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R. Bosotti · SciRah

Researcher profile · Semantic Scholar

R. Bosotti

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R. Bosotti — researcher profile on SciRah

h-index: 19
Works: 50
Citations: 2,653

Most-cited papers

Discovery of drug mode of action and drug repositioning from transcriptional responses
F. Iorio, R. Bosotti, E. Scacheri, V. Belcastro +7 more
2010Proceedings of the National Academy of Sciences of the United States of America763 citations Open access
Semantic Scholar
FAT: a novel domain in PIK-related kinases.
R. Bosotti, A. Isacchi, E. Sonnhammer
2000TIBS -Trends in Biochemical Sciences. Regular ed335 citations
Semantic Scholar
Entrectinib, a Pan–TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications
E. Ardini, M. Menichincheri, P. Banfi, R. Bosotti +24 more
2016Molecular Cancer Therapeutics262 citations Open access
Semantic Scholar
A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response
G. Gambardella, G. Viscido, B. Tumaini, A. Isacchi +2 more
2022Nature Communications173 citations Open access
Semantic Scholar
The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition
E. Ardini, R. Bosotti, A. Borgia, C. De Ponti +24 more
2014Molecular Oncology154 citations Open access
Semantic Scholar
Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer
A. Sartore-Bianchi, E. Ardini, R. Bosotti, A. Amatu +21 more
2015Journal of the National Cancer Institute132 citations Open access
Semantic Scholar
Sequence and structural analysis of kinase ATP pocket residues.
A. Vulpetti, R. Bosotti
2004Il Farmaco95 citations
Semantic Scholar
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
E. Vanotti, R. Amici, A. Bargiotti, J. Berthelsen +20 more
2008Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Drf1, a novel regulatory subunit for human Cdc7 kinase
A. Montagnoli, R. Bosotti, Fabrizio Villa, M. Rialland +4 more
2002EMBO Journal84 citations Open access
Semantic Scholar
Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer
A. Amatu, Alessio Somaschini, G. Cerea, R. Bosotti +18 more
2015British Journal of Cancer78 citations Open access
Semantic Scholar
Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury
P. Magnaghi, B. Salom, L. Cozzi, N. Amboldi +14 more
2017Molecular Cancer Therapeutics67 citations
Semantic Scholar
Cross platform microarray analysis for robust identification of differentially expressed genes
R. Bosotti, G. Locatelli, Sandra Healy, E. Scacheri +4 more
2007BMC Bioinformatics67 citations Open access
Semantic Scholar
Abcg2 Overexpression Represents a Novel Mechanism for Acquired Resistance to the Multi-Kinase Inhibitor Danusertib in BCR-ABL-Positive Cells In Vitro
S. Balabanov, Artur Gontarewicz, G. Keller, L. Raddrizzani +9 more
2011PLoS ONE49 citations Open access
Semantic Scholar
Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds
D. Carrella, I. Manni, B. Tumaini, Rosanna Dattilo +15 more
2016OncoTarget40 citations Open access
Semantic Scholar
Identification of candidate substrates for poly(ADP‐ribose) polymerase‐2 (PARP2) in the absence of DNA damage using high‐density protein microarrays
S. Troiani, R. Lupi, R. Perego, Stefania Re Depaolini +3 more
2011The FEBS Journal37 citations Open access
Semantic Scholar
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
C. Visco, G. Magistrelli, R. Bosotti, R. Perego +5 more
2000Biochemistry36 citations
Semantic Scholar
RNAdetector: a free user-friendly stand-alone and cloud-based system for RNA-Seq data analysis
A. La Ferlita, S. Alaimo, S. Di Bella, Emanuele Martorana +7 more
2021BMC Bioinformatics24 citations Open access
Semantic Scholar
Detection of a polymorphism in exon 8 of the human CD86 gene
Y. Delneste, R. Bosotti, G. Magistrelli, J. Bonnefoy +1 more
2000Immunogenetics24 citations
Semantic Scholar
Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient.
M. Milione, E. Ardini, J. Christiansen, E. Valtorta +11 more
2017OncoTarget21 citations Open access
Semantic Scholar
A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data
S. Di Bella, A. La Ferlita, Giovanni Carapezza, S. Alaimo +4 more
2019Briefings Bioinform.18 citations Open access
Semantic Scholar
PATRI, a Genomics Data Integration Tool for Biomarker Discovery
G. Ukmar, G. Melloni, L. Raddrizzani, P. Rossi +12 more
2018BioMed Research International18 citations Open access
Semantic Scholar
Transcriptional Analysis of an E2F Gene Signature as a Biomarker of Activity of the Cyclin-Dependent Kinase Inhibitor PHA-793887 in Tumor and Skin Biopsies from a Phase I Clinical Study
G. Locatelli, R. Bosotti, M. Ciomei, M. Brasca +12 more
2010Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1
R. Bosotti, P. Magnaghi, S. Di Bella, L. Cozzi +14 more
2017Scientific Reports14 citations Open access
Semantic Scholar
Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient
M. Milione, E. Ardini, J. Christiansen, E. Valtorta +11 more
2017OncoTarget13 citations Open access
Semantic Scholar
Cell Line Identity Finding by Fingerprinting, an Optimized Resource for Short Tandem Repeat Profile Authentication
Alessio Somaschini, N. Amboldi, A. Nuzzo, E. Scacheri +9 more
2013Genetic Testing and Molecular Biomarkers13 citations
Semantic Scholar
Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
