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M. Brugman · SciRah

Researcher profile · Semantic Scholar

M. Brugman

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M. Brugman — researcher profile on SciRah

h-index: 33
Works: 93
Citations: 5,877

Most-cited papers

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
S. Howe, M. Mansour, Kerstin Schwarzwaelder, C. Bartholomae +23 more
2008Journal of Clinical Investigation1,250 citations Open access
Semantic Scholar
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
U. Modlich, S. Navarro, D. Zychlinski, T. Maetzig +8 more
2009Molecular Therapy402 citations Open access
Semantic Scholar
Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti‐inflammatory macrophages
S. Melief, E. Schrama, M. Brugman, M. Tiemessen +3 more
2013Stem Cells398 citations
Semantic Scholar
Stimulation of Id1 Expression by Bone Morphogenetic Protein Is Sufficient and Necessary for Bone Morphogenetic Protein–Induced Activation of Endothelial Cells
Gudrun Valdimarsdottir, M. Goumans, Alexander Rosendahl, M. Brugman +4 more
2002Circulation326 citations
Semantic Scholar
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.
T. Luis, B. A. Naber, P. C. Roozen, M. Brugman +6 more
2011Cell Stem Cell324 citations Open access
Semantic Scholar
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.
Eva Warlich, J. Kuehle, T. Cantz, M. Brugman +9 more
2011Molecular Therapy263 citations Open access
Semantic Scholar
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.
A. Deichmann, S. Hacein-Bey-Abina, M. Schmidt, A. Garrigue +28 more
2007Journal of Clinical Investigation261 citations Open access
Semantic Scholar
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development
T. Luis, M. Ichii, M. Brugman, P. Kincade +1 more
2011Leukemia212 citations Open access
Semantic Scholar
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
Kerstin Schwarzwaelder, S. Howe, M. Schmidt, M. Brugman +21 more
2007Journal of Clinical Investigation205 citations Open access
Semantic Scholar
Resistance of mature T cells to oncogene transformation.
S. Newrzela, K. Cornils, Zhi-Xiong Li, C. Baum +7 more
2008Blood196 citations Open access
Semantic Scholar
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
H. Holstege, W. Pfeiffer, D. Sie, M. Hulsman +14 more
2014Genome Research154 citations Open access
Semantic Scholar
Next‐generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3‐ITD or NPM1 mutations
F. Thol, Britta Kölking, F. Damm, Katarina Reinhardt +9 more
2012Genes, Chromosomes and Cancer131 citations
Semantic Scholar
Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.
F. Weerkamp, M. Baert, M. Brugman, W. A. Dik +6 more
2006Blood126 citations Open access
Semantic Scholar
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U. Modlich, A. Schambach, M. Brugman, D. Wicke +6 more
2008Leukemia101 citations Open access
Semantic Scholar
The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas
M. Tiemessen, M. Baert, T. Schonewille, M. Brugman +7 more
2012PLoS Biology84 citations Open access
Semantic Scholar
Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways
O. Kustikova, H. Geiger, Zhi-Xiong Li, M. Brugman +13 more
200776 citations
Semantic Scholar
Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy
K. Pike-Overzet, D. de Ridder, F. Weerkamp, M. Baert +8 more
2007Leukemia74 citations
Semantic Scholar
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.
O. Kustikova, B. Schiedlmeier, M. Brugman, Maike Stahlhut +3 more
2009Molecular Therapy72 citations Open access
Semantic Scholar
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.
J. D. Suerth, T. Maetzig, M. Brugman, N. Heinz +7 more
2012Molecular Therapy70 citations Open access
Semantic Scholar
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells
O. Kustikova, A. Schwarzer, Maike Stahlhut, M. Brugman +11 more
2013Leukemia68 citations
Semantic Scholar
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
Melanie Galla, A. Schambach, Christine S. Falk, T. Maetzig +9 more
2011Nucleic Acids Research66 citations Open access
Semantic Scholar
Gene therapy: Is IL2RG oncogenic in T-cell development?
K. Pike-Overzet, D. de Ridder, F. Weerkamp, M. Baert +8 more
2006Nature61 citations
Semantic Scholar
High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells
F. Famili, M. Brugman, E. Taskesen, B. A. Naber +2 more
2016Stem Cell Reports58 citations Open access
Semantic Scholar
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
T. Maetzig, M. Brugman, Stefan Bartels, N. Heinz +7 more
2011Blood58 citations
Semantic Scholar
CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes
Y. Kooy-Winkelaar, Dagmar Bouwer, George M. C. Janssen, A. Thompson +11 more
