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Hiroyuki Nakayama · SciRah

Researcher profile · Semantic Scholar

Hiroyuki Nakayama

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Hiroyuki Nakayama — researcher profile on SciRah

h-index: 34
Works: 140
Citations: 5,530

Most-cited papers

Mitochondrial DNA That Escapes from Autophagy Causes Inflammation and Heart Failure
T. Oka, S. Hikoso, Osamu Yamaguchi, Manabu Taneike +10 more
2012Nature1,215 citations Open access
Semantic Scholar
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
Tomokazu Murakawa, Osamu Yamaguchi, Ayako Hashimoto, S. Hikoso +16 more
2015Nature Communications451 citations Open access
Semantic Scholar
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
Hiroyuki Nakayama, Xiong-Wen Chen, C. Baines, R. Klevitsky +8 more
2007Journal of Clinical Investigation441 citations Open access
Semantic Scholar
The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli
Hiroyuki Nakayama, I. Bódi, Marjorie Maillet, J. Desantiago +6 more
2010Circulation Research210 citations Open access
Semantic Scholar
Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases
Hiroyuki Nakayama, K. Otsu
2018Biochemical Journal136 citations Open access
Semantic Scholar
Calcium Influx through Cav1.2 Is a Proximal Signal for Pathological Cardiomyocyte Hypertrophy
Xiong-Wen Chen, Hiroyuki Nakayama, Xiao-Ying Zhang, Xiaojie Ai +10 more
2010Journal of Molecular and Cellular Cardiology119 citations Open access
Semantic Scholar
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.
Hiroyuki Nakayama, I. Bódi, Robert N. Correll, Xiong-Wen Chen +5 more
2009Journal of Clinical Investigation95 citations Open access
Semantic Scholar
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
Tomomi Yamashita, T. Iwakura, K. Matsui, H. Kawaguchi +11 more
2011Cardiovascular Research86 citations Open access
Semantic Scholar
Ca2+ Influx Through T- and L-Type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes
N. Jaleel, Hiroyuki Nakayama, Xiong-Wen Chen, H. Kubo +7 more
2008Circulation Research75 citations Open access
Semantic Scholar
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2
Y. Shintani, H. Drexler, H. Kioka, C. Terracciano +10 more
2014EMBO Reports74 citations Open access
Semantic Scholar
Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart.
Masanori Obana, Kaori Miyamoto, Shiho Murasawa, T. Iwakura +11 more
2012American Journal of Physiology. Heart and Circulatory Physiology61 citations
Semantic Scholar
The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.
Li-Dan Zhang, Yu-taro Noguchi, Hiroyuki Nakayama, Takayuki Kaji +9 more
2019Cell Reports56 citations Open access
Semantic Scholar
Calpain Protects the Heart from Hemodynamic Stress*
Manabu Taneike, Isamu Mizote, T. Morita, Tetsuya Watanabe +13 more
2011Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period*
Takahito Tamai, Osamu Yamaguchi, S. Hikoso, Toshihiro Takeda +13 more
2013Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Increasing Cardiac Contractility After Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction
Hongyu Zhang, Xiong-Wen Chen, E. Gao, S. Macdonnell +15 more
2010Circulation Research52 citations Open access
Semantic Scholar
Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.
Shohei Kumagai, Hiroyuki Nakayama, M. Fujimoto, H. Honda +8 more
2016Cardiovascular Research51 citations Open access
Semantic Scholar
Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading.
Jota Oyabu, Osamu Yamaguchi, S. Hikoso, Toshihiro Takeda +10 more
2013Biochemical and Biophysical Research Communications - BBRC51 citations
Semantic Scholar
Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases.
Y. Fujio, Makiko Maeda, T. Mohri, Masanori Obana +5 more
2011Journal of Pharmacological Sciences50 citations Open access
Semantic Scholar
Macromolecular Degradation Systems and Cardiovascular Aging.
Hiroyuki Nakayama, K. Nishida, K. Otsu
