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A. Grefhorst · SciRah

Researcher profile · Semantic Scholar

A. Grefhorst

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A. Grefhorst — researcher profile on SciRah

h-index: 37
Works: 99
Citations: 5,356

Most-cited papers

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
M. Frank-Kamenetsky, A. Grefhorst, N. Anderson, T. Racie +29 more
2008Proceedings of the National Academy of Sciences of the United States of America663 citations Open access
Semantic Scholar
The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice*
B. Cariou, K. van Harmelen, D. Durán-Sandoval, T. V. van Dijk +8 more
2006Journal of Biological Chemistry554 citations Open access
Semantic Scholar
Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles*
A. Grefhorst, Baukje M. Elzinga, P. Voshol, T. Plösch +7 more
2002Journal of Biological Chemistry543 citations Open access
Semantic Scholar
Hepatic PCSK9 Expression Is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1c*
P. Costet, B. Cariou, G. Lambert, F. Lalanne +5 more
2006Journal of Biological Chemistry320 citations Open access
Semantic Scholar
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity: a novel therapeutic approach to insulin resistance Chapter 5
J. Aerts, R. Ottenhoff, A. Grefhorst, A. Powlson +17 more
2006283 citations
Semantic Scholar
The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition*
D. Durán-Sandoval, B. Cariou, F. Percevault, N. Hennuyer +6 more
2005Journal of Biological Chemistry245 citations Open access
Semantic Scholar
Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences.
Brenda S. Hijmans, A. Grefhorst, M. Oosterveer, A. Groen
2014Biochimie169 citations
Semantic Scholar
Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice*
M. Oosterveer, A. Grefhorst, T. V. van Dijk, R. Havinga +4 more
2009Journal of Biological Chemistry169 citations Open access
Semantic Scholar
Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice.
Kit-Yi Yam, E. Naninck, M. Abbink, S. la Fleur +7 more
2017Psychoneuroendocrinology106 citations Open access
Semantic Scholar
The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease
A. Grefhorst, I. P. van de Peppel, L. E. Larsen, J. Jonker +1 more
2021Frontiers in Endocrinology98 citations Open access
Semantic Scholar
Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis
A. Grefhorst, T. V. van Dijk, A. Hammer, F. H. van der Sluijs +6 more
200693 citations
Semantic Scholar
Transient impairment of the adaptive response to fasting in FXR‐deficient mice
B. Cariou, K. van Harmelen, D. Durán-Sandoval, T. V. van Dijk +6 more
2005FEBS Letters93 citations Open access
Semantic Scholar
Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk
Kasiphak Kaikaew, A. Grefhorst, J. Visser
2021Frontiers in Endocrinology87 citations Open access
Semantic Scholar
The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design.
M. Oosterveer, A. Grefhorst, A. Groen, F. Kuipers
2010Progress in lipid research82 citations
Semantic Scholar
Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions
A. Mahfouz, B. Lelieveldt, A. Grefhorst, Lisa T. C. M. van Weert +7 more
2016Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
Semantic Scholar
A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice
T. V. van Dijk, A. Laskewitz, A. Grefhorst, T. Boer +4 more
2013Laboratory Animals. Journal of the Laboratory Animal Science Association74 citations Open access
Semantic Scholar
Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone
Johanna C. Beukel, A. Grefhorst, C. Quarta, J. Steenbergen +7 more
2014The FASEB Journal73 citations
Semantic Scholar
Des‐acyl ghrelin analogs prevent high‐fat‐diet‐induced dysregulation of glucose homeostasis
P. Delhanty, Martin Huisman, Lucy Y. Baldéon-Rojas, I. Berge +5 more
2013The FASEB Journal73 citations Open access
Semantic Scholar
Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production.
A. Grefhorst, Jildou Hoekstra, T. Derks, D. Ouwens +5 more
2005American Journal of Physiology - Gastrointestinal and Liver Physiology72 citations
Semantic Scholar
An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption in Fxr–/– Mice*
T. V. van Dijk, A. Grefhorst, M. Oosterveer, V. Bloks +3 more
2009Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Sex difference in cold perception and shivering onset upon gradual cold exposure.
Kasiphak Kaikaew, J. C. van den Beukel, S. Neggers, A. Themmen +2 more
2018Journal of Thermal Biology66 citations Open access
Semantic Scholar
Women have more potential to induce browning of perirenal adipose tissue than men
J. C. van den Beukel, A. Grefhorst, M. Hoogduijn, J. Steenbergen +3 more
2015Obesity61 citations Open access
Semantic Scholar
Commentary: Nonalcoholic or metabolic dysfunction-associated fatty liver disease? The epidemic of the 21st century in search of the most appropriate name.
S. Polyzos, E. Kang, E. Tsochatzis, S. Kechagias +12 more
2020Metabolism: Clinical and Experimental59 citations Open access
Semantic Scholar
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
E. Korsheninnikova, G. van der Zon, P. Voshol, G. Janssen +7 more
2006Diabetologia59 citations Open access
Semantic Scholar
Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor
M. Willart, M. V. van Nimwegen, A. Grefhorst, H. Hammad +4 more
2012Allergy. European Journal of Allergy and Clinical Immunology58 citations
Semantic Scholar
Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.
