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N. Trinklein · SciRah

Researcher profile · Semantic Scholar

N. Trinklein

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N. Trinklein — researcher profile on SciRah

h-index: 29
Works: 62
Citations: 6,421

Most-cited papers

The ENCODE (ENCyclopedia Of DNA Elements) Project
E. Feingold, P. Good, M. Guyer, S. Kamholz +193 more
2004Science2,426 citations
Semantic Scholar
An abundance of bidirectional promoters in the human genome.
N. Trinklein, S. F. Aldred, S. J. Hartman, D. I. Schroeder +2 more
2003Genome Research630 citations Open access
Semantic Scholar
The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response.
N. Trinklein, J. I. Murray, S. J. Hartman, D. Botstein +1 more
2003Molecular Biology of the Cell336 citations Open access
Semantic Scholar
Diverse and specific gene expression responses to stresses in cultured human cells.
J. I. Murray, M. Whitfield, N. Trinklein, R. Myers +2 more
2004Molecular Biology of the Cell314 citations Open access
Semantic Scholar
Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.
S. Cooper, N. Trinklein, Elizabeth Anton, Loan Nguyen +1 more
2005Genome Research308 citations Open access
Semantic Scholar
Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue
F. Innocenti, Gregory M. Cooper, I. Stanaway, E. Gamazon +16 more
2011PLoS Genetics257 citations Open access
Semantic Scholar
Functional analysis of transcription factor binding sites in human promoters
T. Whitfield, Jie Wang, P. Collins, E. Partridge +4 more
2012Genome Biology195 citations Open access
Semantic Scholar
Identification and functional analysis of human transcriptional promoters.
N. Trinklein, Shelley Force Aldred, A. Saldanha, R. Myers
2003Genome Research184 citations Open access
Semantic Scholar
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.
David S. Johnson, Wei Li, D. B. Gordon, A. Bhattacharjee +44 more
2008Genome Research147 citations Open access
Semantic Scholar
Transcription factor binding and modified histones in human bidirectional promoters.
J. M. Lin, P. Collins, N. Trinklein, Yutao Fu +3 more
2007Genome Research140 citations Open access
Semantic Scholar
Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
N. Trinklein, Will C. Chen, R. Kingston, R. Myers
2004Cell stress & chaperones (Print)128 citations Open access
Semantic Scholar
Sequence features that drive human promoter function and tissue specificity.
J. Landolin, David S. Johnson, N. Trinklein, S. F. Aldred +4 more
2010Genome Research113 citations Open access
Semantic Scholar
Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Norris Lam, N. Trinklein, B. Buelow, George H. Patterson +2 more
2020Nature Communications105 citations Open access
Semantic Scholar
When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions
A. Bradbury, N. Trinklein, H. Thie, Ian C. Wilkinson +21 more
2018mAbs103 citations Open access
Semantic Scholar
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
N. Trinklein, Duy Pham, U. Schellenberger, B. Buelow +15 more
2019mAbs95 citations Open access
Semantic Scholar
Direct isolation and identification of promoters in the human genome.
Tae Hoon Kim, Leah Barrera, Chunxu Qu, S. Van Calcar +7 more
2005Genome Research93 citations Open access
Semantic Scholar
Serum response factor binding sites differ in three human cell types.
S. Cooper, N. Trinklein, Loan Nguyen, R. Myers
2007Genome Research87 citations Open access
Semantic Scholar
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release
K. Dang, Giulia Castello, S. Clarke, Yu-Ping Li +19 more
2021Journal for ImmunoTherapy of Cancer74 citations Open access
Semantic Scholar
Perspective: Designing T-Cell Engagers With Better Therapeutic Windows
O. Vafa, N. Trinklein
2020Frontiers in Oncology70 citations Open access
Semantic Scholar
Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122*
D. Boutz, P. Collins, U. Suresh, Ming-Zhu Lu +12 more
2011Journal of Biological Chemistry64 citations Open access
Semantic Scholar
A Single Human Papillomavirus Vaccine Dose Improves B Cell Memory in Previously Infected Subjects
E. Scherer, Robin A. Smith, Daniel F. Gallego, Joseph J. Carter +7 more
2016EBioMedicine57 citations Open access
Semantic Scholar
The ets-Related Transcription Factor GABP Directs Bidirectional Transcription
P. Collins, Yuya Kobayashi, Loan Nguyen, N. Trinklein +1 more
2007PLoS Genetics55 citations Open access
Semantic Scholar
Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements
Robin P. Smith, W. Eckalbar, K. Morrissey, M. R. Luizon +11 more
2014PLoS Genetics44 citations Open access
Semantic Scholar
A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
K. Harris, K. Lorentsen, Harbani K. Malik-Chaudhry, Kaitlyn Loughlin +17 more
2021Scientific Reports43 citations Open access
Semantic Scholar
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies
S. Clarke, B. Ma, N. Trinklein, U. Schellenberger +18 more
2019Frontiers in Immunology42 citations Open access
Semantic Scholar
T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma
