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M. Hixon · SciRah

Researcher profile · Semantic Scholar

M. Hixon

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M. Hixon — researcher profile on SciRah

h-index: 27
Works: 83
Citations: 1,993

Most-cited papers

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.
N. Silvaggi, G. Boldt, M. Hixon, J. P. Kennedy +3 more
2007Chemistry and Biology124 citations Open access
Semantic Scholar
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists
L. M. Eubanks, M. Hixon, W. Jin, Sukwon Hong +10 more
2007Proceedings of the National Academy of Sciences of the United States of America119 citations Open access
Semantic Scholar
The Mechanism of Class II, Metal‐Dependent Aldolases
W. Fessner, A. Schneider, H. Held, G. Sinerius +3 more
199688 citations
Semantic Scholar
Metabolomics-Based Discovery of Diagnostic Biomarkers for Onchocerciasis
Judith R. Denery, Ashlee A K Nunes, M. Hixon, T. Dickerson +1 more
2010PLoS Neglected Tropical Diseases80 citations Open access
Semantic Scholar
Addendum: Digestion and depletion of abundant proteins improves proteomic coverage
B. Fonslow, M. Hixon, Benjamin D. Stein, Kristofor J. Webb +4 more
2014Nature Methods76 citations Open access
Semantic Scholar
Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.
G. Boldt, J. P. Kennedy, M. Hixon, Laura A McAllister +3 more
2006Journal of combinatorial chemistry74 citations Open access
Semantic Scholar
Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness
D. Globisch, Amira Y. Moreno, M. Hixon, Ashlee A K Nunes +4 more
2013Proceedings of the National Academy of Sciences of the United States of America72 citations Open access
Semantic Scholar
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
Debra Van Egeren, A. Novokhodko, M. Stoddard, U. Tran +7 more
2021PLoS ONE69 citations Open access
Semantic Scholar
Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2.
M. Hixon, Andy J. Ball, M. Gelb
1998Biochemistry69 citations
Semantic Scholar
Monoclonal Antibodies for Combating Synthetic Opioid Intoxication
Lauren C. Smith, Paul T. Bremer, Candy S. Hwang, Bin Zhou +3 more
2019Journal of the American Chemical Society62 citations Open access
Semantic Scholar
NB2001, a Novel Antibacterial Agent with Broad-Spectrum Activity and Enhanced Potency against β-Lactamase-Producing Strains
Qing Li, Jean-Yong Lee, R. Castillo, M. Hixon +6 more
2002Antimicrobial Agents and Chemotherapy54 citations Open access
Semantic Scholar
Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors
Peter Šilhár, K. Čapková, N. Salzameda, J. Barbieri +2 more
2010Journal of the American Chemical Society51 citations Open access
Semantic Scholar
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay.
Ikuo Miyahisa, Tomoya Sameshima, M. Hixon
2015Angewandte Chemie49 citations Open access
Semantic Scholar
Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
Farideh Ghomashchi, Ying Lin, M. Hixon, Bao-Zhu Yu +3 more
1998Biochemistry46 citations
Semantic Scholar
Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease
L. M. Eubanks, Peter Šilhár, N. Salzameda, Joseph S. Zakhari +5 more
2010ACS Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
A. Mayorov, N. Amara, Jason Y. H. Chang, Jason A. Moss +5 more
2008Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.
Hidehisa Iwata, Shinichi Imamura, A. Hori, M. Hixon +2 more
2011Biochemistry37 citations
Semantic Scholar
Identification and characterization of single chain anti-cocaine catalytic antibodies.
K. Mckenzie, Jenny M. Mee, C. J. Rogers, M. Hixon +2 more
2007Journal of Molecular Biology37 citations Open access
Semantic Scholar
ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid
Christopher J. Smyrniotis, Shannon Barbour, Zexin Xia, M. Hixon +1 more
2014Biochemistry36 citations Open access
Semantic Scholar
Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design
Xiaoqing Cai, Timothy W. Whitfield, M. Hixon, Yanabel Grant +2 more
2013Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Probing the Effects of Hapten Stability on Cocaine Vaccine Immunogenicity
Xiaoqing Cai, Timothy W. Whitfield, Amira Y. Moreno, Yanabel Grant +3 more
2013Molecular Pharmaceutics34 citations Open access
Semantic Scholar
Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations.
K. Čapková, M. Hixon, Laura A McAllister, K. Janda
2008Chemical Communications34 citations
Semantic Scholar
Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library.
T. Dickerson, A. Beuscher, C. J. Rogers, M. Hixon +4 more
2005Biochemistry34 citations
Semantic Scholar
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Ryan J. Shirey, D. Globisch, L. M. Eubanks, M. Hixon +1 more
2018ACS Infectious Diseases30 citations Open access
Semantic Scholar
