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Uimook Choi · SciRah

Researcher profile · Semantic Scholar

Uimook Choi

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Uimook Choi — researcher profile on SciRah

h-index: 31
Works: 83
Citations: 3,209

Most-cited papers

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
S. D. de Ravin, Xiaolin Wu, S. Moir, L. Kardava +25 more
2016Science Translational Medicine255 citations Open access
Semantic Scholar
Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting.
J. Zou, Colin L. Sweeney, Bin-Kuan Chou, Uimook Choi +5 more
2011Blood244 citations Open access
Semantic Scholar
CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
S. D. de Ravin, Lin-Hong Li, Xiaolin Wu, Uimook Choi +16 more
2017Science Translational Medicine232 citations
Semantic Scholar
Lentiviral gene therapy for X-linked chronic granulomatous disease
D. Kohn, C. Booth, E. Kang, S. Pai +34 more
2020Nature Medicine220 citations Open access
Semantic Scholar
Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils.
E. Kang, Uimook Choi, Narda Theobald, G. Linton +3 more
2010Blood181 citations Open access
Semantic Scholar
Targeted Gene Addition to a Safe Harbor locus in human CD34+ Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease
S. D. de Ravin, A. Reik, Pei-Qi Liu, Lin-Hong Li +19 more
2016Nature Biotechnology151 citations Open access
Semantic Scholar
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.
G. Santilli, E. Almarza, C. Brendel, Uimook Choi +9 more
2011Molecular Therapy151 citations Open access
Semantic Scholar
CXCR4‐Transgene Expression Significantly Improves Marrow Engraftment of Cultured Hematopoietic Stem Cells
S. Brenner, N. Whiting-Theobald, T. Kawai, G. Linton +6 more
2004Stem Cells124 citations
Semantic Scholar
PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Cytoskeletal abnormalities and neutrophil dysfunction in WDR 1 de fi ciency
D. Kuhns, D. Fink, Uimook Choi, Colin L. Sweeney +23 more
2016103 citations
Semantic Scholar
Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome.
T. Kawai, Uimook Choi, N. Whiting-Theobald, G. Linton +4 more
2005Experimental Hematology102 citations Open access
Semantic Scholar
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.
T. Kawai, Uimook Choi, Lanise Cardwell, S. DeRavin +6 more
2007Blood98 citations Open access
Semantic Scholar
Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.
R. Merling, Colin L. Sweeney, Uimook Choi, S. D. de Ravin +8 more
2013Blood90 citations Open access
Semantic Scholar
Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration
S. D. de Ravin, Ling Su, Narda Theobald, Uimook Choi +8 more
2014Journal of Virology89 citations Open access
Semantic Scholar
Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.
K. Yamashita, Uimook Choi, Patricia C. Woltz, Susan F. Foster +13 more
2004Blood85 citations
Semantic Scholar
An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.
R. Merling, Colin L. Sweeney, Jessica Y. S. Chu, A. Bodansky +13 more
2015Molecular Therapy71 citations Open access
Semantic Scholar
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
A. Larochelle, Uimook Choi, Y. Shou, N. Naumann +11 more
2009Journal of Clinical Investigation63 citations Open access
Semantic Scholar
Enhanced Homology-directed Repair for Highly Efficient Gene Editing in Hematopoietic Stem/Progenitor Cells.
S. D. de Ravin, J. Brault, R. Meis, Siyuan Liu +19 more
2021Blood62 citations Open access
Semantic Scholar
Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.
Amy Yuan, Ya-Shang Lee, Uimook Choi, G. Moeckel +1 more
2015AJP - Renal Physiology59 citations Open access
Semantic Scholar
Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.
Y. Arai, Uimook Choi, Cristina Corsino, Sherry M. Koontz +6 more
2018Molecular Therapy51 citations Open access
Semantic Scholar
Gene-edited pseudogene resurrection corrects p47phox-deficient chronic granulomatous disease.
R. Merling, D. Kuhns, Colin L. Sweeney, Xiaolin Wu +11 more
2017Blood Advances48 citations Open access
Semantic Scholar
Diprotin A Infusion into Nonobese Diabetic/Severe Combined Immunodeficiency Mice Markedly Enhances Engraftment of Human Mobilized CD34+ Peripheral Blood Cells
T. Kawai, Uimook Choi, Po-Ching Liu, N. Whiting-Theobald +2 more
2007Stem Cells and Development47 citations
Semantic Scholar
Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair
Colin L. Sweeney, M. Pavel-Dinu, Uimook Choi, J. Brault +12 more
2021Gene Therapy46 citations Open access
Semantic Scholar
Targeted Repair of CYBB in X-CGD iPSCs Requires Retention of Intronic Sequences for Expression and Functional Correction.
Colin L. Sweeney, J. Zou, Uimook Choi, R. Merling +6 more
2017Molecular Therapy44 citations Open access
Semantic Scholar
Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy.
K. Ponder, Suk See Ting-De Ravin, D. Kennedy, N. Naumann +9 more
2006Blood43 citations Open access
Semantic Scholar
Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency
S. D. de Ravin, Siyuan Liu, Colin L. Sweeney, J. Brault +21 more
2022Nature Communications41 citations Open access
Semantic Scholar
Progress toward effective gene therapy for chronic granulomatous disease.
