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J. Guikema · SciRah

Researcher profile · Semantic Scholar

J. Guikema

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J. Guikema — researcher profile on SciRah

h-index: 24
Works: 77
Citations: 2,824

Most-cited papers

Mechanism and regulation of class switch recombination.
J. Stavnezer, J. Guikema, C. E. Schrader
2008Annual Review of Immunology1,158 citations Open access
Semantic Scholar
A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi
R. Hoogeboom, K. V. van Kessel, F. Hochstenbach, T. A. Wormhoudt +6 more
2013Journal of Experimental Medicine162 citations Open access
Semantic Scholar
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
J. Guikema, Erin K. Linehan, D. Tsuchimoto, Y. Nakabeppu +3 more
2007Journal of Experimental Medicine117 citations Open access
Semantic Scholar
Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype.
L. Smit, R. J. Bende, J. Aten, J. Guikema +2 more
2003Cancer Research113 citations
Semantic Scholar
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
O. Staszewski, Richard E. Baker, A. Ucher, R. Martier +2 more
2011Molecules and Cells102 citations Open access
Semantic Scholar
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
J. Guikema, Erin K. Linehan, D. Tsuchimoto, Y. Nakabeppu +3 more
2007Journal of Experimental Medicine89 citations Open access
Semantic Scholar
Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair1
C. E. Schrader, J. Guikema, Erin K. Linehan, E. Selsing +1 more
2007Journal of Immunology87 citations Open access
Semantic Scholar
Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer
J. Guikema, M. Amiot, E. Eldering
2017Expert opinion on therapeutic targets80 citations Open access
Semantic Scholar
Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: Validation in Burkitt lymphomas from three geographic regions
E. Haralambieva, E. Schuuring, S. Rosati, C. V. van Noesel +10 more
2004Genes, Chromosomes and Cancer64 citations
Semantic Scholar
The roles of APE1, APE2, DNA polymerase β and mismatch repair in creating S region DNA breaks during antibody class switch
C. E. Schrader, J. Guikema, Xiaoming Wu, J. Stavnezer
2009Philosophical Transactions of the Royal Society B: Biological Sciences52 citations Open access
Semantic Scholar
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins
H. van Andel, Ze-Min Ren, Iris Koopmans, Sander Joosten +8 more
2016Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences
Maria Stratigopoulou, Tijmen P. van Dam, J. Guikema
2020Frontiers in Immunology43 citations Open access
Semantic Scholar
AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma.
Timon A. Bloedjes, G. de Wilde, C. Maas, E. Eldering +5 more
2020Blood Advances37 citations Open access
Semantic Scholar
Salivary Gland Mucosa‐Associated Lymphoid Tissue–Type Lymphoma From Sjögren’s Syndrome Patients in the Majority Express Rheumatoid Factors Affinity‐Selected for IgG
R. J. Bende, Jerry Janssen, Anna Beentjes, T. A. Wormhoudt +5 more
2020Arthritis & Rheumatology35 citations Open access
Semantic Scholar
p53 Represses Class Switch Recombination to IgG2a through its Antioxidant Function
J. Guikema, C. E. Schrader, M. Brodsky, Erin K. Linehan +6 more
2010Journal of Immunology35 citations Open access
Semantic Scholar
A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β
De-Sheng Pei, Xiaojie Yang, Wei Liu, J. Guikema +2 more
2010Nucleic Acids Research32 citations Open access
Semantic Scholar
The DNA Damage Response Regulates RAG1/2 Expression in Pre–B Cells through ATM-FOXO1 Signaling
Katarina Ochodnicka-Mackovicova, Mahnoush Bahjat, C. Maas, Amélie van der Veen +9 more
2016Journal of Immunology31 citations Open access
Semantic Scholar
Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.
V. Lascano, Marco Guadagnoli, Jan-Jaap Schot, Dieuwertje M. P. Luijks +10 more
2013Blood28 citations Open access
Semantic Scholar
AP-Endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge
J. Guikema, Rachel M. Gerstein, Erin K. Linehan, E. K. Cloherty +4 more
2011Journal of Immunology28 citations Open access
Semantic Scholar
Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma
Timon A. Bloedjes, G. de Wilde, J. Guikema
2021Cancers25 citations Open access
Semantic Scholar
B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains.
L. Slot, R. Hoogeboom, L. Smit, T. A. Wormhoudt +10 more
2016American Journal of Pathology25 citations Open access
Semantic Scholar
IGH switch breakpoints in Burkitt lymphoma: Exclusive involvement of noncanonical class switch recombination
J. Guikema, C. de Boer, E. Haralambieva, L. Smit +3 more
2006Genes, Chromosomes and Cancer25 citations Open access
Semantic Scholar
Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help
Elena Merino Tejero, Danial Lashgari, R. García-Valiente, Xuefeng Gao +8 more
2021Frontiers in Immunology24 citations Open access
Semantic Scholar
NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity.
Katarina Ochodnicka-Mackovicova, Mahnoush Bahjat, Timon A. Bloedjes, C. Maas +4 more
2015Blood24 citations Open access
Semantic Scholar
Structure and consequences of IGH switch breakpoints in Burkitt lymphoma.
