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M. Tome · SciRah

Researcher profile · Semantic Scholar

M. Tome

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M. Tome — researcher profile on SciRah

h-index: 24
Works: 62
Citations: 1,802

Most-cited papers

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth.
M. Tome, A. Baker, G. Powis, C. Payne +1 more
2001Cancer Research121 citations
Semantic Scholar
A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis.
M. Tome, D. B. Johnson, L. Rimsza, R. Roberts +4 more
2005Blood106 citations Open access
Semantic Scholar
Molecular modes of action of cantharidin in tumor cells.
T. Efferth, R. Rauh, S. Kahl, M. Tomicic +5 more
2004Biochemical Pharmacology102 citations
Semantic Scholar
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis.
M. Tome, S. M. Fiser, Claire M. Payne, Eugene W. Gerner
1997Biochemical Journal101 citations Open access
Semantic Scholar
Role of antioxidant genes for the activity of artesunate against tumor cells.
T. Efferth, M. Briehl, M. Tome
2003International Journal of Oncology88 citations
Semantic Scholar
Thiol regulation by Mn porphyrins, commonly known as SOD mimics
I. Batinic-Haberle, M. Tome
2019Redox Biology82 citations Open access
Semantic Scholar
Modulation of Human Glutathione S-Transferases by Polyphenon E Intervention
H. Chow, I. A. Hakim, Donna R. Vining, J. Crowell +6 more
2007Cancer Epidemiology, Biomarkers and Prevention81 citations
Semantic Scholar
Manganese Porphyrin, MnTE-2-PyP5+, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells
Melba C. Jaramillo, M. Briehl, J. Crapo, I. Haberle +1 more
2012Free Radical Biology & Medicine75 citations Open access
Semantic Scholar
Increased manganese superoxide dismutase expression or treatment with a manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells
Melba C. Jaramillo, J. Frye, J. Crapo, M. Briehl +1 more
2009Cancer Research75 citations Open access
Semantic Scholar
The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
Charles P. Schaefer, M. Tome, Thomas P. Davis
2017Fluids and Barriers of the CNS74 citations Open access
Semantic Scholar
Copper Chelator ATN-224 Induces Peroxynitrite-Dependent Cell Death in Hematological Malignancies
Kristy Lee, M. Briehl, A. Mazar, I. Batinic-Haberle +4 more
2013Free Radical Biology & Medicine59 citations Open access
Semantic Scholar
P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery
T. Davis, Lucy Sanchez-Covarubias, M. Tome
2014Advances in Pharmacology56 citations Open access
Semantic Scholar
MnTE-2-PyP5+ acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics and enhance the response to chemotherapy in lymphoma cells
Melba C. Jaramillo, M. Briehl, I. Batinic-Haberle, M. Tome
2015Free Radical Biology & Medicine49 citations Open access
Semantic Scholar
Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis.
M. Tome, Eugene W. Gerner
1997Biological signals47 citations
Semantic Scholar
Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate
A. Tovmasyan, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, R. S. Sampaio +8 more
2018Antioxidants and Redox Signaling46 citations Open access
Semantic Scholar
Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis
M. Tome, M. Briehl
2001Cell Death and Differentiation46 citations
Semantic Scholar
Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis.
Aaron Goldman, H. Chen, Heather B. Roesly, K. A. Hill +4 more
2011American Journal of Physiology - Gastrointestinal and Liver Physiology45 citations Open access
Semantic Scholar
Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells.
K. Dvor̆áková, C. Payne, M. Tome, M. Briehl +4 more
2002Molecular Cancer Therapeutics37 citations
Semantic Scholar
Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance.
M. Tome, N. Lutz, M. Briehl
2004Biochimica et Biophysica Acta36 citations Open access
Semantic Scholar
Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery
Karissa E. Cottier, Emily A. Galloway, E. Calabrese, M. Tome +5 more
2018eNeuro33 citations Open access
Semantic Scholar
Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance
M. Tome, J. Frye, D. Coyle, E. Jacobson +4 more
2012Experimental and Therapeutic Medicine29 citations Open access
Semantic Scholar
Glucose 6-Phosphate Dehydrogenase Overexpression Models Glucose Deprivation and Sensitizes Lymphoma Cells to Apoptosis
M. Tome, D. B. Johnson, B. Samulitis, R. Dorr +1 more
2006Antioxidants and Redox Signaling27 citations
Semantic Scholar
Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells
K. Dvor̆áková, C. Payne, T. Landowski, M. Tome +2 more
2002Anti-Cancer Drugs26 citations
Semantic Scholar
Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells
M. Tome, Melba C. Jaramillo, M. Briehl
2011Free Radical Biology & Medicine25 citations Open access
Semantic Scholar
Mitochondria and redox homeostasis as chemotherapeutic targets
M. Briehl, M. Tome, S. Wilkinson, Melba C. Jaramillo +1 more
2014Biochemical Society Transactions23 citations Open access
Semantic Scholar
Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide
S. Sertel, M. Tome, M. Briehl, J. Bauer +3 more
2012PLoS ONE23 citations Open access
Semantic Scholar
The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma
