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P. van Loo · SciRah

Researcher profile · Semantic Scholar

P. van Loo

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P. van Loo — researcher profile on SciRah

h-index: 81
Works: 334
Citations: 48K

Most-cited papers

Lung adenocarcinoma promotion by air pollutants
William Hill, Emilia L. Lim, C. Weeden, Claudia Lee +322 more
2023Nature710 citations Open access
Semantic Scholar
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
C. Abbosh, A. Frankell, T. Harrison, Judit Kisistók +302 more
2023Nature355 citations Open access
Semantic Scholar
The evolution of lung cancer and impact of subclonal selection in TRACERx
A. Frankell, M. Dietzen, Maise Al Bakir, Emilia L. Lim +76 more
2023Nature275 citations Open access
Semantic Scholar
The evolution of non-small cell lung cancer metastases in TRACERx
Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis +282 more
2023Nature217 citations Open access
Semantic Scholar
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
K. Ng, J. Boumelha, K. Enfield, J. Almagro +327 more
2023Nature202 citations Open access
Semantic Scholar
Genomic–transcriptomic evolution in lung cancer and metastasis
Carlos Martínez-Ruiz, J. Black, C. Puttick, M. Hill +42 more
2023Nature190 citations Open access
Semantic Scholar
Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes
S. Heeke, C. Gay, M. Estecio, H. Tran +38 more
2024Cancer Cell134 citations Open access
Semantic Scholar
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
J. Black, G. Bartha, C. Abbott, S. Boyle +276 more
2025Nature Medicine102 citations Open access
Semantic Scholar
Evolutionary characterisation of lung adenocarcinoma morphology in TRACERx
T. Karasaki, D. Moore, S. Veeriah, C. Naceur-Lombardelli +48 more
2023Nature Medicine102 citations Open access
Semantic Scholar
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
K. Huang, Hao-Ran Ma, R. Chong, T. Uchihara +29 more
2023bioRxiv79 citations Open access
Semantic Scholar
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
S. Hobor, Maise Al Bakir, C. Hiley, M. Skrzypski +291 more
2024Nature Communications49 citations Open access
Semantic Scholar
Aneuploidy and complex genomic rearrangements in cancer evolution
Toby M. Baker, S. Waise, M. Tarabichi, P. van Loo
2024Nature Cancer47 citations Open access
Semantic Scholar
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution
C. Puttick, Thomas P. Jones, Michelle M. Leung, Felipe Gálvez-Cancino +18 more
2024Nature Genetics44 citations Open access
Semantic Scholar
Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring
Elena Kuzmin, Toby M. Baker, Tom Lesluyes, Jean Monlong +25 more
2023bioRxiv24 citations Open access
Semantic Scholar
The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia
D. O’Connor, J. Demeulemeester, L. Conde, A. Kirkwood +14 more
2023Journal of Clinical Oncology20 citations Open access
Semantic Scholar
Metastasis-directed radiotherapy without systemic therapy for oligometastatic clear-cell renal-cell carcinoma: primary efficacy analysis of a single-arm, single-centre, phase 2 trial.
Chad Tang, A. Sherry, Aaron Seo, Kieko Hara +26 more
2025The Lancet Oncology19 citations Open access
Semantic Scholar
The history of chromosomal instability in genome doubled tumors
Toby M. Baker, Si-Qi Lai, Andrew R. Lynch, Tom Lesluyes +11 more
2023bioRxiv18 citations Open access
Semantic Scholar
Genomic evolution shapes prostate cancer disease type
D. Woodcock, A. Sahli, Ruxandra Teslo, Vinayak Bhandari +32 more
2024Cell Genomics17 citations Open access
Semantic Scholar
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution
F. Gimeno-Valiente, Carla Castignani, Elizabeth Larose Cadieux, N. Mensah +264 more
2025Nature Genetics15 citations Open access
Semantic Scholar
A guide to transcriptomic deconvolution in cancer
Yao-Yi Dai, Shuai Guo, Yi-Dan Pan, Carla Castignani +3 more
2025Nature Reviews. Cancer13 citations Open access
Semantic Scholar
Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity
T. Watkins, Emma C. Colliver, Matthew R. Huska, Tom L. Kaufmann +7 more
2023PLoS Comput. Biol.12 citations Open access
Semantic Scholar
Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine
Anssi Nurminen, S. Jaatinen, S. Taavitsainen, G. Högnäs +21 more
2023Genome Medicine11 citations Open access
Semantic Scholar
Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies
Z. Megyesfalvi, S. Heeke, B. Drapkin, A. Solta +17 more
2023Cancer Cell9 citations Open access
Semantic Scholar
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis.
S. Zumalave, M. Santamarina, Nuria P. Espasandín, Jorge Zamora +16 more
2026Science8 citations Open access
Semantic Scholar
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
B. Rodriguez-Martin, Eva G. Álvarez, Adrian Baez-Ortega, Jorge Zamora +47 more
2023Nature Genetics8 citations Open access
Semantic Scholar