A. Grefhorst, T. V. van Dijk, A. Hammer, F. H. van der Sluijs +6 more
2005American Journal of Physiology. Endocrinology and Metabolism55 citations
Semantic Scholar
Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice
A. Grefhorst, J. C. van den Beukel, E. V. van Houten, J. Steenbergen +2 more
2015Biology of Sex Differences50 citations Open access
Semantic Scholar
Angiotensin II type 2 receptor- and acetylcholine-mediated relaxation: essential contribution of female sex hormones and chromosomes.
B. S. Pessôa, D. Slump, K. Ibrahimi, A. Grefhorst +6 more
2015HYPERTENSION47 citations Open access
Semantic Scholar
Sex Difference in Corticosterone-Induced Insulin Resistance in Mice
Kasiphak Kaikaew, J. Steenbergen, T. V. van Dijk, A. Grefhorst +1 more
2019Endocrinology46 citations Open access
Semantic Scholar
Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.
J. C. van den Beukel, M. Boon, J. Steenbergen, P. Rensen +3 more
2015Endocrinology44 citations Open access
Semantic Scholar
Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.
A. Grefhorst, M. Oosterveer, G. Brufau, Marije Boesjes +2 more
2012Atherosclerosis43 citations Open access
Semantic Scholar
Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.
F. R. van der Leij, V. Bloks, A. Grefhorst, Jildou Hoekstra +5 more
2007Genomics42 citations Open access
Semantic Scholar
ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia.
L. Reeskamp, Andrea Volta, L. Zuurbier, J. Defesche +2 more
2020Journal of Clinical Lipidology40 citations Open access
Semantic Scholar
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1.
A. Grefhorst, M. Schreurs, M. Oosterveer, V. Cortés +5 more
2010Biochemical Journal39 citations Open access
Semantic Scholar
Lxrα Deficiency Hampers the Hepatic Adaptive Response to Fasting in Mice*
M. Oosterveer, T. V. van Dijk, A. Grefhorst, V. Bloks +3 more
2008Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity
J. Aerts, R. Ottenhoff, A. Powlson, A. Grefhorst +9 more
2007Diabetes38 citations Open access
Semantic Scholar
Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice
T. Derks, T. V. van Dijk, A. Grefhorst, J. Rake +3 more
2008Hepatology37 citations Open access
Semantic Scholar
Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index
M. V. van Lierop, W. Alkema, A. Laskewitz, R. Dijkema +21 more
2012PLoS ONE36 citations Open access
Semantic Scholar
Unacylated Ghrelin Suppresses Ghrelin-Induced Neuronal Activity in the Hypothalamus and Brainstem of Male Rats
D. Stevanović, A. Grefhorst, A. Themmen, V. Popović +5 more
2014PLoS ONE34 citations Open access
Semantic Scholar
Does aerobic exercise reduce NASH and liver fibrosis in patients with non-alcoholic fatty liver disease? A systematic literature review and meta-analysis
V. Houttu, Julia Bouts, Yasaman Vali, J. Daams +3 more
2022Frontiers in Endocrinology33 citations Open access
Semantic Scholar
Sex difference in thermal preference of adult mice does not depend on presence of the gonads
Kasiphak Kaikaew, J. Steenbergen, A. Themmen, J. Visser +1 more
2017Biology of Sex Differences33 citations Open access
Semantic Scholar
The TICE Pathway: Mechanisms and Lipid-Lowering Therapies.
A. Grefhorst, H. Verkade, A. Groen
2019Methodist DeBakey Cardiovascular Journal30 citations Open access
Semantic Scholar
Multiple effects of cold exposure on livers of male mice.
A. Grefhorst, J. C. van den Beukel, W. Dijk, J. Steenbergen +7 more
2018Journal of Endocrinology30 citations Open access
Semantic Scholar
A Deep Intronic Variant in LDLR in Familial Hypercholesterolemia: Time to Widen the Scope?
L. Reeskamp, M. L. Hartgers, J. Peter, G. Dallinga-Thie +4 more
2018Circulation Genomic and Precision Medicine29 citations Open access
Semantic Scholar
Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice This work was supported by a grant from the Ter Meulen Fund, Royal Netherlands Academy of Arts and Science, The Netherlands.
A. Grefhorst, E. Parks
2009Journal of Lipid Research29 citations Open access
Semantic Scholar
The role of the gut microbiome and exercise in non-alcoholic fatty liver disease
V. Houttu, Ulrika Boulund, A. Grefhorst, M. Soeters +3 more
2020Therapeutic Advances in Gastroenterology28 citations Open access
Semantic Scholar
Next-generation sequencing to confirm clinical familial hypercholesterolemia.
L. Reeskamp, T. Tromp, J. Defesche, A. Grefhorst +3 more
2020European Journal of Preventive Cardiology27 citations Open access
Semantic Scholar
Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice.
A. Laskewitz, T. V. van Dijk, V. Bloks, D. Reijngoud +5 more
2010Endocrinology25 citations Open access
Semantic Scholar
A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation
Brenda S. Hijmans, C. Tiemann, A. Grefhorst, Marije Boesjes +6 more
2015The FASEB Journal24 citations Open access
Semantic Scholar
Severe Dyslipidemia Mimicking Familial Hypercholesterolemia Induced by High-Fat, Low-Carbohydrate Diets: A Critical Review
V. Houttu, A. Grefhorst, D. Cohn, J. Levels +4 more
2023Nutrients22 citations Open access
Semantic Scholar

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F. Kuipers×19
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F. Kuipers — researcher profile on SciRah
T. V. van Dijk×13
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T. V. van Dijk — researcher profile on SciRah
A. Groen×10
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J. C. van den Beukel — researcher profile on SciRah