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C. De Santo · SciRah

Researcher profile · Semantic Scholar

C. De Santo

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C. De Santo — researcher profile on SciRah

h-index: 26
Works: 62
Citations: 4,645

Most-cited papers

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.
G. Gallina, L. Dolcetti, P. Serafini, C. De Santo +8 more
2006Journal of Clinical Investigation900 citations Open access
Semantic Scholar
IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice1
V. Bronte, P. Serafini, C. De Santo, Ilaria Marigo +8 more
2003Journal of Immunology578 citations Open access
Semantic Scholar
Derangement of immune responses by myeloid suppressor cells
P. Serafini, C. De Santo, Ilaria Marigo, S. Cingarlini +4 more
2004Cancer Immunology and Immunotherapy380 citations Open access
Semantic Scholar
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
C. De Santo, M. Salio, S. H. Masri, Laurel Yong-Hwa Lee +10 more
2008Journal of Clinical Investigation359 citations Open access
Semantic Scholar
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.
C. De Santo, P. Serafini, Ilaria Marigo, L. Dolcetti +9 more
2005Proceedings of the National Academy of Sciences of the United States of America306 citations Open access
Semantic Scholar
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A
C. De Santo, Ramon Arscott, S. Booth, I. Karydis +5 more
2010Nature Immunology274 citations Open access
Semantic Scholar
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo
P. Barral, J. Eckl-Dorna, Naomi E. Harwood, C. De Santo +5 more
2008Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
Semantic Scholar
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.
Livingstone Fultang, S. Booth, O. Yogev, Barbara Martins da Costa +12 more
2020Blood183 citations Open access
Semantic Scholar
MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
Livingstone Fultang, Silvia Panetti, M. Ng, P. Collins +9 more
2019EBioMedicine154 citations Open access
Semantic Scholar
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.
F. Mussai, S. Egan, Joseph Higginbotham-Jones, T. Perry +10 more
2015Blood151 citations Open access
Semantic Scholar
Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity
F. Mussai, S. Egan, S. Hunter, H. Webber +10 more
2015Cancer Research112 citations Open access
Semantic Scholar
Molecular basis and current strategies of therapeutic arginine depletion for cancer
Livingstone Fultang, A. Vardon, C. De Santo, F. Mussai
2016International Journal of Cancer96 citations Open access
Semantic Scholar
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia
F. Mussai, R. Wheat, Evgenia Sarrou, S. Booth +8 more
2019International Journal of Cancer79 citations Open access
Semantic Scholar
Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia
C. Craddock, D. Slade, C. De Santo, R. Wheat +10 more
2019Journal of Clinical Oncology71 citations Open access
Semantic Scholar
In vivo administration of artificial Antigen Presenting Cells activates low avidity T cells for treatment of cancer
S. Ugel, Alessia Zoso, C. De Santo, Yu Li +7 more
2009Cancer Research70 citations Open access
Semantic Scholar
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100
C. De Santo, S. Booth, A. Vardon, A. Cousins +9 more
2017International Journal of Cancer64 citations Open access
Semantic Scholar
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma
C. De Santo, Paul N. M. Cheng, A. Beggs, S. Egan +2 more
2018Journal of Hematology & Oncology61 citations Open access
Semantic Scholar
Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +19 more
2018Cancer Research56 citations Open access
Semantic Scholar
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Silvia Panetti, N. McJannett, Livingstone Fultang, S. Booth +14 more
2022Blood Advances50 citations Open access
Semantic Scholar
Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Swati Khanna, S. Graef, F. Mussai, Anish Thomas +12 more
2018Clinical Cancer Research50 citations Open access
Semantic Scholar
Effective Genetic Vaccination with a Widely Shared Endogenous Retroviral Tumor Antigen Requires CD40 Stimulation during Tumor Rejection Phase 1
V. Bronte, S. Cingarlini, E. Apolloni, P. Serafini +5 more
2003Journal of Immunology46 citations
Semantic Scholar
Leukocyte Infiltration in Cancer Creates an Unfavorable Environment for Antitumor Immune Responses: A Novel Target for Therapeutic Intervention
V. Bronte, S. Cingarlini, Ilaria Marigo, C. De Santo +6 more
2006Immunological Investigations43 citations
Semantic Scholar
Invariant NKT cells modulate the suppressive activity of Serum Amyloid A-differentiated IL-10-secreting neutrophils
C. De Santo, Ramon Arscott, S. Booth, I. Karydis +5 more
2010Nature Immunology42 citations Open access
Semantic Scholar
TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer
L. Gneo, Nagy Rizkalla, R. Hejmadi, F. Mussai +2 more
2021Cancer Immunology and Immunotherapy33 citations Open access
Semantic Scholar
Interaction Between Invariant NKT Cells and Myeloid-derived Suppressor Cells in Cancer Patients: Evidence and Therapeutic Opportunities
F. Mussai, C. De Santo, V. Cerundolo
2012Journal of immunotherapy31 citations
