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C. Kinnon · SciRah

Researcher profile · Semantic Scholar

C. Kinnon

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C. Kinnon — researcher profile on SciRah

h-index: 43
Works: 176
Citations: 9,087

Most-cited papers

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
S. Howe, M. Mansour, Kerstin Schwarzwaelder, C. Bartholomae +23 more
2008Journal of Clinical Investigation1,250 citations Open access
Semantic Scholar
High-Level Transduction and Gene Expression in Hematopoietic Repopulating Cells Using a Human Imunodeficiency Virus Type 1-Based Lentiviral Vector Containing an Internal Spleen Focus Forming Virus Promoter
C. Demaison, K. Parsley, G. Brouns, M. Scherr +4 more
2002Human Gene Therapy495 citations
Semantic Scholar
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz, K. Balaggan, A. Macneil, S. Howe +13 more
2006Nature Medicine486 citations
Semantic Scholar
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.
H. Gaspar, K. Parsley, S. Howe, D. King +15 more
2004The Lancet296 citations
Semantic Scholar
Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase–Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction
H. Gaspar, S. Cooray, K. Gilmour, K. Parsley +12 more
2011Science Translational Medicine274 citations Open access
Semantic Scholar
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.
H. B. Gaspar, E. Bjorkegren, K. Parsley, Kimberly C. Gilmour +13 more
2006Molecular Therapy232 citations Open access
Semantic Scholar
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.
P. Ancliff, M. Blundell, G. Cory, Y. Calle +10 more
2006Blood227 citations
Semantic Scholar
Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency
H. Gaspar, S. Cooray, K. Gilmour, K. Parsley +8 more
2011Science Translational Medicine225 citations Open access
Semantic Scholar
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
Kerstin Schwarzwaelder, S. Howe, M. Schmidt, M. Brugman +21 more
2007Journal of Clinical Investigation205 citations Open access
Semantic Scholar
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
Fang Zhang, S. Thornhill, S. Howe, M. Ulaganathan +6 more
2007Blood190 citations Open access
Semantic Scholar
Codon optimization of human factor VIII cDNAs leads to high-level expression.
N. Ward, S. Buckley, S. Waddington, T. VandenDriessche +7 more
2011Blood186 citations Open access
Semantic Scholar
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
D. Moulding, M. Blundell, D. Spiller, M. White +8 more
2007Journal of Experimental Medicine167 citations Open access
Semantic Scholar
Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency
S. Thornhill, A. Schambach, Steve Howe, M. Ulaganathan +8 more
2008Molecular Therapy161 citations Open access
Semantic Scholar
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.
G. Santilli, E. Almarza, C. Brendel, Uimook Choi +9 more
2011Molecular Therapy151 citations Open access
Semantic Scholar
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region.
C. Marshall, C. Kinnon, A. Thrasher
2000Blood141 citations Open access
Semantic Scholar
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein.
S. D. de Noronha, Samantha J. Hardy, J. Sinclair, M. Blundell +7 more
2005Blood134 citations Open access
Semantic Scholar
Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells1
Y. Leverrier, R. Lorenzi, M. Blundell, P. Brickell +3 more
2001Journal of Immunology126 citations
Semantic Scholar
Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation.
G. Pahal, E. Jauniaux, C. Kinnon, A. Thrasher +1 more
2000American Journal of Obstetrics and Gynecology79 citations
Semantic Scholar
Phosphorylation of WASp is a key regulator of activity and stability in vivo
M. Blundell, G. Bouma, J. Metelo, A. Worth +11 more
2009Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
The Wiskott–Aldrich syndrome
A. Thrasher, C. Kinnon
2000Clinical and Experimental Immunology67 citations Open access
Semantic Scholar
Intrinsic defects of B cell function in X‐linked severe combined immunodeficiency
Harry N. White, A. Thrasher, P. Veys, C. Kinnon +1 more
2000European Journal of Immunology61 citations Open access
Semantic Scholar
Immunodeficiency: Long-term persistence of a polyclonal t cell repertoire after gene therapy for X-linked severe combined immunodeficiency
H. Gaspar, S. Cooray, KC Gilmour, K. Parsley +8 more
201147 citations
Semantic Scholar
Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.
M. Blundell, G. Bouma, Y. Calle, G. Jones +2 more
2008Molecular Therapy46 citations Open access
Semantic Scholar
Capture and generation of adenovirus specific T cells for adoptive immunotherapy
I. Chatziandreou, Kimberly C. Gilmour, A. Mcnicol, Maurizio Costabile +6 more
2007British Journal of Haematology46 citations
Semantic Scholar
Generation of Trispecific Cytotoxic T Cells Recognizing Cytomegalovirus, Adenovirus, and Epstein-Barr Virus: An Approach for Adoptive Immunotherapy of Multiple Pathogens