Lekha Mikkilineni, E. Manasanch, Norris Lam, Danielle Vanasse +14 more
2019Blood38 citations Open access
Semantic Scholar
Integrated analysis of experimental data sets reveals many novel promoters in 1% of the human genome.
N. Trinklein, Ulas Karaöz, Jia-Qian Wu, Anason S. Halees +8 more
2007Genome Research38 citations Open access
Semantic Scholar
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
Harbani K. Malik-Chaudhry, K. Prabhakar, H. Ugamraj, A. Boudreau +13 more
2021mAbs33 citations Open access
Semantic Scholar
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies
K. Harris, S. F. Aldred, Laura M. Davison, H. Ogana +18 more
2018Frontiers in Immunology30 citations Open access
Semantic Scholar
A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays
Danette Hartzell, N. Trinklein, Jacqui Méndez, Nancy Murphy +3 more
2009BMC Genomics28 citations Open access
Semantic Scholar
Identifying targets of human micrornas with the LightSwitch Luciferase Assay System using 3'UTR-reporter constructs and a microRNA mimic in adherent cells.
S. F. Aldred, P. Collins, N. Trinklein
2011Journal of Visualized Experiments25 citations Open access
Semantic Scholar
A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer
Brian C. Avanzino, K. Prabhakar, Pranjali Dalvi, Sharon Hartstein +21 more
2022Oncoimmunology19 citations Open access
Semantic Scholar
Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma.
B. Buelow, Priya Choudry, S. Clarke, K. Dang +12 more
201819 citations
Semantic Scholar
Identification of a Functional In Vivo p53 Response Element in the Coding Sequence of the Xeroderma Pigmentosum Group C Gene.
K. Hastak, S. Adimoolam, N. Trinklein, R. Myers +1 more
2012Genes & cancer15 citations Open access
Semantic Scholar
T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion
B. Buelow, Duy Pham, P. Choudhry, K. Dang +11 more
201713 citations
Semantic Scholar
T Cells Expressing Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptors with Antigen Recognition Domains Made up of Only Single Human Heavy Chain Variable Domains Specifically Recognize Bcma and Eradicate Tumors in Mice
Norris Lam, Leah M. Alabanza, N. Trinklein, B. Buelow +1 more
20178 citations
Semantic Scholar
TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion
H. Malik, B. Buelow, Udaya S. Rangaswamy, A. Balasubramani +13 more
2019Blood7 citations
Semantic Scholar
New Collembola Symphypleona from the tropical cloud forest of Ecuador (Insecta).
G. Bretfeld, N. Trinklein
20007 citations
Semantic Scholar
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.
S. Clarke, B. Ma, N. Trinklein, U. Schellenberger +18 more
20196 citations Open access
Semantic Scholar
Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma.
B. Buelow, P. Choudhry, S. Clarke, K. Dang +12 more
20176 citations
Semantic Scholar
Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers
Manpreet Kaur, Katja Rüger, Elaine Chen, Udaya S. Rangaswamy +10 more
2025Journal for ImmunoTherapy of Cancer5 citations Open access
Semantic Scholar
A novel T-cell bispecific antibody platform for efficient T-cell mediated killing of tumor cells with minimal cytokine release.
Udaya S. Rangaswamy, A. Boudreau, B. Buelow, S. Clarke +14 more
20184 citations
Semantic Scholar
Author Correction: Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Norris Lam, N. Trinklein, B. Buelow, George H. Patterson +2 more
2020Nature Communications3 citations Open access
Semantic Scholar
Serum proteomics expands on identifying more high-affinity antibodies in immunized rabbits than deep B-cell repertoire sequencing alone
Stefano Bonissonne, N. Castellana, Thiago Lima, K. Harris +4 more
20193 citations Open access
Semantic Scholar
A novel CD3xPSMA bispecific antibody for efficient T cell mediated killing of prostate tumor cells with minimal cytokine release.
S. Clarke, K. Dang, Yu-Ping Li, P. Sankaran +12 more
2019Journal of Clinical Oncology2 citations
Semantic Scholar
Multispecific antibodies targeting CD38 show potent tumor-specific cytotoxicity.
S. F. Aldred, A. Boudreau, B. Buelow, S. Clarke +14 more
20182 citations
Semantic Scholar
A novel CD28 x Nectin-4 costimulatory bispecific antibody for advanced bladder cancer.
Thomas Manley, S. Clarke, Manpreet Kaur, Sebastian Moreno Arteaga +14 more
2025Journal of Clinical Oncology1 citations
Semantic Scholar
939 A novel CD28 x Nectin-4 costimulatory bispecific antibody targeting metastatic bladder cancer
S. Clarke, Elaine C. Chen, N. Trinklein
2024Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
A CD3 x FRα T-cell engaging bispecific antibody for efficient killing of ovarian cancer cells with minimal cytokine release.
B. Buelow, Brian C. Avanzino, A. Balasubramani, A. Boudreau +14 more
20201 citations
Semantic Scholar
A Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills Lymphoma Cells with Minimal Cytokine Secretion
H. Malik, B. Buelow, Brian C. Avanzino, A. Balasubramani +19 more
2018Blood1 citations
Semantic Scholar

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