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L. Crews · SciRah

Researcher profile · Semantic Scholar

L. Crews

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L. Crews — researcher profile on SciRah

h-index: 56
Works: 144
Citations: 13K

Most-cited papers

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
P. Desplats, He-Jin Lee, Eun-Jin Bae, C. Patrick +5 more
2009Proceedings of the National Academy of Sciences of the United States of America1,521 citations Open access
Semantic Scholar
Molecular mechanisms of neurodegeneration in Alzheimer's disease.
L. Crews, E. Masliah
2010Human Molecular Genetics729 citations Open access
Semantic Scholar
Distribution of Aqueous-Deficient and Evaporative Dry Eye in a Clinic-Based Patient Cohort: A Retrospective Study
M. Lemp, L. Crews, A. Bron, G. Foulks +1 more
2012Cornea563 citations
Semantic Scholar
Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
E. Masliah, E. Rockenstein, M. Mante, L. Crews +13 more
2011PLoS ONE426 citations Open access
Semantic Scholar
Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications
B. Sullivan, L. Crews, E. Messmer, G. Foulks +5 more
2014Acta ophthalmologica402 citations Open access
Semantic Scholar
Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
L. Crews, B. Spencer, P. Desplats, C. Patrick +6 more
2010PLoS ONE375 citations Open access
Semantic Scholar
Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases
I. Tsigelny, L. Crews, P. Desplats, G. Shaked +8 more
2008PLoS ONE279 citations Open access
Semantic Scholar
Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and APP transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
E. Pham, L. Crews, K. Ubhi, L. Hansen +9 more
2010The FEBS Journal225 citations Open access
Semantic Scholar
ADAR1 Activation Drives Leukemia Stem Cell Self-renewal by Impairing Let-7 Biogenesis
M. Zipeto, A. Court, A. Sadarangani, Nathaniel P. Delos-Santos +16 more
2016Cell Stem Cell218 citations Open access
Semantic Scholar
Increased BMP6 levels in the brains of Alzheimer’s disease patients and APP transgenic mice are accompanied by impaired neurogenesis
L. Crews, A. Adame, C. Patrick, Alexandra A DeLaney +4 more
2010Journal of Neuroscience218 citations Open access
Semantic Scholar
Clinical Utility of Objective Tests for Dry Eye Disease: Variability Over Time and Implications for Clinical Trials and Disease Management
B. Sullivan, L. Crews, B. Sönmez, M. F. de la Paz +7 more
2012Cornea212 citations
Semantic Scholar
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
I. Tsigelny, Y. Sharikov, W. Wrasidlo, T. González +4 more
2012The FEBS Journal179 citations Open access
Semantic Scholar
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia
Qingfei Jiang, L. Crews, Christian L. Barrett, Hye-Jung E. Chun +13 more
2012Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux
R. Marongiu, B. Spencer, L. Crews, A. Adame +5 more
2009Journal of Neurochemistry157 citations Open access
Semantic Scholar
α-Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice
L. Crews, Hideya Mizuno, P. Desplats, E. Rockenstein +5 more
2008Journal of Neuroscience137 citations Open access
Semantic Scholar
RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML
L. Crews, L. Balaian, Nathaniel P. Delos Santos, Heather Leu +12 more
2016Cell Stem Cell118 citations Open access
Semantic Scholar
APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis
L. Crews, E. Rockenstein, E. Masliah
2009Brain Structure and Function116 citations Open access
Semantic Scholar
Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
E. Lazzari, Phoebe K. Mondala, Nathaniel Delos Santos, A. Miller +12 more
2017Nature Communications112 citations Open access
Semantic Scholar
RNA editing-dependent epitranscriptome diversity in cancer stem cells
Qingfei Jiang, L. Crews, F. Holm, C. Jamieson
2017Nature Reviews. Cancer107 citations Open access
Semantic Scholar
Role of Synucleins in Alzheimer’s Disease
L. Crews, I. Tsigelny, M. Hashimoto, E. Masliah
2009Neurotoxicity research86 citations Open access
Semantic Scholar
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
L. Crews, C. Patrick, A. Adame, E. Rockenstein +1 more
2011Cell Death and Disease84 citations Open access
Semantic Scholar
Neuropeptide Y Fragments Derived from Neprilysin Processing are Neuroprotective in a Transgenic Model of Alzheimer’s Disease
John B. Rose, L. Crews, E. Rockenstein, A. Adame +7 more
2009Journal of Neuroscience82 citations Open access
Semantic Scholar
α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1*
P. Desplats, B. Spencer, L. Crews, Pruthul Pathel +7 more
2012Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Molecular Pathology of Neuro-AIDS (CNS-HIV)
L. Crews, C. Patrick, C. Achim, I. Everall +1 more
2009International Journal of Molecular Sciences66 citations Open access
Semantic Scholar
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.
K. Kawahara, M. Hashimoto, P. Bar-on, G. Ho +5 more
2008Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Selective elimination of leukemia stem cells: hitting a moving target.
L. Crews, C. Jamieson
2013Cancer Letters63 citations
Semantic Scholar
An RNA editing fingerprint of cancer stem cell reprogramming
L. Crews, Qingfei Jiang, M. Zipeto, E. Lazzari +5 more
2015Journal of Translational Medicine61 citations Open access
Semantic Scholar
Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine.