J. Guikema, E. Schuuring, P. Kluin
2008Journal of the National Cancer Institute. Monographs24 citations Open access
Semantic Scholar
AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity
Timon A. Bloedjes, G. de Wilde, Gerarda H. Khan, T. Ashby +7 more
2022Blood Advances23 citations Open access
Semantic Scholar
The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes
Mahnoush Bahjat, J. Guikema
2017International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity
R. J. Bende, Jerry Janssen, T. A. Wormhoudt, K. Wagner +2 more
2016Haematologica22 citations Open access
Semantic Scholar
Lymphoma‐associated mutations in autoreactive memory B cells of patients with Sjögren's syndrome
R. J. Bende, L. Slot, M. Kwakkenbos, T. A. Wormhoudt +6 more
2022Journal of Pathology19 citations Open access
Semantic Scholar
ATM increases AID activity at downstream S regions during class switch recombination
Lyne Khair, J. Guikema, Erin K. Linehan, A. Ucher +5 more
2014Journal of Immunology19 citations Open access
Semantic Scholar
Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires
A. Pélissier, Si-Long Luo, Maria Stratigopoulou, J. Guikema +1 more
2023Frontiers in Immunology18 citations Open access
Semantic Scholar
Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
A. Pélissier, Maria Stratigopoulou, N. Donner, E. Dimitriadis +4 more
2022Life Science Alliance18 citations Open access
Semantic Scholar
AP endonuclease 2 regulates the expansion of germinal centers by protecting against AID-independent DNA damage in B cells
J. Guikema, Erin K. Linehan, N. Esa, D. Tsuchimoto +3 more
2014Journal of Immunology17 citations Open access
Semantic Scholar
APE 1-and APE 2-dependent DNA breaks in immunoglobulin class switch recombination
J. Guikema, Erin K. Linehan, D. Tsuchimoto, Y. Nakabeppu +3 more
17 citations
Semantic Scholar
Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients.
J. Guikema, S. Rosati, K. Akkermans, R. J. Bende +5 more
2005Blood16 citations
Semantic Scholar
Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation
Yvonne J. Thus, M. F. D. de Rooij, Nathalie Swier, R. Beijersbergen +6 more
2022Haematologica14 citations Open access
Semantic Scholar
The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors
Mahnoush Bahjat, G. de Wilde, Tijmen P. van Dam, C. Maas +7 more
2019Cell Cycle11 citations Open access
Semantic Scholar
Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching
J. Guikema, C. E. Schrader, N. Leus, A. Ucher +4 more
2008Journal of Immunology11 citations Open access
Semantic Scholar
Complex biallelic IGH rearrangements in IgM‐expressing Z‐138 cell line: Involvement of downstream immunoglobulin class switch recombination
J. Guikema, J. Fenton, C. de Boer, K. Kleiverda +5 more
2005Genes, Chromosomes and Cancer10 citations
Semantic Scholar
Heterogeneity in the Multiple Myeloma Tumor Clone
J. Guikema, S. Hovenga, E. Vellenga, N. Bos
2004Leukemia and Lymphoma10 citations
Semantic Scholar
Response to Comment on “Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching”
J. Guikema, C. E. Schrader, S. Baker, W. Edelmann +1 more
2009Journal of Immunology9 citations Open access
Semantic Scholar
Levamisole suppresses activation and proliferation of human T cells by the induction of a p53-dependent DNA damage response
Gerarda H. Khan, Floor Veltkamp, Mirte Scheper, R. Hoebe +5 more
2023bioRxiv7 citations Open access
Semantic Scholar
SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma
A. Leeksma, I. Derks, B. Garrick, A. Jongejan +17 more
2022Molecular Oncology7 citations Open access
Semantic Scholar
Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA
E. Slinger, Felix M. Wensveen, J. Guikema, A. Kater +1 more
2016Haematologica7 citations Open access
Semantic Scholar
The role of Apex2 in class-switch recombination of immunoglobulin genes.
J. Guikema, J. Stavnezer, C. E. Schrader
2010International Immunology7 citations Open access
Semantic Scholar
Understanding repertoire sequencing data through a multiscale computational model of the germinal center
R. García-Valiente, Elena Merino Tejero, Maria Stratigopoulou, Daria Balashova +13 more
2023npj Systems Biology and Applications6 citations Open access
Semantic Scholar
Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center
Elena Merino Tejero, Danial Lashgari, R. García-Valiente, Jiaojiao He +5 more
2021Frontiers in Immunology6 citations Open access
Semantic Scholar
Systematic evaluation of B-cell clonal family inference approaches
Daria Balashova, B. V. van Schaik, Maria Stratigopoulou, J. Guikema +8 more
2024BMC Immunology5 citations Open access
Semantic Scholar
DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair
Mahnoush Bahjat, Maria Stratigopoulou, B. Pilzecker, Tijmen P. van Dam +5 more
2020bioRxiv5 citations Open access
Semantic Scholar
DNA damage–induced p53 downregulates expression of RAG1 through a negative feedback loop involving miR-34a and FOXP1
Katarina Ochodnicka-Mackovicova, M. van Keimpema, Marcel Spaargaren, C. V. van Noesel +1 more
2024Journal of Biological Chemistry4 citations Open access
Semantic Scholar

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