Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

J. Albert · SciRah

Researcher profile · Semantic Scholar

J. Albert

Share profile

J. Albert — researcher profile on SciRah

h-index: 19
Works: 50
Citations: 1,383

Most-cited papers

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
P. D. Edwards, J. Albert, M. Sylvester, D. Aharony +18 more
2007Journal of Medicinal Chemistry208 citations Open access
Semantic Scholar
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
S. Geschwindner, L. Olsson, J. Albert, J. Deinum +3 more
2007Journal of Medicinal Chemistry139 citations Open access
Semantic Scholar
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
M. Congreve, D. Aharony, J. Albert, O. Callaghan +10 more
2007Journal of Medicinal Chemistry131 citations Open access
Semantic Scholar
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
J. Albert, N. Blomberg, A. Breeze, Alastair J. H. Brown +10 more
2007Current Topics in Medicinal Chemistry119 citations
Semantic Scholar
Mechanistic studies of alkene epoxidation catalyzed by nickel(II) cyclam complexes. Oxygen-18 labeling and substituent effects.
Joanne F. Kinneary, J. Albert, C. Burrows
1988Journal of the American Chemical Society94 citations
Semantic Scholar
Stabilization of helical domains in short peptides using hydrophobic interactions.
J. Albert, A. D. Hamilton
1995Biochemistry72 citations
Semantic Scholar
Molecular Recognition of Proteins: Sequence-Selective Binding of Aspartate Pairs in Helical Peptides
J. Albert, M. Goodman, A. Hamilton
199560 citations
Semantic Scholar
Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.
J. Albert, D. Aharony, D. Andisik, H. Barthlow +17 more
2002Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Synthetic analogs of the ristocetin binding site: Neutral, multidentate receptors for carboxylate recognition
J. Albert, A. Hamilton
199341 citations
Semantic Scholar
Progress in the development of beta-secretase inhibitors for Alzheimer's disease.
J. Albert
2009Progress in Medicinal Chemistry36 citations
Semantic Scholar
Bromodomain inhibitors regulate the C9ORF72 locus in ALS
Z. Zeier, Rustam Esanov, Kinsley C. Belle, C. Volmar +12 more
2015Experimental Neurology33 citations Open access
Semantic Scholar
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
W. Rumsey, D. Aharony, Russell A. Bialecki, Brian M. Abbott +13 more
2001Journal of Pharmacology and Experimental Therapeutics31 citations Open access
Semantic Scholar
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation☆
J. Albert, M. Peczuh, A. Hamilton
199731 citations
Semantic Scholar
Discovery of novel, orally active dual NK1/NK2 antagonists.
P. Bernstein, David Aharony, J. Albert, Donald W. Andisik +16 more
2001Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties
J. Albert, C. Ohnmacht, P. Bernstein, W. Rumsey +6 more
200426 citations
Semantic Scholar
Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties.
J. Albert, C. Ohnmacht, P. Bernstein, W. Rumsey +9 more
2004Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Neurokinin antagonists and their potential role in treating depression and other stress disorders
J. Albert
200422 citations
Semantic Scholar
Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective.
Shawn Johnstone, J. Albert
2017Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.
S. Geschwindner, N. Dekker, R. Horsefield, Anna Tigerström +3 more
2013Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Roles of TRPA1 in Pain Pathophysiology and Implications for the Development of a New Class of Analgesic Drugs
Olivier Radresa, H. Dahllof, E. Nyman, A. Nolting +2 more
201319 citations Open access
Semantic Scholar
Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists.
C. Ohnmacht, J. Albert, P. Bernstein, W. Rumsey +5 more
2004Bioorganic & Medicinal Chemistry18 citations
Semantic Scholar
Chiral recognition of tartaric acid derivatives by a synthetic receptor
F. García-Tellado, J. Albert, A. Hamilton
199117 citations
Semantic Scholar
Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits.
R. Hopkins, J. Albert, D. Vanengen, Andrew D. Hamilton
1996Bioorganic & Medicinal Chemistry16 citations
Semantic Scholar
Efficient preparation of 2,4-methanoproline
Jeffrey Varnes, G. Lehr, Gary L. Moore, J. Hulsizer +1 more
201013 citations
Semantic Scholar
Progress toward artificial metalloenzymes: New ligands for transition metal ions and neutral molecules
Joanne F. Kinneary, Therese M. Roy, J. Albert, H. Yoon +3 more
198913 citations
Semantic Scholar
Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.
Yung-Jin Hu, Miguel St-Onge, Sébastien Laliberté, F. Vallée +4 more
2014Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Multiple roles of transient receptor potential (TRP) channels in inflammatory conditions and current status of drug development.
Olivier Radresa, Michel Paré, J. Albert
2013Current Topics in Medicinal Chemistry12 citations
Semantic Scholar
Targets and Emerging Therapies for Schizophrenia
J. Albert, Michael W. Wood
201211 citations
Semantic Scholar
Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists.
Sébastien Laliberté, F. Vallée, P. Fournier, Leanne Bédard +2 more
2014Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists.
H. Xiong, James Kang, James M Woods, J. McCauley +6 more
2011Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain.
J. Malmquist, K. Varnäs, M. Svedberg, F. Vallée +3 more
2017ACS Chemical Neuroscience8 citations Open access
Semantic Scholar
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.
Jeffrey Varnes, S. Geschwindner, C. Holmquist, J. Forst +6 more
2016Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1.
Jeffrey Varnes, J. Forst, Tiffany N Hoerter, C. Holmquist +9 more
2010Bioorganic & Medicinal Chemistry Letters6 citations
Semantic Scholar
Efficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor
H. Xiong, W. Frietze, D. Andisik, Glen E. Ernst +5 more
20106 citations
Semantic Scholar
Neurokinin-3 receptor antagonists in schizophrenia
J. Albert, William M. Potts
20066 citations
Semantic Scholar
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.
Jeffrey Varnes, H. Xiong, J. Forst, C. Holmquist +17 more
2018Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Fragment‐Based Lead Discovery
J. Albert
20104 citations
Semantic Scholar
1,3‐Dicyclohexylcarbodiimide
J. Albert, A. Hamilton, C. HartAmy
20103 citations
Semantic Scholar
Identification of High‐Affinity β‐Secretase Inhibitors Using Fragment‐Based Lead Generation
J. Albert, P. D. Edwards
20083 citations
Semantic Scholar
Asymmetric Synthesis of a Potent CXCR7 Modulator Featuring a Hindered Tertiary β-Amino Amide Stereocenter.
Daniel P. Canterbury, F. Godin, S. Desjardins, M. Bayrakdarian +3 more
2018Organic Letters2 citations
Semantic Scholar
Progress in the Exploration and Development of GlyT1 Inhibitors for Schizophrenia
J. Albert, Michael W. Wood
20122 citations
Semantic Scholar
Mechanistic Studies of Alkene Epoxidation Catalyzed by Nickel(II) Cyclam Complexes. 18O Labeling and Substituent Effects.
Joanne F. Kinneary, J. Albert, C. Burrows
19881 citations
Semantic Scholar
Identification and structural characterization of PDE10 fragment inhibitors
P. Johansson, J. Albert, L. Spadola, Tomas Åkerud +9 more
20130 citations
Semantic Scholar
Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors
S. Geschwindner, P. Johansson, L. Spadola, Tomas Åkerud +9 more
20130 citations
Semantic Scholar
X-ray crystal structure of beta secretase complexed with compound 8c
P. D. Edwards, J. Albert, M. Sylvester, D. Aharony +18 more
20070 citations
Semantic Scholar
X-ray crystal structure of beta secretase complexed with compound 24
P. D. Edwards, J. Albert, M. Sylvester, D. Aharony +18 more
20070 citations
Semantic Scholar
X-ray crystal structure of endothiapepsin complexed with compound 1
S. Geschwindner, L. Olsson, J. Deinum, J. Albert +3 more
20070 citations
Semantic Scholar
X-ray crystal structure of beta secretase complexed with compound 27
P. D. Edwards, J. Albert, M. Sylvester, D. Aharony +18 more
20070 citations
Semantic Scholar
1,3‐Dicyclohexylcarbodiimide–4‐Dimethylaminopyridine
J. Albert, A. Hamilton
20010 citations
Semantic Scholar
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation.
J. Albert, M. Peczuh, A. Hamilton
1997Bioorganic & Medicinal Chemistry0 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

D. Aharony×11
Invite
D. Aharony — researcher profile on SciRah
S. Geschwindner×11
Invite
S. Geschwindner — researcher profile on SciRah
P. D. Edwards×9
Invite
P. D. Edwards — researcher profile on SciRah
G. Tian×9
Invite
G. Tian — researcher profile on SciRah

×8

Invite

D. Andisik — researcher profile on SciRah

Invite

G. Koether — researcher profile on SciRah

Invite

R. Folmer — researcher profile on SciRah

Invite

L. Olsson — researcher profile on SciRah

Invite

A. Hamilton — researcher profile on SciRah

William M. Potts×7

Invite

William M. Potts — researcher profile on SciRah

Nathan Spear×6

Invite

Nathan Spear — researcher profile on SciRah

Invite

C. Ohnmacht — researcher profile on SciRah