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C. Kiel · SciRah

Researcher profile · Semantic Scholar

C. Kiel

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C. Kiel — researcher profile on SciRah

h-index: 33
Works: 95
Citations: 5,176

Most-cited papers

Network pharmacology: curing causal mechanisms instead of treating symptoms.
Cristian Nogales, Zeinab M. Mamdouh, M. List, C. Kiel +2 more
2021TIPS - Trends in Pharmacological Sciences1,082 citations Open access
Semantic Scholar
Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.
H. Gohlke, C. Kiel, D. Case
2003Journal of Molecular Biology1,081 citations
Semantic Scholar
Recognizing and defining true Ras binding domains I: biochemical analysis.
Sabine Wohlgemuth, C. Kiel, Astrid Krämer, Luis Serrano +2 more
2005Journal of Molecular Biology183 citations
Semantic Scholar
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Gabriel Markson, C. Kiel, R. Hyde, Stephanie E. Brown +11 more
2009Genome Research181 citations Open access
Semantic Scholar
Engineering signal transduction pathways.
C. Kiel, Eva Yus, L. Serrano
2010Cell135 citations Open access
Semantic Scholar
Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease
T. Winkler, F. Grassmann, Caroline Brandl, C. Kiel +21 more
2019BMC Medical Genomics117 citations Open access
Semantic Scholar
Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations.
C. Kiel, Sabine Wohlgemuth, F. Rousseau, J. Schymkowitz +3 more
2005Journal of Molecular Biology114 citations
Semantic Scholar
Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex.
C. Kiel, Tzvia Selzer, Y. Shaul, G. Schreiber +1 more
2004Proceedings of the National Academy of Sciences of the United States of America113 citations Open access
Semantic Scholar
Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
G. Piccoli, F. Onofri, M. Cirnaru, C. Kaiser +17 more
2014Molecular and Cellular Biology107 citations Open access
Semantic Scholar
Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations.
E. Rakoczy, C. Kiel, R. McKeone, F. Stricher +1 more
2011Journal of Molecular Biology107 citations
Semantic Scholar
An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology
Patricia Berber, F. Grassmann, C. Kiel, B. Weber
2016Molecular Diagnosis & Therapy92 citations Open access
Semantic Scholar
A detailed thermodynamic analysis of ras/effector complex interfaces.
C. Kiel, L. Serrano, C. Herrmann
2004Journal of Molecular Biology91 citations
Semantic Scholar
Analyzing protein interaction networks using structural information.
C. Kiel, P. Beltrão, Luis Serrano
2008Annual Review of Biochemistry90 citations
Semantic Scholar
The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes.
C. Kiel, Luis Serrano
2006Journal of Molecular Biology79 citations
Semantic Scholar
Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling
C. Kiel, Luis Serrano
2009Science Signaling77 citations
Semantic Scholar
Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations
C. Kiel, Luis Serrano
2014Molecular Systems Biology74 citations Open access
Semantic Scholar
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
F. Grassmann, C. Kiel, M. Zimmermann, M. Gorski +161 more
2017Genome Medicine62 citations Open access
Semantic Scholar
Y chromosome mosaicism is associated with age-related macular degeneration
F. Grassmann, C. Kiel, A. den Hollander, D. Weeks +3 more
2018European Journal of Human Genetics61 citations Open access
Semantic Scholar
Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.
M. Ahmadian, C. Kiel, P. Stege, K. Scheffzek
2003Journal of Molecular Biology61 citations
Semantic Scholar
Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage
Camille Ternet, C. Kiel
2021Cell communication and signaling : CCS57 citations Open access
Semantic Scholar
A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration
Tobias Strunz, Susette Lauwen, C. Kiel, A. den Hollander +2 more
2020Scientific Reports55 citations Open access
Semantic Scholar
The Ins and Outs of RAS Effector Complexes
C. Kiel, D. Matallanas, W. Kolch
2021Biomolecules52 citations Open access
Semantic Scholar
Structures in systems biology.
P. Beltrão, C. Kiel, Luis Serrano
2007Current Opinion in Structural Biology51 citations
Semantic Scholar
Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network
C. Kiel, E. Verschueren, Jae-Seong Yang, Luis Serrano
2013Science Signaling49 citations Open access
Semantic Scholar
The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain
T. Linnemann, C. Kiel, P. Herter, C. Herrmann
2002Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Cell Adhesion Molecules in Normal Skin and Melanoma
Cian D'Arcy, C. Kiel
2021Biomolecules47 citations Open access
Semantic Scholar
Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity*
C. Kiel, D. Filchtinski, M. Spoerner, G. Schreiber +2 more
