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S. Iyer · SciRah

Researcher profile · Semantic Scholar

S. Iyer

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S. Iyer — researcher profile on SciRah

h-index: 33
Works: 86
Citations: 4,126

Most-cited papers

Lactoferrin: molecular structure and biological function.
B. Lönnerdal, S. Iyer
1995Annual review of nutrition819 citations
Semantic Scholar
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data
R. Deng, S. Iyer, F. Theil, D. Mortensen +2 more
2011mAbs284 citations Open access
Semantic Scholar
Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor
R. Deng, D. Bumbaca, C. Pastuskovas, C. Boswell +9 more
2016mAbs186 citations Open access
Semantic Scholar
Lactoferrin, lactoferrin receptors and iron metabolism.
S. Iyer, B. Lönnerdal
1993European Journal of Clinical Nutrition186 citations
Semantic Scholar
Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway.
M. Katori, R. Buelow, B. Ke, Jeffrey Ma +5 more
2002Transplantation174 citations Open access
Semantic Scholar
Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?
R. Deng, Feng Jin, S. Prabhu, S. Iyer
2012Expert Opinion on Drug Metabolism & Toxicology130 citations
Semantic Scholar
Gene Transfer of Heme Oxygenase‐1 and Carbon Monoxide Delivery Inhibit Chronic Rejection
C. Chauveau, D. Bouchet, J. Roussel, P. Mathieu +7 more
2002American Journal of Transplantation126 citations Open access
Semantic Scholar
Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32).
J. Woo, S. Iyer, M. Cornejo, N. Mori +4 more
1998Transplant Immunology119 citations Open access
Semantic Scholar
Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys
R. Deng, K. Loyet, S. Lien, S. Iyer +5 more
2010Drug Metabolism And Disposition117 citations
Semantic Scholar
Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
Amrita V. Kamath, S. Iyer
2014Pharmaceutical Research115 citations Open access
Semantic Scholar
Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys
Maya K. Leabman, Y. Meng, R. Kelley, Laura E. Deforge +2 more
2013mAbs108 citations Open access
Semantic Scholar
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
N. Trinklein, Duy Pham, U. Schellenberger, B. Buelow +15 more
2019mAbs95 citations Open access
Semantic Scholar
Computer-assisted rational design of immunosuppressive compounds
G. Grassy, B. Calas, A. Yasri, R. Lahana +5 more
1998Nature Biotechnology91 citations
Semantic Scholar
Induction of long-term cardiac allograft survival by heme oxygenase-1 gene transfer
Cécile Braudeau, D. Bouchet, L. Tesson, S. Iyer +4 more
2004Gene Therapy90 citations
Semantic Scholar
Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling
J. Jackman, Yongmei Chen, A. Huang, B. Moffat +16 more
2010Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse1
J. Araujo, L. Meng, A. Tward, W. Hancock +9 more
2003Journal of Immunology85 citations Open access
Semantic Scholar
Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice
R. Deng, Y. Meng, K. Hoyte, Jeff Lutman +6 more
2012mAbs84 citations Open access
Semantic Scholar
A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes
EG Stefanich, DM Danilenko, H. Wang, S. O'Byrne +17 more
2011British Journal of Pharmacology80 citations Open access
Semantic Scholar
In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide.
Colm C. Magee, H. Azuma, A. Knoflach, Mark D. Denton +4 more
1999Journal of the American Society of Nephrology79 citations Open access
Semantic Scholar
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release
K. Dang, Giulia Castello, S. Clarke, Yu-Ping Li +19 more
2021Journal for ImmunoTherapy of Cancer74 citations Open access
Semantic Scholar
Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model.
Christopher G. Devry, M. Valdez, M. Lazarov, E. Muhr +3 more
2005Journal of Investigative Dermatology74 citations Open access
Semantic Scholar
Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.
Jing Wang, S. Iyer, P. Fielder, John D. Davis +1 more
2016Biopharmaceutics & drug disposition68 citations Open access
Semantic Scholar
Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.
Wei-Yu Lin, Qian Gong, D. Seshasayee, Zhonghua Lin +21 more
2007Blood62 citations
Semantic Scholar
Characterization and Biological Significance of Immunosuppressive Peptide D2702.75–84(E → V) Binding Protein
S. Iyer, Ja-Won Woo, M. Cornejo, Lan Gao +3 more
1998Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Inhibition of graft arteriosclerosis development in rat aortas following heme oxygenase-1 gene transfer.
D. Bouchet, C. Chauveau, Jean-Christian Roussel, Patrick Mathieu +6 more
2002Transplant Immunology54 citations
Semantic Scholar
Inhibition of Tumor Necrosis Factor mRNA Translation by a Rationally Designed Immunomodulatory Peptide*
S. Iyer, D. Kontoyiannis, D. Chevrier, J. Woo +4 more