2016Circulation Research48 citations Open access
Semantic Scholar
Prognostic Value of Rising Serum Albumin During Hospitalization in Patients With Acute Heart Failure.
Hiroyuki Nakayama, S. Koyama, T. Kuragaichi, M. Shiba +3 more
2016American Journal of Cardiology44 citations
Semantic Scholar
Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling.
Daichi Enomoto, Masanori Obana, Akimitsu Miyawaki, Makiko Maeda +2 more
2015American Journal of Physiology. Heart and Circulatory Physiology42 citations
Semantic Scholar
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.
Ming-Xin Tang, Xiao-Ying Zhang, Yingxin Li, Yinzheng Guan +8 more
2010American Journal of Physiology. Heart and Circulatory Physiology42 citations Open access
Semantic Scholar
Translation of hemodynamic stress to sterile inflammation in the heart.
Hiroyuki Nakayama, K. Otsu
2013Trends in endocrinology and metabolism39 citations
Semantic Scholar
STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo.
T. Iwakura, T. Mohri, Tatsuto Hamatani, Masanori Obana +9 more
2011Journal of Molecular and Cellular Cardiology38 citations
Semantic Scholar
Persistent Increases in Ca2+ Influx through Cav1.2 Shortens Action Potential And Causes Ca2+ Overload-induced Afterdepolarizations and Arrhythmias
Xiao-Ying Zhang, Xiaojie Ai, Hiroyuki Nakayama, Bi-Yi Chen +11 more
2015Basic Research in Cardiology34 citations Open access
Semantic Scholar
Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice
Hiromichi Ueda, Osamu Yamaguchi, Manabu Taneike, Y. Akazawa +8 more
2019JACC: Basic to Translational Science32 citations Open access
Semantic Scholar
Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis
Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto +6 more
2017Scientific Reports29 citations Open access
Semantic Scholar
2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice
Hirofumi Morihara, Masanori Obana, Shota Tanaka, Ikki Kawakatsu +10 more
2017PLoS ONE28 citations Open access
Semantic Scholar
Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice
Atsuki Imaeda, Shota Tanaka, Kota Tonegawa, S. Fuchigami +10 more
2019Biochemical and Biophysical Research Communications - BBRC21 citations Open access
Semantic Scholar
Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population
Hiroyuki Nakayama, Hiromi Nagai, K. Matsumoto, R. Oguro +10 more
2011Hypertension Research20 citations Open access
Semantic Scholar
Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1-adrenergic stimulation.
Kota Tonegawa, Wataru Otsuka, Shohei Kumagai, Sachi Matsunami +9 more
2017American Journal of Physiology. Heart and Circulatory Physiology18 citations Open access
Semantic Scholar
JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
T. Mohri, T. Iwakura, Hiroyuki Nakayama, Y. Fujio
2012JAK-STAT18 citations Open access
Semantic Scholar
Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction
Kotaro Matsumoto, Masanori Obana, Arisa Kobayashi, Miho Kihara +7 more
2018Cardiovascular Research17 citations
Semantic Scholar
Corrigendum: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
T. Oka, S. Hikoso, Osamu Yamaguchi, Manabu Taneike +10 more
2012Nature17 citations Open access
Semantic Scholar
Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling.
Shohei Kumagai, K. Matsui, H. Kawaguchi, Tomomi Yamashita +3 more
2013Biochemical and Biophysical Research Communications - BBRC16 citations
Semantic Scholar
[Calcium dependent signaling in cardiac hypertrophy and cell death].
Hiroyuki Nakayama, Y. Fujio, Osamu Yamaguchi
2013Clinical calcium14 citations
Semantic Scholar
The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes
Reo Matsuo, Hirofumi Morihara, T. Mohri, Shiho Murasawa +4 more
2014PLoS ONE12 citations Open access
Semantic Scholar
Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy
Shota Tanaka, Y. Fujio, Hiroyuki Nakayama
2018Frontiers in Physiology11 citations Open access
Semantic Scholar
Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice
Hirofumi Morihara, Tsuyoshi Yamamoto, Harunori Oiwa, Kota Tonegawa +8 more
2017Journal of Cardiovascular Pharmacology and Therapeutics11 citations
Semantic Scholar
Verification of pharmacogenomics-based algorithms to predict warfarin maintenance dose using registered data of Japanese patients
Maki Sasano, Masako Ohno, Y. Fukuda, S. Nonen +9 more
2019European Journal of Clinical Pharmacology9 citations
Semantic Scholar
Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload
Y. Akazawa, Manabu Taneike, Hiromichi Ueda, Rika Kitazume-Taneike +12 more
2022Scientific Reports8 citations Open access
Semantic Scholar
Genetic modulation of the SERCA activity does not affect the Ca(2+) leak from the cardiac sarcoplasmic reticulum.
S. Morimoto, K. Hongo, Y. Kusakari, K. Komukai +7 more
2014Cell Calcium7 citations
Semantic Scholar
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.
Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu +7 more
2016American Journal of Physiology. Heart and Circulatory Physiology6 citations Open access
Semantic Scholar
Mitochondria and sterile inflammation in the heart
Hiroyuki Nakayama, K. Otsu
20185 citations
Semantic Scholar
Safety of Intravenous Autologous Bone Marrow-Derived Mesenchymal Cell Transplantation in 5 Patients With Reduced Left Ventricular Ejection Fraction
Yukihito Sato, T. Kuragaichi, Shunsuke Saga, Hiroyuki Nakayama +6 more
2021Circulation Reports4 citations Open access
Semantic Scholar
RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction
Daichi Enomoto, Kotaro Matsumoto, Tomomi Yamashita, Arisa Kobayashi +4 more
2017PLoS ONE4 citations Open access
Semantic Scholar
The Value of Serum Albumin in Patients with Congestive Heart Failure
Hiroyuki Nakayama, Yukihito Sato, S. Koyama, H. Fujiwara +1 more
20134 citations
Semantic Scholar
Safety of Early Enteral Nutrition for Cardiac Medical Critically Ill Patients ― A Retrospective Observational Study ―
Hiroyuki Nakayama, Y. Nishimoto, K. Hotta, Yukihito Sato
2020Circulation Reports3 citations Open access
Semantic Scholar
Ruptured Abdominal Aortic Aneurysm Treated by Double-Balloon Technique and Endovascular Strategy: Case Series
Hiroyuki Nakayama, Masanao Toma, Taishi Kobayashi, N. Ohno +3 more
2018Annals of Thoracic and Cardiovascular Surgery3 citations Open access
Semantic Scholar
Tetrodotoxin-sensitive Ca2+ currents, but no T-type currents in normal, hypertrophied and failing mouse cardiomyocytes
I. Bódi, Hiroyuki Nakayama, A. Schwartz
2016Journal of Cardiovascular Pharmacology2 citations Open access
Semantic Scholar

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Y. Fujio×22
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Y. Fujio — researcher profile on SciRah
Makiko Maeda×16
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Makiko Maeda — researcher profile on SciRah
Masanori Obana×14
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Masanori Obana — researcher profile on SciRah
K. Otsu×13
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K. Otsu — researcher profile on SciRah

Osamu Yamaguchi

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Osamu Yamaguchi — researcher profile on SciRah

Manabu Taneike×8

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Tomokazu Murakawa×8

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Tomokazu Murakawa — researcher profile on SciRah

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K. Nishida — researcher profile on SciRah

Xiong-Wen Chen×7

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Xiong-Wen Chen — researcher profile on SciRah

J. Molkentin×7

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J. Molkentin — researcher profile on SciRah

Tomomi Yamashita×7

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Tomomi Yamashita — researcher profile on SciRah

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T. Oka — researcher profile on SciRah