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
R. Bentham, Thomas P. Jones, J. Black, Carlos Martínez-Ruiz +10 more
2025Nature Genetics7 citations Open access
Semantic Scholar
Profiling the genomic landscape and evolutionary history of polyploid giant cancer cells in undifferentiated pleomorphic sarcomas.
Amy L. Bowes, S. Waise, Tom Lesluyes, Thomas Butters +13 more
2025Cancer Letters7 citations Open access
Semantic Scholar
Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia
S. Rahman, Gianna Bloye, Nadine Farah, J. Demeulemeester +20 more
2024bioRxiv7 citations Open access
Semantic Scholar
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
W. Cross, Iben Lyskjær, Christopher Davies, A. Bunkum +242 more
2025Genome Biology6 citations Open access
Semantic Scholar
Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesis
S. Zumalave, M. Santamarina, Nuria P. Espasandín, Daniel García-Souto +14 more
2024bioRxiv6 citations
Semantic Scholar
Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice
R. Pourebrahim, Rafael Heinz Montoya, Hiroki Akiyama, Lauren B. Ostermann +10 more
2024Cell Reports Medicine6 citations Open access
Semantic Scholar
Author Correction: The evolutionary history of 2,658 cancers
M. Gerstung, C. Jolly, I. Leshchiner, S. Dentro +42 more
2023Nature6 citations Open access
Semantic Scholar
Oncogenic drivers shape the tumor microenvironment in human gliomas
Bo Zhao, Chae Yun Cho, Lingqun Ye, Tula Keal +25 more
2025bioRxiv4 citations
Semantic Scholar
Dynamics of karyotype evolution.
Elena Kuzmin, Toby M. Baker, P. van Loo, L. Glass
2024Chaos4 citations Open access
Semantic Scholar
Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
A. Frankell, M. Dietzen, Maise Al Bakir, Emilia L. Lim +76 more
2024Nature3 citations Open access
Semantic Scholar
Reconstructing oral cavity tumor evolution through brush biopsy
Evit R. John, Tom Lesluyes, Toby M. Baker, M. Tarabichi +4 more
2023bioRxiv3 citations Open access
Semantic Scholar
Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Yu-Jie Jiang, Matthew D. Montierth, K. Yu, Shuang-Xi Ji +28 more
2024bioRxiv2 citations Open access
Semantic Scholar
Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumour immune microenvironment
Xinyu Yang, Wei Liu, G. Macintyre, P. van Loo +3 more
2023bioRxiv2 citations Open access
Semantic Scholar
An optimised computational approach for the identification of somatic structural variants in cancer
S. Waise, N. Mensah, Tom Lesluyes, J. Demeulemeester +3 more
2025bioRxiv1 citations Open access
Semantic Scholar
Abstract 3888: Exploring intra-tumor heterogeneity in malignant peripheral nerve sheath tumors through single-cell multi-omics
Yi-Dan Pan, Yixiao Cheng, Chunxu Gao, Hai-Xi Yan +10 more
2025Cancer Research1 citations
Semantic Scholar
Evolutionary trajectories of immune escape across cancers
Wenjie Chen, Toby M. Baker, Zhihui Zhang, H. Ogilvie +2 more
2025bioRxiv1 citations
Semantic Scholar
Abstract 1263: Reconstructing small cell lung cancer evolution using deep whole genome sequencing of circulating tumor DNA
B. Morris, Zhihui Zhang, Andrew R. Lynch, Simon Heeke +15 more
2025Cancer Research1 citations
Semantic Scholar
Abstract 1201: Pervasive HLA disruption fuels cancer evolution
C. Puttick, Thomas P. Jones, Michelle M. Leung, O. Pich +17 more
2024Cancer Research1 citations
Semantic Scholar
IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions
S. Rahman, N. Farah, J. Demeulemeester, Joana R. Costa +18 more
2022Blood1 citations Open access
Semantic Scholar
Therapy-resistant subclones as drivers of progression in aggressive variant prostate cancer.
Quang Tran, Shuai Guo, Zhihui Zhang, Noshad Hosseini +3 more
2026Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract 3197: PROMISE, a clonal promoter methylation signature capturing early epigenetic evolution and prognostic programs across epithelial cancers
F. Gimeno-Valiente, Constantino De La Vega, Yun-He Liu, Carla Castignani +10 more
2026Cancer Research0 citations
Semantic Scholar
Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment.
Xinyu Yang, Wei Liu, G. Macintyre, P. van Loo +3 more
2026Cell Reports0 citations Open access
Semantic Scholar
Parent-of-origin phasing of somatic mutations shows equal mutation burden between parental genomes in human cancers
Maxime Lefèbvre, Arnaud Cléris, Mathieu Parmentier, P. van Loo +2 more
2026bioRxiv0 citations Open access
Semantic Scholar
Arborist: Prioritizing Bulk DNA Inferred Tumor Phylogenies via Low-pass Single-cell DNA Sequencing Data
Leah L. Weber, Chi-Yin Ching, Christopher Ly, Yi-Dan Pan +3 more
2026bioRxiv0 citations Open access
Semantic Scholar
Improving computational tumor ploidy estimation in complex cancer genomes through flow-cytometry-guided calibration.
Thomas Butters, D. Oukrif, P. Tannirandorn, I. V. van Belzen +17 more
2026Cell Reports Methods0 citations Open access
Semantic Scholar

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