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D. Leeming · SciRah

Researcher profile · Semantic Scholar

D. Leeming

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D. Leeming — researcher profile on SciRah

h-index: 58
Works: 371
Citations: 11K

Most-cited papers

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study.
Yasaman Vali, Jenny A. Lee, J. Boursier, S. Petta +33 more
2023The Lancet Gastroenterology and Hepatology158 citations Open access
Semantic Scholar
ECM formation and degradation during fibrosis, repair, and regeneration
A. Mayorca‐Guiliani, D. Leeming, Kim Henriksen, J. Mortensen +5 more
2025npj Metabolic Health and Disease150 citations Open access
Semantic Scholar
Comparison of ADAPT, FIB4 and APRI as non-invasive predictors of liver fibrosis and NASH within the CENTAUR Screening Population.
M. Nielsen, D. Leeming, Z. Goodman, S. Friedman +10 more
2021Journal of Hepatology63 citations Open access
Semantic Scholar
The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling
M. Ackermann, J. Kamp, C. Werlein, C. Walsh +28 more
2022EBioMedicine53 citations Open access
Semantic Scholar
Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
S. Qadri, Noora Ahlholm, Ida Lønsmann, P. Pellegrini +17 more
2021Journal of Clinical Endocrinology and Metabolism52 citations Open access
Semantic Scholar
Review: Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases.
Maja Thiele, I. Villesen, L. Niu, Stine Johansen +26 more
2024Journal of Hepatology51 citations Open access
Semantic Scholar
Butyrate Protects against Diet-Induced NASH and Liver Fibrosis and Suppresses Specific Non-Canonical TGF-β Signaling Pathways in Human Hepatic Stellate Cells
Eveline Gart, W. van Duyvenvoorde, K. Toet, M. Caspers +10 more
2021Biomedicines47 citations Open access
Semantic Scholar
Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease
B. Simbrunner, I. Villesen, P. Konigshofer, B. Scheiner +17 more
2022Liver international (Print)45 citations Open access
Semantic Scholar
LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis
B. Decato, D. Leeming, J. Sand, A. Fischer +5 more
2022Respiratory Research39 citations Open access
Semantic Scholar
Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis
E. Erhardtsen, D. Rasmussen, P. Frederiksen, D. Leeming +5 more
2021JHEP Reports36 citations Open access
Semantic Scholar
Progressive alcohol‐related liver fibrosis is characterised by imbalanced collagen formation and degradation
M. Thiele, Stine Johansen, N. Gudmann, Bjørn S. Madsen +18 more
2021Alimentary Pharmacology and Therapeutics36 citations Open access
Semantic Scholar
Among simple non-invasive scores, Pro-C3 and ADAPT best exclude advanced fibrosis in Asian patients with MAFLD.
L. Tang, Hong-Lei Ma, M. Eslam, G. Wong +16 more
2021Metabolism: Clinical and Experimental34 citations Open access
Semantic Scholar
PRO‐C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol‐related liver disease
Bjørn S. Madsen, M. Thiele, S. Detlefsen, M. Kjærgaard +7 more
2021Alimentary Pharmacology and Therapeutics34 citations Open access
Semantic Scholar
Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study
Jenny A. Lee, Max Westphal, Yasman Vali, J. Boursier +37 more
2023Hepatology32 citations Open access
Semantic Scholar
Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial
Elizabeth A. Brown, A. Minnich, A. Sanyal, R. Loomba +7 more
2023JHEP Reports32 citations Open access
Semantic Scholar
Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis
C. Hesse, Valerie Beneke, S. Konzok, C. Diefenbach +8 more
2022Respiratory Research32 citations Open access
Semantic Scholar
Cluster analysis of blood biomarkers to identify molecular patterns in pulmonary fibrosis: assessment of a multicentre, prospective, observational cohort with independent validation.
