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F. Mussai · SciRah

Researcher profile · Semantic Scholar

F. Mussai

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F. Mussai — researcher profile on SciRah

h-index: 20
Works: 57
Citations: 1,595

Most-cited papers

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.
Livingstone Fultang, S. Booth, O. Yogev, Barbara Martins da Costa +12 more
2020Blood183 citations Open access
Semantic Scholar
MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
Livingstone Fultang, Silvia Panetti, M. Ng, P. Collins +9 more
2019EBioMedicine154 citations Open access
Semantic Scholar
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.
F. Mussai, S. Egan, Joseph Higginbotham-Jones, T. Perry +10 more
2015Blood151 citations Open access
Semantic Scholar
Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity
F. Mussai, S. Egan, S. Hunter, H. Webber +10 more
2015Cancer Research112 citations Open access
Semantic Scholar
Molecular basis and current strategies of therapeutic arginine depletion for cancer
Livingstone Fultang, A. Vardon, C. De Santo, F. Mussai
2016International Journal of Cancer96 citations Open access
Semantic Scholar
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia
F. Mussai, R. Wheat, Evgenia Sarrou, S. Booth +8 more
2019International Journal of Cancer78 citations Open access
Semantic Scholar
Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia
F. Mussai, D. Campana, D. Bhojwani, M. Stetler-Stevenson +3 more
2010British Journal of Haematology72 citations Open access
Semantic Scholar
Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia
C. Craddock, D. Slade, C. De Santo, R. Wheat +10 more
2019Journal of Clinical Oncology71 citations Open access
Semantic Scholar
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100
C. De Santo, S. Booth, A. Vardon, A. Cousins +9 more
2017International Journal of Cancer64 citations Open access
Semantic Scholar
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma
C. De Santo, Paul N. M. Cheng, A. Beggs, S. Egan +2 more
2018Journal of Hematology & Oncology61 citations Open access
Semantic Scholar
Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma.
E. Brivio, A. Baruchel, A. Beishuizen, J. Bourquin +11 more
2022European Journal of Cancer56 citations Open access
Semantic Scholar
Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +19 more
2018Cancer Research56 citations Open access
Semantic Scholar
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Silvia Panetti, N. McJannett, Livingstone Fultang, S. Booth +14 more
2022Blood Advances50 citations Open access
Semantic Scholar
Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Swati Khanna, S. Graef, F. Mussai, Anish Thomas +12 more
2018Clinical Cancer Research50 citations Open access
Semantic Scholar
Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial
B. Fisher, T. Veenith, D. Slade, C. Gaskell +54 more
2021The Lancet Respiratory Medicine43 citations Open access
Semantic Scholar
TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer
L. Gneo, Nagy Rizkalla, R. Hejmadi, F. Mussai +2 more
2021Cancer Immunology and Immunotherapy33 citations Open access
Semantic Scholar
Interaction Between Invariant NKT Cells and Myeloid-derived Suppressor Cells in Cancer Patients: Evidence and Therapeutic Opportunities
F. Mussai, C. De Santo, V. Cerundolo
2012Journal of immunotherapy31 citations
Semantic Scholar
Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors
Paul N. M. Cheng, Angela M. Liu, A. Bessudo, F. Mussai
2021Investigational new drugs26 citations Open access
Semantic Scholar
Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies
A. Vardon, M. Dandapani, Daryl Cheng, Paul N. M. Cheng +2 more
2017OncoTarget26 citations Open access
Semantic Scholar
Challenges of Clinical Trial Design for Targeted Agents Against Pediatric Leukemias
F. Mussai, C. Yap, C. Mitchell, P. Kearns
2015Frontiers in Oncology22 citations Open access
Semantic Scholar
Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737
D. Fitzgerald, Elizabeth Moskatel, Gal Ben-Josef, Roberta Traini +7 more
2011Leukemia and Lymphoma20 citations Open access
Semantic Scholar
Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies
Livingstone Fultang, L. Gneo, C. De Santo, F. Mussai
2021Frontiers in Oncology19 citations Open access
Semantic Scholar
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence?
D. Scholfield, M. Brundler, A. McDermott, F. Mussai +1 more
2016Journal of pediatric hematology/oncology19 citations Open access
Semantic Scholar
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment
Victoria Stavrou, Livingstone Fultang, S. Booth, D. de Simone +19 more
2022Cancer Immunology and Immunotherapy15 citations Open access
Semantic Scholar
PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults
N. Fenwick, Rebekah Weston, Keith Wheatley, J. Hodgson +26 more
2024Frontiers in Oncology13 citations Open access
Semantic Scholar
A randomised evaluation of low‐dose Ara‐C plus pegylated recombinant arginase BCT‐100 versus low dose Ara‐C in older unfit patients with acute myeloid leukaemia: Results from the LI‐1 trial
