Debbie C. Mulhearn

Most-cited papers

1. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

   A. Ghosh, Jun Takayama, Kalapala Venkateswara Rao, K. Ratia +8 more

   2010Journal of Medicinal Chemistry142 citations Open access

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2. Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease

   A. Ghosh, Jun Takayama, Yoann Aubin, K. Ratia +10 more

   2009Journal of Medicinal Chemistry123 citations Open access

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3. Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors

   A. Ghosh, G. Gong, Valerie L. Grum-Tokars, Debbie C. Mulhearn +6 more

   2008Bioorganic & Medicinal Chemistry Letters115 citations Open access

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4. Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.

   Nicola J. Beresford, Debbie C. Mulhearn, B. Szczepankiewicz, Gang Liu +5 more

   2009Journal of Antimicrobial Chemotherapy87 citations

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5. Role of antibiotic ligand in nascent peptide-dependent ribosome stalling

   N. Vázquez-Laslop, D. Klepacki, Debbie C. Mulhearn, H. Ramu +3 more

   2011Proceedings of the National Academy of Sciences of the United States of America68 citations Open access

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6. Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design.

   Melissa May, Shahila Mehboob, Debbie C. Mulhearn, Zhi-Qiang Wang +5 more

   2007Journal of Molecular Biology55 citations Open access

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7. Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

   Hyun Lee, A. Mittal, Kavankumar Patel, Joseph L. Gatuz +4 more

   2013Bioorganic & Medicinal Chemistry47 citations Open access

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8. Design and Synthesis of Aryl Ether Inhibitors of the Bacillus Anthracis Enoyl–ACP Reductase

   Suresh K. Tipparaju, Debbie C. Mulhearn, Gary M. Klein, Yu-Feng Chen +11 more

   2008ChemMedChem44 citations Open access

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9. Effect of ring strain on the thiolate-disulfide exchange. A computational study.

   S. Bachrach, Joshua Woody, Debbie C. Mulhearn

   2002Journal of Organic Chemistry35 citations

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10. Nucleophilic Substitution at Sulfur: S N 2 or Addition-Elimination?

    S. Bachrach, Debbie C. Mulhearn

    199634 citations

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11. Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulin.

    B. Layden, W. Saengsawang, R. Donati, Shuo Yang +3 more

    2008Biochimica et Biophysica Acta33 citations Open access

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12. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

    Suresh K. Tipparaju, Sipak Joyasawal, Sara Forrester, Debbie C. Mulhearn +4 more

    2008Bioorganic & Medicinal Chemistry Letters32 citations Open access

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13. Regioselective covalent modification of hemoglobin in search of antisickling agents.

    Soobong Park, Brittany L. Hayes, Fatima Marankan, Debbie C. Mulhearn +5 more

    2003Journal of Medicinal Chemistry32 citations

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14. Selective Nucleophilic Attack of Trisulfides. An ab Initio Study

    Debbie C. Mulhearn, S. Bachrach

    199623 citations

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15. Structure of dihydroorotase from Bacillus anthracis at 2.6 Å resolution.

    Shahila Mehboob, Debbie C. Mulhearn, K. Truong, Michael E. Johnson +1 more

    2010Acta Crystallographica. Section F : Structural Biology and Crystallization Communications12 citations Open access

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16. α-effect in Menschutkin alkylations

    K. R. Fountain, Linda K. Hutchinson, Debbie C. Mulhearn, Yu-Bo Xu

    199312 citations

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17. Theoretical studies of nucleophilic substitution at phosphorus. Phosphine + hydride .fwdarw. H- + PH3

    S. Bachrach, Debbie C. Mulhearn

    19939 citations

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18. Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa.

    Sochanchingwung Rumthao, O. Lee, Qi-Feng Sheng, Wentao Fu +4 more

    2004Bioorganic & Medicinal Chemistry Letters8 citations

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19. Hydrogen Shifts in Formyl- and Diformylphosphine

    Debbie C. Mulhearn, S. Bachrach

    19955 citations

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20. Selective Nucleophilic Attack of Trisulfides. An ab initio Study.

    Debbie C. Mulhearn, S. Bachrach

    19971 citations

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21. Design, Syntheis, and Evaluation of Oxyanion‐Hole Selective Inhibitor Substituents for the S1 Subsite of Factor Xa.

    Sochanchingwung Rumthao, O. Lee, Qi-Feng Sheng, Wentao Fu +4 more

    20050 citations

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22. Inhibiteurs de proteines servant a transporter plusieurs medicaments

    P. Markham, Debbie C. Mulhearn, A. A. Neyfakh, David Crich +2 more

    19990 citations

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23. Ab initio investigation of the diels-alder reaction between 2H-phosphole and phosphaethene: A model for phosphole dimerization

    U. Salzner, S. Bachrach, Debbie C. Mulhearn

    1997Journal of Computational Chemistry0 citations

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24. Ab initio study of pericyclic and substitution reactions in heteroatomic systems.

    Debbie C. Mulhearn

    19960 citations

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