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T. O'Connor · SciRah

Researcher profile · Semantic Scholar

T. O'Connor

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T. O'Connor — researcher profile on SciRah

h-index: 37
Works: 97
Citations: 5,838

Most-cited papers

The importance of intrinsic disorder for protein phosphorylation.
L. Iakoucheva, P. Radivojac, Celeste J. Brown, T. O'Connor +3 more
2004Nucleic Acids Research1,425 citations Open access
Semantic Scholar
Defining the RGG/RG motif.
Palaniraja Thandapani, T. O'Connor, T. Bailey, S. Richard
2013Molecules and Cells635 citations Open access
Semantic Scholar
Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.
S. Boiteux, T. O'Connor, F. Lederer, A. Gouyette +1 more
1990Journal of Biological Chemistry290 citations Open access
Semantic Scholar
XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.
A. Campalans, S. Marsin, Y. Nakabeppu, T. O'Connor +2 more
2005DNA Repair186 citations
Semantic Scholar
The DNA damage spectrum produced by simulated sunlight.
Jung-Hoon Yoon, Chong-soon Lee, T. O'Connor, A. Yasui +1 more
2000Journal of Molecular Biology177 citations
Semantic Scholar
Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues*
Dong-Hyun Lee, Seung-Gi Jin, Sheng Cai, Yuan Chen +2 more
2005Journal of Biological Chemistry145 citations Open access
Semantic Scholar
Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.
T. O'Connor, R. Graves, G. de Murcia, B. Castaing +1 more
1993Journal of Biological Chemistry144 citations Open access
Semantic Scholar
Ring-opened 7-methylguanine residues in DNA are a block to in vitro DNA synthesis
T. O'Connor, S. Boiteux, J. Laval
1988Nucleic Acids Res.141 citations Open access
Semantic Scholar
Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli.
R. Graves, I. Felzenszwalb, Jacques Laval, T. O'Connor
1992Journal of Biological Chemistry121 citations Open access
Semantic Scholar
Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.
Dong-Hyun Lee, T. O'Connor, G. Pfeifer
2002Nucleic Acids Research118 citations Open access
Semantic Scholar
3-Methyladenine-DNA Glycosylase (MPG Protein) Interacts with Human RAD23 Proteins*
Feng Miao, M. Bouziane, R. Dammann, C. Masutani +3 more
2000Journal of Biological Chemistry117 citations Open access
Semantic Scholar
Nucleotide Excision Repair Eliminates Unique DNA-Protein Cross-links from Mammalian Cells*
D. J. Baker, G. Wuenschell, Liqun Xia, J. Termini +3 more
2007Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications.
R. Drouin, H. Rodriguez, Shu-Wei Gao, Zewdu Gebreyes +3 more
1996Free Radical Biology & Medicine112 citations
Semantic Scholar
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease.
Liqun Xia, Li Zheng, Hyun-Wook Lee, S. Bates +3 more
2005Journal of Molecular Biology105 citations
Semantic Scholar
The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts
M. Denissenko, T. Koudriakova, L. Smith, T. O'Connor +2 more
1998Oncogene105 citations
Semantic Scholar
Mapping of Copper/Hydrogen Peroxide-induced DNA Damage at Nucleotide Resolution in Human Genomic DNA by Ligation-mediated Polymerase Chain Reaction (*)
H. Rodriguez, R. Drouin, G. Holmquist, T. O'Connor +4 more
1995Journal of Biological Chemistry88 citations Open access
Semantic Scholar
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
J. Yoon, S. Iwai, T. O'Connor, G. Pfeifer
2003Nucleic Acids Research85 citations Open access
Semantic Scholar
Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells.
Ning Ye, G. P. Holmquist, T. O'Connor
1998Journal of Molecular Biology76 citations
Semantic Scholar
Enhancement of synthetic lethality via combinations of ABT-888 (a PARP inhibitor) and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models
C. Clark, J. Weitzel, T. O'Connor
2012Molecular Cancer Therapeutics72 citations Open access
Semantic Scholar
Stability, miscoding potential, and repair of 2'-deoxyxanthosine in DNA: implications for nitric oxide-induced mutagenesis.
G. Wuenschell, T. O'Connor, J. Termini
2003Biochemistry66 citations
Semantic Scholar
Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites.
Feng Miao, M. Bouziane, T. O'Connor
1998Nucleic Acids Research64 citations Open access
Semantic Scholar
DNA Repair in Human Pluripotent Stem Cells Is Distinct from That in Non-Pluripotent Human Cells
Li Z. Luo, S. Gopalakrishna-Pillai, Stephanie L. Nay, Sang-won Park +4 more
2012PLoS ONE61 citations Open access
Semantic Scholar
Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes
Thai Q. Tran, Mari B. Ishak Gabra, X. Lowman, Ying Yang +4 more
2017PLoS Biology60 citations Open access
Semantic Scholar
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA.
J. Cloutier, R. Drouin, M. Weinfeld, T. O'Connor +1 more
2001Journal of Molecular Biology59 citations
Semantic Scholar
Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.
J. Yoon, Purnima Singh, Dong-Hyun Lee, Jun-Zhuan Qiu +5 more