2000Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Alleviation of graft-versus-host disease after conditioning with cobalt-protoporphyrin, an inducer of heme oxygenase-1.
J. Woo, S. Iyer, N. Mori, R. Buelow
2000Transplantation49 citations Open access
Semantic Scholar
Lactoferrin receptors in piglet small intestine: Lactoferrin binding properties, ontogeny, and regional distribution in the gastrointestinal tract
J. Gíslason, S. Iyer, T. Hutchens, B. Lönnerdal
199349 citations
Semantic Scholar
Challenges and advances in the assessment of the disposition of antibody‐drug conjugates
Amrita V. Kamath, S. Iyer
2015Biopharmaceutics & drug disposition46 citations Open access
Semantic Scholar
RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action
M. Cuturi, F. Christoph, J. Woo, S. Iyer +5 more
1999Molecular Medicine44 citations Open access
Semantic Scholar
A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
K. Harris, K. Lorentsen, Harbani K. Malik-Chaudhry, Kaitlyn Loughlin +17 more
2021Scientific Reports43 citations Open access
Semantic Scholar
Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies
D. Mortensen, S. Prabhu, E. Stefanich, Saloumeh Kadkhodayan-Fischer +7 more
2012mAbs34 citations Open access
Semantic Scholar
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
Harbani K. Malik-Chaudhry, K. Prabhakar, H. Ugamraj, A. Boudreau +13 more
2021mAbs33 citations Open access
Semantic Scholar
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies
K. Harris, S. F. Aldred, Laura M. Davison, H. Ogana +18 more
2018Frontiers in Immunology30 citations Open access
Semantic Scholar
Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey.
C. Ng, K. Loyet, S. Iyer, P. Fielder +1 more
2014European Journal of Pharmaceutical Sciences29 citations
Semantic Scholar
Rational design and development of RDP58.
S. Iyer, R. Lahana, R. Buelow
2002Current pharmaceutical design28 citations
Semantic Scholar
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
H. Ugamraj, K. Dang, L. Ouisse, B. Buelow +16 more
2022mAbs27 citations Open access
Semantic Scholar
Immunosuppression by D-isomers of HLA class I heavy chain (amino acid 75 to 84)-derived peptides is independent of binding to HSC70.
Jacky Woo, S. Iyer, M. Cornejo, Lan Gao +3 more
1997Transplantation26 citations Open access
Semantic Scholar
Evidence for an Asialoglycoprotein Receptor on Nonparenchymal Cells for O-Linked Glycoproteins
E. Stefanich, S. Ren, D. Danilenko, Amy Lim +3 more
2008Journal of Pharmacology and Experimental Therapeutics24 citations
Semantic Scholar
RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis.
Christopher G. Devry, M. Valdez, Lan Gao, Jing Wang +5 more
2004Journal of Neuroimmunology22 citations
Semantic Scholar
A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer
Brian C. Avanzino, K. Prabhakar, Pranjali Dalvi, Sharon Hartstein +21 more
2022Oncoimmunology19 citations Open access
Semantic Scholar
Generation of Heme Oxygenase-1-Transgenic Rats
Cécile Braudeau, D. Bouchet, C. Toquet, L. Tesson +8 more
2003Experimental biology and medicine19 citations
Semantic Scholar
TNB383B.0001: A Multicenter, Phase 1, Open-Label, Dose-Escalation Andexpansion Study of TNB-383B, a Bispecific Antibodytargeting BCMA in Subjects with Relapsed or Refractorymultiple Myeloma
B. Buelow, A. D'Souza, C. Rodriguez, R. Vij +5 more
2019Blood13 citations Open access
Semantic Scholar
T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion
B. Buelow, Duy Pham, P. Choudhry, K. Dang +11 more
201713 citations
Semantic Scholar
Attenuation of aortic graft arteriosclerosis by systemic administration of Allotrap peptide RDP58
Wei Li, S. Iyer, Lina Lu, R. Buelow +4 more
2002Transplant International13 citations
Semantic Scholar
TNB585.001: A multicenter, phase 1, open-label, dose-escalation and expansion study of tnb-585, a bispecific T-cell engager targeting PSMA in subjects with metastatic castrate resistant prostate cancer.
B. Buelow, Pranjali Dalvi, K. Dang, Ajay P Patel +9 more
20219 citations
Semantic Scholar
Inhibition of Cutaneous UV Light–induced Tumor Necrosis Factor-α Protein Production by Allotrap 1258, a Novel Immunomodulatory Peptide¶
T. Oberyszyn, F. Robertson, K. Tober, M. S. Ross +5 more
20019 citations
Semantic Scholar
Binding of porcine milk lactoferrin to piglet intestinal lactoferrin receptor.
J. Gíslason, S. Iyer, G. C. Douglas, T. Hutchens +1 more
1994Advances in Experimental Medicine and Biology8 citations
Semantic Scholar
TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion
H. Malik, B. Buelow, Udaya S. Rangaswamy, A. Balasubramani +13 more
2019Blood7 citations
Semantic Scholar
Lactoferrin-receptor interaction. Effect of surface exposed histidine residues.
S. Iyer, T. Yip, T. Hutchens, B. Lönnerdal
1994Advances in Experimental Medicine and Biology7 citations
Semantic Scholar

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