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D. Wedge · SciRah

Researcher profile · Semantic Scholar

D. Wedge

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D. Wedge — researcher profile on SciRah

h-index: 68
Works: 239
Citations: 45K

Most-cited papers

Disease heterogeneity and personalized prognosis in myeloproliferative neoplasms
J. Grinfeld, J. Nangalia, J. Baxter, D. Wedge +23 more
2018New England Journal of Medicine530 citations Open access
Semantic Scholar
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
T. Mitchell, S. Turajlic, A. Rowan, D. Nicol +43 more
2018Cell464 citations Open access
Semantic Scholar
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
Mia Petljak, L. Alexandrov, Jonathan S Brammeld, S. Price +31 more
2019Cell399 citations Open access
Semantic Scholar
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
B. Rodriguez-Martin, Eva G. Álvarez, Adrian Baez-Ortega, Jorge Zamora +47 more
2020Nature Genetics390 citations Open access
Semantic Scholar
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
S. M. Ashiqul Islam, M. Díaz-Gay, Yang Wu, Mark Barnes +31 more
2020bioRxiv355 citations Open access
Semantic Scholar
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
Xiao-Dun Li, H. Francies, M. Secrier, J. Perner +19 more
2018Nature Communications285 citations Open access
Semantic Scholar
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
F. Maura, N. Bolli, Nicos Angelopoulos, K. Dawson +24 more
2018Nature Communications246 citations Open access
Semantic Scholar
Genomic and evolutionary classification of lung cancer in never smokers
Tong-Wu Zhang, P. Joubert, N. Ansari-Pour, Wei Zhao +57 more
2021Nature Genetics212 citations Open access
Semantic Scholar
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
D. Wedge, G. Gundem, T. Mitchell, D. Woodcock +82 more
2018Nature Genetics209 citations Open access
Semantic Scholar
Promises and challenges of adoptive T-cell therapies for solid tumours
M. Morotti, A. Albukhari, Abdulkhaliq Alsaadi, Mara Artibani +17 more
2021British Journal of Cancer205 citations Open access
Semantic Scholar
Genomic patterns of progression in smoldering multiple myeloma
N. Bolli, F. Maura, S. Minvielle, Dominik Gloznik +20 more
2018Nature Communications202 citations Open access
Semantic Scholar
A practical guide to cancer subclonal reconstruction from DNA sequencing
M. Tarabichi, A. Salcedo, A. Deshwar, Máire Ní Leathlobhair +5 more
2021Nature Methods164 citations Open access
Semantic Scholar
The evolutionary landscape of colorectal tumorigenesis
W. Cross, M. Kováč, V. Mustonen, D. Temko +29 more
2018Nature Ecology & Evolution141 citations Open access
Semantic Scholar
Embryonal precursors of Wilms tumor
T. Coorens, T. D. Treger, R. Al-Saadi, L. Moore +37 more
2019Science119 citations Open access
Semantic Scholar
Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
Xing Hua, Wei Zhao, A. Pesatori, D. Consonni +11 more
2019Nature Communications105 citations Open access
Semantic Scholar
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
A. Noorani, Xiao-Dun Li, M. Goddard, J. Crawte +22 more
2018Nature Genetics75 citations Open access
Semantic Scholar
Tumor heterogeneity.
D. Pe'er, S. Ogawa, O. Elhanani, L. Keren +2 more
2021Cancer Cell73 citations Open access
Semantic Scholar
Genomic copy number predicts esophageal cancer years before transformation
S. Killcoyne, Eleanor Gregson, D. Wedge, D. Woodcock +10 more
2020Nature Medicine73 citations Open access
Semantic Scholar
A community effort to create standards for evaluating tumor subclonal reconstruction
A. Salcedo, M. Tarabichi, S. M. Espiritu, A. Deshwar +29 more
2020Nature Biotechnology69 citations Open access
Semantic Scholar
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups.
R. Hurst, E. Meader, A. Gihawi, Ghanasyam Rallapalli +23 more
2022European Urology Oncology66 citations Open access
Semantic Scholar
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
Michael J. Haley, Leoma D. Bere, James Minshull, Sokratia Georgaka +10 more
2024Science Advances65 citations Open access
Semantic Scholar
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome
C. Palles, Hannah D. West, E. Chew, Sara Galavotti +65 more
2022American Journal of Human Genetics65 citations Open access
Semantic Scholar
African-specific molecular taxonomy of prostate cancer
Weerachai Jaratlerdsiri, Jue Jiang, Ting-Ting Gong, Sean Mark Patrick +17 more
2022Nature65 citations Open access
Semantic Scholar
Genomic copy number predicts oesophageal cancer years before transformation
S. Killcoyne, Eleanor Gregson, D. Wedge, D. Woodcock +9 more
2020bioRxiv53 citations Open access
Semantic Scholar
In utero origin of myelofibrosis presenting in adult monozygotic twins
N. Sousos, Máire Ní Leathlobhair, Christina Simoglou Karali, E. Louka +11 more
2022Nature Medicine46 citations Open access