2005Biochemistry54 citations Open access
Semantic Scholar
TGFβ Induces ‘BRCAness’ and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA Repair Genes
Liang Liu, Weiying Zhou, Chun-Ting Cheng, Xiu-Bao Ren +11 more
2014Molecular Cancer Research52 citations Open access
Semantic Scholar
MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Chun-Ling Jiang, Seung-Gi Jin, Dong Hyun Lee, Zi-Jian Lan +6 more
2002Genomics51 citations
Semantic Scholar
Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.
M. Bouziane, Feng Miao, S. Bates, Lina Somsouk +3 more
2000Mutation research46 citations
Semantic Scholar
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker
Andrew A Beharry, S. Lacoste, T. O'Connor, E. Kool
2016Journal of the American Chemical Society45 citations Open access
Semantic Scholar
The Roles of DNA Polymerases κ and ι in the Error-free Bypass of N2-Carboxyalkyl-2′-deoxyguanosine Lesions in Mammalian Cells*
Bifeng Yuan, Changjun You, Nisana Andersen, Yong Jiang +3 more
2011Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Osiris: an integrated promoter database for Oryza sativa L
Robert T. Morris, T. O'Connor, John J. Wyrick
2008Bioinform.45 citations Open access
Semantic Scholar
Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining.
Sujata Chakraborty, Jeremy M. Stark, Can-Lan Sun, Hardik K. Modi +5 more
2012Blood43 citations Open access
Semantic Scholar
ChromatinDB: a database of genome-wide histone modification patterns for Saccharomyces cerevisiae
T. O'Connor, John J. Wyrick
2007Bioinform.43 citations Open access
Semantic Scholar
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts
Stephanie L. Nay, Dong-Hyun Lee, S. Bates, T. O'Connor
2012DNA Repair42 citations Open access
Semantic Scholar
6-Thioguanine and S6-Methylthioguanine Are Mutagenic in Human Cells
Bifeng Yuan, T. O'Connor, Yin-Sheng Wang
2010ACS Chemical Biology41 citations Open access
Semantic Scholar
DNA advanced glycation end products (DNA-AGEs) are elevated in urine and tissue in an animal model of type 2 diabetes
R. Jaramillo, S. Shuck, Yin S Chan, Xueli Liu +6 more
2017Chemical Research in Toxicology39 citations Open access
Semantic Scholar
HP1β Is a Biomarker for Breast Cancer Prognosis and PARP Inhibitor Therapy
Young-Ho Lee, Xi-Yong Liu, F. Qiu, T. O'Connor +2 more
2015PLoS ONE39 citations Open access
Semantic Scholar
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Malkhey Verma, Hans-Joerg Martin, W. Haq, T. O'Connor +2 more
2008European Journal of Pharmacology36 citations Open access
Semantic Scholar
Combined allelic dosage of Nfia and Nfib regulates cortical development
J. Bunt, J. Osinski, Jonathan W. C. Lim, D. Vidovic +7 more
2017Brain and Neuroscience Advances34 citations Open access
Semantic Scholar
DNA glycosylase activity assay based on streptavidin paramagnetic bead substrate capture.
Liqun Xia, T. O'Connor
2001Analytical Biochemistry32 citations
Semantic Scholar
Algorithm for writing a scientific manuscript
T. O'Connor, G. Holmquist
2009Biochemistry and Molecular Biology Education29 citations Open access
Semantic Scholar
Thermodynamic parameters are sequence-dependent for the supercoil-induced B to Z transition in recombinant plasmids.
T. O'Connor, D. S. Kang, R. Wells
1986Journal of Biological Chemistry29 citations Open access
Semantic Scholar
DNA direct reversal repair and alkylating agent drug resistance
Roberto Gutierrez, T. O'Connor
2021Cancer Drug Resistance28 citations Open access
Semantic Scholar
Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species.
M. Dong, Viengsai Vongchampa, L. Gingipalli, J. Cloutier +3 more
2006Mutation research27 citations
Semantic Scholar
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses
D. L. Wilson, Andrew A Beharry, Avinash C. Srivastava, T. O'Connor +1 more
2018Angewandte Chemie26 citations Open access
Semantic Scholar
Left-handed DNA helices, supercoiling, and the B-Z junction.
Robert D. Wells, R. Brennan, K. Chapman, Thomas C. Goodman +16 more
1983Cold Spring Harbor Symposia on Quantitative Biology25 citations
Semantic Scholar
DNA polymerase δ-dependent repair of DNA single strand breaks containing 3′-end proximal lesions
Jason L. Parsons, B. Preston, T. O'Connor, G. Dianov
2007Nucleic Acids Research24 citations Open access
Semantic Scholar
Ceres: software for the integrated analysis of transcription factor binding sites and nucleosome positions in Saccharomyces cerevisiae
Robert T. Morris, T. O'Connor, John J. Wyrick
2010Bioinform.22 citations Open access
Semantic Scholar
Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase.
P. Reddy, P. Jaruga, T. O'Connor, H. Rodriguez +1 more
2004Protein Expression and Purification22 citations
Semantic Scholar
Repair of DNA alkylation damage.
M. Bouziane, Feng Miao, Ning Ye, G. Holmquist +2 more
1998Acta Biochimica Polonica21 citations Open access
Semantic Scholar

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