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A. Adame · SciRah

Researcher profile · Semantic Scholar

A. Adame

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A. Adame — researcher profile on SciRah

h-index: 69
Works: 188
Citations: 15K

Most-cited papers

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
Shu G. Chen, V. Stribinskis, M. Rane, D. Demuth +12 more
2016Scientific Reports433 citations Open access
Semantic Scholar
Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
D. Games, Elvira Valera, B. Spencer, E. Rockenstein +11 more
2014Journal of Neuroscience311 citations Open access
Semantic Scholar
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Anna G. Orr, Edward C. Hsiao, M. M. Wang, Kaitlyn Ho +11 more
2015Nature Neuroscience275 citations Open access
Semantic Scholar
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
Georgia Minakaki, Stefanie Menges, Á. Kittel, Evangelia Emmanouilidou +17 more
2018Autophagy269 citations Open access
Semantic Scholar
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
E. Rockenstein, S. Nuber, C. Overk, K. Ubhi +13 more
2014Brain : a journal of neurology228 citations Open access
Semantic Scholar
Next-generation active immunization approach for synucleinopathies - implications for Parkinson’s Disease clinical trials
M. Mandler, Elvira Valera, E. Rockenstein, H. Weninger +9 more
2014Acta Neuropathologica223 citations Open access
Semantic Scholar
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
N. Shanbhag, M. Evans, Wenjie Mao, A. Nana +5 more
2019Acta Neuropathologica Communications202 citations Open access
Semantic Scholar
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
Jennifer Ngolab, Ivy Trinh, E. Rockenstein, M. Mante +6 more
2017Acta Neuropathologica Communications185 citations Open access
Semantic Scholar
Molecular and pathologic insights from latent HIV-1 infection in the human brain
P. Desplats, Wilmar Dumaop, David M. Smith, A. Adame +6 more
2013Neurology179 citations Open access
Semantic Scholar
Parkinson’s disease genes VPS35 and EIF4G1 interact genetically and converge on α–synuclein
Nripesh Dhungel, Simona Eleuteri, Ling-Bo Li, N. J. Kramer +11 more
2014Neuron161 citations Open access
Semantic Scholar
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
A. Bender, P. Desplats, B. Spencer, E. Rockenstein +9 more
2013PLoS ONE152 citations Open access
Semantic Scholar
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Changyoun Kim, B. Spencer, E. Rockenstein, H. Yamakado +9 more
2018Molecular Neurodegeneration151 citations Open access
Semantic Scholar
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.
S. Nuber, F. Harmuth, Z. Kohl, A. Adame +18 more
2013Brain : a journal of neurology149 citations Open access
Semantic Scholar
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
M. Mandler, Elvira Valera, E. Rockenstein, M. Mante +9 more
2015Molecular Neurodegeneration145 citations Open access
Semantic Scholar
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Eun-Jin Bae, Dong-kyu Kim, Changyoun Kim, M. Mante +12 more
2018Nature Communications134 citations Open access
Semantic Scholar
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Changyoun Kim, E. Rockenstein, B. Spencer, Hyung-Koo Kim +6 more
2015Cell Reports132 citations Open access
Semantic Scholar
HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders
J. Fields, Wilmar Dumaop, Simona Eleuteri, Simona Elueteri +9 more
2015Journal of Neuroscience122 citations Open access
Semantic Scholar
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice
Meaghan Morris, Patricia Hamto, A. Adame, N. Devidze +2 more
2013Neurobiology of Aging117 citations Open access
Semantic Scholar
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Yingjun Zhao, I-Chu Tseng, C. Heyser, E. Rockenstein +15 more
2015Neuron96 citations Open access
Semantic Scholar
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-Associated Neurocognitive Disorders
J. Fields, Elisabeth Serger, Sofia Campos, Ajit S. Divakaruni +11 more
2015Neurobiology of Disease94 citations Open access
Semantic Scholar
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
B. Spencer, Elvira Valera, E. Rockenstein, C. Overk +9 more
2017Acta Neuropathologica Communications84 citations Open access
Semantic Scholar
The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons
Valeria Avdoshina, J. Fields, Paul Castellano, S. Dedoni +7 more
2016Neurotoxicity research83 citations Open access
Semantic Scholar
ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
B. Spencer, Sharareh Emadi, P. Desplats, Simona Eleuteri +9 more
2014Molecular Therapy80 citations Open access
Semantic Scholar
Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer’s Disease
M. Waragai, A. Adame, Ivy Trinh, K. Sekiyama +4 more
2016Journal of Alzheimer's Disease75 citations Open access
Semantic Scholar