Semantic Scholar
Association of responsiveness to the major pollen allergen of Parietaria officinalis with HLA-DRB1* alleles: a multicenter study.
Mauro D'Amato, A. d'Abusco, E. Maggi, T. Menna +14 more
1996Human Immunology27 citations
Semantic Scholar
Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies
A. Vardon, M. Dandapani, Daryl Cheng, Paul N. M. Cheng +2 more
2017OncoTarget26 citations Open access
Semantic Scholar
Characterising EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells.
P. Collins, C. Fox, Lindsay George, H. Pearce +6 more
2020Blood25 citations Open access
Semantic Scholar
Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes
R. De Palma, Ilaria Marigo, F. del Galdo, C. De Santo +8 more
2004Cancer Research25 citations Open access
Semantic Scholar
Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models
Maryam Arshad, Abul Azad, P. Y. K. Chan, V. Vigneswara +7 more
2024British Journal of Cancer23 citations Open access
Semantic Scholar
Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies
Livingstone Fultang, L. Gneo, C. De Santo, F. Mussai
2021Frontiers in Oncology19 citations Open access
Semantic Scholar
Methotrexate for immunosuppression in life‐supporting pig‐to‐cynomolgus monkey renal xenotransplantation
E. Cozzi, R. Cadrobbi, N. Baldan, A. Dedja +15 more
2003Xenotransplantation16 citations
Semantic Scholar
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment
Victoria Stavrou, Livingstone Fultang, S. Booth, D. de Simone +19 more
2022Cancer Immunology and Immunotherapy15 citations Open access
Semantic Scholar
PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults
N. Fenwick, Rebekah Weston, Keith Wheatley, J. Hodgson +26 more
2024Frontiers in Oncology13 citations Open access
Semantic Scholar
A randomised evaluation of low‐dose Ara‐C plus pegylated recombinant arginase BCT‐100 versus low dose Ara‐C in older unfit patients with acute myeloid leukaemia: Results from the LI‐1 trial
F. Mussai, C. De Santo, Paul N. M. Cheng, Ian Thomas +12 more
2022British Journal of Haematology13 citations Open access
Semantic Scholar
Characterization of a dominant antigenic determinant of Par o I encoded by recombinant DNA
A. Scotto d'Abusco, C. De Santo, Tonino Menna, M. Coscia +3 more
1996Clinical and Experimental Allergy11 citations
Semantic Scholar
G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment
E. Maneta, Livingstone Fultang, J. Taylor, M. Pugh +7 more
2022Clinical & Translational Immunology9 citations Open access
Semantic Scholar
Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy
Monika Bokori-Brown, J. Metz, P. Petrov, F. Mussai +7 more
2018Frontiers in Oncology6 citations Open access
Semantic Scholar
Neuroblastoma arginine addiction subverts the anticancer immune response
C. De Santo, F. Mussai
2016Oncoimmunology4 citations Open access
Semantic Scholar
473 Mavrilimumab, a human monoclonal antibody targeting GM-CSFRα, inhibits polarization to myeloid-derived suppressor cells (MDSCs) that express PD-L1 and restores T-cell proliferation in vitro
L. Carvajal, Luciana Gneo, C. De Santo, Matt Perez +3 more
2020Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
Reply to "Failure to detect production of IL-10 by activated human neutrophils"
C. De Santo, M. Salio, T. Dong, Y. Reiter +1 more
2011Nature Immunology2 citations
Semantic Scholar
1478 DOES HIGH INTENSITY FOCUSED ULTRASOUND FOR RENAL CANCER UPREGULATE ANTI-TUMOUR IMMUNITY IN-VIVO?
R. Ritchie, C. De Santo, Ramon Arscott, T. Leslie +2 more
20102 citations
Semantic Scholar
Combined Azacitidine and High Dose Lenalidomide Therapy Is Well Tolerated and Clinically Active in Patients Who Relapse after Allogeneic Stem Cell Transplantation for Actue Myeloid Leukemia: Results of the Uk Trials Acceleration Programme Viola Trial
C. Craddock, W. Ingram, D. Slade, A. Hodgkinson +7 more
20171 citations
Semantic Scholar
Characterization of a Dominant Epitope of the Major Allergens of Parietaria
A. Ruffilli, Anna Scotto d’Ambusco, C. De Santo
19961 citations
Semantic Scholar
IMP-MEL: a phase I first-in-human study of IMM60 with or without pembrolizumab in advanced melanoma and non-small cell lung cancer (NSCLC)
N. Coupe, Robert Kramer, D. Pinato, Mark R. Middleton +6 more
2026Journal of Translational Medicine0 citations Open access
Semantic Scholar
The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial
C. De Santo, Aimee Jackson, Francis Mussai, S. Al-Taei +10 more
2026Journal of Leukocyte Biology0 citations Open access
Semantic Scholar
712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC)
N. Coupe, D. Pinato, Justin Fairchild, R. Poe +8 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies
M. Haber, Laura D. Gamble, Lin Xiao, Ruby Pandher +50 more
2020Oral Presentations - Invited Abstracts0 citations
Semantic Scholar
IL-1ß and TNF- create an immune-metabolic loop regulating Arginase 2 via p38-ERK in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +24 more
20190 citations
Semantic Scholar
University of Birmingham Tumour-derived GM-CSF promotes granulocyte immunosuppression in mesothelioma patients
Swati Khanna, S. Graef, F. Mussai, Anish Thomas +13 more
20180 citations
Semantic Scholar

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