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Paul N. M. Cheng · SciRah

Researcher profile · Semantic Scholar

Paul N. M. Cheng

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Paul N. M. Cheng — researcher profile on SciRah

h-index: 23
Works: 62
Citations: 1,928

Most-cited papers

Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion.
Paul N. M. Cheng, T. Lam, Wai-Man Lam, Sam-mui Tsui +3 more
2007Cancer Research286 citations Open access
Semantic Scholar
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.
F. Mussai, S. Egan, Joseph Higginbotham-Jones, T. Perry +10 more
2015Blood151 citations Open access
Semantic Scholar
Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses
E. Şahin, S. Haubenwallner, M. Kuttke, Isabella Kollmann +13 more
2014Journal of Immunology140 citations Open access
Semantic Scholar
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
A. Lercher, A. Bhattacharya, A. Popa, Michael Caldera +24 more
2019Immunity111 citations Open access
Semantic Scholar
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
Constantinos Alexandrou, S. Al-Aqbi, Jennifer A. Higgins, William Boyle +12 more
2018Scientific Reports100 citations Open access
Semantic Scholar
Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis
T. Lam, G. Wong, Ho-Yin Chow, H. Chong +6 more
2011Pigment Cell & Melanoma Research94 citations
Semantic Scholar
Deprivation of arginine by recombinant human arginase in prostate cancer cells
E. Hsueh, S. Knebel, Wai-Hung Lo, Y. Leung +2 more
2012Journal of Hematology & Oncology86 citations Open access
Semantic Scholar
Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma
T. Yau, Paul N. M. Cheng, P. Chan, Li Chen +5 more
2015Investigational new drugs82 citations
Semantic Scholar
Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC)
Sam-mui Tsui, Wai-Man Lam, T. Lam, H. Chong +7 more
2009Cancer Cell International80 citations Open access
Semantic Scholar
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia
F. Mussai, R. Wheat, Evgenia Sarrou, S. Booth +8 more
2019International Journal of Cancer78 citations Open access
Semantic Scholar
Environmental arginine controls multinuclear giant cell metabolism and formation
J. Brunner, Loan Vulliard, M. Hofmann, M. Kieler +25 more
2020Nature Communications68 citations Open access
Semantic Scholar
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100
C. De Santo, S. Booth, A. Vardon, A. Cousins +9 more
2017International Journal of Cancer64 citations Open access
Semantic Scholar
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma
C. De Santo, Paul N. M. Cheng, A. Beggs, S. Egan +2 more
2018Journal of Hematology & Oncology61 citations Open access
Semantic Scholar
Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +19 more
2018Cancer Research56 citations Open access
Semantic Scholar
A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma
S. Chan, Paul N. M. Cheng, Angela M. Liu, L. Chan +9 more
2021Investigational new drugs45 citations Open access
Semantic Scholar
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer
Shi Xu, Sze-Kwan Lam, Paul N. M. Cheng, J. Ho
2018Cancer Science38 citations Open access
Semantic Scholar
Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma.
Ariel K. M. Chow, L. Ng, Hung-Sing Li, Chi W. Cheng +6 more
2012Current Cancer Drug Targets32 citations
Semantic Scholar
Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
A. Fouda, Zhimin Xu, J. Suwanpradid, M. Rojas +11 more
2022Cell Death and Disease27 citations Open access
Semantic Scholar
Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors
Paul N. M. Cheng, Angela M. Liu, A. Bessudo, F. Mussai
2021Investigational new drugs26 citations Open access
Semantic Scholar
A phase 1 study of pegylated recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients
T. Yau, Paul N. M. Cheng, J. Chiu, G. Kwok +4 more
2021Investigational new drugs26 citations
Semantic Scholar
Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies
A. Vardon, M. Dandapani, Daryl Cheng, Paul N. M. Cheng +2 more
2017OncoTarget26 citations Open access
Semantic Scholar
A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma
T. Yau, Paul N. M. Cheng, P. Chan, William Chan +5 more
2012Investigational new drugs25 citations Open access
Semantic Scholar
Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells
Zhu-Yun Zhao, Peng Zhang, Wei Li, Dengchuan Wang +5 more
2020Oxidative Medicine and Cellular Longevity24 citations Open access
Semantic Scholar
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts
Sze-Kwan Lam, Yuan-yuan Li, Shi Xu, L. Leung +4 more
2017Respiratory Research23 citations Open access
Semantic Scholar
Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial–mesenchymal transition
Shi Xu, Sze-Kwan Lam, Paul N. M. Cheng, J. Ho
2019Scientific Reports21 citations Open access
Semantic Scholar
L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction
Céline Erens, Jana Van Broeckhoven, C. Hoeks, G. Schabbauer +6 more