C. Patrick, L. Crews, P. Desplats, Wilmar Dumaop +4 more
2011American Journal of Pathology61 citations Open access
Semantic Scholar
Reversal of Malignant ADAR1 Splice Isoform Switching with Rebecsinib
L. Crews, Wen-Xue Ma, Luisa Ladel, Jessica Pham +16 more
2023Cell Stem Cell58 citations Open access
Semantic Scholar
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption
Phoebe K. Mondala, Ashni A. Vora, Tianyuan Zhou, E. Lazzari +7 more
2021Cell Stem Cell56 citations Open access
Semantic Scholar
Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders
J. Fields, Wilmar Dumaop, L. Crews, A. Adame +5 more
2015Current HIV Research51 citations Open access
Semantic Scholar
Chronic Myeloid Leukemia Stem Cell Biology
L. Crews, C. Jamieson
2012Current Hematologic Malignancy Reports48 citations Open access
Semantic Scholar
The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons
D. Langford, Aline Grigorian, R. Hurford, A. Adame +2 more
2011Journal of Neurovirology44 citations
Semantic Scholar
Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin
K. Ubhi, E. Rockenstein, E. Doppler, M. Mante +7 more
2009Acta Neuropathologica44 citations Open access
Semantic Scholar
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches
Wenxue Ma, A. Gutierrez, D. Goff, I. Geron +16 more
2012PLoS ONE43 citations Open access
Semantic Scholar
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
M. Colombo, S. Galletti, G. Bulfamante, M. Falleni +11 more
2016OncoTarget42 citations Open access
Semantic Scholar
Inflammation Driven Deaminase Deregulation Fuels Human Pre-leukemia Stem Cell Evolution
Qingfei Jiang, J. Isquith, Luisa Ladel, Adam M. Mark +26 more
2021Cell Reports41 citations Open access
Semantic Scholar
Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
A. Paulino, K. Ubhi, E. Rockenstein, A. Adame +6 more
2011Journal of Neurovirology39 citations Open access
Semantic Scholar
Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
L. Crews, Rebecca A. S. Ruf, C. Patrick, Wilmar Dumaop +4 more
2011Molecular Neurodegeneration36 citations Open access
Semantic Scholar
Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration
S. Salaria, Haleh Badkoobehi, E. Rockenstein, L. Crews +3 more
2011Journal of Neurovirology28 citations
Semantic Scholar
Neuroprotective effects of the anti‐cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders
W. Wrasidlo, L. Crews, I. Tsigelny, E. Stocking +8 more
2014British Journal of Pharmacology26 citations Open access
Semantic Scholar
Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
I. van der Werf, Phoebe K. Mondala, S. Steel, L. Balaian +16 more
2023Cell Reports Medicine25 citations Open access
Semantic Scholar
Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS
L. Crews, M. Lentz, R. González, H. S. Fox +1 more
2008Journal of Neurovirology24 citations Open access
Semantic Scholar
Regional Comparison of the Neurogenic Effects of CNTF-Derived Peptides and Cerebrolysin in AβPP Transgenic Mice
E. Rockenstein, K. Ubhi, E. Doppler, P. Novak +9 more
2011Journal of Alzheimer's Disease20 citations Open access
Semantic Scholar
Biomarkers In Dry Eye Disease
M. Lemp, B. Sullivan, L. Crews
201216 citations Open access
Semantic Scholar
Correction for Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein, by
P. Desplats, He-Jin Lee, Eun-Jin Bae, C. Patrick +5 more
200914 citations
Semantic Scholar
Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells
Ashni A. Vora, Phoebe K. Mondala, C. Costello, A. Macleod +1 more
2021STAR Protocols7 citations Open access
Semantic Scholar
Correlation between Commonly Used Clinical Tests in the Management of Dry Eye Disease
B. Sullivan, L. Crews, E. Messmer, G. Foulks +2 more
20125 citations
Semantic Scholar
A Highly Selective SF3B1-Targeted Splicing Inhibitor Reduces Human CD34+ Cell Survival and Self-Renewal In Acute Myeloid Leukemia
L. Balaian, L. Crews, M. Zipeto, Kulidjian Anna +3 more
20133 citations
Semantic Scholar
Molecular Evolution of Leukemia Stem Cells
L. Crews, C. Jamieson
20133 citations
Semantic Scholar

Frequent co-authors

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E. Masliah×28
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E. Masliah — researcher profile on SciRah
E. Rockenstein×19
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E. Rockenstein — researcher profile on SciRah
C. Jamieson×16
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C. Jamieson — researcher profile on SciRah
C. Patrick×14
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C. Patrick — researcher profile on SciRah

×13

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A. Adame — researcher profile on SciRah

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B. Spencer — researcher profile on SciRah

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P. Desplats — researcher profile on SciRah

Qingfei Jiang×8

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Qingfei Jiang — researcher profile on SciRah

Phoebe K. Mondala×6

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Phoebe K. Mondala — researcher profile on SciRah

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M. Lemp — researcher profile on SciRah

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B. Sullivan — researcher profile on SciRah

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K. Ubhi — researcher profile on SciRah