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R. Sainson · SciRah

Researcher profile · Semantic Scholar

R. Sainson

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R. Sainson — researcher profile on SciRah

h-index: 26
Works: 65
Citations: 4,921

Most-cited papers

Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.
Martin N. Nakatsu, R. Sainson, Jason Aoto, Kevin L. Taylor +4 more
2003Microvascular Research451 citations
Semantic Scholar
A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane*
A. Pedram, M. Razandi, R. Sainson, J. K. Kim +2 more
2007Journal of Biological Chemistry450 citations Open access
Semantic Scholar
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.
H. Sheldon, Emily B. Heikamp, H. Turley, R. Dragovic +9 more
2010Blood428 citations Open access
Semantic Scholar
Diffusion Limits of an in Vitro Thick Prevascularized Tissue
Craig K. Griffith, Cheryl A. Miller, R. Sainson, J. Calvert +3 more
2005Tissue engineering371 citations
Semantic Scholar
Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery
Suzanne Mosely, J. Prime, R. Sainson, J. Koopmann +20 more
2016Cancer immunology research352 citations Open access
Semantic Scholar
Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.
Ji-Liang Li, R. Sainson, Wen Shi, R. Leek +7 more
2007Cancer Research348 citations Open access
Semantic Scholar
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype.
R. Sainson, Douglas A. Johnston, Henry C. Chu, M. Holderfield +5 more
2008Blood325 citations Open access
Semantic Scholar
Regulation of the anti-tumour immune response by cancer-associated fibroblasts.
J. Harper, R. Sainson
2014Seminars in Cancer Biology253 citations
Semantic Scholar
Cell‐autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis
R. Sainson, Jason Aoto, Martin N. Nakatsu, M. Holderfield +3 more
2005The FASEB Journal244 citations
Semantic Scholar
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.
L. Harrington, R. Sainson, Cassin Kimmel Williams, Jennifer M. Taylor +3 more
2008Microvascular Research239 citations Open access
Semantic Scholar
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.
Ji-Liang Li, R. Sainson, C. Oon, H. Turley +12 more
2011Cancer Research238 citations Open access
Semantic Scholar
The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.
B. Perbal, C. Martinerie, R. Sainson, M. Werner +2 more
1999Proceedings of the National Academy of Sciences of the United States of America144 citations Open access
Semantic Scholar
VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor 2 in an in vitro Angiogenesis Model
Martin N. Nakatsu, R. Sainson, S. Pérez-del-Pulgar, Jason Aoto +4 more
2003Laboratory Investigation139 citations Open access
Semantic Scholar
Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation‐promoting factors
H. Sheldon, M. Andre, John A. Legg, Paul Heal +6 more
2009The FASEB Journal127 citations Open access
Semantic Scholar
MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue
H. Ghadially, L. Brown, Chris Lloyd, Leeanne Lewis +9 more
2017British Journal of Cancer109 citations Open access
Semantic Scholar
Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies
R. Sainson, A. Harris
2008Angiogenesis97 citations
Semantic Scholar
Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?
R. Sainson, A. Harris
2007Trends in Molecular Medicine82 citations
Semantic Scholar
Angiogenesis: an integrative approach from science to medicine
R. Sainson
200879 citations
Semantic Scholar
Hypoxia-regulated differentiation: let's step it up a Notch.
R. Sainson, A. Harris
2006Trends in Molecular Medicine74 citations
Semantic Scholar
Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.
Cassin Kimmel Williams, M. Segarra, M. de la Luz Sierra, R. Sainson +2 more
2008Cancer Research71 citations Open access
Semantic Scholar
Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth
C. Oon, E. Bridges, H. Sheldon, R. Sainson +6 more
2017OncoTarget46 citations Open access
Semantic Scholar
An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression
R. Sainson, A. Thotakura, M. Kosmač, Gwenoline Borhis +25 more
2020Cancer immunology research38 citations Open access
Semantic Scholar
Combining virotherapy and angiotherapy for the treatment of breast cancer
M. Bazan-Peregrino, R. Sainson, R. Carlisle, C. Thoma +5 more
2013Cancer Gene Therapy37 citations
Semantic Scholar
A Phase 1 first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1 in patients with advanced cancer and PD-L1 resistance.
T. Yap, P. LoRusso, D. Wong, S. Hu-Lieskovan +18 more
2022Clinical Cancer Research33 citations Open access
Semantic Scholar
Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent
Bangwen Xie, M. Tomaszewski, A. A. Neves, S. Ros +8 more
2017Clinical Cancer Research27 citations Open access
Semantic Scholar
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC).
F. Hoffman, D. Gavaghan, James M. Osborne, I. Barrett +5 more
2018Journal of Theoretical Biology26 citations Open access
Semantic Scholar
Nuclear and membrane expression of the angiogenesis regulator delta‐like ligand 4 (DLL4) in normal and malignant human tissues
J. Martinez, Marcus M. Müller, H. Turley, G. Steers +6 more