H. Karlsson, J. Brewin, C. Kinnon, P. Veys +1 more
2007Journal of immunotherapy44 citations
Semantic Scholar
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
W. Qasim, T. Mackey, J. Sinclair, I. Chatziandreou +3 more
2007Molecular Therapy41 citations Open access
Semantic Scholar
Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12
S. Barker, SM Grosse, EK Siapati, A. Kritz +3 more
2007British Journal of Cancer36 citations Open access
Semantic Scholar
Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12
K. Siapati, S. Barker, C. Kinnon, A. Michalski +4 more
2003British Journal of Cancer35 citations Open access
Semantic Scholar
T cell transduction and suicide with an enhanced mutant thymidine kinase
W. Qasim, A. Thrasher, J. Buddle, C. Kinnon +2 more
2002Gene Therapy32 citations Open access
Semantic Scholar
Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro
C. Marshall, J. Sinclair, A. Thrasher, C. Kinnon
2007British Journal of Haematology29 citations Open access
Semantic Scholar
Gene therapy of inherited immunodeficiencies.
G. Santilli, S. Thornhill, C. Kinnon, A. Thrasher
2003Expert Opinion on Biological Therapy21 citations
Semantic Scholar
Fetal haemopoietic cells display enhanced migration across endothelium
K. Yong, Anne Fahey, G. Pahal, D. Linch +5 more
2002British Journal of Haematology21 citations
Semantic Scholar
Rapid protein‐based assays for the diagnosis of T–B+ severe combined immunodeficiency
Kimberly C. Gilmour, T. Cranston, S. Loughlin, Jackie Gwyther +9 more
2001British Journal of Haematology17 citations Open access
Semantic Scholar
Gene therapy of inherited immunodeficiencies
G. Santilli, S. Thornhill, C. Kinnon, A. Thrasher
2008Current hematology reports16 citations
Semantic Scholar
Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.
G. Jenkins, S. Hart, Rebecca J. Hodges, Qing‐Hai Meng +3 more
2002Chest16 citations
Semantic Scholar
Protein assays for diagnosis of Wiskott–Aldrich syndrome and X‐linked thrombocytopenia
W. Qasim, Kimberly C. Gilmour, S. Heath, Eleanor Ashton +8 more
2001British Journal of Haematology15 citations Open access
Semantic Scholar
The impact of retroviral suicide gene transduction procedures on T cells
W. Qasim, D. King, J. Buddle, S. Verfuerth +3 more
2003British Journal of Haematology14 citations Open access
Semantic Scholar
Enhancement of integrin‐mediated transfection of haematopoietic cells with a synthetic vector system
A. Uduehi, C. Mailhos, H. Truman, A. Thrasher +2 more
2003Biotechnology and applied biochemistry13 citations
Semantic Scholar
Pillars Article: The Gene Involved in X-linked Agammaglobulinaemia Is a Member of the Src Family of Protein-Tyrosine Kinases. Nature. 1993. 361: 226–233
D. Vetrie, I. Vořechovský, P. Sideras, J. Holland +8 more
2012Journal of Immunology12 citations
Semantic Scholar
Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency
H. Abdul-Razak, C. Rocca, S. Howe, M. E. Alonso-Ferrero +19 more
2018Scientific Reports8 citations Open access
Semantic Scholar
Enhancer‐deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD
O. Schwickerath, G. Brouns, A. Thrasher, C. Kinnon +2 more
2004Journal of Gene Medicine8 citations
Semantic Scholar
Non‐viral, integrin‐mediated gene transfer into fibroblasts from patients with lysosomal storage diseases
Elaine Joanna Estruch, Stephen Lewis Hart, C. Kinnon, Bryan G. Winchester
2001Journal of Gene Medicine7 citations
Semantic Scholar
c-kit Activating Mutations and Mast Cell Proliferation in Human Leukemia
Kunihiko Kobayashi, T. Ariga, M. Yamada, Y. Sakiyama +10 more
20176 citations
Semantic Scholar
Update on treatment of human SCID-X1 by somatic gene therapy using a pseudotyped gammaretroviral vector
H. Gaspar, K. Parsley, S. Howe, KC Gilmour +6 more
20046 citations
Semantic Scholar
Erratum: Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction (Science Translational Medicine (2013) 5 (168er1))
H. Gaspar, S. Cooray, KC Gilmour, K. Parsley +12 more
20135 citations
Semantic Scholar
p 22-phox-Deficient Chronic Granulomatous Disease : Reconstitution by Retrovirus-Mediated Expression and Identification of a Biosynthetic Intermediate of gp 91-phox
Colin, Potter, Moharned, Parkar +6 more
20025 citations
Semantic Scholar
Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors
M. Alonso-Ferrero, N. V. van Til, K. Bartolović, M. Mata +7 more
2018Experimental Hematology4 citations Open access
Semantic Scholar
Successful treatment of human X-SCID using a GALV-pseudotyped retroviral vector
K. Parsley, K. Gilmour, G. Brouns, S. Howe +5 more
20023 citations Open access
Semantic Scholar
Genetic mapping of two loci, DXS454 and DXS458, with respect to the X-linked agammaglobulinemia gene locus
M. Parkar, R. Lovering, R. Levinsky, C. Kinnon
2004Human Genetics2 citations
Semantic Scholar
Sap gene transfer restores cytotoxic function in EBV-CTLS generated from individuals with XLP.
B. Gaspar, Reza Sharifi, C. Kinnon, A. Peter +1 more
20012 citations
Semantic Scholar

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