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P. Whittamore · SciRah

Researcher profile · Semantic Scholar

P. Whittamore

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P. Whittamore — researcher profile on SciRah

h-index: 8
Works: 19
Citations: 360

Most-cited papers

A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
D. Buttar, N. Colclough, S. Gerhardt, P. Macfaul +7 more
2010Bioorganic & Medicinal Chemistry86 citations
Semantic Scholar
Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.
S. Andersson, Alan Armstrong, Annika Björe, S. Bowker +21 more
2009Drug Discovery Today70 citations
Semantic Scholar
Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).
James S. Scott, S. Bowker, J. Deschoolmeester, S. Gerhardt +14 more
2012Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
James S. Scott, J. Deschoolmeester, E. Kilgour, R. Mayers +9 more
2012Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
A. M. Birch, P. Kenny, N. Oikonomakos, L. Otterbein +3 more
2007Bioorganic & Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors.
A. M. Birch, P. Kenny, Iain Simpson, P. Whittamore
2009Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
Reduction of acyl glucuronidation in a series of acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors: the discovery of AZD6925
James S. Scott, Peter Barton, S. Bennett, J. Deschoolmeester +9 more
201212 citations
Semantic Scholar
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors.
James S. Scott, A. Gill, Linda Godfrey, S. Groombridge +7 more
2012Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.
S. Bennett, A. Campbell, A. Hancock, C. Johnstone +8 more
2010Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
W. McCoull, M. Augustin, C. Blake, A. Ertan +13 more
20145 citations
Semantic Scholar
11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one
W. McCoull, M. Augustin, C. Blake, A. Ertan +13 more
20140 citations
Semantic Scholar
Human serum albumin in complex with compound 2
D. Buttar, N. Colclough, S. Gerhardt, P. Macfaul +7 more
20100 citations
Semantic Scholar
Phenoxypropylamines: A New Series of Squalene Synthase Inhibitors.
G. R. Brown, R. Butlin, S. Chapman, M. Eakin +12 more
20100 citations
Semantic Scholar
Human serum albumin in complex with compound 3
D. Buttar, N. Colclough, S. Gerhardt, P. Macfaul +7 more
20100 citations
Semantic Scholar
Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone
A. M. Birch, P. Kenny, N. Oikonomakos, L. Otterbein +8 more
20060 citations
Semantic Scholar
Heterocyclic amide derivatives with glycogen phosphorylase inhibitory effect
S. Bennett, Iain Simpson, P. Whittamore
20030 citations
Semantic Scholar
Benzenasulfonamida derivatives and their use as medicines
R. Butlin, J. Burrows, David S. Clarke, T. Nowak +1 more
19990 citations
Semantic Scholar
Benzenesulfonamide derivatives and their application as a drug
R. Butlin, J. Burrows, David S. Clarke, T. Nowak +1 more
19990 citations
Semantic Scholar
Bencenosulfonamina derivatives and their use as medicines.
J. Burrows, R. Butlin, David S. Clarke, T. Nowak +1 more
19990 citations
Semantic Scholar

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