H. Fainberg, Y. Moodley, I. Triguero, T. Corte +17 more
2024The Lancet Respiratory Medicine31 citations Open access
Semantic Scholar
Biomarkers of extracellular matrix formation are associated with acute-on-chronic liver failure
A. Kerbert, Saurabh Gupta, Eman Alabsawy, I. Dobler +18 more
2021JHEP Reports31 citations Open access
Semantic Scholar
Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis
D. Leeming, F. Genovese, J. Sand, D. Rasmussen +5 more
2021Respiratory Research31 citations Open access
Semantic Scholar
Forced vital capacity trajectories in patients with idiopathic pulmonary fibrosis: a secondary analysis of a multicentre, prospective, observational cohort
H. Fainberg, J. Oldham, P. Molyneaux, R. Allen +17 more
2022The Lancet Digital Health30 citations Open access
Semantic Scholar
High turnover of types III and VI collagen in progressive idiopathic pulmonary fibrosis
N. Hoyer, H. Jessen, T. Prior, J. Sand +6 more
2021Respirology (Carlton South. Print)26 citations
Semantic Scholar
Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome
B. Simbrunner, I. Villesen, B. Scheiner, R. Paternostro +11 more
2023Hepatology International25 citations Open access
Semantic Scholar
Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr−/−.Leiden Mice
M. Morrison, Eveline Gart, W. van Duyvenvoorde, Jessica Snabel +4 more
2022International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease
A. Armandi, C. Rosso, A. Nicolosi, G. Caviglia +10 more
2022Journal of Clinical Medicine23 citations Open access
Semantic Scholar
A prospective pilot study of a gluten‐free diet for primary sclerosing cholangitis and associated colitis
T. Liwinski, S. Hübener, L. Henze, P. Huebener +15 more
2022Alimentary Pharmacology and Therapeutics22 citations Open access
Semantic Scholar
The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis
S. Nielsen, A. Edsfeldt, C. Tengryd, H. Gustafsson +9 more
2021Journal of Internal Medicine22 citations Open access
Semantic Scholar
The fibroblast hormone endotrophin is a biomarker of mortality in chronic diseases.
Federica Genovese, C. Bager, Peder Frederiksen, Dario Vazquez +30 more
2024Matrix Biology21 citations Open access
Semantic Scholar
Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO‐C3)
Nikolaj Torp, M. Israelsen, M. Nielsen, C. Åstrand +10 more
2021Liver international (Print)21 citations Open access
Semantic Scholar
Validation of scores of PRO‐C3 to predict liver‐related events in alcohol‐related liver disease
Stine Johansen, M. Israelsen, I. Villesen, Nikolaj Torp +11 more
2023Liver international (Print)20 citations Open access
Semantic Scholar
PRO-C3 is a predictor of clinical outcomes in distinct cohorts of patients with advanced liver disease
M. Nielsen, G. Dolman, Rebecca Harris, P. Frederiksen +7 more
2023JHEP Reports20 citations Open access
Semantic Scholar
An MMP‐degraded and cross‐linked fragment of type III collagen as a non‐invasive biomarker of hepatic fibrosis resolution
M. Pehrsson, T. Manon-Jensen, Shu Sun, I. Villesen +9 more
2022Liver international (Print)20 citations Open access
Semantic Scholar
Stage-dependent expression of fibrogenic markers in alcohol-related liver disease.
M. Sørensen, M. Thiele, A. Krag, S. Daniels +3 more
2022Pathology, Research and Practice19 citations Open access
Semantic Scholar
COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy
M. Weckmann, T. Bahmer, J. Sand, Sarah Rank Rønnow +27 more
2021European Respiratory Journal18 citations Open access
Semantic Scholar
Longitudinal serological assessment of type VI collagen turnover is related to progression in a real-world cohort of idiopathic pulmonary fibrosis
H. Jessen, N. Hoyer, T. Prior, P. Frederiksen +6 more
2021BMC Pulmonary Medicine17 citations Open access
Semantic Scholar
Considerations for understanding protein measurements: Identification of formation, degradation and more pathological relevant epitopes.
