. Hecht
1984Journal of the National Cancer Institute41 citations
Semantic Scholar
Strain A/J Mouse Lung Adenoma Growth Patterns Vary When Induced by Different Carcinogens
W. Gunning, A. Castonguay, P. Goldblatt, G. Stoner
1991Toxicologic pathology (Print)39 citations Open access
Semantic Scholar
Optimal conditions to use Pfu exo(-) DNA polymerase for highly efficient ligation-mediated polymerase chain reaction protocols.
Martin Angers, J. Cloutier, A. Castonguay, R. Drouin
2001Nucleic Acids Research36 citations Open access
Semantic Scholar
DNA single-strand breaks and toxicity induced by 4-(methyl-nitrosamino)-1-(3- pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver.
R. Jorquera, A. Castonguay, H. Schuller
1994Carcinogenesis36 citations
Semantic Scholar
Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes.
Li-Li Liu, M. Alaoui-Jamali, N. El Alami, A. Castonguay
1990Cancer Research34 citations
Semantic Scholar
Modulation of the uptake and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by nicotine in hamster lung.
H. Schuller, A. Castonguay, M. Orloff, G. Rossignol
1991Cancer Research30 citations
Semantic Scholar
Study of DNA methylation by tobacco-specific N-nitrosamines.
A. Castonguay, P. Foiles, N. Trushin, S. Hecht
1985Environmental Health Perspectives29 citations Open access
Semantic Scholar
Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
S. Hecht, D. Lin, A. Castonguay
1983Carcinogenesis29 citations
Semantic Scholar
Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
S. Lacoste, A. Castonguay, R. Drouin
2006Mutation research27 citations
Semantic Scholar
C-Alkylation of 1,3-dihydroxyanthraquinones. Total syntheses of (±)-averufin and (±)-bipolarin
A. Castonguay, P. Brassard
197726 citations Open access
Semantic Scholar
Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes.
R. Jorquera, A. Castonguay, H. Schuller
1992Drug Metabolism And Disposition24 citations
Semantic Scholar
Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes.
A. Castonguay, P. Pépin, N. Brière
1991Cancer Letters24 citations
Semantic Scholar
Metabolism and tissue distribution of tobacco-specific N-nitrosamines in the marmoset monkey (Callithrix jacchus).
A. Castonguay, N. Trushin, H. Tjãlve, R. D'argy +1 more
1985Carcinogenesis24 citations
Semantic Scholar
Metabolism and DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in fetal tissues of the Syrian golden hamster.
G. Rossignol, M. Alaoui-Jamali, A. Castonguay, H. Schuller
1989Cancer Research23 citations
Semantic Scholar
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages
N. Rioux, A. Castonguay
2001Cancer Immunology and Immunotherapy22 citations
Semantic Scholar
Ki‐ras mutations in 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone—initiated and butylated hydroxytoluene—promoted lung tumors in A/J mice
Steven A. Matzinger, W. Gunning, M. You, A. Castonguay
1994Molecular Carcinogenesis22 citations
Semantic Scholar
Cytokine production by alveolar macrophages is down regulated by the alpha-methylhydroxylation pathway of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
L. Proulx, A. Castonguay, É. Bissonnette
2004Carcinogenesis21 citations
Semantic Scholar
In vitro and in vivo modulation of the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in hamster lung tissues.
M. Charest, G. Rossignol, A. Castonguay
1989Chemico-Biological Interactions21 citations
Semantic Scholar
Tobacco-specific nitrosamines in Canadian cigarettes
S. Fischer, A. Castonguay, M. Kaiserman, B. Spiegelhalder +1 more
2005Journal of Cancer Research and Clinical Oncology20 citations Open access
Semantic Scholar
Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
S. Hecht, D. Lin, A. Castonguay, A. Rivenson
1987Carcinogenesis20 citations
Semantic Scholar
Reactions with Deoxyguanosine of 4-(Carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a Model Compound for α-Hydroxylation of Tobacco-Specific Nitrosamines
S. Hecht, D. Lin, Julia M. Chuang, A. Castonguay
198617 citations
Semantic Scholar
Carbon-13 nuclear magnetic resonance studies of anthraquinones Part II—hydroxymethoxyanthraquinones, acetoxymethoxyanthraquinones and naturally occuring anthraquinone analogues†
Y. Berger, A. Castonguay, P. Brassard
198017 citations
Semantic Scholar
Chemical carcinogenesis, mutagenesis, and teratogenesis.
Peter J. O'Brien, B. Hales, P. Josephy, A. Castonguay +2 more
1996Canadian Journal of Physiology and Pharmacology16 citations
Semantic Scholar
Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells.
S. Lacoste, A. Castonguay, R. Drouin
2007Mutation research14 citations
Semantic Scholar
Transplacental carcinogenicity of low doses of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone administered subcutaneously or intratracheally to hamsters
H. Schuller, R. Jorquera, X. Lu, A. Riechert +1 more
2005Journal of Cancer Research and Clinical Oncology14 citations Open access
Semantic Scholar
In vitro genotoxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone activated by hamster maternal and fetal tissues.
M. Alaoui-Jamali, A. Castonguay, H. Schuller
1988Carcinogenesis14 citations
Semantic Scholar
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human kidney epithelial cells transfected with rat CYP2B1 cDNA.
D. Lacroix, M. Desrochers, A. Castonguay, A. Anderson
1993Carcinogenesis13 citations
Semantic Scholar
Carbon‐13 nuclear magnetic resonance studies of anthraquinones. IV—correlation of substituent effects for 1‐substituted anthraquinones
Y. Berger, M. Berger-Deguée, A. Castonguay
198111 citations
Semantic Scholar
Synthesis of nornicotine analogs to use as haptens for immunoassays
A. Castonguay, H. van Vunakis
197911 citations
Semantic Scholar
Comparison of DNA alkali-labile sites induced by 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone and 4-oxo-4-(3-pyridyl)butanal in rat hepatocytes.
K. Demkowicz-Dobrzański, A. Castonguay
1991Carcinogenesis10 citations
Semantic Scholar
Induction of COX expression by a tobacco carcinogen: Implication in lung cancer chemoprevention
N. Rioux, A. Castonguay
1999Inflammation Research9 citations
Semantic Scholar

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H. Schuller×9
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D. Lin×5
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A. Rivenson×5
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N. Rioux — researcher profile on SciRah

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N. Trushin — researcher profile on SciRah

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R. Drouin — researcher profile on SciRah

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G. Stoner — researcher profile on SciRah

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H. Tjãlve — researcher profile on SciRah

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Y. Berger — researcher profile on SciRah

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R. Jorquera — researcher profile on SciRah

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M. Alaoui-Jamali — researcher profile on SciRah