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D. Rigel · SciRah

Researcher profile · Semantic Scholar

D. Rigel

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D. Rigel — researcher profile on SciRah

h-index: 24
Works: 60
Citations: 2,269

Most-cited papers

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual‐Acting Angiotensin Receptor—Neprilysin Inhibitor (ARNi)
Jessie Gu, A. Noè, Priya Chandra, Suliman Al-fayoumi +9 more
2010Journal of clinical pharmacology502 citations
Semantic Scholar
Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney*
T. Yin, Gulzar S. Sandhu, C. Wolfgang, A. Burrier +4 more
1997Journal of Biological Chemistry388 citations Open access
Semantic Scholar
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Ken Yamada, Hyi-Man Park, D. Rigel, K. DiPetrillo +57 more
2016Nature Chemical Biology142 citations Open access
Semantic Scholar
Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes.
A. Balasubramaniam, Sulaiman Sheriff, D. Rigel, J. E. Fischer
1990Peptides88 citations
Semantic Scholar
Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT.
D. Rigel
1988American Journal of Physiology86 citations
Semantic Scholar
Echocardiographic examination in rats and mice.
Jing Liu, D. Rigel
2009Methods in molecular biology72 citations
Semantic Scholar
Pharmacodynamic and Pharmacokinetic Characterization of the Aldosterone Synthase Inhibitor FAD286 in Two Rodent Models of Hyperaldosteronism: Comparison with the 11β-Hydroxylase Inhibitor Metyrapone
D. Rigel, Fu-Min Fu, M. Beil, Chii-Whei Hu +2 more
2010Journal of Pharmacology and Experimental Therapeutics58 citations
Semantic Scholar
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects
J. Menard, D. Rigel, C. Watson, Arco Y. Jeng +11 more
2014Journal of Translational Medicine52 citations Open access
Semantic Scholar
Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization.
Robert D. Riley, Hiroki Sato, Zhi-Qing Zhao, V. Thourani +10 more
2000Journal of Thoracic and Cardiovascular Surgery52 citations Open access
Semantic Scholar
Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats.
P. Pedersen, B. Warner, H. Bjornson, D. Hiyama +4 more
1989Surgery, gynecology & obstetrics50 citations
Semantic Scholar
Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles.
D. Rigel, I. Grupp, A. Balasubramaniam, G. Grupp
1989American Journal of Physiology48 citations
Semantic Scholar
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis.
D. Rigel, R. W. Olson, Rodney W. Lappe
1993Circulation Research45 citations Open access
Semantic Scholar
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
E. Meredith, G. Ksander, L. Monovich, J. Papillon +14 more
2013ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Excess tachycardia: heart rate after antimuscarinic agents in conscious dogs.
D. Rigel, D. Lipson, P. Katona
1984American Journal of Physiology40 citations
Semantic Scholar
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
Ken Yamada, Julian R. Levell, Tae-Yong Yoon, D. Kohls +21 more
2017Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Differential responsiveness of conduit and resistance coronary arteries to endothelin A and B receptor stimulation in anesthetized dogs.
D. Rigel, Rodney W. Lappe
1993Journal of Cardiovascular Pharmacology35 citations Open access
Semantic Scholar
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
Nelleke Snelder, B. Ploeger, Olivier Luttringer, D. Rigel +4 more
2014British Journal of Pharmacology34 citations Open access
Semantic Scholar
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
J. Papillon, C. Adams, Qi-Ying Hu, C. Lou +17 more
2015Journal of Medicinal Chemistry33 citations
Semantic Scholar
Vagal cooling blocks circulating neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) release.
M. Rudnicki, D. Rigel, D. Mcfadden
1991Journal of Surgical Research33 citations
Semantic Scholar
Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of total and myofibrillar protein breakdown in control and septic muscle: results from a preliminary study.
D. Benson, P. Hasselgren, D. Hiyama, J. James +3 more
1989Surgery33 citations
Semantic Scholar
Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.
D. Rigel, David A. Lathrop
1990Circulation Research32 citations Open access
Semantic Scholar
Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation
J. Mochel, C. Teng, Mathieu Peyrou, J. Giraudel +2 more
2018bioRxiv30 citations Open access
Semantic Scholar
PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats
N. Snelder, B. Ploeger, O. Luttringer, D. Rigel +7 more
2013British Journal of Pharmacology29 citations Open access
Semantic Scholar
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
J. Papillon, C. Lou, Alok K Singh, C. Adams +14 more
2015Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Superoxide dismutase in rats with sepsis. Effect on survival rate and amino acid transport.
