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W. McEwan · SciRah

Researcher profile · Semantic Scholar

W. McEwan

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W. McEwan — researcher profile on SciRah

h-index: 29
Works: 65
Citations: 4,124

Most-cited papers

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
D. Mallery, W. McEwan, S. Bidgood, G. Towers +2 more
2010Proceedings of the National Academy of Sciences of the United States of America533 citations Open access
Semantic Scholar
A Method for the Acute and Rapid Degradation of Endogenous Proteins
D. Clift, W. McEwan, Larisa I. Labzin, Vera Konieczny +3 more
2017Cell485 citations Open access
Semantic Scholar
Intracellular antibody-bound pathogens stimulate immune signaling via Fc-receptor TRIM21
W. McEwan, Jerry C. H. Tam, R. Watkinson, Susanna R. Bidgood +2 more
2013Nature Immunology372 citations Open access
Semantic Scholar
Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
A. Price, D. Jacques, W. McEwan, Adam J. Fletcher +5 more
2014PLoS Pathogens283 citations Open access
Semantic Scholar
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
D. Jacques, W. McEwan, L. Hilditch, A. Price +2 more
2016Nature227 citations Open access
Semantic Scholar
Intracellular sensing of complement C3 activates cell autonomous immunity
Jerry C. H. Tam, S. Bidgood, W. McEwan, L. James
2014Science188 citations Open access
Semantic Scholar
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
W. McEwan, B. Falcon, M. Vaysburd, D. Clift +4 more
2017Proceedings of the National Academy of Sciences of the United States of America176 citations Open access
Semantic Scholar
Acute and rapid degradation of endogenous proteins by Trim-Away
D. Clift, C. So, W. McEwan, L. James +1 more
2018Nature Protocols164 citations
Semantic Scholar
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
D. Mallery, Chantal L. Márquez, W. McEwan, C. Dickson +7 more
2018eLife162 citations Open access
Semantic Scholar
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
Eliana Nachman, A. Wentink, K. Madiona, L. Bousset +9 more
2019Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
J. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, W. McEwan +3 more
2021bioRxiv117 citations Open access
Semantic Scholar
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization
F. Hauler, D. Mallery, W. McEwan, S. Bidgood +1 more
2012Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus
R. Watkinson, W. McEwan, Jerry C. H. Tam, M. Vaysburd +1 more
2015PLoS Pathogens98 citations Open access
Semantic Scholar
Target-induced clustering activates Trim-Away of pathogens and proteins
Jingwei Zeng, A. F. Santos, Aamir S. Mukadam, Mariana Osswald +12 more
2021Nature Structural & Molecular Biology96 citations Open access
Semantic Scholar
Regulation of Virus Neutralization and the Persistent Fraction by TRIM21
W. McEwan, F. Hauler, C. Williams, S. Bidgood +3 more
2012Journal of Virology88 citations Open access
Semantic Scholar
Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells
S. Bidgood, Jerry C. H. Tam, W. McEwan, D. Mallery +1 more
2014Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
Franziska Kundel, Liu Hong, B. Falcon, W. McEwan +7 more
2018ACS Chemical Neuroscience76 citations Open access
Semantic Scholar
Truncation of TRIM5 in the Feliformia Explains the Absence of Retroviral Restriction in Cells of the Domestic Cat
W. McEwan, T. Schaller, L. Ylinen, M. Hosie +2 more
2009Journal of Virology67 citations Open access
Semantic Scholar
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, A. Davies +6 more
2023bioRxiv66 citations Open access
Semantic Scholar
Intracellular antibody‐mediated immunity and the role of TRIM21
W. McEwan, D. Mallery, D. Rhodes, J. Trowsdale +1 more
2011Bioessays66 citations
Semantic Scholar
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Aamir S. Mukadam, Lauren V. C. Miller, Annabel E. Smith, M. Vaysburd +20 more
2023Science65 citations Open access
Semantic Scholar
Cholesterol determines the cytosolic entry and seeded aggregation of tau
Benjamin J. Tuck, Lauren V. C. Miller, Taxiarchis Katsinelos, Annabel E. Smith +9 more
2022Cell Reports45 citations Open access
Semantic Scholar
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration
Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, W. McEwan
2019Frontiers in Immunology40 citations Open access
Semantic Scholar
TRIM21-dependent intracellular antibody neutralization of virus infection.
W. McEwan, L. James
2015Progress in Molecular Biology and Translational Science38 citations
Semantic Scholar
Type-I Interferons in Alzheimer's Disease and Other Tauopathies
Sophie A. I. Sanford, W. McEwan
2022Frontiers in Cellular Neuroscience35 citations Open access
Semantic Scholar
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.
Y. Aman, Brent J. Ryan, S. B. Torsetnes, A. Knapskog +3 more