H. Malech, Uimook Choi, S. Brenner
2004Japanese journal of infectious diseases (Print)39 citations
Semantic Scholar
Molecular analysis of neutrophil differentiation from human iPSCs delineates the kinetics of key regulators of hematopoiesis
Colin L. Sweeney, Rui-Feng Teng, Hongmei Wang, R. Merling +5 more
2016Stem Cells36 citations Open access
Semantic Scholar
CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes.
J. Brault, Taylor Liu, Ezekiel A Bello, Siyuan Liu +19 more
2021Blood35 citations Open access
Semantic Scholar
Defining a new immune deficiency syndrome: MAN2B2-CDG
Jan Verheijen, Sun-Nie Y. Wong, J. Rowe, K. Raymond +19 more
2019Journal of Allergy and Clinical Immunology35 citations Open access
Semantic Scholar
p47(phox) directs murine macrophage cell fate decisions.
Liang Yi, Qi Liu, M. Orandle, S. Sadiq-Ali +4 more
2012American Journal of Pathology31 citations Open access
Semantic Scholar
Simian immunodeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft
N. Naumann, S. D. de Ravin, Uimook Choi, M. Moayeri +4 more
2007Gene Therapy31 citations Open access
Semantic Scholar
CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells
J. Brault, Taylor Liu, Siyuan Liu, Amanda Lawson +17 more
2023Frontiers in Immunology30 citations Open access
Semantic Scholar
Metabolic routing maintains the unique fatty acid composition of phosphoinositides
Y. J. Kim, Nivedita Sengupta, Mira Sohn, Amrita Mandal +3 more
2022EMBO Reports28 citations Open access
Semantic Scholar
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells
Naritaka Tamaoki, Stefan Siebert, T. Maeda, Ngoc-Han Ha +22 more
2021bioRxiv27 citations Open access
Semantic Scholar
Extracellular Vesicles from Thapsigargin-Treated Mesenchymal Stem Cells Ameliorated Experimental Colitis via Enhanced Immunomodulatory Properties
Hansol Joo, Mi-Kyung Oh, Ji-Ye-On Kang, Hyun Sung Park +9 more
2021Biomedicines23 citations Open access
Semantic Scholar
Unique abnormalities of CD4(+) and CD8(+) central memory cells associated with chronic graft-versus-host disease improve after extracorporeal photopheresis.
K. Yamashita, M. Horwitz, Akua Kwatemaa, Effie Y. H. Nomicos +15 more
2006Biology of Blood and Marrow Transplantation21 citations Open access
Semantic Scholar
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
Vera Bzhilyanskaya, Linyuan Ma, Siyuan Liu, Lauren R. Fox +16 more
2024Science Translational Medicine20 citations
Semantic Scholar
Generation of functionally mature neutrophils from induced pluripotent stem cells.
Colin L. Sweeney, R. Merling, Uimook Choi, D. L. Long Priel +3 more
2014Methods in molecular biology20 citations
Semantic Scholar
CRISPR-Mediated Knockout of Cybb in NSG Mice Establishes a Model of Chronic Granulomatous Disease for Human Stem-Cell Gene Therapy Transplants
Colin L. Sweeney, Uimook Choi, Cheng-Yu Liu, Sherry M. Koontz +2 more
2017Human Gene Therapy15 citations Open access
Semantic Scholar
A Novel Method for Screening Adenosine Receptor Specific Agonists for Use in Adenosine Drug Development
Karlie R. Jones, Uimook Choi, Ji-Liang Gao, R. Thompson +3 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Byung-Chul Lee, Ashley L. Gin, Chuanfeng Wu, Komudi Singh +11 more
2024Cell Stem Cell13 citations Open access
Semantic Scholar
Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway
Hyun Sung Park, Mi-Kyung Oh, Joong Won Lee, Dong-Hoon Chae +12 more
2021International Journal of Stem Cells13 citations Open access
Semantic Scholar
Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.
Uimook Choi, S. DeRavin, K. Yamashita, N. Whiting-Theobald +4 more
2004Experimental Hematology13 citations Open access
Semantic Scholar
Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells.
S. Brenner, M. Ryser, Uimook Choi, N. Whiting-Theobald +11 more
2006Molecular Therapy12 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated Cxcr4 Disease Allele Inactivation for Gene Therapy in a Mouse Model of WHIM Syndrome.
Ji-Liang Gao, A. Owusu-Ansah, Alexander Yang, E. Yim +7 more
2023Blood8 citations Open access
Semantic Scholar
Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Byung-Chul Lee, Ashley L. Gin, Chuanfeng Wu, Komudi Singh +11 more
2023bioRxiv8 citations Open access
Semantic Scholar
Gene Editing in Chronic Granulomatous Disease.
Colin L. Sweeney, R. Merling, S. D. de Ravin, Uimook Choi +1 more
2019Methods in molecular biology7 citations
Semantic Scholar
The regulatory role of ACP5 in the diesel exhaust particle-induced AHR inflammatory signaling pathway in a human bronchial epithelial cell line
Aaron Yu, Dankyu Yoon, Hye Bin An, Uimook Choi +14 more
2025Scientific Reports5 citations Open access
Semantic Scholar
Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Byung-Chul Lee, Ashley L. Gin, Chuan-Feng Wu, Komudi Singh +11 more
2024Cell Stem Cell4 citations Open access
Semantic Scholar
Preclinical Optimization and Safety Studies of a New Lentiviral Gene Therapy for p47phox-Deficient Chronic Granulomatous Disease
A. Schejtman, W. Vetharoy, Uimook Choi, C. Rivat +14 more
2021Human Gene Therapy4 citations Open access
Semantic Scholar

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