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Brinley F Furey · SciRah

Researcher profile · Semantic Scholar

Brinley F Furey

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Brinley F Furey — researcher profile on SciRah

h-index: 9
Works: 22
Citations: 638

Most-cited papers

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)
U. Germann, Brinley F Furey, W. Markland, R. R. Hoover +17 more
2017Molecular Cancer Therapeutics204 citations Open access
Semantic Scholar
Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
Amy B. Hall, D. Newsome, Yuxin Wang, D. Boucher +16 more
2014OncoTarget186 citations Open access
Semantic Scholar
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
F. Foijer, L. Albacker, B. Bakker, D. Spierings +11 more
2017eLife55 citations Open access
Semantic Scholar
Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine.
R. Winquist, D. Boucher, M. Wood, Brinley F Furey
2009Biochemical Pharmacology49 citations
Semantic Scholar
Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
Tiansheng Wang, J. Duffy, Jian Wang, S. Halas +19 more
2009Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Cancer stem cells as the relevant biomass for drug discovery.
R. Winquist, Brinley F Furey, D. Boucher
2010Current opinion in pharmacology (Print)35 citations
Semantic Scholar
Abstract 4693: The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance
U. Germann, Brinley F Furey, J. Roix, W. Markland +17 more
201521 citations
Semantic Scholar
Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease
Brandon Zimmerman, Leslie Dakin, Anne Fortier, Evanthia Nanou +30 more
2025Nature Communications16 citations Open access
Semantic Scholar
Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.
Jon H Come, Timothy J Senter, Michael P Clark, John J. Court +40 more
2021Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Evaluating the immortal strand hypothesis in cancer stem cells: symmetric/self-renewal as the relevant surrogate marker of tumorigenicity.
R. Winquist, Amy B. Hall, Brenda K. Eustace, Brinley F Furey
2014Biochemical Pharmacology9 citations
Semantic Scholar
Abstract 3716: Potent radiation enhancement with VX-984, a selective DNA-PKcs inhibitor for the treatment of NSCLC
D. Boucher, R. R. Hoover, Yuxin Wang, Yong Gu +15 more
20168 citations
Semantic Scholar
The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.
J. Jain, Jianguo Ma, Brinley F Furey, C. Récher +13 more
20044 citations
Semantic Scholar
Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype
James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou +17 more
2024Communications Biology3 citations Open access
Semantic Scholar
Contributions of the kinase cross-reactivity profile of MK-0457 to clinical activity
C. Buser, Brinley F Furey, R. R. Hoover, M. Harding +1 more
20072 citations
Semantic Scholar
Small Molecule Inhibition of APOL1 Channel Activity Protects Podocytes from Mitochondrial Dysfunction, Cell Death, and Barrier Disruption Induced by APOL1 Risk Variants
S. Galvani, Kelly E. Sullivan, Heather Weber, Michael Parsons +7 more
2024Journal of the American Society of Nephrology0 citations
Semantic Scholar
Small Molecule APOL1 Channel Inhibitor Reduces Proteinuria, Rescues Podocyte Injury, and Reverses eGFR Decline in an APOL1-Mediated Kidney Disease Mouse Model
Angelo Blasio, Gizelle Mccarthy, Shyamesh Kumar, K. Stavropoulos +5 more
2024Journal of the American Society of Nephrology0 citations
Semantic Scholar
APOL1 Inhibitors Reverse Established Proteinuria in an APOL1-Mediated Kidney Disease Mouse Model
Angelo Blasio, Kelly E. Sullivan, James J. Mann, Guan-Yu Wang +15 more
2022Journal of the American Society of Nephrology0 citations
Semantic Scholar
Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
F. Foijer, L. Albacker, B. Bakker, D. Spierings +11 more
20170 citations Open access
Semantic Scholar
Proof of Principle for Local Delivery of a c-Met Inhibitor.
Howard Li, I. Kadiyala, M. Briggs, R. Shawgo +7 more
2017Journal of Pharmacy and Science0 citations
Semantic Scholar
Abstract 1644: VX-970, the first-in-class inhibitor of the DNA damage repair enzyme ATR
J. Pollard, P. Reaper, Julie Jones, C. S. Barnes +23 more
20150 citations
Semantic Scholar
Abstract LB-299: Comprehensive preclinical evaluation of VE-822, the first ATR-targeted drug candidate: a novel approach to transforming the efficacy of DNA damaging agents.
D. Boucher, P. Charlton, J. Charrier, Brinley F Furey +12 more
20130 citations
Semantic Scholar
Efficacy of MK-0457 (VX-680) in combination with docetaxel in a p53 shRNA/vector dual flank NSCLC xenograft model
Brinley F Furey, Jianguo Ma, Guizhi Yang, Jianbo Zhang +2 more
20070 citations
Semantic Scholar

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