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A. Mesecar · SciRah

Researcher profile · Semantic Scholar

A. Mesecar

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A. Mesecar — researcher profile on SciRah

h-index: 65
Works: 253
Citations: 15K

Most-cited papers

The SARS-Coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
Y. M. Báez-Santos, S. E. St. John, A. Mesecar
2014Antiviral Research787 citations Open access
Semantic Scholar
Discovery of SARS-CoV-2 Antivirals through Large-scale Drug Repositioning
L. Riva, Shuo-Feng Yuan, Xin Yin, Laura Martin-Sancho +41 more
2020Nature544 citations Open access
Semantic Scholar
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
A. Ghosh, M. Brindisi, D. Shahabi, Mackenzie E. Chapman +1 more
2020ChemMedChem251 citations Open access
Semantic Scholar
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
B. Boras, Rhys M. Jones, B. Anson, D. Arenson +48 more
2021Nature Communications231 citations Open access
Semantic Scholar
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
K. Ratia, Andy Kilianski, Y. M. Báez-Santos, S. Baker +1 more
2014PLoS Pathogens214 citations Open access
Semantic Scholar
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
Y. M. Báez-Santos, Scott J. Barraza, M. Wilson, Michael P. Agius +5 more
2014Journal of Medicinal Chemistry210 citations Open access
Semantic Scholar
Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities
A. Mielech, Ya-Fang Chen, A. Mesecar, S. Baker
2014Virus Research182 citations Open access
Semantic Scholar
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
S. Hattori, Nobuyo Higashi-Kuwata, H. Hayashi, S. Allu +19 more
2021Nature Communications154 citations Open access
Semantic Scholar
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)
S. Tomar, Melanie L. Johnston, S. E. St. John, Heather L. Osswald +5 more
2015Journal of Biological Chemistry136 citations Open access
Semantic Scholar
Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus
Y. M. Báez-Santos, A. Mielech, Xu-Fang Deng, S. Baker +1 more
2014Journal of Virology126 citations Open access
Semantic Scholar
Structural insights into the interaction of coronavirus papain-like proteases and interferon-stimulated gene product 15 from different species
C. Daczkowski, J. V. Dzimianski, Jozlyn R. Clasman, O. Goodwin +2 more
2017Journal of Molecular Biology101 citations Open access
Semantic Scholar
Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators
Atul Jain, Haranatha R. Potteti, B. Richardson, Laura J. Kingsley +7 more
2015European journal of medicinal chemistry101 citations Open access
Semantic Scholar
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19
B. Boras, Rhys M. Jones, B. Anson, D. Arenson +45 more
2020bioRxiv96 citations Open access
Semantic Scholar
Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Heng Zhang, Zhuang Li, C. Daczkowski, C. Gabel +2 more
2019Cell Host and Microbe86 citations Open access
Semantic Scholar
Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance
Xu-Fang Deng, S. StJohn, Heather L. Osswald, A. O'Brien +5 more
2014Journal of Virology85 citations Open access
Semantic Scholar
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity and X-ray Structural Studies
A. Ghosh, Jakka Raghavaiah, D. Shahabi, M. Yadav +6 more
2021Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
Targeting zoonotic viruses: structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 – the likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
S. E. St. John, S. Tomar, S. Stauffer, A. Mesecar
2015Bioorganic & Medicinal Chemistry78 citations Open access
Semantic Scholar
A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant
S. Agnihothram, B. Yount, Eric F. Donaldson, Jeremy Huynh +15 more
2014mBio69 citations Open access
Semantic Scholar
Genetic Variants of Phospholipase C-γ2 Alter the Phenotype and Function of Microglia and Confer Differential Risk for Alzheimer’s Disease
A. Tsai, Chuan-Peng Dong, P. Lin, Adrian L. Oblak +21 more
2023Immunity61 citations Open access
Semantic Scholar
Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis
A. Mielech, Xu-Fang Deng, Ya-Fang Chen, Eveline Kindler +5 more
2015Journal of Virology56 citations Open access
Semantic Scholar
Structure of COVID-19 main protease bound to potent broad-spectrum non-covalent inhibitor X77
A. Mesecar
202051 citations
Semantic Scholar
Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs
B. Anson, Mackenzie E. Chapman, E. Lendy, S. Pshenychnyi +3 more
202042 citations Open access
Semantic Scholar
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 and Covid‐19
A. Ghosh, Jennifer L. Mishevich, A. Mesecar, H. Mitsuya
2022ChemMedChem41 citations Open access
Semantic Scholar
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design
Jozlyn R. Clasman, Y. M. Báez-Santos, Robert C. Mettelman, A. O'Brien +2 more
2017Scientific Reports41 citations Open access