2020International review of neurobiology30 citations
Semantic Scholar
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Eleni Dimou, Taxiarchis Katsinelos, G. Meisl, Benjamin J. Tuck +9 more
2023Cell Reports29 citations Open access
Semantic Scholar
Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates.
Morgane Darricau, Taxiarchis Katsinelos, F. Raschellà, T. Milekovic +7 more
2022Brain : a journal of neurology29 citations Open access
Semantic Scholar
Diverse HIV viruses are targeted by a conformationally dynamic antiviral
M. Caines, K. Bichel, A. Price, W. McEwan +4 more
2012Nature Structural &Molecular Biology29 citations Open access
Semantic Scholar
Targeted protein degradation using intracellular antibodies and its application to neurodegenerative disease.
Jonathan Benn, Aamir S. Mukadam, W. McEwan
2021Seminars in Cell and Developmental Biology28 citations
Semantic Scholar
The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology
Sophie A. I. Sanford, Lauren V. C. Miller, M. Vaysburd, Sophie Keeling +6 more
2023Alzheimer's & Dementia26 citations Open access
Semantic Scholar
Intracellular Antibody Immunity
R. Watkinson, W. McEwan, L. James
2014Journal of Clinical Immunology23 citations
Semantic Scholar
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, M. Vaysburd +9 more
2021bioRxiv22 citations Open access
Semantic Scholar
Potent Lentiviral Restriction by a Synthetic Feline TRIM5 Cyclophilin A Fusion
Isabelle Dietrich, A. Macintyre, Elizabeth L. McMonagle, A. Price +4 more
2010Journal of Virology18 citations Open access
Semantic Scholar
Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21
W. McEwan
2016Antibodies17 citations Open access
Semantic Scholar
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology
Jun-Ping Pan, Ping-Jie Wang, Jian-Ying Zhang, Anne-Brita Knapskog +36 more
2026Nature Aging16 citations Open access
Semantic Scholar
Identification of cis-acting determinants mediating the unconventional secretion of tau
Taxiarchis Katsinelos, W. McEwan, T. Jahn, W. Nickel
2021Scientific Reports14 citations Open access
Semantic Scholar
State-selective small molecule degraders that preferentially remove aggregates and oligomers
J. Luptak, D. Clift, Aamir S. Mukadam, Jonathan Benn +8 more
2025Nature Communications9 citations Open access
Semantic Scholar
Genetically Divergent Strains of Feline Immunodeficiency Virus from the Domestic Cat (Felis catus) and the African Lion (Panthera leo) Share Usage of CD134 and CXCR4 as Entry Receptors
W. McEwan, Elizabeth L. McMonagle, N. Logan, R. Serra +4 more
2008Journal of Virology9 citations Open access
Semantic Scholar
Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away
D. Clift, C. So, W. McEwan, L. James +1 more
2018Nature Protocols6 citations Open access
Semantic Scholar
Restriction of the felid lentiviruses by a synthetic feline TRIM5-CypA fusion
Isabelle Dietrich, W. McEwan, M. Hosie, B. Willett
2011Veterinary Immunology and Immunopathology5 citations Open access
Semantic Scholar
Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation
Benjamin J. Tuck, Lauren V. C. Miller, E. Wilson, Taxiarchis Katsinelos +7 more
2021bioRxiv3 citations Open access
Semantic Scholar
Factors affecting replication and cross-species transmission of feline immunodeficiency virus
W. McEwan
20102 citations
Semantic Scholar
A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling
Sophia F. Mersmann, E. Johns, Tracer Yong, W. McEwan +3 more
2022Scientific Reports1 citations Open access
Semantic Scholar
Antibodies in the intracellular domain
W. McEwan
2022Seminars in Cell and Developmental Biology1 citations Open access
Semantic Scholar
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, M. Vaysburd +9 more
2021Acta Neuropathologica Communications1 citations Open access
Semantic Scholar
Substrate-induced clustering activates Trim-Away of pathogens and proteins
Jingwei Zeng, A. F. Santos, Aamir S. Mukadam, Mariana Osswald +10 more
2020bioRxiv1 citations Open access
Semantic Scholar
Learning to count: determining the stoichiometry of bio-molecular complexes using fluorescence microscopy and statistical modelling
Sophia F. Mersmann, E. Johns, Tracer Yong, W. McEwan +3 more
2020bioRxiv1 citations Open access
Semantic Scholar
Author response: IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
D. Mallery, Chantal L. Márquez, W. McEwan, C. Dickson +7 more
20181 citations Open access
Semantic Scholar
Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains
Christopher Green, K. Winklhofer, Adam J. Fletcher, L. James +3 more
2024bioRxiv0 citations Open access
Semantic Scholar

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L. James — researcher profile on SciRah
Taxiarchis Katsinelos×11
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Benjamin J. Tuck×9
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