Semantic Scholar
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types
S. Dentro, I. Leshchiner, K. Haase, M. Tarabichi +42 more
2018bioRxiv46 citations Open access
Semantic Scholar
A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease.
A. Erickson, A. Hayes, T. Rajakumar, C. Verill +6 more
2021European Urology Oncology40 citations Open access
Semantic Scholar
APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types
G. M. Jakobsdottir, D. Brewer, C. Cooper, C. Green +1 more
2022BMC Biology37 citations Open access
Semantic Scholar
Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity
A. Katz-Summercorn, S. Jammula, A. Frangou, I. Peneva +14 more
2022Nature Communications35 citations Open access
Semantic Scholar
Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.
M. Landi, N. Synnott, J. Rosenbaum, Tong-Wu Zhang +18 more
2020American Journal of Epidemiology35 citations Open access
Semantic Scholar
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie, N. Ansari-Pour, O. Cast, Doreen Lau +19 more
2020Nature Communications31 citations Open access
Semantic Scholar
The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Bin Zhu, M. L. Poeta, M. Costantini, Tong-Wu Zhang +22 more
2020Nature Communications29 citations Open access
Semantic Scholar
Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils
Y. Kwon, Kevin Gori, Naomi Park, Nicole Potts +22 more
2020PLoS Biology28 citations Open access
Semantic Scholar
Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers
B. Hancock, Yu-Hsiang Chen, Jeffrey P. Solzak, M. N. Ahmad +13 more
2019Breast Cancer Research27 citations Open access
Semantic Scholar
Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression
S. Mamlouk, T. Simon, Laura Tomás, D. Wedge +8 more
2020BMC Biology22 citations Open access
Semantic Scholar
Benchmarking small-variant genotyping in polyploids
Daniel P Cooke, D. Wedge, G. Lunter
2021bioRxiv19 citations Open access
Semantic Scholar
Re-evaluating experimental validation in the Big Data Era: a conceptual argument
Mohieddin Jafari, Y. Guan, D. Wedge, N. Ansari-Pour
2021Genome Biology19 citations Open access
Semantic Scholar
Genomic evolution shapes prostate cancer disease type
D. Woodcock, A. Sahli, Ruxandra Teslo, Vinayak Bhandari +32 more
2024Cell Genomics17 citations Open access
Semantic Scholar
Clonal diversification and histogenesis of malignant germ cell tumours
Thomas R. W. Oliver, Lia Chappell, R. Sanghvi, Lauren Deighton +21 more
2022Nature Communications17 citations Open access
Semantic Scholar
Ultrasensitive Detection of Circulating Tumour DNA enriches for Patients with a Greater Risk of Recurrence of Clinically Localised Prostate Cancer.
B. Pope, G. Park, E. Lau, J. Belic +18 more
2024European Urology16 citations Open access
Semantic Scholar
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
A. Cornish, Andreas J. Gruber, B. Kinnersley, D. Chubb +30 more
2022bioRxiv16 citations Open access
Semantic Scholar
SC-JNMF: single-cell clustering integrating multiple quantification methods based on joint non-negative matrix factorization
Mikio Shiga, S. Seno, Makoto Onizuka, H. Matsuda +313 more
2020bioRxiv15 citations Open access
Semantic Scholar
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Arne V. Pladsen, Gro Nilsen, O. Rueda, M. R. Aure +15 more
2020Communications Biology13 citations Open access
Semantic Scholar
Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences
S. Nik-Zainal, H. Davies, J. Staaf, M. Ramakrishna +84 more
2019Nature13 citations Open access
Semantic Scholar
Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity
K. Ketola, H. Kaljunen, S. Taavitsainen, R. Kaarijärvi +8 more
2021Cancer Research12 citations Open access
Semantic Scholar
Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine
Anssi Nurminen, S. Jaatinen, S. Taavitsainen, G. Högnäs +21 more
2023Genome Medicine11 citations Open access
Semantic Scholar
Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy–driven Metabolic Reprogramming
M. McClure, Yasunori Kogure, N. Ansari-Pour, Y. Saito +8 more
2023Cancer Research Communications11 citations Open access
Semantic Scholar
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction
A. Salcedo, M. Tarabichi, Alex Buchanan, S. M. Espiritu +24 more
2022bioRxiv11 citations Open access
Semantic Scholar
Detailed molecular and immune marker profiling of archival prostate cancer samples reveals an inverse association between TMPRSS2:ERG fusion status and immune cell infiltration.
Srinivasa R. Rao, N. Alham, E. Upton, S. McIntyre +15 more
2020Journal of Molecular Diagnostics11 citations Open access
Semantic Scholar
Reference bias in the Illumina Isaac aligner
A. Cornish, D. Chubb, A. Frangou, P. Hoang +3 more
2020Bioinform.11 citations Open access
Semantic Scholar

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