Semantic Scholar
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
Ya-Fang Chen, Sergey N. Savinov, A. Mielech, T. Cao +2 more
2015Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Synthesis of 3-(3-Aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines That Have Antibacterial Activity and Also Inhibit Inorganic Pyrophosphatase
Wei-Ke Lv, Biplab Banerjee, K. Molland, M. Seleem +6 more
2013Bioorganic & Medicinal Chemistry37 citations Open access
Semantic Scholar
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit
M. Hall, James M. Anderson, Annaliesa S. Anderson, D. Baker +38 more
2021Journal of Infectious Diseases35 citations Open access
Semantic Scholar
A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
K. Molland, Qing Zhou, A. Mesecar
2014Acta Crystallographica Section F Structural Biology Communications32 citations Open access
Semantic Scholar
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
Xu-Fang Deng, Ya-Fang Chen, A. Mielech, M. Hackbart +6 more
2019Journal of Virology27 citations Open access
Semantic Scholar
Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer
Renee E. Vickman, S. Crist, Kevin S. Kerian, L. Eberlin +7 more
2016Molecular Cancer Research26 citations Open access
Semantic Scholar
Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2′-O-methyl transfer by SARS-CoV-2 nsp16
G. Minasov, M. Rosas-Lemus, L. Shuvalova, Nicole l. Inniss +5 more
2021Science Signaling24 citations Open access
Semantic Scholar
A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-Like Proteases of Emerging Coronaviruses
Xu-Fang Deng, S. Agnihothram, A. Mielech, D. Nichols +7 more
2014Journal of Virology21 citations Open access
Semantic Scholar
Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2
S. E. St. John, Katherine C. Jensen, Soosung Kang, Ya-Fang Chen +3 more
2013Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus
A. Abuhammad, Rua'a A. Al-Aqtash, B. Anson, A. Mesecar +1 more
2017Journal of Molecular Recognition20 citations Open access
Semantic Scholar
X-Ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: structural implications for drug design
S. E. St. John, Matthew D. Therkelsen, Prasanth R. Nyalapatla, Heather L. Osswald +2 more
2015Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Exploration of P1 and P4 Modifications of Nirmatrelvir: Design, Synthesis, Biological Evaluation, and X-ray Structural Studies of SARS-CoV-2 Mpro Inhibitors
Arun K. Ghosh, Monika Yadav, Satyanarayana Iddum, Somayeh Ghazi +9 more
2024European journal of medicinal chemistry19 citations Open access
Semantic Scholar
X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus
S. E. St. John, B. Anson, A. Mesecar
2016Scientific Reports17 citations Open access
Semantic Scholar
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand
A. Ghosh, M. Brindisi, Y. Yen, Xiaoming Xu +7 more
2014Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors
Y. Yen, Annalissa Kammeyer, Katherine C. Jensen, Jagannadharao Tirlangi +2 more
2019Biochemistry14 citations Open access
Semantic Scholar
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
Arun K. Ghosh, D. Shahabi, M. Imhoff, Satish Kovela +5 more
2023Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies
A. Ghosh, M. Brindisi, Y. Yen, E. Lendy +8 more
2019ChemMedChem13 citations Open access
Semantic Scholar
Design, synthesis, and X-ray structural studies of BACE-1 Inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands
A. Ghosh, M. Brindisi, Y. Yen, E. L. Cárdenas +5 more
2017Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes
A. Ghosh, B. S. Reddy, Y. Yen, E. L. Cárdenas +5 more
2016Chemical Science12 citations Open access
Semantic Scholar
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease
Cynthia D. Jesudason, Emily R. Mason, Shao-You Chu, Adrian L. Oblak +24 more
2023Alzheimer's & Dementia11 citations Open access
Semantic Scholar
Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro
Jon Jacobs, Sandra Zhou, Eric S. Dawson, J. S. Daniels +5 more
201311 citations
Semantic Scholar
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
S. Bose, C. Steussy, Daneli López-Pérez, T. Schmidt +6 more
2023Communications Biology10 citations Open access
Semantic Scholar
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors
A. Ghosh, D. Shahabi, M. Yadav, Satish Kovela +9 more
2021Molecules10 citations Open access
Semantic Scholar
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme
Nicole M Hjortland, A. Mesecar
2016Archives of Biochemistry and Biophysics10 citations Open access
Semantic Scholar
Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis
R. Yadav, S. Govindan, C. Daczkowski, A. Mesecar +2 more
2021bioRxiv9 citations Open access
Semantic Scholar
X-ray Structure of SARS-CoV-2 main protease bound to Boceprevir at 1.45 A
B. Anson, A. Mesecar
20209 citations
Semantic Scholar

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