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S. Klein · SciRah

Researcher profile · Semantic Scholar

S. Klein

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S. Klein — researcher profile on SciRah

h-index: 33
Works: 129
Citations: 3,654

Most-cited papers

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis
L. Verbeke, I. Mannaerts, R. Schierwagen, O. Govaere +10 more
2016Scientific Reports227 citations Open access
Semantic Scholar
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
R. Schierwagen, L. Maybüchen, S. Zimmer, K. Hittatiya +13 more
2015Scientific Reports174 citations Open access
Semantic Scholar
Quantification of Liver Fibrosis at T1 and T2 Mapping with Extracellular Volume Fraction MRI: Preclinical Results.
J. Luetkens, S. Klein, F. Träber, F. C. Schmeel +11 more
2018Radiology141 citations
Semantic Scholar
Extracellular Matrix Remodeling in Chronic Liver Disease
Cristina Ortiz, R. Schierwagen, L. Schaefer, S. Klein +2 more
2021Current Tissue Microenvironment Reports122 citations Open access
Semantic Scholar
G-Protein–Coupled Receptor MrgD Is a Receptor for Angiotensin-(1–7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A
Anja Tetzner, Kinga Gebolys, C. Meinert, S. Klein +4 more
2016HYPERTENSION119 citations Open access
Semantic Scholar
Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation
Sofia Monteiro, J. Grandt, F. Uschner, N. Kimer +17 more
2020Gut85 citations Open access
Semantic Scholar
Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis
C. Hackstein, Lisa M. Assmus, M. Welz, S. Klein +11 more
2016Gut77 citations
Semantic Scholar
Statins improve NASH via inhibition of RhoA and Ras.
R. Schierwagen, L. Maybüchen, K. Hittatiya, S. Klein +11 more
2016American Journal of Physiology - Gastrointestinal and Liver Physiology76 citations Open access
Semantic Scholar
CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt.
M. Berres, S. Asmacher, J. Lehmann, C. Jansen +11 more
2015Journal of Hepatology70 citations
Semantic Scholar
Rationale for the use of statins in liver disease.
R. Schierwagen, F. Uschner, F. Magdaleno, S. Klein +1 more
2017American Journal of Physiology - Gastrointestinal and Liver Physiology67 citations Open access
Semantic Scholar
Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis
S. Klein, J. Rick, J. Lehmann, R. Schierwagen +12 more
2015Gut67 citations
Semantic Scholar
Combination of CCl4with alcoholic and metabolic injuries mimics human liver fibrosis.
M. Brol, Felicitas Rösch, R. Schierwagen, F. Magdaleno +15 more
2019American Journal of Physiology - Gastrointestinal and Liver Physiology58 citations Open access
Semantic Scholar
Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure
M. Praktiknjo, Sofia Monteiro, J. Grandt, N. Kimer +16 more
2020Liver international (Print)54 citations Open access
Semantic Scholar
Novel role of nuclear receptor rev‐erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury
Ting Li, Ashley L. Eheim, S. Klein, F. Uschner +6 more
2014Hepatology54 citations Open access
Semantic Scholar
Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS
Alexander Queck, R. Carnevale, F. Uschner, R. Schierwagen +9 more
2019Gut53 citations Open access
Semantic Scholar
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Matthias Mann, L. Niu, P. Geyer, Rajat Gupta +9 more
2022bioRxiv52 citations Open access
Semantic Scholar
Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension
F. Uschner, G. Ranabhat, Steve S. Choi, M. Granzow +10 more
2015Scientific Reports52 citations Open access
Semantic Scholar
Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis
Alexander Queck, H. Bode, F. Uschner, M. Brol +11 more
2020Frontiers in Immunology44 citations Open access
Semantic Scholar
Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis
J. Görtzen, R. Schierwagen, J. Bierwolf, S. Klein +7 more
2015Frontiers in Physiology43 citations Open access
Semantic Scholar
Assessment of response to beta-blockers by expression of βArr2 and RhoA/ROCK2 in antrum mucosa in cirrhotic patients.
J. Trebicka, Matthias von Heydebrand, J. Lehmann, F. Tofteng +10 more
2016Journal of Hepatology35 citations
Semantic Scholar
Quantitative liver MRI including extracellular volume fraction for non-invasive quantification of liver fibrosis: a prospective proof-of-concept study
J. Luetkens, S. Klein, F. Traeber, F. C. Schmeel +10 more
2017Gut34 citations
Semantic Scholar
The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension
F. Uschner, Florian Schueller, I. Nikolova, S. Klein +11 more
2018OncoTarget33 citations Open access
Semantic Scholar
Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
S. Klein, C. Herath, R. Schierwagen, J. Grace +7 more
2015PLoS ONE32 citations Open access
Semantic Scholar
Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats
S. Klein, Franziska Frohn, F. Magdaleno, C. Reker-Smit +10 more
2019Scientific Reports31 citations Open access
Semantic Scholar
Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation
S. Casey, R. Schierwagen, Kai Mak, S. Klein +9 more
