J. Barbieri

Most-cited papers

Novel bacterial ADP-ribosylating toxins: structure and function
Nathan C. Simon, K. Aktories, J. Barbieri
2014Nature Reviews Microbiology199 citations Open access
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Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins.
Qing Deng, J. Barbieri
2008Annual Review of Microbiology178 citations
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Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F
Z. Fu, Chen Chen, J. Barbieri, Jung-Ja P. Kim +1 more
2009Biochemistry144 citations Open access
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Subunit Vaccine against the Seven Serotypes of Botulism
M. R. Baldwin, W. Tepp, A. Przedpelski, Christina L. Pier +3 more
2007Infection and Immunity122 citations Open access
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Gangliosides as High Affinity Receptors for Tetanus Neurotoxin*
Chen Chen, Z. Fu, Jung-Ja P. Kim, J. Barbieri +1 more
2009Journal of Biological Chemistry121 citations Open access
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An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists
L. M. Eubanks, M. Hixon, W. Jin, Sukwon Hong +10 more
2007Proceedings of the National Academy of Sciences of the United States of America119 citations Open access
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Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor
Jing Zhao, Yu-Hong Du, J. Horton, A. Upadhyay +11 more
2011Proceedings of the National Academy of Sciences of the United States of America101 citations Open access
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Unique Substrate Recognition by Botulinum Neurotoxins Serotypes A and E*
Sheng Chen, J. Barbieri
2006Journal of Biological Chemistry93 citations Open access
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Mechanism of Substrate Recognition by Botulinum Neurotoxin Serotype A*
Sheng Chen, Jung-Ja P. Kim, J. Barbieri
2007Journal of Biological Chemistry90 citations Open access
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Toxins from Bacteria
J. S. Henkel, M. R. Baldwin, J. Barbieri
2010EXS88 citations Open access
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Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
M. R. Baldwin, J. Barbieri
2007Biochemistry83 citations
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Engineering botulinum neurotoxin to extend therapeutic intervention
Sheng Chen, J. Barbieri
2009Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
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Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.
G. Boldt, J. P. Kennedy, M. Hixon, Laura A McAllister +3 more
2006Journal of combinatorial chemistry74 citations Open access
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The ADP-Ribosylation Domain of Pseudomonas aeruginosa ExoS Is Required for Membrane Bleb Niche Formation and Bacterial Survival within Epithelial Cells
A. A. Angus, D. Evans, J. Barbieri, S. Fleiszig
2010Infection and Immunity71 citations Open access
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Catalytic Properties of Botulinum Neurotoxins Subtypes A3 and A4
J. S. Henkel, Mark J. Jacobson, W. Tepp, Christina L. Pier +2 more
2009Biochemistry69 citations Open access
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Substrate Recognition of VAMP-2 by Botulinum Neurotoxin B and Tetanus Neurotoxin*
Sheng Chen, Cherisse L. Hall, J. Barbieri
2008Journal of Biological Chemistry69 citations Open access
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The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes
S. Pellett, M. Bradshaw, W. Tepp, Christina L. Pier +4 more
2018mBio63 citations Open access
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Pseudomonas aeruginosa Utilizes the Type III Secreted Toxin ExoS to Avoid Acidified Compartments within Epithelial Cells
S. Heimer, D. Evans, M. Stern, J. Barbieri +2 more
2013PLoS ONE63 citations Open access
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Molecular basis for tetanus toxin coreceptor interactions.
Chen Chen, M. R. Baldwin, J. Barbieri
2008Biochemistry62 citations
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Recombinant Holotoxoid Vaccine against Botulism
Christina L. Pier, W. Tepp, M. Bradshaw, E. Johnson +2 more
2007Infection and Immunity61 citations Open access
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Tetanus Toxin and Botulinum Toxin A Utilize Unique Mechanisms To Enter Neurons of the Central Nervous System
Faith C. Blum, Chen Chen, A. Kroken, J. Barbieri
2012Infection and Immunity60 citations Open access
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Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA
A. Karalewitz, A. Kroken, Z. Fu, M. R. Baldwin +2 more
2010Biochemistry60 citations Open access
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Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
Z. Fu, Sheng Chen, M. R. Baldwin, G. Boldt +4 more
2006Biochemistry60 citations
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Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry*
A. Karalewitz, Z. Fu, M. R. Baldwin, Jung-Ja P. Kim +1 more
2012Journal of Biological Chemistry55 citations Open access
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General aspects and recent advances on bacterial protein toxins.
