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Brent J. Ryan · SciRah

Researcher profile · Semantic Scholar

Brent J. Ryan

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Brent J. Ryan — researcher profile on SciRah

h-index: 26
Works: 45
Citations: 3,140

Most-cited papers

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
Brent J. Ryan, S. Hoek, E. Fon, R. Wade-Martins
2015TIBS -Trends in Biochemical Sciences. Regular ed514 citations
Semantic Scholar
Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy.
A. Malpartida, M. Williamson, Derek P. Narendra, R. Wade-Martins +1 more
2020TIBS -Trends in Biochemical Sciences. Regular ed451 citations
Semantic Scholar
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
Hugo J. R. Fernandes, E. Hartfield, H. Christian, Evangelia Emmanoulidou +16 more
2016Stem Cell Reports332 citations Open access
Semantic Scholar
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
Stephanie Janezic, S. Threlfell, Paul D. Dodson, M. Dowie +16 more
2013Proceedings of the National Academy of Sciences of the United States of America328 citations Open access
Semantic Scholar
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
Federico Zambon, Marta Cherubini, Hugo J. R. Fernandes, Charmaine Lang +12 more
2019Human Molecular Genetics155 citations Open access
Semantic Scholar
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
Charmaine Lang, Kieran R. Campbell, Brent J. Ryan, Phillippa J. Carling +10 more
2019Cell Stem Cell143 citations Open access
Semantic Scholar
Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
Brent J. Ryan, A. Nissim, P. Winyard
2014Redox Biology114 citations Open access
Semantic Scholar
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
Amy M. Smith, Constanze Depp, Brent J. Ryan, Geoffrey I. Johnston +8 more
2018Movement Disorders106 citations Open access
Semantic Scholar
Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.
P. Winyard, Brent J. Ryan, P. Eggleton, A. Nissim +10 more
2011Biochemical Society Transactions95 citations
Semantic Scholar
Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis
A. Burska, L. Hunt, M. Boissinot, Rocky Strollo +6 more
2014Mediators of Inflammation92 citations Open access
Semantic Scholar
PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
H. Bogetofte, Pia Jensen, Matias Ryding, S. I. Schmidt +12 more
2019Frontiers in Cellular Neuroscience59 citations Open access
Semantic Scholar
Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells.
J. Tarr, P. Winyard, Brent J. Ryan, L. Harries +3 more
2010Arthritis & Rheumatism59 citations Open access
Semantic Scholar
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, S. Senior +14 more
2014Neurobiology of Disease54 citations Open access
Semantic Scholar
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models
M. Williamson, Marta Madureira, William McGuinness, Rachel Heon‐Roberts +13 more
2023Human Molecular Genetics52 citations Open access
Semantic Scholar
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
Jade D. Bailey, A. Shaw, R. Fischer, Brent J. Ryan +5 more
2017Free Radical Biology & Medicine49 citations Open access
Semantic Scholar
Oxidative and other posttranslational modifications in extracellular vesicle biology.
K. Szabó-Taylor, Brent J. Ryan, X. Osteikoetxea, Tamás G. Szabó +7 more
2015Seminars in Cell and Developmental Biology48 citations
Semantic Scholar
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
H. Bogetofte, Brent J. Ryan, Pia Jensen, S. I. Schmidt +19 more
2023Cell Reports45 citations Open access
Semantic Scholar
Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid
L. Winchester, I. Barber, Michael A. Lawton, Jessica Ash +15 more
2022Brain Communications39 citations Open access
Semantic Scholar
Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation.
H. Bogetofte, Pia Jensen, Justyna Okarmus, S. I. Schmidt +10 more
2019Neurobiology of Disease39 citations Open access
Semantic Scholar
A requirement for Gch1 and tetrahydrobiopterin in embryonic development
G. Douglas, Ashley B. Hale, M. Crabtree, Brent J. Ryan +6 more
2015Developmental Biology39 citations Open access
Semantic Scholar
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield +7 more
2023bioRxiv38 citations Open access
Semantic Scholar
C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function
Jens Buttgereit, J. Shanks, Dan Li, G. Hao +14 more
2016Cardiovascular Research37 citations Open access
Semantic Scholar
Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens.