2022Biomedicines19 citations Open access
Semantic Scholar
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models
Sze-Kwan Lam, Pong U. Kin, Yuan-yuan Li, Shi Xu +2 more
2018Oncology Report19 citations Open access
Semantic Scholar
Preclinical investigation of pegylated arginase 1 as a treatment for retina and brain injury
Abdelrahman Y. Fouda, Wael Eldahshan, Zhimin Xu, T. Lemtalsi +7 more
2021Experimental Neurology16 citations Open access
Semantic Scholar
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment
Victoria Stavrou, Livingstone Fultang, S. Booth, D. de Simone +19 more
2022Cancer Immunology and Immunotherapy15 citations Open access
Semantic Scholar
Small cell lung cancer with an epidermal growth factor receptor mutation in primary gefitinib-resistant adenocarcinoma of the lung
Ada T. W. Ma, W. Chan, Edmond S. K. Ma, T. Cheng +1 more
2012Acta oncologica14 citations Open access
Semantic Scholar
Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy
Ammar A. Abdelrahman, Katharine L. Bunch, Porsche V. Sandow, Paul N. M. Cheng +2 more
2022Cells13 citations Open access
Semantic Scholar
A randomised evaluation of low‐dose Ara‐C plus pegylated recombinant arginase BCT‐100 versus low dose Ara‐C in older unfit patients with acute myeloid leukaemia: Results from the LI‐1 trial
F. Mussai, C. De Santo, Paul N. M. Cheng, Ian Thomas +12 more
2022British Journal of Haematology13 citations Open access
Semantic Scholar
Synchronous primary lung cancer and epidermal growth factor receptor mutation.
Edmond S. K. Ma, Paul N. M. Cheng, C. Wong, A. Yim
2010Annals of Thoracic Surgery12 citations Open access
Semantic Scholar
Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma
Sze-Kwan Lam, Sheng Yan, Shi Xu, K. U +2 more
2019Oncogenesis11 citations Open access
Semantic Scholar
A phase I study of recombinant human arginase I (rhArgI) for patients with advanced hepatocellular carcinoma
C. Yau, P. Chan, R. Pang, W. Chan +2 more
20108 citations
Semantic Scholar
Immunohistological characteristics of the infiltrating lymphoid cells and expression of HLA class I and II antigens in nasopharyngeal carcinoma
F. Lai, Paul N. M. Cheng, S. Tsao, K. N. Lai
2005Virchows Archiv8 citations
Semantic Scholar
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Kevin M. Rattigan, Martha M. Zarou, Zuzana Brabcová, B. Prasad +14 more
2023EMBO Reports6 citations Open access
Semantic Scholar
Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics, and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma.
T. Yau, Paul N. M. Cheng, P. Chan, R. Pang +1 more
20145 citations
Semantic Scholar
A rational approach to the systemic treatment of cancer involving medium-term depletion of arginine
D. Wheatley, E. Campbell, P. B. Lai, Paul N. M. Cheng
20054 citations
Semantic Scholar
A phase 1 study of recombinant human arginase 1 (PEG-BCT- 100) in combination with capecitabine and oxaliplatin in advanced hepatocellular carcinoma patients.
T. Yau, J. Chiu, To-Ng Chi, R. Leung +1 more
2017Annals of Oncology3 citations Open access
Semantic Scholar
P2.15-006 The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo
Shi Xu, S. Lam, Paul N. M. Cheng, J. Ho
20172 citations Open access
Semantic Scholar
Pegylated Recombinant Human Arginase, Rharg-Peg5,000MW, Targets Cell Cycle Machinery in Multiple Myeloma Cells.
De-Long Liu, Xianghua Lin, Quanyi Lu, T. W. Leung +2 more
20071 citations
Semantic Scholar
PEG-BCT-100 in Combination With Capecitabine and Oxaliplatin (PACOX) in Patients With Advanced Hepatocellular Carcinoma: A Phase I Study Results
T. Yau, Paul N. M. Cheng, J. Chiu, G. Kwok +4 more
20210 citations Open access
Semantic Scholar
Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies
M. Haber, Laura D. Gamble, Lin Xiao, Ruby Pandher +50 more
2020Oral Presentations - Invited Abstracts0 citations
Semantic Scholar
IL-1ß and TNF- create an immune-metabolic loop regulating Arginase 2 via p38-ERK in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +24 more
20190 citations
Semantic Scholar
Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity
A. Lercher, A. Bhattacharya, A. Popa, Michael Caldera +17 more
2019bioRxiv0 citations Open access
Semantic Scholar
Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models.
J. Ho, Shi Xu, Paul N. M. Cheng, Sze-Kwan Lam
20180 citations
Semantic Scholar
P3.12-08 The Role of Contactin 1 on Acquired Resistance to Pegylated Arginase in Small Cell Lung Cancer
Shi Xu, S. Yan, Sze-Kwan Lam, Paul N. M. Cheng +1 more
2018Journal of Thoracic Oncology0 citations Open access
Semantic Scholar
University of Birmingham Macrophage-derived IL-1 and TNF- regulate arginine metabolism in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +21 more
20180 citations
Semantic Scholar
Title Growth suppressive effect of pegylated arginase in malignantpleural mesothelioma xenografts
Sze-Kwan Lam, Yuan-yuan Li, Shi Xu, L. Leung +4 more
20170 citations
Semantic Scholar

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