2009Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Challenges ahead in signal transduction: MAPK as an example.
C. Kiel, L. Serrano
2012Current Opinion in Biotechnology45 citations Open access
Semantic Scholar
A genome-wide Ras-effector interaction network.
C. Kiel, Mathilde Foglierini, N. Kuemmerer, P. Beltrão +1 more
2007Journal of Molecular Biology44 citations
Semantic Scholar
Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
F. Grassmann, Sebastian Harsch, Caroline Brandl, C. Kiel +13 more
2019JAMA ophthalmology40 citations Open access
Semantic Scholar
A mega-analysis of expression quantitative trait loci in retinal tissue
Tobias Strunz, C. Kiel, F. Grassmann, R. Ratnapriya +8 more
2020PLoS Genetics39 citations Open access
Semantic Scholar
Structural and functional protein network analyses predict novel signaling functions for rhodopsin
C. Kiel, A. Vogt, A. Campagna, A. Chatr-aryamontri +8 more
2011Molecular Systems Biology38 citations Open access
Semantic Scholar
Analysis of the human E 2 ubiquitin conjugating enzyme protein interaction network
Gabriel Markson, C. Kiel, R. Hyde, Stephanie E. Brown +11 more
200934 citations
Semantic Scholar
The yin–yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF
C. Kiel, H. Benisty, V. Lloréns-Rico, Luis Serrano
2016eLife32 citations Open access
Semantic Scholar
A Comprehensive View of the β-Arrestinome
P. Crépieux, A. Poupon, Nathalie Langonné-Gallay, E. Reiter +5 more
2017Frontiers in Endocrinology30 citations Open access
Semantic Scholar
Protein Conservation and Variation Suggest Mechanisms of Cell Type-Specific Modulation of Signaling Pathways
Martin H. Schaefer, Jae-Seong Yang, Luis Serrano, C. Kiel
2014PLoS Comput. Biol.28 citations Open access
Semantic Scholar
Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration
Frances M. Pool, C. Kiel, Luis Serrano, P. Luthert
2020npj Aging and Mechanisms of Disease27 citations Open access
Semantic Scholar
Phylogeographic and evolutionary history analyses of the warty crab Eriphia verrucosa (Decapoda, Brachyura, Eriphiidae) unveil genetic imprints of a late Pleistocene vicariant event across the Gibraltar Strait, erased by postglacial expansion and admixture among refugial lineages
T. Deli, C. Kiel, C. Schubart
2019BMC Evolutionary Biology25 citations Open access
Semantic Scholar
Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa
R. McKeone, M. Wikström, C. Kiel, P. Rakoczy
2014Molecular Vision25 citations
Semantic Scholar
Protein design in biological networks: from manipulating the input to modifying the output.
A. M. van der Sloot, C. Kiel, L. Serrano, F. Stricher
2009Protein engineering, design & selection : PEDS25 citations
Semantic Scholar
Predicted ‘wiring landscape’ of Ras-effector interactions in 29 human tissues
Simona Catozzi, M. Halasz, C. Kiel
2021npj Systems Biology and Applications24 citations Open access
Semantic Scholar
Dissecting the Calcium-Induced Differentiation of Human Primary Keratinocytes Stem Cells by Integrative and Structural Network Analyses
Kiana Toufighi, Jae-Seong Yang, N. Luis, Salvador Aznar Benitah +3 more
2015PLoS Comput. Biol.23 citations Open access
Semantic Scholar
Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved
C. Kiel, Dorothee Aydin, Luis Serrano
2008PLoS Comput. Biol.21 citations Open access
Semantic Scholar
Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration
Tobias Strunz, C. Kiel, Bastian L Sauerbeck, B. Weber
2020Cells19 citations Open access
Semantic Scholar
Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context
Verónica Ibáňez Gaspar, Simona Catozzi, Camille Ternet, P. Luthert +1 more
2020Small GTPases19 citations Open access
Semantic Scholar
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
Jayshree Advani, Ximena Corso-Díaz, Madeline Kwicklis, F. van Asten +13 more
2023Research Square18 citations Open access
Semantic Scholar
The metabolic environment of the developing embryo: A multidisciplinary approach on oilseed rapeseed.
H. Rolletschek, Simon Mayer, B. Boughton, Steffen Wagner +4 more
2021Journal of plant physiology18 citations Open access
Semantic Scholar
A RAC-GEF network critical for early intestinal tumourigenesis
K. Pickering, K. Gilroy, J. Cassidy, S. Fey +29 more
2021Nature Communications18 citations Open access
Semantic Scholar
Interaction Dynamics Determine Signaling and Output Pathway Responses.
Klement Stojanovski, Tony Ferrar, H. Benisty, Friedemann Uschner +8 more
2017Cell Reports17 citations Open access
Semantic Scholar
Reconstruction and analysis of a large-scale binary Ras-effector signaling network
Simona Catozzi, Camille Ternet, Alize Gourrege, K. Wynne +2 more
2022Cell Communication and Signaling15 citations Open access
Semantic Scholar

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