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C. Manera · SciRah

Researcher profile · Semantic Scholar

C. Manera

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C. Manera — researcher profile on SciRah

h-index: 30
Works: 194
Citations: 3,039

Most-cited papers

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation
S. Carpi, E. Scoditti, M. Massaro, Beatrice Polini +12 more
2019Nutrients91 citations Open access
Semantic Scholar
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells
S. Fogli, Chiara Arena, S. Carpi, Beatrice Polini +9 more
2016Nutrition and Cancer79 citations Open access
Semantic Scholar
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.
Beatrice Polini, M. Digiacomo, S. Carpi, S. Bertini +6 more
2018Toxicology in Vitro71 citations Open access
Semantic Scholar
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.
F. Gado, L. di Cesare Mannelli, E. Lucarini, S. Bertini +8 more
2018Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Carlotta Granchi, F. Rizzolio, Stefano Palazzolo, S. Carmignani +6 more
2016Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides
Valentina Lucchesi, Dow P. Hurst, Derek M. Shore, S. Bertini +12 more
2014Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress
L. Giusti, C. Angeloni, M. Barbalace, S. Lacerenza +9 more
2018International Journal of Molecular Sciences49 citations Open access
Semantic Scholar
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Mojgan Aghazadeh Tabrizi, P. Baraldi, S. Baraldi, E. Ruggiero +13 more
2018Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs.
G. Saccomanni, S. Del Carlo, M. Giorgi, Marco Macchia +2 more
2010Journal of Pharmaceutical and Biomedical Analysis47 citations
Semantic Scholar
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
C. Manera, G. Saccomanni, A. Malfitano, S. Bertini +11 more
2012European journal of medicinal chemistry43 citations Open access
Semantic Scholar
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.
C. Manera, A. Malfitano, Teija Parkkari, Valentina Lucchesi +14 more
2015European journal of medicinal chemistry37 citations Open access
Semantic Scholar
miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells
S. Carpi, Beatrice Polini, C. Manera, M. Digiacomo +4 more
2020Frontiers in Pharmacology36 citations Open access
Semantic Scholar
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists.
Sari Yrjölä, M. Sarparanta, A. Airaksinen, M. Hytti +9 more
2015European Journal of Pharmaceutical Sciences34 citations Open access
Semantic Scholar
The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver
D. Gabbia, S. Carpi, S. Sarcognato, L. Cannella +12 more
2021Frontiers in Nutrition32 citations Open access
Semantic Scholar
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery.
F. Gado, Serena Meini, S. Bertini, M. Digiacomo +2 more
2019Future Medicinal Chemistry32 citations Open access
Semantic Scholar
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands
F. Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A. Mohamed +15 more
2022Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis
A. Malfitano, C. Laezza, Alba D'Alessandro, C. Procaccini +7 more
2013PLoS ONE30 citations Open access
Semantic Scholar
Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
A. Capozzi, Daniela Caissutti, V. Mattei, F. Gado +9 more
2021Molecules29 citations Open access
Semantic Scholar
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors
Carlotta Granchi, F. Rizzolio, Vittorio Bordoni, Isabella Caligiuri +6 more
2016Journal of Enzyme Inhibition and Medicinal Chemistry29 citations Open access
Semantic Scholar
Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles.
M. Giorgi, G. Saccomanni, S. Del Carlo, C. Manera +1 more
2012The Veterinary Journal29 citations
Semantic Scholar
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases.
A. Chicca, Chiara Arena, C. Manera
2016Recent Patents on CNS Drug Discovery26 citations Open access
Semantic Scholar
Composition of health-promoting phenolic compounds in two extra virgin olive oils and diversity of associated yeasts
Michela Palla, M. Digiacomo, C. Cristani, S. Bertini +4 more
2018Journal of Food Composition and Analysis23 citations Open access
Semantic Scholar
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma
S. Tampucci, S. Carpi, M. Digiacomo, Beatrice Polini +6 more
2019Molecules22 citations Open access
Semantic Scholar
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.
S. Bertini, Teija Parkkari, Juha R. Savinainen, Chiara Arena +10 more
2015European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.
Lindsey Shapiro, F. Gado, C. Manera, A. Escayg
2021Neuropharmacology21 citations Open access
Semantic Scholar
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.
F. Gado, Kawthar A. Mohamed, Serena Meini, Rebecca Ferrisi +7 more
2020European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.
A. Chicca, Chiara Arena, S. Bertini, F. Gado +10 more
2018European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells
A. Capozzi, V. Mattei, S. Martellucci, V. Manganelli +5 more
