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T. Saido · SciRah

Researcher profile · Semantic Scholar

T. Saido

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T. Saido — researcher profile on SciRah

h-index: 115
Works: 824
Citations: 51K

Most-cited papers

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Andrew Octavian Sasmita, Constanze Depp, T. Nazarenko, T. Sun +31 more
2024Nature Neuroscience98 citations Open access
Semantic Scholar
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Naoto Watamura, M. Foiani, S. Bez, M. Bourdenx +24 more
2024Nature Neuroscience61 citations Open access
Semantic Scholar
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
Ting Wang, A. Sobue, Seiji Watanabe, Okiru Komine +3 more
2024Journal of Neuroinflammation45 citations Open access
Semantic Scholar
The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain
Naoto Watamura, Naomasa Kakiya, Ryo Fujioka, Naoko Kamano +6 more
2024Science Signaling37 citations
Semantic Scholar
Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation
A. Sobue, Okiru Komine, F. Endo, Chihiro Kakimi +8 more
2024Cell Death and Disease34 citations Open access
Semantic Scholar
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Nicholas Sweeney, Tae Yeon Kim, C. Morrison, Liangping Li +20 more
2024Acta Neuropathologica26 citations Open access
Semantic Scholar
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
R. Kaneko, Ako Matsui, Mahiro Watanabe, Y. Harada +10 more
2023Inflammation and Regeneration26 citations Open access
Semantic Scholar
Mass spectrometry imaging highlights dynamic patterns of lipid co‐expression with Aβ plaques in mouse and human brains
H. Huang, P. Inglese, Jiabin Tang, Riad Yagoubi +13 more
2024Journal of Neurochemistry23 citations Open access
Semantic Scholar
Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda +3 more
2023Fluids and Barriers of the CNS20 citations Open access
Semantic Scholar
Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL−F/NL−F knock-in mouse model of Alzheimer’s disease
Emelie Andersson, Nina Schultz, T. Saito, T. Saido +4 more
2023Alzheimer's Research & Therapy19 citations Open access
Semantic Scholar
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer’s disease models
Stephanie R. Miller, Kevin Luxem, K. Lauderdale, Pranav Nambiar +21 more
2024Cell Reports16 citations Open access
Semantic Scholar
The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease
Takahiro Morito, Shoko Hashimoto, Risa Takamura, Naoto Watamura +13 more
2025Journal of Neuroscience14 citations Open access
Semantic Scholar
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community
Takahiro Morito, Mohan Qi, Naoko Kamano, H. Sasaguri +14 more
2025Cell Reports Methods14 citations Open access
Semantic Scholar
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer’s disease
Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito +18 more
2024Frontiers in Immunology13 citations Open access
Semantic Scholar
Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice
Xiance Ni, Ran Inoue, Yi Wu, T. Yoshida +6 more
2023Frontiers in Aging Neuroscience13 citations Open access
Semantic Scholar
Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia
Y. Matsuba, K. Nagata, Yosuke Kadota, N. Sahara +2 more
2025Journal of Neuroinflammation12 citations Open access
Semantic Scholar
Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice
K. Nagata, Shoko Hashimoto, Daisuke Joho, Ryo Fujioka +11 more
2024eNeuro12 citations Open access
Semantic Scholar
β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease
Lu-Lu Jiang, Rebecca Roberts, Melissa Wong, Lu-Shuang Zhang +18 more
2024Frontiers in Neuroscience12 citations Open access
Semantic Scholar
Production of a heterozygous exon skipping model of common marmosets using gene-editing technology
Kenya Sato, Hiroki Sasaguri, Wakako Kumita, T. Sakuma +13 more
2024Lab animal10 citations Open access
Semantic Scholar
Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno +4 more
2024Neurosciences research9 citations Open access
Semantic Scholar
High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APPNL−G−F mice
Shuhan Yang, Hirofumi Miyazaki, Tunyanat Wannakul, E. Amo +5 more
2025Molecular Neurobiology8 citations
Semantic Scholar
Involvement of CRMP2 Phosphorylation in Amyloid Beta-induced Tau Phosphorylation of Hippocampal Neurons in Alzheimer’s Disease Mouse Model
Daisuke Noguchi, Naoto Watamura, Miyu Nikkuni, T. Saido +2 more
2025Molecular Neurobiology8 citations
Semantic Scholar
Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
Lidia Sánchez-Puebla, R. de Hoz, E. Salobrar-García, Alberto Arias-Vázquez +13 more
2024International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi +18 more
2024bioRxiv8 citations Open access
Semantic Scholar
Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice.
M. Furukawa, Hirobumi Tada, Resmi Raju, Jingshu Wang +6 more
2024Journal of Oral Biosciences8 citations Open access
Semantic Scholar
Retinal Vascular and Structural Changes in the Murine Alzheimer’s APPNL-F/NL-F Model from 6 to 20 Months