2019Journal of Clinical Medicine31 citations Open access
Semantic Scholar
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.
C. Hackstein, Jasper Spitzer, K. Symeonidis, Helena Horvatic +20 more
2023Journal of Hepatology30 citations Open access
Semantic Scholar
Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity
A. Riva, E. Palma, Dhruti Devshi, D. Corrigall +22 more
2021Frontiers in Physiology28 citations Open access
Semantic Scholar
Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties.
T. Beiert, V. Knappe, V. Tiyerili, F. Stöckigt +10 more
2018International Journal of Cardiology28 citations
Semantic Scholar
The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury
Linda Sevelsted-Møller, A. Fialla, R. Schierwagen, M. Biagini +13 more
2016Scientific Reports27 citations Open access
Semantic Scholar
Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties.
T. Beiert, V. Tiyerili, V. Knappe, V. Effelsberg +8 more
2017Biochemical and Biophysical Research Communications - BBRC26 citations
Semantic Scholar
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
Sandra Torres, M. Brol, F. Magdaleno, R. Schierwagen +15 more
2021Frontiers in Molecular Biosciences24 citations Open access
Semantic Scholar
Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion
Xiao-Jie Yu, N. Elfimova, Marion Müller, Daniel Bachurski +13 more
2022Cellular and Molecular Gastroenterology and Hepatology22 citations Open access
Semantic Scholar
Myostatin is associated with the presence and development of acute-on-chronic liver failure
A. Ruiz-Margáin, A. Pohlmann, Silke Lanzerath, M. Langheinrich +11 more
2023JHEP Reports21 citations Open access
Semantic Scholar
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
S. Torres, Cristina Ortiz, Nadine Bachtler, W. Gu +18 more
2022Hepatology21 citations Open access
Semantic Scholar
Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
K. Rheinwalt, U. Drebber, R. Schierwagen, S. Klein +10 more
2020Journal of Clinical Medicine21 citations Open access
Semantic Scholar
The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease
R. Schierwagen, F. Uschner, Cristina Ortiz, Sandra Torres +15 more
2020Frontiers in Immunology20 citations Open access
Semantic Scholar
Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1
Cristina Ortiz, S. Klein, W. Reul, F. Magdaleno +21 more
2021Cell Reports19 citations Open access
Semantic Scholar
Quantification of liver fibrosis: extracellular volume fraction using an MRI bolus-only technique in a rat animal model
J. Luetkens, S. Klein, F. Träber, W. Block +8 more
2019European Radiology Experimental19 citations Open access
Semantic Scholar
Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension.
S. Klein, R. Schierwagen, F. Uschner, J. Trebicka
2017Methods in molecular biology19 citations
Semantic Scholar
Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension
S. Klein, Christian Hinüber, K. Hittatiya, R. Schierwagen +5 more
2016Zeitschrift für Gastroenterologie - German Journal of Gastroenterology19 citations Open access
Semantic Scholar
Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure.
R. Schierwagen, W. Gu, A. Brieger, B. Brüne +29 more
2023American Journal of Physiology - Cell Physiology18 citations Open access
Semantic Scholar
Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview
Sandra Torres, Zeinab Abdullah, M. Brol, C. Hellerbrand +13 more
2020International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension
J. Trebicka, C. Wix, Matthias von Heydebrand, K. Hittatiya +10 more
2015Liver international (Print)14 citations
Semantic Scholar
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
M. Nielsen, J. Lehmann, D. Leeming, R. Schierwagen +9 more
2015Digestive Diseases and Sciences14 citations
Semantic Scholar
The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells
Nadine Bachtler, Sandra Torres, Cristina Ortiz, R. Schierwagen +10 more
2023PLoS ONE13 citations Open access
Semantic Scholar
Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?
K. Schwarzkopf, L. Eberle, F. Uschner, S. Klein +10 more
2020Journal of Hepatology13 citations Open access
Semantic Scholar
Combination of phosphodiesterase‐5‐inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction
F. Uschner, Kathleen Glückert, R. Paternostro, Thorsten Gnad +15 more
2020Liver international (Print)13 citations Open access
Semantic Scholar
Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models
Johannes Chang, J. Meinke, M. Geck, Marc Hebest +17 more
2021Frontiers in Physiology12 citations Open access
Semantic Scholar
Fecal Cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure
P. Hartmann, S. Lang, R. Schierwagen, S. Klein +3 more
2023Hepatobiliary & Pancreatic Diseases International11 citations Open access
Semantic Scholar
Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice
E. Dorochow, Nico Kraus, Nicolas Chenaux-Repond, Sandra C. Pierre +9 more
2023International Journal of Molecular Sciences11 citations Open access
Semantic Scholar

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