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Guan-Jin Chen · SciRah

Researcher profile · Semantic Scholar

Guan-Jin Chen

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Guan-Jin Chen — researcher profile on SciRah

h-index: 15
Works: 74
Citations: 835

Most-cited papers

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
A. Aronov, Qing Tang, Gabriel Martínez-Botella, G. Bemis +17 more
2009Journal of Medicinal Chemistry145 citations Open access
Semantic Scholar
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Ken Yamada, Hyi-Man Park, D. Rigel, K. DiPetrillo +57 more
2016Nature Chemical Biology142 citations Open access
Semantic Scholar
Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.
A. Aronov, C. Baker, G. Bemis, Jing-Rong Cao +13 more
2007Journal of Medicinal Chemistry120 citations Open access
Semantic Scholar
Mechanistic studies on the aminopeptidase from Aeromonas proteolytica: a two-metal ion mechanism for peptide hydrolysis.
Guan-Jin Chen, Tanya Edwards, Ventris M. D'Souza, R. Holz
1997Biochemistry82 citations
Semantic Scholar
Kinetic mechanism of the p38-alpha MAP kinase: phosphoryl transfer to synthetic peptides.
Guan-Jin Chen, M. Porter, John R. Bristol, M. Fitzgibbon +1 more
2000Biochemistry52 citations
Semantic Scholar
Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Maria Brousseau, K. B. Clairmont, G. Spraggon, Alec N Flyer +38 more
2021Cell Chemical Biology42 citations Open access
Semantic Scholar
Induction of immune responses in mice by vaccination with Liposome-entrapped DNA complexes encoding Toxoplasma gondii SAG1 and ROP1 genes.
Hai-Chin Chen, Guan-Jin Chen, Huan-Qin Zheng, Hong Guo
2003Chinese Medical Journal30 citations
Semantic Scholar
Structurally distinct active sites in the copper(II)-substituted aminopeptidases from Aeromonas proteolytica and Escherichia coli.
B. Bennett, W. Antholine, Ventris M. D'Souza, Guan-Jin Chen +2 more
2002Journal of the American Chemical Society30 citations Open access
Semantic Scholar
Proton NMR Spectroscopy as a Probe of Dinuclear Copper(II) Active Sites in Metalloproteins. Characterization of the Hyperactive Copper(II)-Substituted Aminopeptidase from Aeromonas proteolytica
R. Holz, B. Bennett, Guan-Jin Chen, Li-June Ming
199826 citations Open access
Semantic Scholar
Immunity induced by DNA vaccine of plasmid encoding the rhoptry protein 1 gene combined with the genetic adjuvant of pcIFN-gamma against Toxoplasma gondii in mice.
Hong Guo, Guan-Jin Chen, Feng Lu, Hong-Duo Chen +1 more
2001Chinese Medical Journal23 citations
Semantic Scholar
Abstract 4693: The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance
U. Germann, Brinley F Furey, J. Roix, W. Markland +17 more
201521 citations
Semantic Scholar
Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia.
R. Davies, Albert C. Pierce, C. Forster, Ronald L Grey +11 more
2011Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Function of the signal peptide and N- and C-terminal propeptides in the leucine aminopeptidase from Aeromonas proteolytica.
K. Bzymek, Ventris M. D'Souza, Guan-Jin Chen, Heidi J. Campbell +2 more
2004Protein Expression and Purification19 citations
Semantic Scholar
Protective effect of DNA-mediated immunization with a combination of SAG1 and IL-2 gene adjuvant against infection of Toxoplasma gondii in mice.