M. Karsdal, F. Genovese, D. Rasmussen, A. Bay-Jensen +11 more
2021Clinical Biochemistry16 citations
Semantic Scholar
Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis?
M. Ruigrok, Khaled E. M. El Amasi, D. Leeming, J. Sand +3 more
2021Frontiers in Medicine14 citations Open access
Semantic Scholar
Evaluation of Laboratory and Sonographic Parameters for Detection of Portal Hypertension in Patients with Common Variable Immunodeficiency
A. Globig, Valentina Strohmeier, R. Surabattula, D. Leeming +12 more
2022Journal of Clinical Immunology13 citations Open access
Semantic Scholar
Fibrogenesis marker PRO-C3 is higher in advanced liver fibrosis and improves in patients undergoing bariatric surgery.
Pierre Bel Lassen, Nicole Nori, P. Bedossa, L. Genser +8 more
2021Journal of Clinical Endocrinology and Metabolism13 citations Open access
Semantic Scholar
N-terminal propeptide of type 3 collagen-based sequential algorithm can identify high-risk steatohepatitis and fibrosis in MAFLD
Liang-Jie Tang, Gang Li, M. Eslam, Pei-Wu Zhu +15 more
2022Hepatology International12 citations Open access
Semantic Scholar
A Serological Neoepitope Biomarker of Neutrophil Elastase-Degraded Calprotectin, Associated with Neutrophil Activity, Identifies Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease More Effectively Than Total Calprotectin
A. Hansen, J. Mortensen, S. Rønnow, M. Karsdal +2 more
2023Journal of Clinical Medicine10 citations Open access
Semantic Scholar
Serum PRO‐C3 is useful for risk prediction and fibrosis assessment in MAFLD with chronic kidney disease in an Asian cohort
Liang-Jie Tang, Dan-Qin Sun, S. J. Song, T. Yip +14 more
2024Liver international (Print)9 citations Open access
Semantic Scholar
Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD
Hannes Hegmar, Thomas Wiggers, P. Nasr, Johan Vessby +9 more
2024Journal of Internal Medicine9 citations Open access
Semantic Scholar
Comorbidity profiles in chronic obstructive pulmonary disease: a multicohort study
Line Egerod, E. T. ter Haar, M. Karsdal, D. Leeming +6 more
2025ERJ Open Research8 citations Open access
Semantic Scholar
Serologic extracellular matrix remodeling markers are related to fibrosis stage and prognosis in a phase 2b trial of simtuzumab in patients with primary sclerosing cholangitis
D. Thorburn, D. Leeming, William T. Barchuk, Ya Wang +9 more
2024Hepatology Communications8 citations Open access
Semantic Scholar
Cross-Sectional and Longitudinal Performance of Non-Invasive Tests of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
A. Armandi, C. Rosso, R. Younes, D. Leeming +10 more
2023Journal of Clinical Medicine8 citations Open access
Semantic Scholar
A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype
S. Rønnow, J. Sand, Line Mærsk Staunstrup, T. Bahmer +12 more
2022Asthma Research and Practice8 citations Open access
Semantic Scholar
Biomarkers of tissue remodelling are elevated in serum of COVID-19 patients who develop interstitial lung disease - an exploratory biomarker study
H. W. Breisnes, D. Leeming, M. Karsdal, H. Burke +4 more
2024BMC Pulmonary Medicine7 citations Open access
Semantic Scholar
Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767
Prakash Ramachandran, M. Brice, E. F. Sutherland, A. Hoy +16 more
2024Hepatology Communications7 citations Open access
Semantic Scholar
Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study
Yiwen Fan, J. Moser, M. van Meurs, D. Kiers +6 more
2024Critical Care7 citations Open access
Semantic Scholar
A serologically assessed neo-epitope biomarker of cellular fibronectin degradation is related to pulmonary fibrosis.
A. Hansen, H. W. Breisnes, T. Prior, O. Hilberg +10 more
2023Clinical Biochemistry7 citations Open access
Semantic Scholar

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