Lidia Sánchez-Puebla, I. López-Cuenca, E. Salobrar-García, María González-Jiménez +13 more
2024Biomolecules7 citations Open access
Semantic Scholar
The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo
S. Shimohama, Ryo Fujioka, Naomi Mihira, Misaki Sekiguchi +8 more
2024Journal of Neuroscience7 citations Open access
Semantic Scholar
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice.
Ryo Inagaki, Tohru Yamakuni, Takashi Saito, T. Saido +1 more
2024Neurobiology of Aging7 citations Open access
Semantic Scholar
Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi +19 more
2025Alzheimer's Research & Therapy6 citations Open access
Semantic Scholar
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer's disease model mice.
S. Hirabayashi, Akiko Uyeda, I. Manabe, Y. Yonezu +6 more
2025Journal of Pharmacological Sciences6 citations Open access
Semantic Scholar
The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice.
Akira Uruno, Shiori Kadoguchi-Igarashi, Ritsumi Saito, Shohei Koiso +7 more
2024Journal of Biochemistry (Tokyo)6 citations Open access
Semantic Scholar
Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain
Y. Yamamoto, Toshiki Kubota, Daisuke Noguchi, T. Saido +1 more
2025Molecular Neurobiology5 citations
Semantic Scholar
Long term rescue of Alzheimer’s deficits in vivo by one-time gene-editing of App C-terminus
Brent D. Aulston, Kirstan Gimse, Hannah O. Bazick, E. Kramár +19 more
2024bioRxiv5 citations Open access
Semantic Scholar
Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice
Khairun-Nisa Hashim, Y. Matsuba, Mika Takahashi, Naoko Kamano +3 more
2024FEBS Letters5 citations Open access
Semantic Scholar
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono +10 more
2024PLoS ONE5 citations Open access
Semantic Scholar
Reduced Autophagy in Aged Trigeminal Neurons Causes Amyloid β Diffusion
R. Sonoda, E. Kuramoto, S. Minami, S. Matsumoto +5 more
2023Journal of dentistry research5 citations
Semantic Scholar
Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy
Julie R. Dumont, Paul A. S. Sheppard, Chris Fodor, M. Coto +8 more
2025Genes, Brain and Behavior4 citations Open access
Semantic Scholar
Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity
Simin Song, Qian-Min Liu, Ruixiang Chen, Ping Chen +12 more
2025Acta Neuropathologica Communications4 citations Open access
Semantic Scholar
Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppNL−G−F/NL−G−F mice
Kasumi Maekawa, A. Sobue, Okiru Komine, Yuko Saito +4 more
2025Scientific Reports4 citations Open access
Semantic Scholar
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
Nobuhisa Iwata, S. Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata +16 more
2024Life Science Alliance4 citations Open access
Semantic Scholar
Temporal Alterations in White Matter in An App Knock-In Mouse Model of Alzheimer’s Disease
Zachery D. Morrissey, Jin Gao, Aashutosh Shetti, Wenping Li +9 more
2024eNeuro4 citations Open access
Semantic Scholar
An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience
C. Vicidomini, Travis D. Goode, Kathleen Mcavoy, Rui-Lin Yu +19 more
2024bioRxiv4 citations Open access
Semantic Scholar
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice
Suzuko Ochi, Kumiko Yamada, Takashi Saito, T. Saido +3 more
2024Frontiers in Aging Neuroscience4 citations Open access
Semantic Scholar
Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease
Tatsuki Nakagawa, Jiayu Xie, Kiwon Park, Kai Cao +9 more
2026Nature Neuroscience3 citations Open access
Semantic Scholar
Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice
Praveen Bathini, Stephan Schilling, J. Rahfeld, David M. Holtzman +2 more
2026bioRxiv3 citations Open access
Semantic Scholar
Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice
Praveen Bathini, Stephan Schilling, J. Rahfeld, David M. Holtzman +2 more
2026Molecular Neurodegeneration3 citations Open access
Semantic Scholar
Involvement of orexin nerves in early stage of Alzheimer's disease model mice and preventive effect of orexin receptor antagonists
Kazuhiro Hada, Yuki Murata, Yoshiaki Ohi, Sana Hashimoto +8 more
2025bioRxiv3 citations Open access
Semantic Scholar
Advances in non-human primate models for Alzheimer's disease research.
Daisuke Joho, Kenya Sato, Wakako Kumita, T. Saido +2 more
2025Neurosciences research3 citations Open access
Semantic Scholar
Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock‐In Mice
Itsumi Nagai-Arakawa, Ikunobu Muramatsu, Junsuke Uwada, Yoshitaka Tsuda +11 more
2025Journal of Neurochemistry3 citations Open access
Semantic Scholar
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer’s Disease Spectrum
S. Bay, Anna Rodina, Florence Haut, Tanaya Roychowdhury +27 more
2025Research Square3 citations
Semantic Scholar

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Shoko Hashimoto

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Hiroki Sasaguri×6

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T. Saito — researcher profile on SciRah

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