2018International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Beatrice Polini, C. Cervetto, S. Carpi, Simone Pelassa +6 more
2020Life20 citations Open access
Semantic Scholar
Carbazole-containing arylcarboxamides as BACE1 inhibitors.
S. Bertini, Valentina Asso, Elisa Ghilardi, Carlotta Granchi +7 more
2011Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
F. Saponaro, Rebecca Ferrisi, F. Gado, Beatrice Polini +3 more
2021International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor.
G. Saccomanni, Giancarlo Pascali, S. Del Carlo, D. Panetta +7 more
2015Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis
A. Caddeo, M. Serra, Francesca Sedda, A. Bacci +5 more
2023Frontiers in Oncology18 citations Open access
Semantic Scholar
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Chiara Arena, F. Gado, L. di Cesare Mannelli, C. Cervetto +18 more
2020European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis
F. Gado, M. Digiacomo, M. Macchia, S. Bertini +1 more
2018Medicines16 citations Open access
Semantic Scholar
Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects
Simona Sestito, R. Ibba, F. Riu, Sara Carpi +7 more
2024Food Science & Nutrition15 citations Open access
Semantic Scholar
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases.
Rebecca Ferrisi, Costanza Ceni, S. Bertini, M. Macchia +2 more
2021Pharmacological Research15 citations Open access
Semantic Scholar
The isoprenoid derivative N6‐benzyladenosine CM223 exerts antitumor effects in glioma patient‐derived primary cells through the mevalonate pathway
E. Ciaglia, M. Grimaldi, M. Abate, M. Scrima +9 more
2017British Journal of Pharmacology15 citations Open access
Semantic Scholar
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor
S. Bertini, A. Chicca, F. Gado, Chiara Arena +8 more
2017Bioorganic & Medicinal Chemistry15 citations Open access
Semantic Scholar
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.
Valentina Lucchesi, Teija Parkkari, Juha R. Savinainen, A. Malfitano +11 more
2014European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.
S. Bertini, A. Chicca, Chiara Arena, Stefano Chicca +4 more
2016European journal of medicinal chemistry14 citations Open access
Semantic Scholar
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography
E. Serni, V. Audino, S. Del Carlo, C. Manera +2 more
2013Natural Product Research14 citations
Semantic Scholar
Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)
Rebecca Ferrisi, F. Gado, Beatrice Polini, Caterina Ricardi +9 more
2022Frontiers in Chemistry13 citations Open access
Semantic Scholar
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives
A. Malfitano, C. Laezza, G. Saccomanni, T. Tuccinardi +7 more
2013Journal of Neuroimmune Pharmacology13 citations Open access
Semantic Scholar
Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
Caterina Ricardi, Anna Mazzierli, Stefano Guglielmo, Nicola Origlia +4 more
2025International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system.
F. Gado, Chiara Arena, Cristiana La Fauci, Ines Reynoso-Moreno +9 more
2019Bioorganic chemistry (Print)11 citations
Semantic Scholar
A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.
A. Capozzi, E. Mantuano, P. Matarrese, G. Saccomanni +6 more
2012Anti-Cancer Agents in Medicinal Chemistry11 citations
Semantic Scholar
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology
G. Saccomanni, M. Giorgi, S. Del Carlo, C. Manera +2 more
2011Analytical and Bioanalytical Chemistry11 citations
Semantic Scholar
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation
M. Barbalace, M. Freschi, Irene Rinaldi, Lorenzo Zallocco +11 more
2024Antioxidants10 citations Open access
Semantic Scholar
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2
Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, F. Gado +11 more
2023International Journal of Molecular Sciences10 citations Open access
Semantic Scholar

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M. Macchia×29
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M. Macchia — researcher profile on SciRah
G. Saccomanni×23
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G. Saccomanni — researcher profile on SciRah
S. Bertini×21
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S. Bertini — researcher profile on SciRah
M. Digiacomo×18
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M. Digiacomo — researcher profile on SciRah

×18

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F. Gado — researcher profile on SciRah

Beatrice Polini×12

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Beatrice Polini — researcher profile on SciRah

T. Tuccinardi×11

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T. Tuccinardi — researcher profile on SciRah

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P. Nieri — researcher profile on SciRah

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S. Carpi — researcher profile on SciRah

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A. Chicca — researcher profile on SciRah

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M. Bifulco — researcher profile on SciRah