P. Eggleton, A. Nissim, Brent J. Ryan, M. Whiteman +1 more
2013Free Radical Biology & Medicine35 citations
Semantic Scholar
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease
Brent J. Ryan, Lara L Lourenço-Venda, M. Crabtree, Ashley B. Hale +2 more
2013Free Radical Biology & Medicine32 citations Open access
Semantic Scholar
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.
Y. Aman, Brent J. Ryan, S. B. Torsetnes, A. Knapskog +3 more
2020International review of neurobiology30 citations
Semantic Scholar
Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson’s disease
Harriet A. Keane, Brent J. Ryan, B. Jackson, Alan Whitmore +1 more
2015Scientific Reports29 citations Open access
Semantic Scholar
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model
Brent J. Ryan, N. Bengoa-Vergniory, M. Williamson, Ecem Kirkiz +10 more
2021Journal of Neuroscience26 citations Open access
Semantic Scholar
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
S. Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Natalie Connor-Robson +9 more
2021Frontiers in Cellular Neuroscience22 citations Open access
Semantic Scholar
Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase
M. Finelli, T. Paramo, Elisabete Pires, Brent J. Ryan +4 more
2018Molecular Neurobiology21 citations Open access
Semantic Scholar
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
Phillippa J. Carling, Brent J. Ryan, William McGuinness, Shikha Kataria +8 more
2022Autophagy17 citations Open access
Semantic Scholar
Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
M. Lai, Anne-Laure Bechy, F. Denk, Emma M Collins +5 more
2017Molecular Neurodegeneration14 citations Open access
Semantic Scholar
Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.
Brent J. Ryan, P. Eggleton
2014Methods in molecular biology6 citations
Semantic Scholar
Syddansk Universitet ER Stress and Autophagic Perturbations Lead to Elevated Extracellular-Synuclein in GBA-N 370 S Parkinson ' s iPSC-Derived Dopamine Neurons
Hugo J. R. Fernandes, E. Hartfield, H. Christian, Evangelia Emmanoulidou +16 more
6 citations
Semantic Scholar
Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
Hugo J. R. Fernandes, Brent J. Ryan, R. Wade-Martins
2016Frontiers in Neuroscience4 citations Open access
Semantic Scholar
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Brent J. Ryan, M. Crabtree, K. Channon, R. Wade-Martins
2015Brain : a journal of neurology4 citations Open access
Semantic Scholar
Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus
Brent J. Ryan, P. Eggleton, Simon B. Brown, N. Viner +4 more
20104 citations
Semantic Scholar
Identification of a novel proteomic Biomarker in Parkinson's Disease: Discovery and Replication in Blood, brain and CSF
L. Winchester, Michael A. Lawton, I. Barber, Jessica A. Ash +16 more
2021medRxiv2 citations Open access
Semantic Scholar
Reactive Oxygen Species
Brent J. Ryan, M. L. Faro, M. Whiteman, P. Winyard
20152 citations
Semantic Scholar
Proteomic analysis of Parkinson’s disease patient cohorts show similarities in mechanism to Alzheimer’s disease
Laura M. Winchester, Michael A. Lawton, I. Barber, Samuel G. Evetts +7 more
2021Alzheimer's & Dementia1 citations Open access
Semantic Scholar
POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS
P. Eggleton, Brent J. Ryan, Simon B. Brown, S. Johnson +5 more
20111 citations
Semantic Scholar
University of Southern Denmark ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N 370 S Parkinson ' s iPSC-Derived Dopamine Neurons
Hugo J. R. Fernandes, E. Hartfield, H. Christian, Evangelia Emmanoulidou +16 more
1 citations
Semantic Scholar
Erratum: Ryan et al., “REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model”
Brent J. Ryan, N. Bengoa-Vergniory, M. Williamson, Ecem Kirkiz +9 more
2021Journal of Neuroscience0 citations Open access
Semantic Scholar
Mitochondrial bioenergetics in a cell culture model of Parkinson's disease
Brent J. Ryan, Harriet A. Keane, M. Crabtree, K. Channon +1 more
20120 citations
Semantic Scholar
Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases
P. Winyard, A. Nissim, Brent J. Ryan, M. Whiteman +1 more
20120 citations
Semantic Scholar
OP5. INFLAMMATORY POLYARTHRITIS PATIENTS WITH ANTI-CYCLIC CITRULLINATED PEPTIDE (ANTI-CCP) ANTIBODIES DO NOT BENEFIT FROM EARLY TREATMENT IN TERMS OF LONG-TERM FUNCTIONAL DISABILITY AS WELL AS THOSE WITHOUT ANTI-CCP ANTIBODIES
T. Farragher, M. Lunt, D. Bunn, D. Symmons +14 more
20090 citations
Semantic Scholar

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