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S. Nuber · SciRah

Researcher profile · Semantic Scholar

S. Nuber

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S. Nuber — researcher profile on SciRah

h-index: 28
Works: 64
Citations: 3,177

Most-cited papers

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
D. Games, Elvira Valera, B. Spencer, E. Rockenstein +11 more
2014Journal of Neuroscience311 citations Open access
Semantic Scholar
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
S. Fanning, Aftabul Haque, Thibaut Imberdis, V. Baru +27 more
2018Molecules and Cells262 citations Open access
Semantic Scholar
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
E. Rockenstein, S. Nuber, C. Overk, K. Ubhi +13 more
2014Brain : a journal of neurology228 citations Open access
Semantic Scholar
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
Marusela Oliveras-Salvá, A. Van der Perren, N. Casadei, Stijn Stroobants +4 more
2013Molecular Neurodegeneration180 citations Open access
Semantic Scholar
Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
S. Nuber, E. Petrasch‐Parwez, B. Winner, J. Winkler +17 more
2008Journal of Neuroscience175 citations Open access
Semantic Scholar
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.
S. Nuber, F. Harmuth, Z. Kohl, A. Adame +18 more
2013Brain : a journal of neurology149 citations Open access
Semantic Scholar
Abrogating native α-synuclein tetramers in mice causes a L-DOPA responsive motor syndrome closely resembling Parkinson’s disease
S. Nuber, Molly Rajsombath, Georgia Minakaki, J. Winkler +5 more
2018Neuron138 citations Open access
Semantic Scholar
Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway
J. Klucken, Anne-Maria Poehler, Darius Ebrahimi‐Fakhari, J. Schneider +7 more
2012Autophagy138 citations Open access
Semantic Scholar
A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
A. Kurz, K. Double, I. Lastres-Becker, A. Tozzi +14 more
2010PLoS ONE138 citations Open access
Semantic Scholar
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.
Meike Diepenbroek, N. Casadei, H. Esmer, T. Saido +12 more
2014Human Molecular Genetics119 citations Open access
Semantic Scholar
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
Nagendran Ramalingam, Shan-xue Jin, Tim E. Moors, L. Fonseca-Ornelas +19 more
2023npj Parkinson's Disease111 citations Open access
Semantic Scholar
First appraisal of brain pathology owing to A30P mutant alpha‐synuclein
K. Seidel, L. Schöls, S. Nuber, E. Petrasch‐Parwez +11 more
2010Annals of Neurology111 citations Open access
Semantic Scholar
Loss of native &agr;-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells
Ulf Dettmer, Nagendran Ramalingam, Victoria E. von Saucken, Tae-Eun Kim +9 more
2017Human Molecular Genetics103 citations Open access
Semantic Scholar
Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3.
J. Boy, Thorsten Schmidt, H. Wolburg, A. Mack +7 more
2009Human Molecular Genetics103 citations
Semantic Scholar
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
A. Van der Perren, J. Toelen, C. Casteels, F. Macchi +14 more
2015Neurobiology of Aging95 citations Open access
Semantic Scholar
Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.
D. Games, P. Seubert, E. Rockenstein, C. Patrick +8 more
2013American Journal of Pathology94 citations Open access
Semantic Scholar
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha‐synuclein
F. Marxreiter, S. Nuber, Mahesh Kandasamy, J. Klucken +6 more
2009European Journal of Neuroscience77 citations Open access
Semantic Scholar
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy
V. May, Benjamin Ettle, Anne-Maria Poehler, S. Nuber +6 more
2014Neurobiology of Aging66 citations Open access
Semantic Scholar
A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice
S. Nuber, A. Y. Nam, Molly Rajsombath, Haley Cirka +12 more
2020Annals of Neurology58 citations Open access
Semantic Scholar
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice
F. Marxreiter, Benjamin Ettle, V. May, H. Esmer +8 more
2013Neurobiology of Disease46 citations Open access
Semantic Scholar
Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice
Molly Rajsombath, A. Y. Nam, M. Ericsson, S. Nuber
2019Journal of Neuroscience43 citations Open access
Semantic Scholar
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
L. Fonseca-Ornelas, Thibault Viennet, Matteo Rovere, Haiyang Jiang +5 more
2021Cell Reports40 citations Open access
Semantic Scholar
Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice
Kelly E. Glajch, Tim E. Moors, Yi Chen, Pascal A. Bechade +8 more
2021Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α‐synuclein
J. Schlachetzki, T. Grimm, Zinayida Schlachetzki, N. B. Ben Abdallah +6 more
2016Journal of Neuroscience Research36 citations
Semantic Scholar
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD
S. Nuber, Danielle Tadros, J. Fields, C. Overk +6 more
2014Acta Neuropathologica34 citations Open access