B. Warner, P. Hasselgren, J. James, H. Bialkowska +3 more
1987Archives of Surgery24 citations
Semantic Scholar
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
N. Ostermann, S. Ruedisser, C. Ehrhardt, W. Breitenstein +21 more
2013Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Glycine-extended anglerfish peptide YG (aPY) a neuropeptide Y (NPY) homologue may be a precursor of a biologically active peptide.
A. Balasubramaniam, P. C. Andrews, V. Renugopalakrishnan, D. Rigel
1989Peptides21 citations
Semantic Scholar
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
E. Lorthiois, W. Breitenstein, F. Cumin, C. Ehrhardt +11 more
2013Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies
Magdalena Koziczak-Holbro, D. Rigel, B. Dumotier, D. Sykes +15 more
2019Journal of Pharmacology and Experimental Therapeutics16 citations Open access
Semantic Scholar
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
T. Ehara, O. Irie, T. Kosaka, T. Kanazawa +16 more
2014ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Chronic measurement of left ventricular pressure in freely moving rats.
Ellyce Stehlin, S. Malpas, D. Budgett, C. Barrett +6 more
2013Journal of applied physiology14 citations Open access
Semantic Scholar
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
C. Adams, Chii-Whei Hu, Arco Y. Jeng, R. Karki +12 more
2010Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats.
A. Balasubramaniam, D. Rigel, William T. Chance, M. Stein +3 more
1990Peptides13 citations
Semantic Scholar
Syntheses and receptor affinities of partial sequences of peptide YY (PYY).
A. Balasubramaniam, A. Servin, D. Rigel, C. Rouyer‐Fessard +1 more
1988Peptide research12 citations
Semantic Scholar
Synthesis and biological properties of 4-norleucine-neuropeptide Y; secondary structure of neuropeptide Y.
A. Balasubramaniam, V. Renugopalakrishnan, D. Rigel, M. Nussbaum +4 more
1989Biochimica et Biophysica Acta11 citations
Semantic Scholar
Effects of antihistamines and local anesthetics on excess tachycardia in conscious dogs.
D. Rigel, P. Katona
1986Journal of Pharmacology and Experimental Therapeutics11 citations
Semantic Scholar
1085-195 The renin inhibitor aliskiren is a potent and long-acting antihypertensive in double transgenic rats expressing human renin and angiotensinogen genes
D. Rigel, Fu-Min Fu, Shaoyong Li, W. Maniara +2 more
20049 citations Open access
Semantic Scholar
Central and peripheral effects of sculpin pancreatic polypeptide and anglerfish peptide Y in rats.
A. Balasubramaniam, D. Rigel, William T. Chance, J. E. Fischer
1992Peptide research9 citations
Semantic Scholar
Vasoactive intestinal polypeptide enhances automaticity of supraventricular pacemakers in anesthetized dogs.
D. Rigel, D. Lathrop
1991American Journal of Physiology9 citations
Semantic Scholar
Interaction of 125I-neuropeptide Y with rat cardiac membranes.
S. Sheriff, D. Rigel, J. E. Fischer, A. Balasubramaniam
1990Neuropeptides9 citations
Semantic Scholar
A novel model of conduit coronary constriction reveals local actions of endothelin-1 and prostaglandin F2alpha.
D. Rigel, S. Shetty
1997American Journal of Physiology8 citations
Semantic Scholar
Reduced Amino Acid Transport in Skeletal Muscle Caused by a Circulating Factor During Endotoxemia
B. Warner, P. Hasselgren, J. James, R. Hummel +2 more
1990Annals of Surgery8 citations Open access
Semantic Scholar
Effects of Calcium Channel Antagonists on Carotid Sinus Baroreflex Control of Arterial Pressure and Heart Rate in Anesthetized Dogs
D. Rigel, R. Millard
1989Circulation Research8 citations Open access
Semantic Scholar
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
T. Kawanami, R. Karki, Emma Cody, Qian Liu +23 more
2020ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach
N. Snelder, B. Ploeger, O. Luttringer, D. Rigel +7 more
2017Journal of Pharmacology and Experimental Therapeutics7 citations Open access
Semantic Scholar
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
Ken Yamada, Maria Brousseau, Wataru Honma, A. Iimura +14 more
2017Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
N-α-biotinylated-neuropeptide Y analogs : syntheses, cardiovascular properties, and application to cardiac NPY receptor visualization
A. Balasubramaniam, Sulaiman Sheriff, D. G. Ferguson, M. Stein +1 more
19906 citations
Semantic Scholar
Synthesis of anglerfish peptide YG (APY)
A. Balasubramaniam, D. Rigel, P. Andrews, J. Dixon +2 more
19886 citations
Semantic Scholar
A conundrum with reciprocal cardiorespiratory variables : illustration by differential baroreflex control of heart period and heart rate in selected vertebrates
D. Rigel, R. Millard
19923 citations
Semantic Scholar
Discovery of LFF269, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects
C. Lou, Alok K Singh, C. Adams, G. Ksander +12 more
20151 citations
Semantic Scholar

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