E. Lemichez, J. Barbieri
2013Cold Spring Harbor Perspectives in Medicine51 citations Open access
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Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors
Peter Šilhár, K. Čapková, N. Salzameda, J. Barbieri +2 more
2010Journal of the American Chemical Society51 citations Open access
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Pseudomonas aeruginosa ExoS ADP‐ribosyltransferase inhibits ERM phosphorylation
A. Maresso, Qing Deng, Michael S. Pereckas, Bassam T. Wakim +1 more
2007Cellular Microbiology50 citations Open access
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Multiple Pocket Recognition of SNAP25 by Botulinum Neurotoxin Serotype E*
Sheng Chen, J. Barbieri
2007Journal of Biological Chemistry50 citations Open access
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Vaccines against botulism.
A. Karalewitz, J. Barbieri
2012Current Opinion in Microbiology48 citations Open access
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Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease
L. M. Eubanks, Peter Šilhár, N. Salzameda, Joseph S. Zakhari +5 more
2010ACS Medicinal Chemistry Letters44 citations Open access
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Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence
Victoria Hritonenko, James J. Mun, Connie Tam, Nathan C. Simon +3 more
2011Microbial Pathogenesis43 citations Open access
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Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into Neurons*
A. Kroken, A. Karalewitz, Z. Fu, Jung-Ja P. Kim +1 more
2011Journal of Biological Chemistry41 citations Open access
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Association of Botulinum Neurotoxin Serotype A Light Chain with Plasma Membrane-bound SNAP-25*
Sheng Chen, J. Barbieri
2011Journal of Biological Chemistry41 citations Open access
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A Leucine-Rich Motif Targets Pseudomonas aeruginosa ExoS within Mammalian Cells
Yue Zhang, J. Barbieri
2005Infection and Immunity39 citations Open access
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The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAX Motif*
Nathan J. Schuld, Jeffrey S. Vervacke, E. Lorimer, Nathan C. Simon +4 more
2014Journal of Biological Chemistry37 citations Open access
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Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial
M. Anstead, S. Heltshe, Umer Khan, J. Barbieri +8 more
2012Journal of Cystic Fibrosis36 citations Open access
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A Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding
J. Schmitt, A. Karalewitz, Desirée A. Benefield, Darren J. Mushrush +4 more
2010Biochemistry36 citations Open access
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Light Chain Diversity among the Botulinum Neurotoxins
A. Gardner, J. Barbieri
2018Toxins35 citations Open access
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Intracellular Localization of Type III-delivered Pseudomonas ExoS with Endosome Vesicles*
Yue Zhang, Qing Deng, J. Barbieri
2007Journal of Biological Chemistry35 citations Open access
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Protein Toxins that Utilize Gangliosides as Host Receptors
Madison Zuverink, J. Barbieri
2018Progress in Molecular Biology and Translational Science32 citations Open access
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Vaccines against Botulism
G. Sundeen, J. Barbieri
2017Toxins31 citations Open access
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Association of Botulinum neurotoxins with synaptic vesicle protein complexes
M. R. Baldwin, J. Barbieri
2008Toxicon31 citations Open access
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Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons
A. Kroken, Faith C. Blum, Madison Zuverink, J. Barbieri
2016Infection and Immunity30 citations Open access
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Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease
G. N. Stowe, Peter Šilhár, M. Hixon, N. Silvaggi +5 more
2010Organic Letters30 citations Open access
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Enhancing toxin-based vaccines against botulism
A. Przedpelski, W. Tepp, Madison Zuverink, E. Johnson +2 more
2018Vaccine29 citations Open access
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Benzylidene cyclopentenediones: First Irreversible Inhibitors against Botulinum Neurotoxin A’s Zinc Endopeptidase
K. Čapková, M. Hixon, S. Pellett, J. Barbieri +2 more
2009Bioorganic & Medicinal Chemistry Letters29 citations Open access
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Botulinum neurotoxin B–host receptor recognition: it takes two receptors to tango
M. R. Baldwin, Jung-Ja P. Kim, J. Barbieri
2007Nature Structural &Molecular Biology29 citations
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Enhancing the Protective Immune Response against Botulism
A. Przedpelski, W. Tepp, A. Kroken, Z. Fu +3 more
2013Infection and Immunity25 citations Open access
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Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS
Yue Zhang, Qing Deng, J. Porath, Carol L. Williams +2 more
2007Cellular Microbiology25 citations Open access
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Insights into the different catalytic activities of Clostridium Neurotoxins
Sheng Chen, A. Karalewitz, J. Barbieri
2012Biochemistry23 citations Open access
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