2017Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors
T. Maetzig, M. Galla, M. Brugman, R. Loew +2 more
2010Gene Therapy47 citations Open access
Semantic Scholar
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
A. Deichmann, M. Brugman, C. Bartholomae, Kerstin Schwarzwaelder +25 more
2011Molecular Therapy45 citations Open access
Semantic Scholar
Sustained Engraftment of Cryopreserved Human Bone Marrow CD34+ Cells in Young Adult NSG Mice
A. Wiekmeijer, K. Pike-Overzet, M. Brugman, D. Salvatori +4 more
2014BioResearch Open Access44 citations Open access
Semantic Scholar
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.
M. Huston, N. V. van Til, T. Visser, S. Arshad +14 more
2011Molecular Therapy43 citations Open access
Semantic Scholar
Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus
M. Brugman, A. Wiekmeijer, M. van Eggermond, I. Wolvers-Tettero +7 more
2015Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy
C. Vink, J. Counsell, D. Perocheau, R. Karda +7 more
2017Molecular Therapy39 citations Open access
Semantic Scholar
TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression
Silvia Stockinger, C. Duerr, M. Fulde, Tamas Dolowschiak +8 more
2014Journal of Immunology39 citations Open access
Semantic Scholar
Rapid Lentiviral Vector Producer Cell Line Generation Using a Single DNA Construct
Yu-Hua Chen, C. Pallant, Christopher J. Sampson, Alessia Boiti +23 more
2020Molecular Therapy: Methods & Clinical Development36 citations Open access
Semantic Scholar
Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.
K. Cornils, C. Lange, A. Schambach, M. Brugman +4 more
2009Molecular Therapy33 citations Open access
Semantic Scholar
Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.
A. Wiekmeijer, K. Pike-Overzet, Hanna IJspeert, M. Brugman +8 more
2016Journal of Allergy and Clinical Immunology32 citations Open access
Semantic Scholar
Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
D. Heckl, D. Wicke, M. Brugman, Johann Meyer +5 more
2011Blood30 citations
Semantic Scholar
The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease
Frederike Schmitz, Y. Kooy-Winkelaar, A. Wiekmeijer, M. Brugman +7 more
2015Gut29 citations Open access
Semantic Scholar
The genomic risk of somatic gene therapy.
O. Kustikova, M. Brugman, C. Baum
2010Seminars in Cancer Biology29 citations
Semantic Scholar
Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents
I. Rittelmeyer, M. Rothe, M. Brugman, M. Iken +5 more
2013Hepatology28 citations Open access
Semantic Scholar
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells.
C. Brendel, Benjamin Goebel, A. Daniela, M. Brugman +11 more
2015Molecular Therapy27 citations Open access
Semantic Scholar
Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells
M. Pincha, G. Salguero, D. Wedekind, B. Sundarasetty +9 more
2011Gene Therapy26 citations Open access
Semantic Scholar
Functional definition of a transcription factor hierarchy regulating T cell lineage commitment
L. Garcia-Perez, F. Famili, Martijn Cordes, M. Brugman +8 more
2020Science Advances25 citations Open access
Semantic Scholar
Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia
A. Schwarzer, H. Holtmann, M. Brugman, J. Meyer +6 more
2014Oncogene24 citations
Semantic Scholar
Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples
M. Brugman, J. D. Suerth, M. Rothe, S. Suerbaum +4 more
2013Human Gene Therapy Methods22 citations Open access
Semantic Scholar
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
O. Kustikova, Hartmut Geiger, Zhi-Xiong Li, M. Brugman +13 more
2007Blood21 citations Open access
Semantic Scholar
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian
E. B. van den Akker, Stavros Makrodimitris, M. Hulsman, M. Brugman +10 more
2019Leukemia17 citations Open access
Semantic Scholar
Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches
P. C. Roozen, M. Brugman, F. Staal
2012Annals of the New York Academy of Sciences17 citations
Semantic Scholar
Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance
Saskia Kohlscheen, S. Wintterle, A. Schwarzer, C. Kamp +5 more
2015PLoS ONE15 citations Open access
Semantic Scholar
Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms.
A. Wiekmeijer, K. Pike-Overzet, M. Brugman, M. van Eggermond +8 more
2016Experimental Hematology14 citations Open access
Semantic Scholar
Comprehensive Investigation of Parameter Choice in Viral Integration Site Analysis and Its Effects on the Gene Annotations Produced
M. Huston, M. Brugman, Sebastiaan Horsman, A. Stubbs +2 more
2012Human Gene Therapy14 citations Open access
Semantic Scholar

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