Giovanni Magistrelli, R. Bosotti, Barbara Valsasina, C. Visco +4 more
1999European Journal of Biochemistry8 citations
Semantic Scholar
Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.
R. Bosotti, P. Carpinelli, Sandra Healy, G. Locatelli +5 more
2012Gene7 citations
Semantic Scholar
A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug response
G. Gambardella, G. Viscido, B. Tumaini, A. Isacchi +2 more
2021bioRxiv4 citations Open access
Semantic Scholar
A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML
M. Ciomei, L. Zanetta, F. Lussana, E. Ravelli +16 more
2019Blood4 citations Open access
Semantic Scholar
Abstract 1638: Preclinical characterization of the novel TTK kinase inhibitor S81694 for the treatment of triple negative breast cancer
R. Colombo, M. Burbridge, Marianne Rodriguez, F. Cantero +10 more
20154 citations
Semantic Scholar
Mining potentially actionable kinase gene fusions in cancer cell lines with the KuNG FU database
Alessio Somaschini, S. Di Bella, Carlo Cusi, L. Raddrizzani +5 more
2020Scientific Data3 citations Open access
Semantic Scholar
KAOS: a new automated computational method for the identification of overexpressed genes
A. Nuzzo, Giovanni Carapezza, S. Di Bella, A. Pulvirenti +2 more
2016BMC Bioinformatics2 citations Open access
Semantic Scholar
The human RNA-DNA interactome is cell type-specific and dynamic
A. Lambolez, P. Sahlén, Wenjing Kang, Xu-Feng Shu +127 more
2026bioRxiv1 citations Open access
Semantic Scholar
Comprehensive kinome NGS targeted expression profiling by KING-REX
Giovanni Carapezza, Carlo Cusi, E. Rizzo, L. Raddrizzani +10 more
2019BMC Genomics1 citations Open access
Semantic Scholar
Abstract 74: Establishment and characterization of the new sacral chordoma cell line Chor-IN-1
P. Magnaghi, R. Bosotti, N. Amboldi, L. Cozzi +13 more
20151 citations
Semantic Scholar
Preface: BITS2014, the annual meeting of the Italian Society of Bioinformatics
A. Facchiano, C. Angelini, R. Bosotti, A. Guffanti +6 more
2015BMC Bioinformatics1 citations Open access
Semantic Scholar
Summarizing Probe Intensities of Affymetrix GeneChip 3' Expression Arrays Taking into Account Day-to-Day Variability
P. Magni, A. Simeone, Sandra Healy, A. Isacchi +1 more
2011IEEE/ACM Transactions on Computational Biology & Bioinformatics1 citations
Semantic Scholar
Non-parametric MANOVA Methods for Detecting Differentially Expressed Genes in Real-Time RT-PCR Experiments
N. Bassani, F. Ambrogi, R. Bosotti, M. Bertolotti +2 more
2009Computational Intelligence Methods for Bioinformatics and Biostatistics1 citations
Semantic Scholar
Abstract 4790: Identification and characterization of ATP-mimetic choline kinase inhibitors
P. Gnocchi, F. Quartieri, Alessandra Badari, R. Bosotti +16 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
KING-REX: a custom end-to-end solution for kinome gene expression profiling
Giovanni Carapezza, Carlo Cusi, E. Rizzo, L. Raddrizzani +9 more
20180 citations
Semantic Scholar
Additional file 1: of KAOS: a new automated computational method for the identification of overexpressed genes
A. Nuzzo, Giovanni Carapezza, S. Di Bella, A. Pulvirenti +2 more
20160 citations
Semantic Scholar
The Gatekeeper Through Evolution
D. Bella, C. Alli, Giovanni Carapezza, A. Pulvirenti +2 more
20150 citations
Semantic Scholar
Abstract 2851: Preclinical characterization of NMS-P648, a novel and potent PARP-1/-3 inhibitor
A. Montagnoli, G. Papeo, Sonia Rainoldi, A. Cirla +13 more
20150 citations
Semantic Scholar
An interactive tool enabling a comparative analysis of STR profiles
G. Ukmar, R. Bosotti, Alessio Somaschini, J. Malysko +5 more
20120 citations Open access
Semantic Scholar
A comprehensive 16 loci-based DNA fingerprinting dataset of a broad tumor cell line panel for cancer research
Alessio Somaschini, E. Scacheri, A. Nuzzo, N. Amboldi +4 more
20120 citations Open access
Semantic Scholar
A–C: Contribution of BCR-ABL and aurora kinase inhibition to the pro-apoptotic effects of Danusertib.
S. Balabanov, Artur Gontarewicz, G. Keller, L. Raddrizzani +9 more
20110 citations Open access
Semantic Scholar
Abstract #5445: Biomarker analysis by gene expression profiling of tumor and skin biopsies from a Phase I clinical study with the CDK inhibitor PHA-793887
G. Locatelli, R. Bosotti, M. Ciomei, W. Pastori +8 more
20090 citations
Semantic Scholar
Day-to-day variability in microarray experiment: a new algorithm to summarize probe levels and minimize this effect
R. Bosotti, P. Magni, A. Simeone
2008European Conference on Computational Biology0 citations
Semantic Scholar
Erratum: PoInTree: A polar and interactive phylogenetic tree (Genomics, Protoemics and Bioinformatics 3 (58-60))
Marco Carreras, Eleonora Gianti, Luca Sartori, S. Plyte +2 more
20050 citations
Semantic Scholar
Homologue humain de la proteine dbf4/ask1, acides nucleiques et procedes correspondants
J. Berthelsen, R. Bosotti, A. Isacchi, S. Plyte
20010 citations
Semantic Scholar

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Giovanni Carapezza — researcher profile on SciRah

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E. Ardini — researcher profile on SciRah

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M. Ciomei — researcher profile on SciRah