2009Histopathology22 citations
Semantic Scholar
Detailed bladder cancer immunoprofiling reveals new clues for immunotherapeutic strategies
Nicole Viveiros, B. Flores, J. Lobo, Cláudia Martins-Lima +7 more
2022Clinical & Translational Immunology18 citations Open access
Semantic Scholar
A phase 1/2 open-label study of KY1044, an anti-ICOS antibody with dual mechanism of action, as single agent and in combination with atezolizumab, in adult patients with advanced malignancies.
M. Patel, A. Naing, H. Burris, Chia-Chi Lin +10 more
202114 citations
Semantic Scholar
Preclinical modelling of immune checkpoint blockade (P2012)
R. Stewart, S. Mullins, A. Watkins, Michelle Morrow +4 more
2013Journal of Immunology9 citations
Semantic Scholar
A first-in-human study of KY1044, a fully human anti-ICOS IgG1 antibody as monotherapy and in combination with atezolizumab in patients with selected advanced malignancies.
S. Quaratino, R. Sainson, A. Thotakura, Simon J. Henderson +4 more
2019Journal of Clinical Oncology7 citations
Semantic Scholar
ICOS-Positive Regulatory T Cells in Hepatocellular Carcinoma: The Perspective from Digital Pathology Analysis
Li-Chun Lu, C. Deantonio, C. Palu, Yi-Hsuan Lee +9 more
2022Oncology6 citations
Semantic Scholar
Abstract LB-153: KY1055, a novel ICOS-PD-L1 bispecific antibody, efficiently enhances T cell activation and delivers a potent anti-tumour response in vivo
R. Sainson, Nahida Parveen, Gwenoline Borhis, M. Kosmač +7 more
2018Clinical research6 citations
Semantic Scholar
Downregulation of Manic fringe impedes angiogenesis and cell migration of renal carcinoma.
Wei-Kang Chen, C. Oon, G. Kaur, R. Sainson +1 more
2022Microvascular Research5 citations
Semantic Scholar
Characterization and application of two RANK-specific antibodies with different biological activities.
Mélanie Chypre, J. Seaman, Olga G. Cordeiro, L. Willen +7 more
2016Immunology Letters4 citations Open access
Semantic Scholar
353 Amlitelimab reduces serum IL-13 in a phase 2a clinical trial in atopic dermatitis without impacting T-cell expansion in a T-cell recall assay
S. Weidinger, Michael J. Cork, Adam Reich, T. Bieber +8 more
2023British Journal of Dermatology3 citations Open access
Semantic Scholar
Nuclear and membrane expression of the angiogenesis regulator Delta Like Ligand 4(DLL4) in normal and malignant human tissues (Histopathology (2009) 54 (598-606))
H. Turley, G. Steers, Ji-Liang Li, R. Sainson +3 more
20093 citations
Semantic Scholar
Abstract 2792: The combination of immune checkpoint blockers with the anti-ICOS KY1044 antibody results in a strong tumor response
R. Sainson, M. Mccourt, A. Thotakura, Nahida Parveen +10 more
2018Immunology2 citations
Semantic Scholar
KY1044 to target the ICOS pathways inducing intratumoral Treg depletion and agonism of effector T cells: Preliminary pharmacodynamic markers from a phase 1/2 multicenter trial.
Chia-Chi Lin, A. Naing, M. Patel, H. Burris +13 more
20211 citations
Semantic Scholar
A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression
R. Sainson, A. Thotakura, M. Kosmač, Gwenoline Borhis +24 more
20191 citations Open access
Semantic Scholar
360 Role of DLL4 and JAG1 in tumour angiogenesis
C. Oon, Ji-Liang Li, R. Sainson, H. Sheldon +3 more
20101 citations
Semantic Scholar
Virotherapy expressing regulatory angiogenic gene therapy in treatment of breast cancer
M. Bazan-Peregrino, R. Sainson, R. Carlisle, R. Waters +3 more
20081 citations
Semantic Scholar
First-in-human, phase 1, open-label study of alomfilimab, an anti-ICOS antibody, as a single agent and in combination with anti-PD-L1 in advanced malignancies
A. Naing, Chia-Chi Lin, Manish R. Patel, G. Curigliano +12 more
2026Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Abstract 1590: High ICOS/FOXP3 Tregs content in the tumor microenvironment is associated with poorer survival in patients with hepatocellular carcinoma
Li-Chun Lu, C. Deantonio, L. Mitchell, Yi-Hsuan Lee +10 more
2020Tumor Biology0 citations
Semantic Scholar
Abstract 4953: Differential expression of ICOS on circulating immune cells and tumor infiltrating lymphocytes in patient with solid tumors
R. Sainson, M. Kosmač, R. Kimber, J. Carvalho +4 more
2019Immunology0 citations
Semantic Scholar
Molecular Infection in Tumor Growth Through Hypoxic Disorder
Iman Mostafa, S. Bray, R. Sainson, A. Harris +45 more
2019<The> Journal of applied sciences research0 citations Open access
Semantic Scholar
Abstract 2866: Volumetric optoacoustic imaging of tumor cell death using a targeted imaging agent
Bangwen Xie, M. Tomaszewski, A. A. Neves, S. Mullins +5 more
20170 citations
Semantic Scholar
Multispecific antibody with combination therapy for immuno-oncology
Jamie Campbell, N. Sandy, Cassandra Van Krinks, S. Arkinstall +10 more
20170 citations
Semantic Scholar
Anticorps multispécifiques pour l'immuno-oncologie
Jamie Campbell, Nikole Sandy, Cassandra Van Krinks, S. Arkinstall +10 more
20170 citations
Semantic Scholar
Abstract 4186: Syngenomic fingerprint: the biomic characterization of the mouse syngeneic tumor models
J. Prime, Suzanne Mosely, J. Koopmann, Dennis Wang +16 more
20160 citations
Semantic Scholar

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