Kristy Lee, Matthew R Hart, M. Briehl, A. Mazar +1 more
2014International Journal of Oncology21 citations Open access
Semantic Scholar
Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels
Charles P. Schaefer, Nathan B Arkwright, Leigh M Jacobs, Chelsea K Jarvis +4 more
2018PLoS ONE20 citations Open access
Semantic Scholar
Mitochondria are the primary source of the H2O2 signal for glucocorticoid-induced apoptosis of lymphoma cells
M. Tome, Kristy Lee, Melba C. Jaramillo, M. Briehl
2012Experimental and Therapeutic Medicine20 citations Open access
Semantic Scholar
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain
M. Tome, Joseph M. Herndon, Charles P. Schaefer, Leigh M Jacobs +3 more
2016Journal of Cerebral Blood Flow and Metabolism19 citations Open access
Semantic Scholar
Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels
M. Tome, Charles P. Schaefer, Leigh M Jacobs, Yifeng Zhang +3 more
2015Journal of Neurochemistry19 citations Open access
Semantic Scholar
Overexpression of catalase or Bcl-2 delays or prevents alterations in phospholipid metabolism during glucocorticoid-induced apoptosis in WEHI7.2 cells.
M. Tome, N. Lutz, M. Briehl
2003Biochimica et Biophysica Acta19 citations Open access
Semantic Scholar
Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone‐induced apoptosis. A 31P NMR spectroscopic study of cell extracts
N. Lutz, M. Tome, N. Aiken, M. Briehl
2002NMR in Biomedicine18 citations
Semantic Scholar
Development and Maintenance of the Blood–Brain Barrier
Joseph M. Herndon, M. Tome, T. Davis
201717 citations
Semantic Scholar
Manganese Porphyrin Glutathionylates the p65 Subunit of NF-κB to Potentiate Glucocorticoid-induced Apoptosis in Lymphoma
Melba C. Jaramillo, M. Briehl, M. Tome
201017 citations
Semantic Scholar
Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking
M. Tome, Chelsea K Jarvis, Charles P. Schaefer, Leigh M Jacobs +6 more
2018Journal of Cerebral Blood Flow and Metabolism14 citations Open access
Semantic Scholar
Mitochondrial Adaptations to Oxidative Stress Confer Resistance to Apoptosis in Lymphoma Cells
S. Wilkinson, M. Tome, M. Briehl
2012International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Increased cytochrome c correlates with poor survival in aggressive lymphoma
S. Wilkinson, D. B. Johnson, Heather L. Tardif, M. Tome +1 more
2010Oncology Letters12 citations Open access
Semantic Scholar
Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-gamma/TNF-alpha in HT-29 cells.
N. Lutz, M. Tome, P. Cozzone
2003FEBS Letters12 citations
Semantic Scholar
30 – Inhibition of the Electron Transport Chain Via the Pro-Oxidative Activity of Manganese Porphyrin-Based SOD Mimetics Modulates Bioenergetics and Enhances the Response to Chemotherapy
Melba C. Jaramillo, M. Briehl, I. Batinic-Haberle, M. Tome
201310 citations
Semantic Scholar
SFRBM 2013 DISCOVERY AWARD LECTUREPSS307 - We Have Come a Long Way with Mn Porphyrins: from Superoxide Dismutation to H2O2-Driven Pathways
A. Tovmasyan, T. Weitner, Melba C. Jaramillo, Rudolf Wedmann +7 more
201310 citations
Semantic Scholar
Effects of diethyldithiocarbamate and endogenous polyamine content on cellular responses to hydrogen peroxide cytotoxicity.
P. Harari, M. Tome, D. J. Fuller, S. Carper +1 more
1989Biochemical Journal10 citations Open access
Semantic Scholar
Understanding Differences in Mechanisms of Action of Fe vs Mn Porphyrins: Comparison of Their Reactivities Towards Cellular Reductants and Reactive Species
A. Tovmasyan, T. Weitner, E. R. Roberts, Melba C. Jaramillo +5 more
20129 citations
Semantic Scholar
A Strategy for Full Interrogation of Prognostic Gene Expression Patterns: Exploring the Biology of Diffuse Large B Cell Lymphoma
L. Rimsza, J. Unger, M. Tome, M. LeBlanc
2011PLoS ONE9 citations Open access
Semantic Scholar
Mechanistic Considerations of the Therapeutic Effects of Mn Porphyrins, Commonly Regarded as SOD Mimics, in Anticancer Therapy: Lessons from Brain and Lymphoma Studies
I. Batinic-Haberle, A. Tovmasyan, T. Weitner, Z. Rajić +13 more
20137 citations
Semantic Scholar
Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile.
M. Tome, M. Briehl, N. Lutz
2005International Journal of Molecular Medicine7 citations
Semantic Scholar
Optimizing assessment of CD30 expression in Hodgkin lymphoma by controlling for low expression
S. Sarwar, M. Tome, D. Billheimer, C. Spier +3 more
2023Histology and Histopathology2 citations
Semantic Scholar
Tumor Growth Glucocorticoid-induced Apoptosis and Exhibit Increased Net Catalase-overexpressing Thymocytes Are Resistant to Updated Version
M. Tome, A. Baker, G. Powis, C. Payne +1 more
20012 citations
Semantic Scholar
Rapamycin Treatment of Mantle Cell LymphomaInhibits MTORC2 Signaling, Resulting in IncreasedMnSOD Expression and Hydrogen PeroxideGeneration
M. Briehl, Heather L. Gustafson, Kristy Lee, M. Tome
20121 citations
Semantic Scholar
Induced Major Histocompatibility Class II (MHCII) Expression Does Not Alter Chemosensitivity, Radiosensitivity, Redox Potential, or Proliferation Rate in a CIITA-Transfected Diffuse Large B Cell Lymphoma (DLBCL) Cell Line.
B. Glinsmann-Gibson, Kelly A. Cycon, S. Murphy, T. Miller +4 more
20061 citations
Semantic Scholar

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