Guan-Jin Chen, Hai-Chin Chen, Hong Guo, Huan-Qin Zheng
2002Chinese Medical Journal17 citations
Semantic Scholar
VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia.
D. Heidary, George Huang, D. Boucher, Jianguo Ma +12 more
2012Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
The in vitro growth patterns and drug sensitivities of leukemic blast progenitors among the subtypes of acute myelocytic leukemia.
Nobuo Nara, Guan-Jin Chen, I. Murohashi, S. Tohda +6 more
1992Experimental Hematology10 citations
Semantic Scholar
GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury.
Jie-Hong Li, Yijian Li, Guan-Jin Chen, Yan Liang +7 more
2024American Journal of Pathology8 citations
Semantic Scholar
IRE1α/XBP-1 promotes β-catenin signaling activation of airway epithelium in lipopolysaccharide-induced acute lung injury.
Hai-Ling Zhang, Jie-Hong Li, Xi-Long Wang, Kai Wang +6 more
2023Pulmonary Pharmacology & Therapeutics6 citations
Semantic Scholar
Immunity induced by DNA vaccine of plasmid encoding the rhoptry protein 1 gene combined with the genetic adjuvant of pcIFN-γ against Toxoplasma gondii in mice
Hong Guo, Guan-Jin Chen, Fang Lv, Hai-Chin Chen +1 more
20015 citations
Semantic Scholar
辅酶B_(12)模型化合物的研究(IV)——气相色谱法鉴定烷基钴席夫碱配合物热分解气体产物
Guan-Jin Chen
19915 citations Open access
Semantic Scholar
Microencapsulated phase change materials functionalized with PBA for enhancing the flame retardancy of thermally regulated rigid polyurethane foam
Gaoyuan Li, Ze-Xuan Zhao, Jia-Xin Sun, Guan-Jin Chen +4 more
2025Polymer degradation and stability4 citations
Semantic Scholar
Effect of Recombinant Human D‐Factor on the Growth of Leukemic Blast Progenitors from Acute Myeloblastic Leukemia Patients
Guan-Jin Chen, M. Tomida, M. Hozumi, N. Nara
1992Japanese journal of cancer research : Gann4 citations Open access
Semantic Scholar
Development and Characterization of a Novel Rat Model for Emulating COPD-Associated Cor Pulmonale.
Zhuoji Ma, Sui-Yang Tong, Yu-Hang Huang, Neng Wang +9 more
2025American Journal of Pathology3 citations Open access
Semantic Scholar
Research on Control Strategy and Experiment of Electronic Mechanical Continuously Variable Transmission
Lei Zhang, Yan Zhai, Hai Zhao, Guan-Jin Chen
20112 citations Open access
Semantic Scholar
Simulating Cor pulmonale in chronic obstructive pulmonary disease via cigarette smoke exposure and left pulmonary artery ligation in mice
Xi-Long Wang, Guan-Jin Chen, Qian-Wen Bai, Yu-Hang Huang +6 more
2026Physiological Reports1 citations
Semantic Scholar
Surgical Excision of Symptomatic Nonunions of the Fifth Metatarsal Base Fractures: A Systematic Review of Outcomes and Complications
Zack Hill, Ceclina Cao, Patcharathorn Pookun, Fely Jhae D. Ebanculla +1 more
2025Foot & Ankle Surgery: Techniques, Reports & Cases1 citations Open access
Semantic Scholar
Clinical Observation on TCM Syndrome Differentiation with Tripterygium Glycosides Treatment of Children Anaphylatic Purpura Nephritis
Guan-Jin Chen
20121 citations
Semantic Scholar
Strengthening the "Power Electronics" Course Teaching, Focusing on Students’ Capacity-Building
Xiu-Min Yang, Guan-Jin Chen, Bo Wan, Yongshu Guo +1 more
20111 citations
Semantic Scholar
9-Ethyl-3-(imidazo[1,2-a]pyrimidin-3-yl)-9H-carbazole
Ping-Hsin Huang, Guan-Jin Chen, Y. Wen
