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L. Bousset · SciRah

Researcher profile · Semantic Scholar

L. Bousset

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L. Bousset — researcher profile on SciRah

h-index: 53
Works: 140
Citations: 11K

Most-cited papers

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
W. Peelaerts, L. Bousset, A. Van der Perren, A. Moskalyuk +5 more
2015Nature1,071 citations Open access
Semantic Scholar
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
S. Holmqvist, Oldriska Chutna, L. Bousset, Patrick Aldrin-Kirk +6 more
2014Acta Neuropathologica864 citations Open access
Semantic Scholar
G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome
S. Lesage, M. Anheim, F. Letournel, L. Bousset +8 more
2013Annals of Neurology695 citations
Semantic Scholar
Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
S. Abounit, L. Bousset, F. Loría, Seng Zhu +5 more
2016EMBO Journal358 citations Open access
Semantic Scholar
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
H. Scheiblich, C. Dansokho, Dilek Mercan, S. Schmidt +11 more
2021Cell317 citations Open access
Semantic Scholar
α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
P. Alam, L. Bousset, R. Melki, D. Otzen
2019Journal of Neurochemistry271 citations Open access
Semantic Scholar
Alpha‐synuclein transfers from neurons to oligodendrocytes
J. Reyes, Nolwen L. Rey, L. Bousset, R. Melki +2 more
2014Glia266 citations
Semantic Scholar
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
R. Guerrero-Ferreira, N. Taylor, A. Arteni, P. Kumari +12 more
2019eLife265 citations Open access
Semantic Scholar
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
M. Tardivel, S. Bégard, L. Bousset, Simon Dujardin +4 more
2016Acta Neuropathologica Communications255 citations Open access
Semantic Scholar
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
Nolwen L. Rey, Géraldine H. Petit, L. Bousset, R. Melki +1 more
2013Acta Neuropathologica255 citations Open access
Semantic Scholar
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading
F. Loría, Jessica Y. Vargas, L. Bousset, S. Syan +3 more
2017Acta Neuropathologica247 citations Open access
Semantic Scholar
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
W. Flavin, L. Bousset, Z. Green, Y. Chu +5 more
2017Acta Neuropathologica239 citations
Semantic Scholar
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
A. Van der Perren, G. Gelders, Alexis Fenyi, L. Bousset +6 more
2020Acta Neuropathologica226 citations Open access
Semantic Scholar
Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
Simon Dujardin, S. Bégard, R. Caillierez, C. Lachaud +11 more
2014PLoS ONE224 citations Open access
Semantic Scholar
α‐synuclein assemblies sequester neuronal α3‐Na+/K+‐ATPase and impair Na+ gradient
A. Shrivastava, V. Redeker, Nicolas Fritz, Laura Pieri +9 more
2015EMBO Journal195 citations Open access
Semantic Scholar
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
Gregor Bieri, M. Brahic, L. Bousset, Julien Couthouis +9 more
2019bioRxiv165 citations Open access
Semantic Scholar
Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease
Veselin Grozdanov, L. Bousset, M. Hoffmeister, Corinna Bliederhaeuser +11 more
2019Annals of Neurology144 citations Open access
Semantic Scholar
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
M. Brahic, L. Bousset, Gregor Bieri, R. Melki +1 more
2016Acta Neuropathologica138 citations Open access
Semantic Scholar
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
Eliana Nachman, A. Wentink, K. Madiona, L. Bousset +9 more
2019Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity
J. Gath, L. Bousset, B. Habenstein, R. Melki +2 more
2014PLoS ONE126 citations Open access
Semantic Scholar
Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*
Magnus E. Jakobsson, A. Moen, L. Bousset, W. Egge-Jacobsen +3 more
2013Journal of Biological Chemistry112 citations Open access
Semantic Scholar
ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences
W. Peelaerts, L. Bousset, V. Baekelandt, R. Melki
2018Cell and Tissue Research109 citations Open access
Semantic Scholar
Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies
H. Scheiblich, L. Bousset, S. Schwartz, A. Griep +3 more
2020Journal of Immunology101 citations Open access
Semantic Scholar
The role of Galectin-3 in α-synuclein-induced microglial activation
A. Boza-Serrano, J. Reyes, Nolwen L. Rey, H. Leffler +6 more
2014Acta Neuropathologica Communications99 citations Open access
Semantic Scholar
α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
Nolwen L. Rey, L. Bousset, Sonia George, Zachary B. Madaj +5 more
2019Acta Neuropathologica Communications97 citations Open access
Semantic Scholar
Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
Benedict Tanudjojo, Samiha S. Shaikh, Alexis Fenyi, L. Bousset +8 more
2021Nature Communications85 citations Open access
Semantic Scholar
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.
Alexis Fenyi, L. Leclair-Visonneau, T. Clairembault, E. Coron +4 more
2019Neurobiology of Disease80 citations Open access
Semantic Scholar
Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation*
E. Monsellier, V. Redeker, Gemma Ruiz-Arlandis, L. Bousset +1 more
2014Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein
A. Makky, L. Bousset, J. Polesel-Maris, R. Melki
2016Scientific Reports73 citations Open access
Semantic Scholar
Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs
A. Shrivastava, L. Bousset, Marianne Renner, V. Redeker +3 more
2020Biophysical Journal70 citations Open access
Semantic Scholar
The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding
J. Courte, L. Bousset, Y. von Boxberg, C. Villard +2 more
2020Scientific Reports69 citations Open access
Semantic Scholar
Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis
Jian-Jun Guo, F. Yue, Dong-Yan Song, L. Bousset +9 more
2021Cell Death and Disease66 citations Open access
Semantic Scholar
Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms
M. Masnata, G. Sciacca, Alexander Maxan, L. Bousset +8 more
2019Acta Neuropathologica65 citations Open access
Semantic Scholar
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
D. Bétemps, Jérémy Verchère, Sébastien Brot, E. Morignat +5 more
2014Acta Neuropathologica Communications65 citations Open access
Semantic Scholar
Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors
A. Shrivastava, V. Redeker, Laura Pieri, L. Bousset +8 more
2019EMBO Journal57 citations Open access
Semantic Scholar
Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
J. M. Peralta Ramos, P. Iribarren, L. Bousset, R. Melki +2 more
2019Frontiers in Immunology55 citations Open access
Semantic Scholar
Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects.
M. Garten, C. Prévost, Clotilde Cadart, R. Gautier +4 more
2015Physical Chemistry, Chemical Physics - PCCP53 citations Open access
Semantic Scholar
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons
Kevin J. Burbidge, David J. Rademacher, Jessica E Mattick, Stephanie R. Zack +7 more
2021Autophagy52 citations Open access
Semantic Scholar
Yet another polymorph of α-synuclein: solid-state sequential assignments
J. Gath, L. Bousset, B. Habenstein, R. Melki +2 more
2013Biomolecular NMR Assignments50 citations Open access
Semantic Scholar
Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons
Ichiro Kawahata, L. Bousset, R. Melki, K. Fukunaga
2019International Journal of Molecular Sciences47 citations Open access
Semantic Scholar
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.
Kaspar Russ, Gabriel N. Teku, L. Bousset, V. Redeker +13 more
2021Cell Reports46 citations Open access
Semantic Scholar
Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph
J. Verasdonck, L. Bousset, J. Gath, R. Melki +2 more
2016Biomolecular NMR Assignments44 citations
Semantic Scholar
α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane
E. Monsellier, L. Bousset, R. Melki
2016Scientific Reports43 citations Open access
Semantic Scholar
Effect of tolytoxin on tunneling nanotube formation and function
Aysegul Dilsizoglu Senol, A. Pepe, Clara Grudina, N. Sassoon +6 more
2019Scientific Reports41 citations Open access
Semantic Scholar
An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials
L. Bousset, P. Brundin, A. Böckmann, B. Meier +1 more
2015Journal of Parkinson's Disease40 citations Open access
Semantic Scholar
The conformation of the prion domain of Sup35p in isolation and in the full-length protein.
Nina Luckgei, Anne K. Schütz, L. Bousset, B. Habenstein +5 more
2013Angewandte Chemie39 citations Open access
Semantic Scholar
Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
M. Pantazopoulou, Viviana Brembati, Angeliki Kanellidi, L. Bousset +2 more
2020Journal of Neurochemistry35 citations Open access
Semantic Scholar
The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo
Jeshlee Vijayakumar, Charlène Perrois, Marjorie Heim, L. Bousset +2 more
2019Nature Communications34 citations Open access
Semantic Scholar
Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains
Domenic Burger, Alexis Fenyi, L. Bousset, H. Stahlberg +1 more
2021bioRxiv31 citations Open access
Semantic Scholar
Probing amyloid fibril secondary structures by infrared nanospectroscopy: experimental and theoretical considerations.
Jehan Waeytens, J. Mathurin, A. Deniset-Besseau, V. Arluison +4 more
2020In Analysis31 citations
Semantic Scholar

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