Widespread micro-RNA dysregulation in Multiple System Atrophy: disease-related alteration in miR-96
K. Ubhi, E. Rockenstein, C. Kragh, C. Inglis +6 more
2013European Journal of Neuroscience74 citations Open access
Semantic Scholar
Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo
Charisse N. Winston, Brent D. Aulston, E. Rockenstein, A. Adame +5 more
2018Journal of Alzheimer's Disease70 citations Open access
Semantic Scholar
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
Changyoun Kim, A. Beilina, Nathan Smith, Yan Li +15 more
2020Science Translational Medicine69 citations Open access
Semantic Scholar
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
O. El-Agnaf, C. Overk, E. Rockenstein, M. Mante +8 more
2017Neurobiology of Disease68 citations Open access
Semantic Scholar
Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease
K. Ubhi, E. Rockenstein, R. Vázquez-Roque, M. Mante +8 more
2013Journal of Neuroscience Research67 citations
Semantic Scholar
Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer
J. Fields, Wilmar Dumaop, E. Rockenstein, M. Mante +7 more
2013Journal of Neurovirology63 citations Open access
Semantic Scholar
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.
B. Spencer, Changyoun Kim, T. González, Alejandro Bisquertt +6 more
2016Human Molecular Genetics56 citations Open access
Semantic Scholar
Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease*
B. Spencer, Rewati Potkar, Jeff Metcalf, Ivy Thrin +3 more
2015Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model
Ji-Qing Xu, F. De Winter, C. Farrokhi, E. Rockenstein +6 more
2016Scientific Reports51 citations Open access
Semantic Scholar
Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders
J. Fields, Wilmar Dumaop, L. Crews, A. Adame +5 more
2015Current HIV Research51 citations Open access
Semantic Scholar
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
E. Rockenstein, J. Clarke, Catherine Viel, Nicholas Panarello +10 more
2016Human Molecular Genetics50 citations Open access
Semantic Scholar
Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy
Elvira Valera, B. Spencer, J. Fields, Ivy Trinh +5 more
2017Acta Neuropathologica Communications49 citations Open access
Semantic Scholar
MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy
Elvira Valera, B. Spencer, Jennifer Mott, Margarita Trejo +7 more
2017Frontiers in Molecular Neuroscience49 citations Open access
Semantic Scholar
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease
B. Spencer, Ivy Trinh, E. Rockenstein, M. Mante +6 more
2019Neurobiology of Disease46 citations Open access
Semantic Scholar
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
B. Spencer, Elvira Valera, E. Rockenstein, M. Trejo-Morales +2 more
2015Molecular Neurodegeneration46 citations Open access
Semantic Scholar
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies
E. Rockenstein, Gary R. Ostroff, Fusun Dikengil, Florentina Rus +8 more
2017Journal of Neuroscience45 citations Open access
Semantic Scholar
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model
B. Spencer, P. Desplats, C. Overk, Elvira Valera-Martin +7 more
2016Journal of Neuroscience45 citations Open access
Semantic Scholar
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies
D. Price, E. Rockenstein, M. Mante, A. Adame +6 more
2016Scientific Reports44 citations Open access
Semantic Scholar
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease
Changyoun Kim, E. Ojo-Amaize, B. Spencer, E. Rockenstein +10 more
2015Journal of Neuroinflammation44 citations Open access
Semantic Scholar
Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease.
E. Rockenstein, P. Desplats, K. Ubhi, M. Mante +6 more
2015Stem Cell Research40 citations Open access
Semantic Scholar
α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
B. Spencer, Stephanie M. Williams, E. Rockenstein, Elvira Valera +6 more
2016Annals of Clinical and Translational Neurology38 citations Open access
Semantic Scholar
RETRACTED ARTICLE: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
Changyoun Kim, Somin Kwon, M. Iba, B. Spencer +8 more
2021Experimental and Molecular Medicine37 citations Open access
Semantic Scholar
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology
J. Gerez, N. Prymaczok, E. Rockenstein, U. Herrmann +10 more
2019Science Translational Medicine37 citations Open access
Semantic Scholar
Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies
Z. Kohl, J. Schlachetzki, Judith Feldewerth, Philipp Hornauer +5 more
2017Journal of Neural Transplantation and Plasticity37 citations Open access
Semantic Scholar
A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis*
B. Spencer, I. Verma, P. Desplats, D. Morvinski +3 more
2014Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity
J. Fields, C. Overk, A. Adame, J. Florio +6 more
2016Journal of Neuroinflammation36 citations Open access
Semantic Scholar

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