Semantic Scholar
Expression mapping of tetracycline-responsive prion protein promoter: Digital atlasing for generating cell-specific disease models
J. Boy, T. Leergaard, Thorsten Schmidt, Francis Odeh +8 more
2006NeuroImage34 citations
Semantic Scholar
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
N. Casadei, Anna Pöhler, C. Tomás-Zapico, J. Torres-Peraza +12 more
2014Human Molecular Genetics33 citations Open access
Semantic Scholar
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity
S. Nuber, C. Chung, D. Tardiff, Pascal A. Bechade +15 more
2022Neurotherapeutics31 citations Open access
Semantic Scholar
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.
S. Nuber, E. Petrasch‐Parwez, Ó. Arias-Carrión, L. Koch +14 more
2011Neurobiology of Disease26 citations Open access
Semantic Scholar
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
S. Nuber, T. Franck, H. Wolburg, U. Schumann +13 more
2010Neurogenetics25 citations
Semantic Scholar
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis
A. Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, A. Newman +7 more
2022Journal of Neuroscience22 citations Open access
Semantic Scholar
Increased palmitoylation improves estrogen receptor alpha–dependent hippocampal synaptic deficits in a mouse model of synucleinopathy
Tim E. Moors, Shaoming Li, T. McCaffery, Gary P. H. Ho +4 more
2023Science Advances16 citations Open access
Semantic Scholar
The Parkinson-associated toxin paraquat shifts physiological αS tetramers toward monomers that can be calpain-truncated and form oligomers.
S. Nuber, D. Selkoe
2023American Journal of Pathology16 citations Open access
Semantic Scholar
Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
N. Casadei, P. Sood, T. Ulrich, P. Fallier-Becker +13 more
2016Human Molecular Genetics15 citations Open access
Semantic Scholar
Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism
M. A. Adom, W. Hahn, T. McCaffery, T. E. Moors +5 more
2024Neurobiology of Disease12 citations Open access
Semantic Scholar
Caspase-1 clipping causes complications for α-synuclein
S. Nuber, D. Selkoe
2016Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
S. Nuber, Xiao-Qun Zhang, T. McCaffery, T. E. Moors +8 more
2024npj Parkinson's Disease10 citations Open access
Semantic Scholar
Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
N. Casadei, P. Sood, T. Ulrich, P. Fallier-Becker +13 more
2016Human Molecular Genetics10 citations
Semantic Scholar
Genetic causes of Parkinson's disease: extending the pathway.
O. Riess, R. Krüger, Helmine Hochstrasser, A. Soehn +3 more
2006Journal of neural transmission. Supplementum10 citations Open access
Semantic Scholar
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
S. Nuber, Harrison Hsiang, Esra'a Keewan, T. E. Moors +14 more
2025JCI Insight9 citations Open access
Semantic Scholar
Errata
K. Seidel, L. Schöls, S. Nuber, E. Petrasch‐Parwez +11 more
20103 citations Open access
Semantic Scholar
Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity
S. Nuber, C. Chung, D. Tardiff, Pascal A. Bechade +15 more
2022Neurotherapeutics2 citations Open access
Semantic Scholar
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
Marusela Oliveras-Salvá, A. Van der Perren, N. Casadei, Stijn Stroobants +4 more
2013Molecular Neurodegeneration1 citations Open access
Semantic Scholar
Conditional control of human wildtype and mutated [A30P] alpha-synuclein in a mouse model of Parkinson's disease
S. Nuber, Thorsten Schmidt, Hans‐Werner Habbes, Marlen Löbbecke-Schumacher +16 more
20051 citations
Semantic Scholar
Aberrant Cerebellar-Recipient Thalamic Activity in Two Mouse Models with Prominent Tremor or Bradykinesia
Shruti Nanivadekar, Isabella Salas-Allende, S. Nuber, R. S. Turner +1 more
2026Journal of Neuroscience0 citations Open access
Semantic Scholar
Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein
M. M. Bolsinger, T. E. Moors, Lisa Brontesi, S. Nuber +2 more
2025Metabolic brain disease0 citations Open access
Semantic Scholar
Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
S. Nuber, Xiao-Qun Zhang, T. McCaffery, T. E. Moors +8 more
2024npj Parkinson's Disease0 citations Open access
Semantic Scholar
Altered Conformation of α-Synuclein Drives Malfunction of Synaptic Vesicles in a Model of Parkinson's Disease
L. Fonseca-Ornelas, Thibault Viennet, Matteo Rovere, Haiyang Jiang +5 more
20200 citations
Semantic Scholar
Dose-dependent therapeutic effects of FK506 on dopaminergic neurodegeneration and neuroinflammation in a viral vector-based α-synuclein rat model for Parkinson’s disease
A. Van der Perren, F. Macchi, A. Van Rompuy, C. Casteels +12 more
20130 citations
Semantic Scholar
3.119 STRIATAL LONG-TERM DEPRESSION AND DOPAMINE SIGNALING IMPAIRMENT IN A53T-ALPHA-SYNUCLEIN OVEREXPRESSING MICE
G. Auburger, A. Kurz, K. Double, I. Lastres-Becker +14 more
20120 citations
Semantic Scholar

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