2008Acta Crystallographica Section E1 citations Open access
Semantic Scholar
Comparison of T-lymphocyte Subsets and Phenotypes between HIV-positive Subjects and HIV-negative Subjects
Xiaoping Chen, Guan-Jin Chen, B. Xiao, Wen-Jun Shi +2 more
20011 citations
Semantic Scholar
A fluorescent GelMA hydrogel with covalently anchored nitrogen-doped carbon dots for efficient adsorption and sensitive detection of Cu(II)
Guan-Jin Chen, Dan Qiu, Li Xu, Guang-Jie Liang +4 more
2026Separation and Purification Technology0 citations
Semantic Scholar
Individualized precision therapy for severe asthma: clinical applications of biological agents and frontiers of cell therapy
Guan-Jin Chen, Chunyan Wang, Yi Han, Zhi-Tao Jiang
2026Frontiers in Immunology0 citations
Semantic Scholar
Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function
Xi-Long Wang, Kai Zhong, Rui Li, Lin Huang +3 more
2025International Journal of COPD0 citations Open access
Semantic Scholar
Abstract 10516: Identification of a PCSK9-LDLR Disruptor Macrocycle with in vivo Function
Maria Brousseau, K. B. Clairmont, G. Spraggon, Alec N Flyer +30 more
2021Circulation0 citations
Semantic Scholar
數位轉型、供應鏈整合與供應鏈績效關係之研究 -以T公司為例
Guan-Jin Chen, K. Chen
20190 citations
Semantic Scholar
DVR已老，NVR太嫩，iSCSI才是潜力股—视频监控系统的存储发展方向分析
Guan-Jin Chen
20140 citations
Semantic Scholar
少年印第安补天第十四季秘籍
Guan-Jin Chen
20140 citations
Semantic Scholar
热性惊厥与肌钙蛋白I的关系
Guan-Jin Chen, Jian-Yang Wen
20100 citations
Semantic Scholar
肺炎支原体感染276例诊治分析
Guan-Jin Chen
20090 citations
Semantic Scholar
Analysis of polymorphism in chromosome DNAs of Toxoplasma gondii isolates by pulsed field gel electrophoresis
Guan-Jin Chen
20080 citations
Semantic Scholar
以“能力動機理論”作為大學選修體育課程意願、需求與考量因素調查之理論基礎初探
Guan-Jin Chen, Yan-Ming Liang
20070 citations
Semantic Scholar
含Imidazo[1,2-a]pyrimidine 單元的光電材料;Photoelectric material including unit Imidazo[1,2-a]pyrimidine
Guan-Jin Chen, Kuangmin Chen
20060 citations
Semantic Scholar
Induction of immune responses in mice by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii SAG1 and SAG3 genes
Guan-Jin Chen
20060 citations
Semantic Scholar
含Imidazo[1,2-a]pyrimidine 單元的光電材料
Guan-Jin Chen
20060 citations
Semantic Scholar
弓形虫核酸（DNA）免疫系列研究
Guan-Jin Chen, Huan-Qin Zheng, Yong-Cen Zhou, Hong Guo +1 more
20060 citations
Semantic Scholar
Induction of immune responses in mice by the combined use of the recombinant plasmid encoding the surface antigen SAG3 of Toxoplasma gondii and the IL-2 gene adjuvant
Guan-Jin Chen
20050 citations
Semantic Scholar
弓形虫不同分离株α-Tubulin和β-Tubulin基因PCR-RFLP分析及其探针制备
Hua-Wen Li, Guan-Jin Chen, Huan-Qin Zheng, Hai Wang +4 more
20040 citations
Semantic Scholar
Research on intracellular immunization to dengue virus in the mosquito, Aedes albopictus cells
Chun Ge, Jiongli Huang, Guan-Jin Chen, Yu Wu +1 more
20030 citations
Semantic Scholar
弓形虫病基因诊断的研究进展
Yong Zhou, Xin-bing Yu, Guan-Jin Chen
20030 citations
Semantic Scholar
Induction of immune responses in mice by vaccination with Liposome-entrapped DNA complexes encoding Toxoplasma gondii SAG1 and ROPI genes
Yong-Cen Zhou, Xin-bing Yu, Hai-Chin Chen, Huanquin Zheng +3 more
20030 citations
Semantic Scholar

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Huan-Qin Zheng×6
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