F. Mussai, C. De Santo, Paul N. M. Cheng, Ian Thomas +12 more
2022British Journal of Haematology13 citations Open access
Semantic Scholar
Developing guidelines for medical students about the examination of patients under 18 years old
T. Hope, P. Frith, J. Craze, F. Mussai +2 more
2005British medical journal11 citations Open access
Semantic Scholar
G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment
E. Maneta, Livingstone Fultang, J. Taylor, M. Pugh +7 more
2022Clinical & Translational Immunology9 citations Open access
Semantic Scholar
Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion
E. Bishop, M. Dimitrova, Alexander Froggatt, Maria Estevez-Cebrero +5 more
2022BioMed Research International8 citations Open access
Semantic Scholar
The development of targeted new agents to improve the outcome for children with leukemia
Francisco Bautista, J. van der Lugt, P. Kearns, F. Mussai +2 more
2016Expert Opinion on Drug Discovery8 citations Open access
Semantic Scholar
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Kevin M. Rattigan, Martha M. Zarou, Zuzana Brabcová, B. Prasad +14 more
2023EMBO Reports6 citations Open access
Semantic Scholar
Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy
Monika Bokori-Brown, J. Metz, P. Petrov, F. Mussai +7 more
2018Frontiers in Oncology6 citations Open access
Semantic Scholar
Hypocalcemia in a Patient With Osteosarcoma and 22q11.2 Deletion Syndrome
F. Mussai, L. Cunningham, Geoffrey Rezvani, C. Stratakis +7 more
2008Journal of pediatric hematology/oncology6 citations Open access
Semantic Scholar
Neuroblastoma arginine addiction subverts the anticancer immune response
C. De Santo, F. Mussai
2016Oncoimmunology4 citations Open access
Semantic Scholar
CD22 Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia.
A. Jegalian, A. Wayne, R. Kreitman, F. Mussai +3 more
20093 citations
Semantic Scholar
473 Mavrilimumab, a human monoclonal antibody targeting GM-CSFRα, inhibits polarization to myeloid-derived suppressor cells (MDSCs) that express PD-L1 and restores T-cell proliferation in vitro
L. Carvajal, Luciana Gneo, C. De Santo, Matt Perez +3 more
2020Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
Disseminated Congenital Malignant Rhabdoid Tumor Misdiagnosed as Multiple Congenital Hemangiomas.
G. Petrof, Genevieve Casey, I. Colmenero, F. Mussai +1 more
2019Journal of pediatric hematology/oncology2 citations
Semantic Scholar
DIPG-16. COMBINATION OF ARGININE DEPLETION AND POLYAMINE INHIBITION AS AN ANTICANCER STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
Aaminah Khan, Laura D. Gamble, Ruby Pandher, M. Burns +5 more
2020Neuro-Oncology1 citations Open access
Semantic Scholar
Combined Azacitidine and High Dose Lenalidomide Therapy Is Well Tolerated and Clinically Active in Patients Who Relapse after Allogeneic Stem Cell Transplantation for Actue Myeloid Leukemia: Results of the Uk Trials Acceleration Programme Viola Trial
C. Craddock, W. Ingram, D. Slade, A. Hodgkinson +7 more
20171 citations
Semantic Scholar
Immunotherapy and immunomodulation for haematological malignancies
F. Mussai
20121 citations
Semantic Scholar
Abstract CT220: The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and re-programmes CD33+ myeloid-derived suppressor cells in patients with metastatic cancer
Gary Middleton, Aimee Jackson, S. Al-Taei, Victoria Kunene +5 more
2025Cancer Research0 citations
Semantic Scholar
University of Birmingham Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors
Paul N Cheng, A. Liu, A. Bessudo, F. Mussai
20210 citations
Semantic Scholar
A Randomised Evaluation of Low-Dose Ara-C Plus BCT-100 Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia: Results from the LI-1 Trial
F. Mussai, Ian Thomas, C. Ariti, Laura Upton +8 more
2021Blood0 citations Open access
Semantic Scholar
Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies
M. Haber, Laura D. Gamble, Lin Xiao, Ruby Pandher +50 more
2020Oral Presentations - Invited Abstracts0 citations
Semantic Scholar
A study to see if a drug called Gemtuzumab Ozogamicin is a useful treatment for patients with immune disorders called Haemophagocytic lymphohistiocytosis (HLH) or Macrophage activation syndrome (MAS), or for patients with cancer
F. Mussai
2020http://isrctn.com/0 citations
Semantic Scholar
IL-1ß and TNF- create an immune-metabolic loop regulating Arginase 2 via p38-ERK in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +24 more
20190 citations
Semantic Scholar
Haemorrhage after a fairground ride
Miriam Pavon-Mengual, F. Mussai
2019British medical journal0 citations
Semantic Scholar
University of Birmingham Tumour-derived GM-CSF promotes granulocyte immunosuppression in mesothelioma patients
Swati Khanna, S. Graef, F. Mussai, Anish Thomas +13 more
20180 citations
Semantic Scholar
Interactions Between Immunotoxins and the Plasma Membrane
M. Bokori-Brown, J. Metz, P. Petrov, F. Mussai +7 more
20180 citations
Semantic Scholar
University of Birmingham Macrophage-derived IL-1 and TNF- regulate arginine metabolism in neuroblastoma
Livingstone Fultang, Laura D. Gamble, L. Gneo, Andrea M. Berry +21 more
20180 citations
Semantic Scholar

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