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
Hidehisa Iwata, H. Oki, K. Okada, T. Takagi +8 more
2012ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease
G. N. Stowe, Peter Šilhár, M. Hixon, N. Silvaggi +5 more
2010Organic Letters30 citations Open access
Semantic Scholar
Benzylidene cyclopentenediones: First Irreversible Inhibitors against Botulinum Neurotoxin A’s Zinc Endopeptidase
K. Čapková, M. Hixon, S. Pellett, J. Barbieri +2 more
2009Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.
A. Gangloff, Jason Brown, R. de Jong, D. Dougan +8 more
2013Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-diaminopyridine prodrug design and characterization
Joseph S. Zakhari, I. Kinoyama, M. Hixon, A. Di Mola +2 more
2011Bioorganic & Medicinal Chemistry26 citations Open access
Semantic Scholar
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
Mark E. Adams, Toshitake Kobayashi, J. Lawson, Morihisa Saitoh +9 more
2016Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation
Jie-Ping Zhu, M. Hixon, D. Globisch, G. Kaufmann +1 more
2013Journal of the American Chemical Society24 citations Open access
Semantic Scholar
Benzoquinones as Inhibitors of Botulinum Neurotoxin Serotype A
Paul T. Bremer, M. Hixon, K. Janda
2014Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Identification of α2-Macroglobulin as a Major Serum Ghrelin Esterase
Lisa M. Eubanks, G. N. Stowe, Sandra De Lamo Marin, A. Mayorov +2 more
2011Angewandte Chemie20 citations Open access
Semantic Scholar
Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.
Hidehisa Iwata, Shinichi Imamura, A. Hori, M. Hixon +2 more
2011Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
General Method for the Study of Solute-Surfactant Association Equilibria of Volatile Solutes by Head Space Gas Chromatography
A. Hussam, S. Basu, M. Hixon, Z. Olumee
199520 citations
Semantic Scholar
Antibody-catalyzed anaerobic destruction of methamphetamine
Yang Xu, M. Hixon, N. Yamamoto, Laura A McAllister +3 more
2007Proceedings of the National Academy of Sciences of the United States of America18 citations Open access
Semantic Scholar
Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin.
Laura A McAllister, M. Hixon, J. P. Kennedy, T. Dickerson +1 more
2006Journal of the American Chemical Society18 citations Open access
Semantic Scholar
Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity.
H. Seki, Song Xue, M. Hixon, S. Pellett +3 more
2015Chemical Communications17 citations
Semantic Scholar
Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers.
Jason A. Moss, Shula Stokols, M. Hixon, Fawn T. Ashley +2 more
2006Biomacromolecules17 citations Open access
Semantic Scholar
Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
M. Lanier, D. Cole, Yelena Istratiy, M. G. Klein +4 more
2017Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.
Mark Sabat, Haixia Wang, N. Scorah, J. Lawson +4 more
2017Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Zum Mechanismus der metallabhängigen Aldolasen der Klasse II
Wolf-Dieter Fessner, A. Schneider, H. Held, Gudrun Sinerius +3 more
199616 citations
Semantic Scholar
Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7
V. Grattan, A. Vaino, Z. Prensky, M. Hixon
2019ACS Omega15 citations Open access
Semantic Scholar
The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft
Peter Šilhár, Matthew A. Lardy, M. Hixon, C. Shoemaker +5 more
2012ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Beta-alanine transaminase activity in black and suppressor of black mutations of Drosophila melanogaster.
Jon P. Weber, Richard J. Bolin, M. Hixon, Allen F. Sherald
1992Biochimica et Biophysica Acta15 citations
Semantic Scholar
A Cross-over Inhibitor of the Botulinum Neurotoxin Light Chain B: A Natural Product Implicating an Exosite Mechanism of Action
N. Salzameda, L. M. Eubanks, Joseph S. Zakhari, K. Tsuchikama +4 more
2011Chemical Communications14 citations Open access
Semantic Scholar
Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein–Protein Interaction Inhibitors
Karol R. Francisco, Jessica Bruystens, C. Varricchio, Sara McCurdy +8 more
2023ACS Pharmacology & Translational Science12 citations Open access
Semantic Scholar
Salicylanilide analog minimizes relapse of Clostridioides difficile infection in mice.
Steven Blake, R. Thanissery, A. J. Rivera, M. Hixon +3 more
2020Journal of Medicinal Chemistry12 citations
Semantic Scholar
T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.
Ikuo Miyahisa, Hideo Suzuki, Atsushi Mizukami, Y. Tanaka +3 more
2016ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
M. Lanier, G. Ambrus, D. Cole, R. Davenport +14 more
2014Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar

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